Incidental Mutation 'R5113:Reg3g'
ID 394015
Institutional Source Beutler Lab
Gene Symbol Reg3g
Ensembl Gene ENSMUSG00000030017
Gene Name regenerating islet-derived 3 gamma
Synonyms RegIII (gamma)
MMRRC Submission 042701-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R5113 (G1)
Quality Score 225
Status Not validated
Chromosome 6
Chromosomal Location 78443252-78445855 bp(-) (GRCm39)
Type of Mutation splice site
DNA Base Change (assembly) A to T at 78443544 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000032089 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000032089]
AlphaFold O09049
Predicted Effect probably null
Transcript: ENSMUST00000032089
SMART Domains Protein: ENSMUSP00000032089
Gene: ENSMUSG00000030017

DomainStartEndE-ValueType
signal peptide 1 26 N/A INTRINSIC
CLECT 40 171 1.79e-30 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000176650
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.4%
  • 10x: 96.4%
  • 20x: 92.6%
Validation Efficiency
MGI Phenotype FUNCTION: This gene encodes a C-type lectin that demonstrates bactericidal activity. This gene is predominantly expressed in the distal small intestine where the encoded protein undergoes proteolytic processing by trypsin. Mice lacking the encoded protein exhibit altered mucus distribution, increased bacterial contact with the epithelium, and elevated inflammatory markers in the ileum, and low-grade inflammation. [provided by RefSeq, Jun 2016]
PHENOTYPE: Mice homozygous for a knock-out allele eshibit increased mucosal bacterial loads, T-helper 1 cells, and intestinal permeability. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 50 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Alox12e A G 11: 70,206,821 (GRCm39) V622A possibly damaging Het
Ankef1 A G 2: 136,394,361 (GRCm39) N590S probably benign Het
Anks6 C T 4: 47,030,795 (GRCm39) G601S probably damaging Het
Ano3 A T 2: 110,491,825 (GRCm39) N867K possibly damaging Het
Ash1l T C 3: 88,973,582 (GRCm39) V2547A probably damaging Het
Chil5 A T 3: 105,925,294 (GRCm39) V209E possibly damaging Het
Cltc A T 11: 86,613,147 (GRCm39) C459S probably damaging Het
Col6a4 T A 9: 105,944,159 (GRCm39) D1105V possibly damaging Het
Cyp2c66 A G 19: 39,151,882 (GRCm39) D199G probably benign Het
Cyp4f18 A G 8: 72,742,902 (GRCm39) probably null Het
Cysrt1 A T 2: 25,129,363 (GRCm39) C50S possibly damaging Het
Dapk1 A G 13: 60,869,592 (GRCm39) K278R probably benign Het
Eefsec C A 6: 88,258,557 (GRCm39) S512I probably damaging Het
Emilin1 T C 5: 31,077,964 (GRCm39) F908L possibly damaging Het
Eml1 T C 12: 108,503,596 (GRCm39) V731A possibly damaging Het
Erc2 T C 14: 27,374,829 (GRCm39) S16P probably benign Het
Gfpt2 A G 11: 49,714,626 (GRCm39) R342G probably damaging Het
Gpr142 A T 11: 114,695,143 (GRCm39) Q36L probably benign Het
Grik5 A G 7: 24,714,952 (GRCm39) S681P probably damaging Het
Hecw1 A T 13: 14,520,614 (GRCm39) S208T possibly damaging Het
Hmgcr G A 13: 96,793,240 (GRCm39) A464V probably benign Het
Igkv2-109 A G 6: 68,280,069 (GRCm39) T97A possibly damaging Het
Ino80 G T 2: 119,262,426 (GRCm39) Q687K probably damaging Het
Kdm4d T C 9: 14,375,409 (GRCm39) N150D probably damaging Het
Klf4 A G 4: 55,530,481 (GRCm39) I210T possibly damaging Het
Klkb1 C A 8: 45,723,734 (GRCm39) Q560H probably benign Het
Lce1a2 A T 3: 92,576,442 (GRCm39) V40E unknown Het
Maob T C X: 16,582,662 (GRCm39) T400A probably benign Het
Mipol1 C T 12: 57,543,285 (GRCm39) T393I probably benign Het
Mst1 A G 9: 107,959,446 (GRCm39) D244G probably damaging Het
Nexn G A 3: 151,949,525 (GRCm39) R258C probably damaging Het
Optc T C 1: 133,828,715 (GRCm39) probably benign Het
Or10d5 T C 9: 39,861,221 (GRCm39) N282S probably damaging Het
Or11h23 A C 14: 50,948,371 (GRCm39) I195L probably benign Het
Or6c207 A G 10: 129,104,535 (GRCm39) I219T probably damaging Het
Or7a37 A G 10: 78,806,037 (GRCm39) I185V probably benign Het
Pabpc2 C A 18: 39,908,436 (GRCm39) P567Q probably benign Het
Pierce2 T A 9: 72,887,175 (GRCm39) R111* probably null Het
Ppm1j A G 3: 104,691,990 (GRCm39) H324R possibly damaging Het
Sipa1l1 C T 12: 82,487,682 (GRCm39) A1652V probably benign Het
Ski T C 4: 155,243,849 (GRCm39) T554A probably benign Het
Slfn5 G A 11: 82,852,522 (GRCm39) V883M probably benign Het
Stradb T C 1: 59,030,333 (GRCm39) probably benign Het
Tex19.1 A G 11: 121,038,625 (GRCm39) T328A probably benign Het
Tpsab1 T C 17: 25,564,373 (GRCm39) N27S possibly damaging Het
Ttn A T 2: 76,641,587 (GRCm39) L5176Q possibly damaging Het
Ttn A T 2: 76,643,244 (GRCm39) L13225Q probably damaging Het
Vmn1r28 A G 6: 58,242,843 (GRCm39) T229A probably benign Het
Wapl A G 14: 34,446,711 (GRCm39) K600E probably damaging Het
Zfp217 T C 2: 169,955,978 (GRCm39) probably null Het
Other mutations in Reg3g
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00088:Reg3g APN 6 78,443,762 (GRCm39) missense probably benign
IGL01778:Reg3g APN 6 78,443,816 (GRCm39) missense probably benign
R0389:Reg3g UTSW 6 78,445,544 (GRCm39) start codon destroyed probably null 1.00
R0513:Reg3g UTSW 6 78,444,827 (GRCm39) nonsense probably null
R0562:Reg3g UTSW 6 78,444,471 (GRCm39) missense possibly damaging 0.91
R1872:Reg3g UTSW 6 78,444,836 (GRCm39) nonsense probably null
R2402:Reg3g UTSW 6 78,444,475 (GRCm39) missense probably damaging 1.00
R4896:Reg3g UTSW 6 78,444,793 (GRCm39) missense probably benign
R7352:Reg3g UTSW 6 78,443,842 (GRCm39) nonsense probably null
R8880:Reg3g UTSW 6 78,444,788 (GRCm39) missense probably benign 0.14
R9698:Reg3g UTSW 6 78,444,805 (GRCm39) missense probably benign 0.32
Predicted Primers PCR Primer
(F):5'- GCCATAGTGCACACAGAGTTC -3'
(R):5'- GGGCAGTCCTCTCTGAAAAC -3'

Sequencing Primer
(F):5'- TAGTGCACACAGAGTTCCTCAAATG -3'
(R):5'- GTCCTCTCTGAAAACCAGTGG -3'
Posted On 2016-06-15