Incidental Mutation 'R5126:Or14j9'
ID 393582
Institutional Source Beutler Lab
Gene Symbol Or14j9
Ensembl Gene ENSMUSG00000051611
Gene Name olfactory receptor family 14 subfamily J member 9
Synonyms GA_x6K02T2PSCP-2023769-2022807, Olfr112, MOR218-4, 4930580F03Rik
MMRRC Submission 042714-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.067) question?
Stock # R5126 (G1)
Quality Score 225
Status Not validated
Chromosome 17
Chromosomal Location 37874031-37880342 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to T at 37874719 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Lysine at position 161 (T161K)
Ref Sequence ENSEMBL: ENSMUSP00000150904 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000085548] [ENSMUST00000174798] [ENSMUST00000208832] [ENSMUST00000213274]
AlphaFold Q8C0S2
Predicted Effect probably benign
Transcript: ENSMUST00000085548
AA Change: T161K

PolyPhen 2 Score 0.217 (Sensitivity: 0.91; Specificity: 0.88)
SMART Domains Protein: ENSMUSP00000082684
Gene: ENSMUSG00000051611
AA Change: T161K

DomainStartEndE-ValueType
Pfam:7tm_4 31 308 4.3e-45 PFAM
Pfam:7TM_GPCR_Srsx 35 305 5.3e-7 PFAM
Pfam:7tm_1 41 290 8.1e-23 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000173676
Predicted Effect probably benign
Transcript: ENSMUST00000174798
AA Change: T161K

PolyPhen 2 Score 0.217 (Sensitivity: 0.91; Specificity: 0.88)
SMART Domains Protein: ENSMUSP00000133654
Gene: ENSMUSG00000051611
AA Change: T161K

DomainStartEndE-ValueType
Pfam:7TM_GPCR_Srsx 35 296 3.2e-7 PFAM
Pfam:7tm_1 41 290 8.2e-30 PFAM
Pfam:7tm_4 139 283 1.7e-42 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000208832
AA Change: T161K

PolyPhen 2 Score 0.217 (Sensitivity: 0.91; Specificity: 0.88)
Predicted Effect probably benign
Transcript: ENSMUST00000213274
AA Change: T161K

PolyPhen 2 Score 0.217 (Sensitivity: 0.91; Specificity: 0.88)
Coding Region Coverage
  • 1x: 98.9%
  • 3x: 98.0%
  • 10x: 95.1%
  • 20x: 88.0%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 48 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adamts13 G A 2: 26,886,927 (GRCm39) probably null Het
Ahdc1 T A 4: 132,790,833 (GRCm39) F691L probably benign Het
Ahsa2 T A 11: 23,441,036 (GRCm39) I202F possibly damaging Het
Akap10 C T 11: 61,807,015 (GRCm39) A72T probably damaging Het
Ccnb1 C G 13: 100,918,283 (GRCm39) Q121H possibly damaging Het
Cep164 A G 9: 45,698,722 (GRCm39) probably null Het
Cltc A G 11: 86,603,495 (GRCm39) V781A probably damaging Het
Dchs1 A G 7: 105,402,724 (GRCm39) S3273P probably damaging Het
Dnajc16 C A 4: 141,501,820 (GRCm39) V337L probably benign Het
Fstl4 T C 11: 53,077,388 (GRCm39) V715A possibly damaging Het
Grik1 C T 16: 87,744,747 (GRCm39) G502S probably damaging Het
Ifi213 A G 1: 173,417,581 (GRCm39) V277A possibly damaging Het
Ints15 G T 5: 143,293,701 (GRCm39) P259T probably benign Het
Jph3 T C 8: 122,479,787 (GRCm39) V155A possibly damaging Het
Katnal2 T C 18: 77,105,294 (GRCm39) E51G probably benign Het
Kcna2 T A 3: 107,011,550 (GRCm39) F44I probably damaging Het
Kcna6 T C 6: 126,715,695 (GRCm39) E398G probably damaging Het
Kif15 A T 9: 122,804,823 (GRCm39) H190L probably damaging Het
Lmbrd2 A G 15: 9,194,788 (GRCm39) R597G possibly damaging Het
Lrtm2 T A 6: 119,294,400 (GRCm39) M244L probably benign Het
Ly6c2 A C 15: 74,983,492 (GRCm39) S9A possibly damaging Het
Mbd4 T A 6: 115,825,929 (GRCm39) probably null Het
Mfsd2b A G 12: 4,916,183 (GRCm39) I269T probably benign Het
Muc6 A T 7: 141,237,564 (GRCm39) C218S probably damaging Het
Nlrc5 G T 8: 95,201,299 (GRCm39) R131L possibly damaging Het
Nlrp1b A T 11: 71,072,359 (GRCm39) C495S possibly damaging Het
Nsf C A 11: 103,773,618 (GRCm39) E299* probably null Het
Obscn T A 11: 58,967,889 (GRCm39) E336D probably damaging Het
Pan3 A G 5: 147,464,008 (GRCm39) N587S probably benign Het
Pgap6 T C 17: 26,340,614 (GRCm39) I666T probably damaging Het
Plch2 T C 4: 155,084,976 (GRCm39) D321G probably damaging Het
Plscr4 G A 9: 92,370,794 (GRCm39) D254N probably damaging Het
Pnma8a A C 7: 16,695,242 (GRCm39) M366L probably benign Het
Pnpla7 G T 2: 24,870,056 (GRCm39) C12F possibly damaging Het
Ptprk G T 10: 28,451,640 (GRCm39) probably null Het
Rgs22 A G 15: 36,040,790 (GRCm39) V899A probably damaging Het
Ruvbl1 T A 6: 88,462,883 (GRCm39) C336S probably benign Het
Slc27a5 T A 7: 12,725,247 (GRCm39) H400L probably damaging Het
Slc66a1 T C 4: 139,029,843 (GRCm39) T63A probably benign Het
Slco1a4 A T 6: 141,761,308 (GRCm39) V435D possibly damaging Het
Snx14 A T 9: 88,264,152 (GRCm39) Y818N probably damaging Het
Tln2 A G 9: 67,165,817 (GRCm39) I2098T probably damaging Het
Tlr11 T C 14: 50,598,287 (GRCm39) L91P probably damaging Het
Tmem208 T A 8: 106,061,282 (GRCm39) F103I probably benign Het
Vmn2r3 C T 3: 64,166,740 (GRCm39) C797Y probably damaging Het
Vwde T A 6: 13,187,259 (GRCm39) M743L probably benign Het
Wdcp C A 12: 4,900,617 (GRCm39) R158S probably damaging Het
Zfp773 T C 7: 7,139,623 (GRCm39) T9A unknown Het
Other mutations in Or14j9
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02270:Or14j9 APN 17 37,874,471 (GRCm39) missense possibly damaging 0.94
IGL02900:Or14j9 APN 17 37,874,740 (GRCm39) missense possibly damaging 0.72
IGL03352:Or14j9 APN 17 37,874,681 (GRCm39) missense probably damaging 1.00
R0945:Or14j9 UTSW 17 37,874,278 (GRCm39) missense probably benign 0.00
R2475:Or14j9 UTSW 17 37,874,602 (GRCm39) missense probably benign
R4459:Or14j9 UTSW 17 37,874,365 (GRCm39) missense probably damaging 0.99
R4601:Or14j9 UTSW 17 37,875,076 (GRCm39) missense probably damaging 1.00
R6745:Or14j9 UTSW 17 37,874,470 (GRCm39) missense probably damaging 1.00
R7806:Or14j9 UTSW 17 37,875,112 (GRCm39) missense probably damaging 1.00
R9309:Or14j9 UTSW 17 37,875,049 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- ACATAGGAGATGACAATCCCAG -3'
(R):5'- AGTTCCCTGGCACAAAGTGG -3'

Sequencing Primer
(F):5'- TGACAATCCCAGTGAAACAGG -3'
(R):5'- GGCTACATTTCATATGCACAGTGC -3'
Posted On 2016-06-15