Incidental Mutation 'R5045:Vmn2r59'
ID 394321
Institutional Source Beutler Lab
Gene Symbol Vmn2r59
Ensembl Gene ENSMUSG00000092032
Gene Name vomeronasal 2, receptor 59
Synonyms EG628444
MMRRC Submission 042635-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.079) question?
Stock # R5045 (G1)
Quality Score 225
Status Not validated
Chromosome 7
Chromosomal Location 41661216-41708405 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 41695496 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Aspartic acid to Glutamic Acid at position 305 (D305E)
Ref Sequence ENSEMBL: ENSMUSP00000131856 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000168489]
AlphaFold E9PUT5
Predicted Effect noncoding transcript
Transcript: ENSMUST00000121359
Predicted Effect possibly damaging
Transcript: ENSMUST00000168489
AA Change: D305E

PolyPhen 2 Score 0.929 (Sensitivity: 0.81; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000131856
Gene: ENSMUSG00000092032
AA Change: D305E

DomainStartEndE-ValueType
signal peptide 1 17 N/A INTRINSIC
Pfam:ANF_receptor 77 471 1.8e-44 PFAM
Pfam:NCD3G 514 567 4.3e-23 PFAM
Pfam:7tm_3 600 835 5.4e-53 PFAM
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.5%
  • 10x: 96.8%
  • 20x: 93.8%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 57 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1810062G17Rik T C 3: 36,530,327 (GRCm39) probably benign Het
2210408I21Rik A G 13: 77,415,927 (GRCm39) probably null Het
4930519P11Rik A T 2: 154,454,950 (GRCm39) C136* probably null Het
4930519P11Rik G T 2: 154,454,982 (GRCm39) probably benign Het
Adgrb3 T A 1: 25,113,860 (GRCm39) H1189L probably damaging Het
Arhgap24 A G 5: 103,039,743 (GRCm39) I227V possibly damaging Het
Arhgap29 C A 3: 121,796,244 (GRCm39) N445K probably benign Het
Atp13a3 T C 16: 30,158,694 (GRCm39) H811R probably benign Het
Cd2ap T C 17: 43,118,851 (GRCm39) N529S probably benign Het
Cdh20 T A 1: 110,026,080 (GRCm39) S439T probably benign Het
Ces3a G T 8: 105,777,248 (GRCm39) probably null Het
Cftr T A 6: 18,230,080 (GRCm39) N408K probably benign Het
Chil5 T C 3: 105,931,456 (GRCm39) N136S possibly damaging Het
Col20a1 A G 2: 180,648,638 (GRCm39) D933G probably damaging Het
Crh A T 3: 19,748,153 (GRCm39) L163* probably null Het
Ctps1 A C 4: 120,410,075 (GRCm39) probably null Het
Cyb5d2 A G 11: 72,686,401 (GRCm39) V63A probably damaging Het
Cyp2d11 T A 15: 82,275,272 (GRCm39) probably null Het
Dclk3 A T 9: 111,296,856 (GRCm39) E133D probably damaging Het
Dhrs9 A G 2: 69,223,339 (GRCm39) D29G probably benign Het
Disp2 G A 2: 118,622,543 (GRCm39) E1092K probably benign Het
Enpp3 A G 10: 24,652,665 (GRCm39) I764T probably damaging Het
Epm2aip1 C A 9: 111,102,427 (GRCm39) R467S possibly damaging Het
Fam20a T C 11: 109,568,711 (GRCm39) I272V probably benign Het
Fgb T C 3: 82,950,680 (GRCm39) Y358C probably damaging Het
Gm11596 A T 11: 99,683,695 (GRCm39) S142T unknown Het
Golga4 A G 9: 118,394,724 (GRCm39) T9A probably benign Het
Hmcn2 C T 2: 31,299,093 (GRCm39) P2813L probably damaging Het
Ighv1-9 C T 12: 114,547,440 (GRCm39) G34R probably damaging Het
Kalrn A C 16: 34,134,722 (GRCm39) Y353* probably null Het
Klrk1 T C 6: 129,594,466 (GRCm39) Y42C probably benign Het
Lin9 T A 1: 180,496,763 (GRCm39) L351I probably benign Het
Mbtd1 T C 11: 93,822,641 (GRCm39) Y484H probably benign Het
Mki67 T C 7: 135,309,633 (GRCm39) R273G possibly damaging Het
Myh11 A T 16: 14,057,391 (GRCm39) L308* probably null Het
Nacc2 G A 2: 25,980,150 (GRCm39) probably null Het
Nadsyn1 A G 7: 143,360,706 (GRCm39) L354P probably damaging Het
Ntrk3 T A 7: 78,110,172 (GRCm39) Q354L probably benign Het
Or10ag58 A T 2: 87,265,490 (GRCm39) I220L probably damaging Het
Or52r1c G A 7: 102,735,664 (GRCm39) G308E probably benign Het
Phactr3 T C 2: 177,973,412 (GRCm39) I470T probably damaging Het
Pkd1l3 C T 8: 110,349,787 (GRCm39) P211S unknown Het
Potefam1 T A 2: 111,023,804 (GRCm39) Q110L unknown Het
Prickle2 T C 6: 92,353,375 (GRCm39) D753G probably damaging Het
Prr12 A G 7: 44,699,318 (GRCm39) probably benign Het
Psd3 T C 8: 68,166,477 (GRCm39) E917G probably damaging Het
Rgsl1 T A 1: 153,697,268 (GRCm39) K551* probably null Het
Stag3 T C 5: 138,302,740 (GRCm39) L1033P probably damaging Het
Tcaf3 T A 6: 42,570,618 (GRCm39) Q378L possibly damaging Het
Tdpoz8 G T 3: 92,981,524 (GRCm39) D181Y probably damaging Het
Tespa1 A T 10: 130,197,904 (GRCm39) K309* probably null Het
Trim69 A G 2: 122,004,727 (GRCm39) T275A probably benign Het
Txndc17 T C 11: 72,098,537 (GRCm39) Y30H probably damaging Het
Ugt2a2 A T 5: 87,622,751 (GRCm39) F72L probably damaging Het
Vmn2r71 A G 7: 85,273,597 (GRCm39) I804V probably benign Het
Zfy2 T C Y: 2,107,159 (GRCm39) K492E possibly damaging Het
Zkscan1 A G 5: 138,099,182 (GRCm39) H375R probably damaging Het
Other mutations in Vmn2r59
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00088:Vmn2r59 APN 7 41,661,488 (GRCm39) missense possibly damaging 0.91
IGL01432:Vmn2r59 APN 7 41,661,983 (GRCm39) missense possibly damaging 0.82
IGL02119:Vmn2r59 APN 7 41,695,593 (GRCm39) missense probably benign 0.36
IGL02216:Vmn2r59 APN 7 41,661,817 (GRCm39) missense probably damaging 1.00
IGL02327:Vmn2r59 APN 7 41,661,655 (GRCm39) missense probably benign
IGL03346:Vmn2r59 APN 7 41,693,253 (GRCm39) missense probably benign 0.00
IGL03411:Vmn2r59 APN 7 41,708,340 (GRCm39) missense probably benign 0.43
IGL03412:Vmn2r59 APN 7 41,661,862 (GRCm39) missense probably benign
PIT4366001:Vmn2r59 UTSW 7 41,695,205 (GRCm39) missense possibly damaging 0.91
R0068:Vmn2r59 UTSW 7 41,695,725 (GRCm39) missense probably damaging 0.99
R0094:Vmn2r59 UTSW 7 41,661,722 (GRCm39) missense probably benign 0.07
R0179:Vmn2r59 UTSW 7 41,696,432 (GRCm39) nonsense probably null
R0370:Vmn2r59 UTSW 7 41,662,150 (GRCm39) missense probably benign 0.23
R0412:Vmn2r59 UTSW 7 41,695,916 (GRCm39) splice site probably benign
R0465:Vmn2r59 UTSW 7 41,696,332 (GRCm39) missense probably benign
R0487:Vmn2r59 UTSW 7 41,696,528 (GRCm39) nonsense probably null
R0576:Vmn2r59 UTSW 7 41,696,529 (GRCm39) missense probably benign 0.01
R0632:Vmn2r59 UTSW 7 41,708,308 (GRCm39) missense probably damaging 1.00
R1356:Vmn2r59 UTSW 7 41,661,218 (GRCm39) makesense probably null
R1387:Vmn2r59 UTSW 7 41,695,521 (GRCm39) missense probably damaging 1.00
R1388:Vmn2r59 UTSW 7 41,695,133 (GRCm39) missense probably benign 0.01
R1435:Vmn2r59 UTSW 7 41,695,629 (GRCm39) missense possibly damaging 0.50
R1750:Vmn2r59 UTSW 7 41,695,251 (GRCm39) missense possibly damaging 0.50
R2020:Vmn2r59 UTSW 7 41,693,203 (GRCm39) missense probably damaging 1.00
R2249:Vmn2r59 UTSW 7 41,708,326 (GRCm39) missense probably benign 0.00
R2256:Vmn2r59 UTSW 7 41,661,669 (GRCm39) nonsense probably null
R2257:Vmn2r59 UTSW 7 41,661,669 (GRCm39) nonsense probably null
R2441:Vmn2r59 UTSW 7 41,695,570 (GRCm39) missense probably benign 0.00
R2511:Vmn2r59 UTSW 7 41,693,190 (GRCm39) missense probably damaging 1.00
R2860:Vmn2r59 UTSW 7 41,696,427 (GRCm39) missense possibly damaging 0.79
R2861:Vmn2r59 UTSW 7 41,696,427 (GRCm39) missense possibly damaging 0.79
R3690:Vmn2r59 UTSW 7 41,661,370 (GRCm39) missense possibly damaging 0.77
R3912:Vmn2r59 UTSW 7 41,695,744 (GRCm39) missense probably benign 0.00
R4167:Vmn2r59 UTSW 7 41,670,732 (GRCm39) intron probably benign
R4357:Vmn2r59 UTSW 7 41,661,644 (GRCm39) missense probably damaging 1.00
R4445:Vmn2r59 UTSW 7 41,691,874 (GRCm39) missense probably damaging 1.00
R4542:Vmn2r59 UTSW 7 41,695,497 (GRCm39) missense possibly damaging 0.93
R4587:Vmn2r59 UTSW 7 41,695,648 (GRCm39) missense probably benign 0.00
R4616:Vmn2r59 UTSW 7 41,661,862 (GRCm39) missense probably benign
R4653:Vmn2r59 UTSW 7 41,693,228 (GRCm39) missense probably benign 0.19
R4703:Vmn2r59 UTSW 7 41,661,686 (GRCm39) missense probably benign 0.01
R4895:Vmn2r59 UTSW 7 41,695,218 (GRCm39) missense probably damaging 0.98
R4910:Vmn2r59 UTSW 7 41,693,077 (GRCm39) missense probably benign
R5105:Vmn2r59 UTSW 7 41,696,529 (GRCm39) missense probably benign 0.01
R5153:Vmn2r59 UTSW 7 41,691,834 (GRCm39) critical splice donor site probably null
R5566:Vmn2r59 UTSW 7 41,696,247 (GRCm39) missense possibly damaging 0.92
R5586:Vmn2r59 UTSW 7 41,695,105 (GRCm39) missense probably benign 0.12
R5606:Vmn2r59 UTSW 7 41,695,318 (GRCm39) missense probably benign 0.27
R5616:Vmn2r59 UTSW 7 41,708,191 (GRCm39) splice site probably null
R5625:Vmn2r59 UTSW 7 41,695,884 (GRCm39) missense probably benign 0.03
R5696:Vmn2r59 UTSW 7 41,695,468 (GRCm39) missense probably benign 0.00
R5982:Vmn2r59 UTSW 7 41,695,491 (GRCm39) missense probably benign 0.00
R6106:Vmn2r59 UTSW 7 41,661,749 (GRCm39) nonsense probably null
R6196:Vmn2r59 UTSW 7 41,661,679 (GRCm39) missense probably benign 0.36
R6228:Vmn2r59 UTSW 7 41,691,835 (GRCm39) critical splice donor site probably null
R6590:Vmn2r59 UTSW 7 41,695,890 (GRCm39) missense probably damaging 1.00
R6625:Vmn2r59 UTSW 7 41,693,177 (GRCm39) missense probably benign 0.02
R6690:Vmn2r59 UTSW 7 41,695,890 (GRCm39) missense probably damaging 1.00
R6768:Vmn2r59 UTSW 7 41,661,392 (GRCm39) missense probably benign 0.17
R6830:Vmn2r59 UTSW 7 41,693,171 (GRCm39) missense probably benign 0.10
R6859:Vmn2r59 UTSW 7 41,693,277 (GRCm39) missense probably damaging 1.00
R7034:Vmn2r59 UTSW 7 41,695,644 (GRCm39) missense probably benign 0.03
R7036:Vmn2r59 UTSW 7 41,695,644 (GRCm39) missense probably benign 0.03
R7145:Vmn2r59 UTSW 7 41,695,188 (GRCm39) missense probably damaging 1.00
R7556:Vmn2r59 UTSW 7 41,695,233 (GRCm39) missense probably damaging 1.00
R7733:Vmn2r59 UTSW 7 41,661,443 (GRCm39) missense probably benign 0.17
R7770:Vmn2r59 UTSW 7 41,708,336 (GRCm39) missense probably damaging 1.00
R7812:Vmn2r59 UTSW 7 41,695,196 (GRCm39) nonsense probably null
R7867:Vmn2r59 UTSW 7 41,661,707 (GRCm39) missense probably damaging 1.00
R7975:Vmn2r59 UTSW 7 41,693,199 (GRCm39) missense probably damaging 1.00
R7999:Vmn2r59 UTSW 7 41,696,256 (GRCm39) missense probably damaging 1.00
R8267:Vmn2r59 UTSW 7 41,661,521 (GRCm39) missense probably damaging 0.97
R8367:Vmn2r59 UTSW 7 41,661,247 (GRCm39) missense probably benign 0.44
R9106:Vmn2r59 UTSW 7 41,695,884 (GRCm39) missense probably benign 0.03
R9135:Vmn2r59 UTSW 7 41,693,127 (GRCm39) missense
R9135:Vmn2r59 UTSW 7 41,693,125 (GRCm39) missense probably benign 0.33
R9234:Vmn2r59 UTSW 7 41,661,907 (GRCm39) missense possibly damaging 0.67
R9273:Vmn2r59 UTSW 7 41,695,286 (GRCm39) nonsense probably null
R9432:Vmn2r59 UTSW 7 41,696,254 (GRCm39) missense probably damaging 1.00
R9433:Vmn2r59 UTSW 7 41,695,590 (GRCm39) missense probably damaging 0.99
R9616:Vmn2r59 UTSW 7 41,661,299 (GRCm39) missense probably damaging 1.00
R9654:Vmn2r59 UTSW 7 41,693,217 (GRCm39) missense probably benign 0.10
R9741:Vmn2r59 UTSW 7 41,708,209 (GRCm39) missense probably damaging 0.99
X0025:Vmn2r59 UTSW 7 41,695,365 (GRCm39) missense probably damaging 1.00
Z1088:Vmn2r59 UTSW 7 41,661,838 (GRCm39) missense possibly damaging 0.85
Z1176:Vmn2r59 UTSW 7 41,691,941 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- CCAAAGAAGCATTGGGTTGG -3'
(R):5'- TCTGGCACATGGAATGCATATTC -3'

Sequencing Primer
(F):5'- GGCAGTTCTCCAAAAGTTGAC -3'
(R):5'- GAATGCATATTCCAATGAACAATGG -3'
Posted On 2016-06-15