Mutagenetix > Incidental Mutations

Incidental Mutation 'R5048:Lilra6'

394458

Institutional Source

Beutler Lab

Gene Symbol

Lilra6

Ensembl Gene

ENSMUSG00000030427

Gene Name

leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 6

Synonyms

Pira3, 7M1

MMRRC Submission

042638-MU

Accession Numbers

Is this an essential gene?

Probably non essential (E-score: 0.072) question?

Stock #

R5048 (G1)

Quality Score

225

Status

Validated

Chromosome

Chromosomal Location

3908280-3915503 bp(-) (GRCm38)

Type of Mutation

critical splice donor site (1 bp from exon)

DNA Base Change (assembly)

C to T at 3915441 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000088188 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000038176] [ENSMUST00000090689] [ENSMUST00000206077]

AlphaFold

A0A0B4J1F3

Predicted Effect

probably null
Transcript: ENSMUST00000038176

SMART Domains

Protein: ENSMUSP00000042636
Gene: ENSMUSG00000030427

Domain	Start	End	E-Value	Type
low complexity region	8	17	N/A	INTRINSIC
IG_like	40	105	3.11e0	SMART
IG	129	315	4.53e-2	SMART
IG_like	237	302	1.54e-1	SMART
IG_like	328	415	1.79e1	SMART
IG_like	429	517	2.66e1	SMART
IG	529	618	8.59e-3	SMART
low complexity region	637	646	N/A	INTRINSIC

Predicted Effect

probably null
Transcript: ENSMUST00000090689

SMART Domains

Protein: ENSMUSP00000088188
Gene: ENSMUSG00000030427

Domain	Start	End	E-Value	Type
low complexity region	8	17	N/A	INTRINSIC
IG_like	34	118	7.25e0	SMART
IG_like	129	220	1.62e2	SMART
IG_like	290	377	1.79e1	SMART
IG_like	391	479	2.66e1	SMART
IG	491	580	8.59e-3	SMART
low complexity region	599	608	N/A	INTRINSIC

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000131255

Predicted Effect

probably benign
Transcript: ENSMUST00000206077

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000206851

Meta Mutation Damage Score

0.8661

Coding Region Coverage

1x: 99.1%
3x: 98.3%
10x: 96.2%
20x: 92.1%

Validation Efficiency

98% (64/65)

Allele List at MGI

Other mutations in this stock

Total: 55 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abcb11	T	C	2: 69,308,506	I144V	probably benign	Het
Abhd5	T	C	9: 122,377,903	Y85H	probably damaging	Het
Acadsb	G	A	7: 131,437,469	G323D	probably damaging	Het
Amotl2	A	G	9: 102,723,798	R322G	probably benign	Het
Aox1	A	T	1: 58,059,482		probably benign	Het
Aste1	C	T	9: 105,396,989	R82W	probably damaging	Het
Atg4b	T	C	1: 93,775,658	I139T	possibly damaging	Het
Btnl5-ps	T	A	17: 34,488,723		noncoding transcript	Het
Ccdc85c	A	G	12: 108,221,707		probably null	Het
Clasp1	A	G	1: 118,547,610		probably benign	Het
Defb10	G	A	8: 21,861,871	C44Y	probably damaging	Het
Dhrs9	T	C	2: 69,394,400	V144A	probably damaging	Het
Dnhd1	G	C	7: 105,693,697	S1416T	probably benign	Het
Dok1	T	A	6: 83,032,106		probably benign	Het
Emilin2	G	A	17: 71,273,967	T588M	probably damaging	Het
Fam181b	A	G	7: 93,079,939		probably benign	Het
Fhad1	T	C	4: 141,964,676		probably null	Het
Foxi2	A	G	7: 135,411,635	E198G	probably damaging	Het
Fsip2	C	A	2: 82,993,150	A6409E	probably damaging	Het
Gje1	T	C	10: 14,717,277	Y65C	probably damaging	Het
Gm38394	T	C	1: 133,658,724	S292G	probably damaging	Het
Gm6401	T	C	14: 41,967,767		probably null	Het
Gprc5c	T	C	11: 114,870,351	*442Q	probably null	Het
Iars	T	A	13: 49,688,237	I67N	probably damaging	Het
Igkv4-79	T	C	6: 69,042,987	S115G	probably benign	Het
Itga4	C	A	2: 79,273,034	S156R	probably benign	Het
Majin	C	A	19: 6,222,654	A208E	probably benign	Het
Megf8	A	G	7: 25,331,092	Q490R	possibly damaging	Het
Mfng	C	T	15: 78,764,388	R163H	probably benign	Het
Mgarp	G	A	3: 51,391,286	R88C	probably damaging	Het
Msh2	T	C	17: 87,672,768	F58S	probably damaging	Het
Nemp1	T	C	10: 127,690,935		probably null	Het
Nlrp10	A	T	7: 108,924,565	N569K	probably benign	Het
Nxpe2	T	C	9: 48,326,088		probably null	Het
Olfr1140	C	A	2: 87,746,319	A41E	probably benign	Het
Olfr1204	T	C	2: 88,852,463	V171A	possibly damaging	Het
Pdcd11	C	A	19: 47,107,115	S625R	probably benign	Het
Pigb	T	A	9: 73,029,708		probably null	Het
Pitpnb	T	C	5: 111,383,003	F221L	possibly damaging	Het
Prox2	A	T	12: 85,094,341	W363R	probably damaging	Het
Psmg1	T	A	16: 95,983,971	R139S	probably benign	Het
Rab11fip3	A	G	17: 26,067,580		probably null	Het
Samd9l	G	A	6: 3,374,157	R1035C	probably benign	Het
Shkbp1	G	A	7: 27,352,096		probably benign	Het
Slc30a5	C	A	13: 100,806,741	L536F	probably damaging	Het
Slc6a17	A	T	3: 107,471,437	L643*	probably null	Het
Slit3	T	C	11: 35,588,985	Y330H	probably damaging	Het
St13	G	C	15: 81,399,585	R4G	probably benign	Het
Stoml3	A	C	3: 53,500,792	K86N	possibly damaging	Het
Tmtc1	A	T	6: 148,237,846	L926Q	possibly damaging	Het
Tns4	T	G	11: 99,078,779	R285S	possibly damaging	Het
Uncx	C	T	5: 139,547,119	T313M	probably benign	Het
Vmn2r75	G	A	7: 86,165,527	R253C	possibly damaging	Het
Zfp143	A	G	7: 110,074,118	T142A	probably damaging	Het
Zfp287	T	C	11: 62,714,951	K366E	probably damaging	Het

Other mutations in Lilra6

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00508:Lilra6	APN	7	3911554	missense	probably benign	0.04
IGL00569:Lilra6	APN	7	3914589	missense	probably damaging	0.99
IGL00899:Lilra6	APN	7	3913057	missense	probably damaging	1.00
IGL00955:Lilra6	APN	7	3911404	splice site	probably benign
IGL01585:Lilra6	APN	7	3914499	missense	probably benign	0.01
IGL02195:Lilra6	APN	7	3914550	missense	probably benign	0.00
IGL02586:Lilra6	APN	7	3908820	missense	probably benign	0.36
IGL02719:Lilra6	APN	7	3912992	missense	possibly damaging	0.96
IGL03166:Lilra6	APN	7	3912627	missense	possibly damaging	0.69
IGL03329:Lilra6	APN	7	3914648	splice site	probably benign
R0233:Lilra6	UTSW	7	3914936	missense	possibly damaging	0.69
R0233:Lilra6	UTSW	7	3914936	missense	possibly damaging	0.69
R0423:Lilra6	UTSW	7	3914775	splice site	probably benign
R0483:Lilra6	UTSW	7	3913139	missense	probably benign	0.02
R0511:Lilra6	UTSW	7	3912785	missense	possibly damaging	0.77
R1472:Lilra6	UTSW	7	3912719	missense	probably damaging	1.00
R1560:Lilra6	UTSW	7	3911408	critical splice donor site	probably null
R1584:Lilra6	UTSW	7	3912662	missense	probably damaging	1.00
R1781:Lilra6	UTSW	7	3915067	missense	probably benign	0.28
R2411:Lilra6	UTSW	7	3911454	missense	probably damaging	1.00
R2420:Lilra6	UTSW	7	3914858	missense	probably damaging	1.00
R4021:Lilra6	UTSW	7	3911418	missense	probably benign	0.20
R4074:Lilra6	UTSW	7	3914890	missense	probably benign	0.23
R4284:Lilra6	UTSW	7	3908804	missense	possibly damaging	0.76
R4508:Lilra6	UTSW	7	3912029	nonsense	probably null
R4894:Lilra6	UTSW	7	3912531	missense	probably benign	0.01
R4977:Lilra6	UTSW	7	3914383	missense	probably benign	0.01
R5164:Lilra6	UTSW	7	3914881	missense	probably damaging	1.00
R5185:Lilra6	UTSW	7	3914636	missense	probably benign	0.00
R5527:Lilra6	UTSW	7	3914587	start gained	probably benign
R6281:Lilra6	UTSW	7	3911973	missense	probably damaging	1.00
R6480:Lilra6	UTSW	7	3912933	missense	probably damaging	1.00
R6512:Lilra6	UTSW	7	3914388	missense	probably benign	0.06
R6565:Lilra6	UTSW	7	3915020	missense	probably benign
R7017:Lilra6	UTSW	7	3908708	missense	possibly damaging	0.93
R7095:Lilra6	UTSW	7	3913197	missense	probably damaging	1.00
R7747:Lilra6	UTSW	7	3912996	missense	probably benign	0.16
R8056:Lilra6	UTSW	7	3912552	missense	probably damaging	1.00
R8280:Lilra6	UTSW	7	3913047	missense	probably benign	0.01
R9197:Lilra6	UTSW	7	3912717	missense	possibly damaging	0.94
R9354:Lilra6	UTSW	7	3911629	missense	probably damaging	1.00
R9379:Lilra6	UTSW	7	3913167	missense	probably damaging	1.00
R9406:Lilra6	UTSW	7	3914854	missense	probably benign
Z1176:Lilra6	UTSW	7	3915074	critical splice acceptor site	probably null
Z1177:Lilra6	UTSW	7	3912581	missense	possibly damaging	0.48

Predicted Primers

PCR Primer
(F):5'- ATCCAGAGCCTCAGAGTCAGTC -3'
(R):5'- CTGGCCTAGTCACACCATTG -3'

Sequencing Primer
(F):5'- CCTCAGAGTCAGTCCTGGAAGAG -3'
(R):5'- TAGTCACACCATTGAGGAAGTC -3'

Posted On

2016-06-15