Incidental Mutation 'R5113:Or6c207'
ID 394027
Institutional Source Beutler Lab
Gene Symbol Or6c207
Ensembl Gene ENSMUSG00000062914
Gene Name olfactory receptor family 6 subfamily C member 207
Synonyms Olfr777, MOR114-9, GA_x6K02T2PULF-10955551-10954616
MMRRC Submission 042701-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.067) question?
Stock # R5113 (G1)
Quality Score 225
Status Not validated
Chromosome 10
Chromosomal Location 129104255-129105190 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 129104535 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Threonine at position 219 (I219T)
Ref Sequence ENSEMBL: ENSMUSP00000145475 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000080313] [ENSMUST00000204573] [ENSMUST00000213512]
AlphaFold Q8VFH3
Predicted Effect probably damaging
Transcript: ENSMUST00000080313
AA Change: I219T

PolyPhen 2 Score 0.984 (Sensitivity: 0.74; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000079191
Gene: ENSMUSG00000062914
AA Change: I219T

DomainStartEndE-ValueType
Pfam:7tm_4 28 307 1.4e-42 PFAM
Pfam:7tm_1 38 287 1.5e-22 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000204573
AA Change: I219T

PolyPhen 2 Score 0.984 (Sensitivity: 0.74; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000145475
Gene: ENSMUSG00000062914
AA Change: I219T

DomainStartEndE-ValueType
Pfam:7tm_4 28 307 1.4e-42 PFAM
Pfam:7tm_1 38 287 1.5e-22 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000213512
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.4%
  • 10x: 96.4%
  • 20x: 92.6%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 50 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Alox12e A G 11: 70,206,821 (GRCm39) V622A possibly damaging Het
Ankef1 A G 2: 136,394,361 (GRCm39) N590S probably benign Het
Anks6 C T 4: 47,030,795 (GRCm39) G601S probably damaging Het
Ano3 A T 2: 110,491,825 (GRCm39) N867K possibly damaging Het
Ash1l T C 3: 88,973,582 (GRCm39) V2547A probably damaging Het
Chil5 A T 3: 105,925,294 (GRCm39) V209E possibly damaging Het
Cltc A T 11: 86,613,147 (GRCm39) C459S probably damaging Het
Col6a4 T A 9: 105,944,159 (GRCm39) D1105V possibly damaging Het
Cyp2c66 A G 19: 39,151,882 (GRCm39) D199G probably benign Het
Cyp4f18 A G 8: 72,742,902 (GRCm39) probably null Het
Cysrt1 A T 2: 25,129,363 (GRCm39) C50S possibly damaging Het
Dapk1 A G 13: 60,869,592 (GRCm39) K278R probably benign Het
Eefsec C A 6: 88,258,557 (GRCm39) S512I probably damaging Het
Emilin1 T C 5: 31,077,964 (GRCm39) F908L possibly damaging Het
Eml1 T C 12: 108,503,596 (GRCm39) V731A possibly damaging Het
Erc2 T C 14: 27,374,829 (GRCm39) S16P probably benign Het
Gfpt2 A G 11: 49,714,626 (GRCm39) R342G probably damaging Het
Gpr142 A T 11: 114,695,143 (GRCm39) Q36L probably benign Het
Grik5 A G 7: 24,714,952 (GRCm39) S681P probably damaging Het
Hecw1 A T 13: 14,520,614 (GRCm39) S208T possibly damaging Het
Hmgcr G A 13: 96,793,240 (GRCm39) A464V probably benign Het
Igkv2-109 A G 6: 68,280,069 (GRCm39) T97A possibly damaging Het
Ino80 G T 2: 119,262,426 (GRCm39) Q687K probably damaging Het
Kdm4d T C 9: 14,375,409 (GRCm39) N150D probably damaging Het
Klf4 A G 4: 55,530,481 (GRCm39) I210T possibly damaging Het
Klkb1 C A 8: 45,723,734 (GRCm39) Q560H probably benign Het
Lce1a2 A T 3: 92,576,442 (GRCm39) V40E unknown Het
Maob T C X: 16,582,662 (GRCm39) T400A probably benign Het
Mipol1 C T 12: 57,543,285 (GRCm39) T393I probably benign Het
Mst1 A G 9: 107,959,446 (GRCm39) D244G probably damaging Het
Nexn G A 3: 151,949,525 (GRCm39) R258C probably damaging Het
Optc T C 1: 133,828,715 (GRCm39) probably benign Het
Or10d5 T C 9: 39,861,221 (GRCm39) N282S probably damaging Het
Or11h23 A C 14: 50,948,371 (GRCm39) I195L probably benign Het
Or7a37 A G 10: 78,806,037 (GRCm39) I185V probably benign Het
Pabpc2 C A 18: 39,908,436 (GRCm39) P567Q probably benign Het
Pierce2 T A 9: 72,887,175 (GRCm39) R111* probably null Het
Ppm1j A G 3: 104,691,990 (GRCm39) H324R possibly damaging Het
Reg3g A T 6: 78,443,544 (GRCm39) probably null Het
Sipa1l1 C T 12: 82,487,682 (GRCm39) A1652V probably benign Het
Ski T C 4: 155,243,849 (GRCm39) T554A probably benign Het
Slfn5 G A 11: 82,852,522 (GRCm39) V883M probably benign Het
Stradb T C 1: 59,030,333 (GRCm39) probably benign Het
Tex19.1 A G 11: 121,038,625 (GRCm39) T328A probably benign Het
Tpsab1 T C 17: 25,564,373 (GRCm39) N27S possibly damaging Het
Ttn A T 2: 76,641,587 (GRCm39) L5176Q possibly damaging Het
Ttn A T 2: 76,643,244 (GRCm39) L13225Q probably damaging Het
Vmn1r28 A G 6: 58,242,843 (GRCm39) T229A probably benign Het
Wapl A G 14: 34,446,711 (GRCm39) K600E probably damaging Het
Zfp217 T C 2: 169,955,978 (GRCm39) probably null Het
Other mutations in Or6c207
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01302:Or6c207 APN 10 129,104,392 (GRCm39) missense probably benign 0.18
IGL01782:Or6c207 APN 10 129,104,908 (GRCm39) missense probably benign 0.00
R0554:Or6c207 UTSW 10 129,104,368 (GRCm39) missense probably benign 0.00
R0594:Or6c207 UTSW 10 129,105,021 (GRCm39) missense possibly damaging 0.95
R1792:Or6c207 UTSW 10 129,105,112 (GRCm39) missense probably benign 0.20
R2357:Or6c207 UTSW 10 129,104,642 (GRCm39) missense probably benign 0.31
R2426:Or6c207 UTSW 10 129,105,135 (GRCm39) missense probably benign 0.00
R3757:Or6c207 UTSW 10 129,104,934 (GRCm39) missense probably damaging 0.99
R3758:Or6c207 UTSW 10 129,104,934 (GRCm39) missense probably damaging 0.99
R3962:Or6c207 UTSW 10 129,104,535 (GRCm39) missense probably damaging 1.00
R4600:Or6c207 UTSW 10 129,104,274 (GRCm39) missense probably benign 0.01
R4603:Or6c207 UTSW 10 129,104,274 (GRCm39) missense probably benign 0.01
R4611:Or6c207 UTSW 10 129,104,274 (GRCm39) missense probably benign 0.01
R6415:Or6c207 UTSW 10 129,104,890 (GRCm39) missense probably benign 0.01
R7540:Or6c207 UTSW 10 129,105,003 (GRCm39) missense probably benign 0.31
R7909:Or6c207 UTSW 10 129,105,136 (GRCm39) missense probably benign 0.00
R8170:Or6c207 UTSW 10 129,104,917 (GRCm39) missense possibly damaging 0.80
R9079:Or6c207 UTSW 10 129,104,466 (GRCm39) missense possibly damaging 0.90
Predicted Primers PCR Primer
(F):5'- TGGGTTCAACATAGGAGCAATG -3'
(R):5'- TGTGATCCTGCCACCACTTAG -3'

Sequencing Primer
(F):5'- TGGAAGTGGTGAGAACCATC -3'
(R):5'- CTGGGCCTCAAGCTGAAATTCTG -3'
Posted On 2016-06-15