Incidental Mutation 'R5116:Dnajc16'
ID 394186
Institutional Source Beutler Lab
Gene Symbol Dnajc16
Ensembl Gene ENSMUSG00000040697
Gene Name DnaJ heat shock protein family (Hsp40) member C16
Synonyms 4732437J24Rik, 2900037O03Rik
MMRRC Submission 042704-MU
Accession Numbers
Essential gene? Probably essential (E-score: 0.763) question?
Stock # R5116 (G1)
Quality Score 225
Status Validated
Chromosome 4
Chromosomal Location 141760189-141790931 bp(-) (GRCm38)
Type of Mutation nonsense
DNA Base Change (assembly) A to T at 141767969 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Tyrosine to Stop codon at position 479 (Y479*)
Ref Sequence ENSEMBL: ENSMUSP00000048714 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000038014]
AlphaFold Q80TN4
PDB Structure Solution structure of the J domain of the pseudo DnaJ protein, mouse hypothetical mKIAA0962 [SOLUTION NMR]
Predicted Effect probably null
Transcript: ENSMUST00000038014
AA Change: Y479*
SMART Domains Protein: ENSMUSP00000048714
Gene: ENSMUSG00000040697
AA Change: Y479*

DomainStartEndE-ValueType
DnaJ 28 85 4.5e-30 SMART
Pfam:Thioredoxin 142 243 4.4e-8 PFAM
low complexity region 537 549 N/A INTRINSIC
low complexity region 730 750 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000138654
Meta Mutation Damage Score 0.9755 question?
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.2%
  • 10x: 95.8%
  • 20x: 90.5%
Validation Efficiency 97% (59/61)
Allele List at MGI
Other mutations in this stock
Total: 55 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcb9 T C 5: 124,078,867 (GRCm38) H429R probably damaging Het
Adam39 G T 8: 40,825,001 (GRCm38) C143F probably damaging Het
Adamts19 T C 18: 58,902,994 (GRCm38) V417A possibly damaging Het
Adcy10 C A 1: 165,519,500 (GRCm38) A362E probably damaging Het
Akap6 A G 12: 53,141,515 (GRCm38) E1904G probably benign Het
Aldh18a1 A G 19: 40,553,505 (GRCm38) M89T probably benign Het
Alyref G T 11: 120,597,728 (GRCm38) F91L probably benign Het
Capn3 G T 2: 120,485,292 (GRCm38) M248I probably benign Het
Catsper4 A T 4: 134,226,680 (GRCm38) I56N probably damaging Het
Ccdc151 A G 9: 21,990,128 (GRCm38) *595Q probably null Het
Cckbr T A 7: 105,433,655 (GRCm38) I75N probably damaging Het
Ccr8 T C 9: 120,094,029 (GRCm38) I70T probably benign Het
Cdh24 T C 14: 54,636,413 (GRCm38) D428G probably benign Het
Cdk5rap2 G T 4: 70,307,238 (GRCm38) Q557K possibly damaging Het
Clip1 C T 5: 123,630,707 (GRCm38) A610T probably benign Het
Fpr-rs3 A G 17: 20,624,300 (GRCm38) V193A probably benign Het
Gm29125 T C 1: 80,383,973 (GRCm38) noncoding transcript Het
Hist1h1e A G 13: 23,622,287 (GRCm38) Y71H probably damaging Het
Ifi208 A G 1: 173,677,983 (GRCm38) probably benign Het
Immp1l G A 2: 105,965,295 (GRCm38) R155H probably benign Het
Itgad C A 7: 128,203,893 (GRCm38) T7K probably damaging Het
Itgb3 T C 11: 104,641,077 (GRCm38) V370A probably benign Het
Jak1 A G 4: 101,155,113 (GRCm38) I1053T probably benign Het
Kif21b A G 1: 136,152,783 (GRCm38) R572G probably damaging Het
Lama2 A T 10: 27,118,560 (GRCm38) D1784E probably benign Het
Ltbp2 A T 12: 84,809,737 (GRCm38) V651D probably damaging Het
Mrpl47 A G 3: 32,733,601 (GRCm38) L100S probably damaging Het
Mx1 T G 16: 97,457,479 (GRCm38) N6T possibly damaging Het
Nde1 T A 16: 14,183,487 (GRCm38) M133K probably benign Het
Nlrc5 T C 8: 94,481,860 (GRCm38) L778P probably damaging Het
Olfr1156 G A 2: 87,949,529 (GRCm38) R235C probably benign Het
Olfr603 G A 7: 103,383,864 (GRCm38) T46I probably benign Het
Olfr803 A G 10: 129,691,397 (GRCm38) S215P probably damaging Het
Olfr850 A G 9: 19,477,798 (GRCm38) S151P possibly damaging Het
Olfr885 T C 9: 38,061,338 (GRCm38) V6A probably benign Het
Otog T C 7: 46,273,767 (GRCm38) V1022A probably benign Het
Pcdhac1 G A 18: 37,091,447 (GRCm38) V438M probably damaging Het
Pcsk5 G A 19: 17,463,434 (GRCm38) S1264F possibly damaging Het
Pfas T C 11: 68,990,990 (GRCm38) probably benign Het
Pigr T A 1: 130,849,031 (GRCm38) F648I probably benign Het
Pla2r1 A C 2: 60,448,906 (GRCm38) Y777D probably damaging Het
Pnpla7 G T 2: 25,021,970 (GRCm38) G716V probably damaging Het
Rab11fip5 C T 6: 85,348,807 (GRCm38) E206K probably damaging Het
S100a10 A G 3: 93,560,940 (GRCm38) probably null Het
Slc35f1 T C 10: 53,021,895 (GRCm38) I134T probably benign Het
Smarcd1 C T 15: 99,702,488 (GRCm38) A56V probably benign Het
Snrk A G 9: 122,160,330 (GRCm38) T247A probably benign Het
Srgap1 A G 10: 121,792,379 (GRCm38) L896P possibly damaging Het
Tmem19 A T 10: 115,343,746 (GRCm38) F167I probably benign Het
Tmprss11f T C 5: 86,539,696 (GRCm38) S118G probably benign Het
Tnc A G 4: 63,967,215 (GRCm38) probably null Het
Trem3 T C 17: 48,249,552 (GRCm38) L17P probably benign Het
Upp2 A G 2: 58,771,542 (GRCm38) Y67C probably damaging Het
Zfp276 A G 8: 123,264,977 (GRCm38) probably benign Het
Zfp932 T A 5: 110,009,376 (GRCm38) D280E probably benign Het
Other mutations in Dnajc16
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00495:Dnajc16 APN 4 141,763,563 (GRCm38) splice site probably null
IGL00840:Dnajc16 APN 4 141,768,003 (GRCm38) missense probably damaging 1.00
IGL01503:Dnajc16 APN 4 141,763,697 (GRCm38) missense possibly damaging 0.65
IGL01919:Dnajc16 APN 4 141,774,629 (GRCm38) missense probably benign 0.06
IGL02065:Dnajc16 APN 4 141,776,933 (GRCm38) missense probably damaging 1.00
IGL02544:Dnajc16 APN 4 141,764,647 (GRCm38) missense probably damaging 1.00
IGL03028:Dnajc16 APN 4 141,767,732 (GRCm38) nonsense probably null
PIT4418001:Dnajc16 UTSW 4 141,770,949 (GRCm38) missense probably damaging 0.99
PIT4585001:Dnajc16 UTSW 4 141,764,685 (GRCm38) missense probably damaging 1.00
R0071:Dnajc16 UTSW 4 141,768,007 (GRCm38) missense probably benign
R0415:Dnajc16 UTSW 4 141,789,048 (GRCm38) nonsense probably null
R0532:Dnajc16 UTSW 4 141,789,009 (GRCm38) missense probably damaging 1.00
R1418:Dnajc16 UTSW 4 141,767,741 (GRCm38) nonsense probably null
R2959:Dnajc16 UTSW 4 141,766,545 (GRCm38) nonsense probably null
R3025:Dnajc16 UTSW 4 141,774,611 (GRCm38) missense probably benign
R3796:Dnajc16 UTSW 4 141,767,737 (GRCm38) missense probably benign
R3854:Dnajc16 UTSW 4 141,763,653 (GRCm38) nonsense probably null
R3856:Dnajc16 UTSW 4 141,763,653 (GRCm38) nonsense probably null
R4661:Dnajc16 UTSW 4 141,763,548 (GRCm38) missense probably damaging 1.00
R4841:Dnajc16 UTSW 4 141,774,625 (GRCm38) missense probably damaging 1.00
R4842:Dnajc16 UTSW 4 141,774,625 (GRCm38) missense probably damaging 1.00
R5126:Dnajc16 UTSW 4 141,774,509 (GRCm38) missense probably benign 0.01
R5140:Dnajc16 UTSW 4 141,764,683 (GRCm38) missense possibly damaging 0.85
R5275:Dnajc16 UTSW 4 141,767,928 (GRCm38) missense possibly damaging 0.82
R5295:Dnajc16 UTSW 4 141,767,928 (GRCm38) missense possibly damaging 0.82
R5891:Dnajc16 UTSW 4 141,775,392 (GRCm38) missense probably benign
R6888:Dnajc16 UTSW 4 141,776,992 (GRCm38) missense probably benign 0.24
R7062:Dnajc16 UTSW 4 141,766,690 (GRCm38) missense probably damaging 1.00
R7441:Dnajc16 UTSW 4 141,763,813 (GRCm38) missense probably damaging 1.00
R7684:Dnajc16 UTSW 4 141,774,568 (GRCm38) missense probably benign 0.02
R8843:Dnajc16 UTSW 4 141,764,691 (GRCm38) missense possibly damaging 0.87
R8924:Dnajc16 UTSW 4 141,766,707 (GRCm38) nonsense probably null
R9005:Dnajc16 UTSW 4 141,764,634 (GRCm38) missense possibly damaging 0.95
R9053:Dnajc16 UTSW 4 141,783,060 (GRCm38) missense probably benign 0.28
R9550:Dnajc16 UTSW 4 141,767,747 (GRCm38) missense possibly damaging 0.95
Predicted Primers PCR Primer
(F):5'- CAGCGTCCTACCAGTTACTG -3'
(R):5'- GGCTCAAGCTCTTGATCCTC -3'

Sequencing Primer
(F):5'- AGCGTCCTACCAGTTACTGTGAAG -3'
(R):5'- AAGCTCTTGATCCTCTTAACCTCAG -3'
Posted On 2016-06-15