Mutagenetix > Incidental Mutations

Incidental Mutation 'R5115:Vmn1r71'

394148

Institutional Source

Beutler Lab

Gene Symbol

Vmn1r71

Ensembl Gene

ENSMUSG00000059206

Gene Name

vomeronasal 1 receptor 71

Synonyms

V1re13

MMRRC Submission

042703-MU

Accession Numbers

Is this an essential gene?

Probably non essential (E-score: 0.051) question?

Stock #

R5115 (G1)

Quality Score

225

Status

Validated

Chromosome

Chromosomal Location

10744543-10754364 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to A at 10747958 bp

Zygosity

Heterozygous

Amino Acid Change

Methionine to Leucine at position 202 (M202L)

Ref Sequence

ENSEMBL: ENSMUSP00000153870 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000079113] [ENSMUST00000226874] [ENSMUST00000227003] [ENSMUST00000227702] [ENSMUST00000227940] [ENSMUST00000228098] [ENSMUST00000228248] [ENSMUST00000228374] [ENSMUST00000228526] [ENSMUST00000228561]

Predicted Effect

probably benign
Transcript: ENSMUST00000079113
AA Change: M268L

PolyPhen 2 Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)

SMART Domains

Protein: ENSMUSP00000078116
Gene: ENSMUSG00000059206
AA Change: M268L

Domain	Start	End	E-Value	Type
Pfam:TAS2R	3	304	2e-8	PFAM
Pfam:7tm_1	22	289	3.1e-6	PFAM
Pfam:V1R	34	297	4.8e-28	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000210233

Predicted Effect

probably benign
Transcript: ENSMUST00000226874
AA Change: M268L

PolyPhen 2 Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)

Predicted Effect

probably benign
Transcript: ENSMUST00000227003
AA Change: M268L

PolyPhen 2 Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)

Predicted Effect

probably benign
Transcript: ENSMUST00000227702
AA Change: M268L

PolyPhen 2 Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)

Predicted Effect

probably benign
Transcript: ENSMUST00000227940
AA Change: M268L

PolyPhen 2 Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)

Predicted Effect

probably benign
Transcript: ENSMUST00000228098
AA Change: M268L

PolyPhen 2 Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)

Predicted Effect

probably benign
Transcript: ENSMUST00000228248
AA Change: M268L

PolyPhen 2 Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)

Predicted Effect

probably benign
Transcript: ENSMUST00000228374
AA Change: M268L

PolyPhen 2 Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)

Predicted Effect

probably benign
Transcript: ENSMUST00000228526
AA Change: M268L

PolyPhen 2 Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)

Predicted Effect

probably benign
Transcript: ENSMUST00000228561
AA Change: M202L

PolyPhen 2 Score 0.005 (Sensitivity: 0.97; Specificity: 0.74)

Meta Mutation Damage Score

0.0898

Coding Region Coverage

1x: 99.0%
3x: 98.0%
10x: 95.2%
20x: 88.2%

Validation Efficiency

100% (47/47)

Allele List at MGI

Other mutations in this stock

Total: 31 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Acsl6	C	T	11: 54,340,498		probably null	Het
Asic1	C	T	15: 99,672,052	L85F	probably damaging	Het
Atic	G	A	1: 71,557,275		probably null	Het
Atp1b2	T	C	11: 69,603,473	T65A	probably damaging	Het
C2cd6	T	A	1: 59,051,261	I446L	probably benign	Het
Cep83	A	G	10: 94,768,889	H488R	probably benign	Het
Cwc15	A	G	9: 14,507,896	I163V	probably benign	Het
Cyp11b2	A	T	15: 74,855,428		probably null	Het
Fat2	A	G	11: 55,296,333	V1229A	probably damaging	Het
Fbn1	T	C	2: 125,332,383	D1851G	probably damaging	Het
Golga7	A	T	8: 23,245,970		probably null	Het
Gsdmc2	A	T	15: 63,827,768	H270Q	probably benign	Het
Kdm4a	G	T	4: 118,162,581	P326Q	possibly damaging	Het
Kng1	G	A	16: 23,069,282	R209H	possibly damaging	Het
Mfn1	T	C	3: 32,564,307		probably null	Het
Mllt6	G	A	11: 97,669,500	S210N	possibly damaging	Het
Nlrc5	G	A	8: 94,476,819	V516I	possibly damaging	Het
Nrbp1	T	G	5: 31,243,715	Y96*	probably null	Het
Papola	T	C	12: 105,826,960	V513A	probably benign	Het
Pikfyve	T	C	1: 65,224,117		probably benign	Het
Plin1	AGGCCACCAGGGGGTGGGC	AGGC	7: 79,729,944		probably benign	Het
Prkdc	A	G	16: 15,790,580	Q3082R	probably benign	Het
Rbfox1	A	G	16: 7,409,772	S405G	probably damaging	Het
Recql	T	C	6: 142,358,559		probably benign	Het
Serpina3c	T	C	12: 104,147,392	E365G	probably damaging	Het
Slc17a5	A	G	9: 78,577,112	V122A	probably benign	Het
Sprr2b	G	T	3: 92,317,555	C36F	unknown	Het
Stk36	T	C	1: 74,635,827	I1307T	probably damaging	Het
Tmc6	G	A	11: 117,775,188	T300I	probably damaging	Het
Ttll9	C	A	2: 152,989,590		probably benign	Het
Zfp276	A	G	8: 123,264,977		probably benign	Het

Other mutations in Vmn1r71

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00984:Vmn1r71	APN	7	10748119	missense	probably damaging	0.99
IGL01921:Vmn1r71	APN	7	10748272	missense	probably benign	0.16
IGL02397:Vmn1r71	APN	7	10748272	missense	probably benign	0.27
IGL02654:Vmn1r71	APN	7	10748315	missense	probably benign	0.42
IGL02900:Vmn1r71	APN	7	10748674	missense	probably benign	0.28
IGL03236:Vmn1r71	APN	7	10748284	missense	probably benign	0.11
IGL03269:Vmn1r71	APN	7	10748644	missense	possibly damaging	0.88
FR4976:Vmn1r71	UTSW	7	10748121	missense	probably benign
R0389:Vmn1r71	UTSW	7	10748311	missense	probably benign	0.05
R0443:Vmn1r71	UTSW	7	10748311	missense	probably benign	0.05
R0470:Vmn1r71	UTSW	7	10748092	missense	possibly damaging	0.64
R0471:Vmn1r71	UTSW	7	10748092	missense	possibly damaging	0.64
R0472:Vmn1r71	UTSW	7	10748092	missense	possibly damaging	0.64
R0567:Vmn1r71	UTSW	7	10748629	missense	probably damaging	1.00
R1498:Vmn1r71	UTSW	7	10748648	missense	probably benign	0.01
R1745:Vmn1r71	UTSW	7	10748269	missense	probably benign	0.05
R2350:Vmn1r71	UTSW	7	10747919	missense	probably benign	0.00
R2970:Vmn1r71	UTSW	7	10748714	missense	possibly damaging	0.67
R3522:Vmn1r71	UTSW	7	10747865	missense	probably benign	0.03
R4193:Vmn1r71	UTSW	7	10748248	missense	possibly damaging	0.55
R4736:Vmn1r71	UTSW	7	10747864	missense	possibly damaging	0.94
R6108:Vmn1r71	UTSW	7	10748618	missense	probably benign	0.01
R6455:Vmn1r71	UTSW	7	10748404	missense	probably benign	0.01
R6582:Vmn1r71	UTSW	7	10748681	missense	probably benign	0.00
R6696:Vmn1r71	UTSW	7	10748474	missense	probably damaging	0.96
R6778:Vmn1r71	UTSW	7	10748216	missense	probably benign	0.02
R7347:Vmn1r71	UTSW	7	10748501	missense	not run
R7631:Vmn1r71	UTSW	7	10748451	missense	probably damaging	1.00
R7795:Vmn1r71	UTSW	7	10748209	missense	probably damaging	0.98
R7820:Vmn1r71	UTSW	7	10748725	missense	possibly damaging	0.85
R7836:Vmn1r71	UTSW	7	10748350	missense	possibly damaging	0.51

Predicted Primers

PCR Primer
(F):5'- GACAAGGAATGGCTCTCTTAATG -3'
(R):5'- TTGGCAAGTGTCTCCATGATTG -3'

Sequencing Primer
(F):5'- GGCTCTCTTAATGTTCTTTATTGACC -3'
(R):5'- CCATGATTGTCATTCTGTACAGACAC -3'

Posted On

2016-06-15