Incidental Mutation 'R5047:Tatdn3'
ID 394400
Institutional Source Beutler Lab
Gene Symbol Tatdn3
Ensembl Gene ENSMUSG00000026632
Gene Name TatD DNase domain containing 3
Synonyms 1500010M24Rik
MMRRC Submission 042637-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R5047 (G1)
Quality Score 225
Status Validated
Chromosome 1
Chromosomal Location 190778023-190795129 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 190778475 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Phenylalanine at position 239 (I239F)
Ref Sequence ENSEMBL: ENSMUSP00000106518 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000027945] [ENSMUST00000077889] [ENSMUST00000085633] [ENSMUST00000110891] [ENSMUST00000110893] [ENSMUST00000192151]
AlphaFold no structure available at present
Predicted Effect probably damaging
Transcript: ENSMUST00000027945
AA Change: I238F

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000027945
Gene: ENSMUSG00000026632
AA Change: I238F

DomainStartEndE-ValueType
Pfam:TatD_DNase 6 263 5e-57 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000077889
Predicted Effect probably benign
Transcript: ENSMUST00000085633
SMART Domains Protein: ENSMUSP00000082773
Gene: ENSMUSG00000026632

DomainStartEndE-ValueType
Pfam:TatD_DNase 6 170 1.1e-32 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000110891
SMART Domains Protein: ENSMUSP00000106516
Gene: ENSMUSG00000026632

DomainStartEndE-ValueType
Pfam:TatD_DNase 6 231 2.3e-46 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000110893
AA Change: I239F

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000106518
Gene: ENSMUSG00000026632
AA Change: I239F

DomainStartEndE-ValueType
Pfam:TatD_DNase 6 264 1.8e-57 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000156341
Predicted Effect probably benign
Transcript: ENSMUST00000192151
Meta Mutation Damage Score 0.8422 question?
Coding Region Coverage
  • 1x: 99.0%
  • 3x: 98.1%
  • 10x: 95.5%
  • 20x: 89.5%
Validation Efficiency 96% (49/51)
Allele List at MGI
Other mutations in this stock
Total: 42 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930503E14Rik A T 14: 44,406,698 (GRCm39) M117K possibly damaging Het
Adamts13 G A 2: 26,886,922 (GRCm39) A1020T probably damaging Het
Armh4 G T 14: 50,007,895 (GRCm39) A526D probably damaging Het
Atg3 C A 16: 44,998,595 (GRCm39) D132E probably benign Het
Blzf1 A G 1: 164,134,037 (GRCm39) M4T possibly damaging Het
Cdon G A 9: 35,389,935 (GRCm39) R863Q probably damaging Het
Cyp2d40 C T 15: 82,644,460 (GRCm39) R255H unknown Het
Evi5 T C 5: 107,969,740 (GRCm39) K57R probably damaging Het
Fam186b T C 15: 99,178,567 (GRCm39) E253G probably damaging Het
Fcgr1 A T 3: 96,193,200 (GRCm39) F266I probably benign Het
Fchsd1 C T 18: 38,092,926 (GRCm39) probably benign Het
Gm10142 G T 10: 77,551,996 (GRCm39) C119F probably damaging Het
Gpr63 A G 4: 25,008,202 (GRCm39) S309G probably benign Het
Herc3 C T 6: 58,832,745 (GRCm39) Q137* probably null Het
Jmy T A 13: 93,578,080 (GRCm39) H696L possibly damaging Het
Kif13a T C 13: 46,941,561 (GRCm39) H972R probably benign Het
Lama1 C T 17: 68,050,276 (GRCm39) Q296* probably null Het
Lmf1 C T 17: 25,850,812 (GRCm39) probably benign Het
Lpp T C 16: 24,790,596 (GRCm39) C352R probably damaging Het
Ltbp1 T C 17: 75,599,881 (GRCm39) probably benign Het
Maml3 G T 3: 51,598,262 (GRCm39) D807E possibly damaging Het
Mdc1 T A 17: 36,158,736 (GRCm39) V372D probably benign Het
Mst1 C A 9: 107,961,508 (GRCm39) H579Q probably benign Het
Or11g24 T C 14: 50,662,696 (GRCm39) F240S probably damaging Het
Or1r1 T C 11: 73,875,204 (GRCm39) T77A probably damaging Het
Or4a39 A G 2: 89,237,057 (GRCm39) V122A probably damaging Het
Or8d1 G A 9: 38,766,585 (GRCm39) V76I probably benign Het
Pcdhb22 G T 18: 37,652,179 (GRCm39) G216C probably damaging Het
Phlpp2 A T 8: 110,640,251 (GRCm39) H472L probably benign Het
Plscr3 A G 11: 69,740,917 (GRCm39) probably null Het
Rab7 A T 6: 87,982,205 (GRCm39) probably null Het
Rad50 A G 11: 53,565,523 (GRCm39) probably null Het
Scgb1b20 A G 7: 33,072,737 (GRCm39) probably null Het
Scn9a A C 2: 66,392,824 (GRCm39) L256R probably damaging Het
Spag1 G T 15: 36,195,588 (GRCm39) Q260H probably damaging Het
Tcof1 A G 18: 60,964,986 (GRCm39) S578P possibly damaging Het
Top3b A G 16: 16,709,282 (GRCm39) T657A probably benign Het
Tstd3 A G 4: 21,759,621 (GRCm39) probably null Het
Ttc4 A T 4: 106,525,435 (GRCm39) L233H probably damaging Het
Vmn2r130 T A 17: 23,282,794 (GRCm39) M158K probably benign Het
Yeats2 A T 16: 20,027,215 (GRCm39) Q822L probably damaging Het
Zfp976 A T 7: 42,262,843 (GRCm39) C331* probably null Het
Other mutations in Tatdn3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01383:Tatdn3 APN 1 190,787,578 (GRCm39) splice site probably benign
IGL02819:Tatdn3 APN 1 190,787,541 (GRCm39) missense probably benign 0.04
IGL02898:Tatdn3 APN 1 190,778,507 (GRCm39) makesense probably null
R0718:Tatdn3 UTSW 1 190,785,046 (GRCm39) splice site probably benign
R0892:Tatdn3 UTSW 1 190,795,002 (GRCm39) missense probably benign 0.22
R1635:Tatdn3 UTSW 1 190,792,373 (GRCm39) missense probably benign
R2018:Tatdn3 UTSW 1 190,781,477 (GRCm39) critical splice donor site probably null
R2088:Tatdn3 UTSW 1 190,785,073 (GRCm39) missense possibly damaging 0.59
R2243:Tatdn3 UTSW 1 190,785,097 (GRCm39) missense probably damaging 1.00
R3933:Tatdn3 UTSW 1 190,778,521 (GRCm39) splice site probably null
R4676:Tatdn3 UTSW 1 190,781,531 (GRCm39) missense probably damaging 1.00
R5923:Tatdn3 UTSW 1 190,781,507 (GRCm39) missense probably damaging 1.00
R6044:Tatdn3 UTSW 1 190,788,558 (GRCm39) critical splice donor site probably null
R6066:Tatdn3 UTSW 1 190,778,465 (GRCm39) missense probably benign 0.24
R7770:Tatdn3 UTSW 1 190,791,053 (GRCm39) missense probably benign 0.05
R8331:Tatdn3 UTSW 1 190,778,408 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- TTCTCTGAGGCCACTAAAGC -3'
(R):5'- TGCCAAGTTCATCCACCCTG -3'

Sequencing Primer
(F):5'- GGCCACTAAAGCAAGCCCTTG -3'
(R):5'- AAAGGAATGTCAGCTCCTTCATAGAG -3'
Posted On 2016-06-15