Mutagenetix > Incidental Mutation

Incidental Mutation 'R5052:Gm5866'

394692

Institutional Source

Beutler Lab

Gene Symbol

Gm5866

Ensembl Gene

ENSMUSG00000095078

Gene Name

predicted gene 5866

Synonyms

MMRRC Submission

042642-MU

Accession Numbers

Essential gene?

Possibly non essential (E-score: 0.436) question?

Stock #

R5052 (G1)

Quality Score

212

Status

Validated

Chromosome

Chromosomal Location

52739416-52740388 bp(+) (GRCm39)

Type of Mutation

exon

DNA Base Change (assembly)

T to G at 52740234 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Gene Model

predicted gene model for transcript(s):

AlphaFold

no structure available at present

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000177881

SMART Domains

Protein: ENSMUSP00000137023
Gene: ENSMUSG00000095078

Domain	Start	End	E-Value	Type
Pfam:Nuc_sug_transp	3	239	4.6e-32	PFAM

Coding Region Coverage

1x: 99.1%
3x: 98.0%
10x: 94.8%
20x: 86.2%

Validation Efficiency

100% (58/58)

Allele List at MGI

Other mutations in this stock

Total: 42 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abcd3	A	T	3: 121,563,162 (GRCm39)		probably null	Het
Adgrv1	T	C	13: 81,676,940 (GRCm39)	T1964A	probably damaging	Het
Agbl5	C	T	5: 31,048,558 (GRCm39)	T210I	possibly damaging	Het
Ak5	T	C	3: 152,366,204 (GRCm39)	T66A	probably benign	Het
Aktip	G	A	8: 91,856,279 (GRCm39)	T66I	possibly damaging	Het
Aldh1l2	T	C	10: 83,344,556 (GRCm39)	Y330C	possibly damaging	Het
Btbd19	T	G	4: 116,979,454 (GRCm39)	K122Q	possibly damaging	Het
Cd180	A	G	13: 102,841,403 (GRCm39)	T150A	probably benign	Het
Celsr2	A	G	3: 108,319,674 (GRCm39)	I1046T	probably damaging	Het
Cep170	C	T	1: 176,621,117 (GRCm39)	R20Q	probably damaging	Het
Cercam	T	A	2: 29,765,639 (GRCm39)	N260K	probably damaging	Het
Cfh	T	A	1: 140,071,782 (GRCm39)	H284L	probably damaging	Het
Chmp5	A	G	4: 40,948,608 (GRCm39)	M1V	probably null	Het
Elp3	A	T	14: 65,815,389 (GRCm39)	I220N	probably damaging	Het
Esyt2	A	G	12: 116,331,416 (GRCm39)	T765A	probably damaging	Het
Evi5l	T	C	8: 4,256,019 (GRCm39)		probably benign	Het
Grik1	C	A	16: 87,746,986 (GRCm39)	G417V	probably benign	Het
Gtpbp1	T	G	15: 79,600,170 (GRCm39)	I399R	probably damaging	Het
Il17rc	T	C	6: 113,449,284 (GRCm39)	C14R	probably damaging	Het
Ipo9	T	C	1: 135,316,349 (GRCm39)		probably null	Het
Kazn	G	A	4: 141,845,514 (GRCm39)		probably benign	Het
Map3k15	T	C	X: 158,771,742 (GRCm39)	V105A	possibly damaging	Het
Mitf	A	G	6: 97,987,406 (GRCm39)	T320A	possibly damaging	Het
Ncapd3	T	G	9: 26,963,015 (GRCm39)	L440R	probably damaging	Het
Nrxn2	C	G	19: 6,505,234 (GRCm39)	A359G	probably damaging	Het
P2rx3	T	G	2: 84,829,368 (GRCm39)	I371L	probably benign	Het
Pde1b	C	A	15: 103,436,075 (GRCm39)	Q493K	possibly damaging	Het
Ptpn13	T	C	5: 103,709,846 (GRCm39)	F1503S	probably damaging	Het
Ptprz1	T	G	6: 23,045,625 (GRCm39)	W1283G	probably damaging	Het
Rasd2	T	A	8: 75,948,564 (GRCm39)	D163E	possibly damaging	Het
Rgs11	A	G	17: 26,426,947 (GRCm39)		probably benign	Het
Scap	T	C	9: 110,182,220 (GRCm39)	I37T	possibly damaging	Het
Sgms2	C	T	3: 131,124,005 (GRCm39)	V232M	probably benign	Het
Slc25a54	A	G	3: 109,010,016 (GRCm39)	I172V	probably benign	Het
Sympk	C	T	7: 18,769,967 (GRCm39)	R215C	probably benign	Het
Tacc2	T	A	7: 130,336,744 (GRCm39)	D171E	probably damaging	Het
Tmco4	A	G	4: 138,785,817 (GRCm39)	E629G	probably benign	Het
Trav7-1	T	G	14: 52,892,765 (GRCm39)	L106R	possibly damaging	Het
Ugt1a1	CAGAGAGAGAGAGA	CAGAGAGAGAGA	1: 88,139,706 (GRCm39)		probably benign	Het
Utf1	T	C	7: 139,524,814 (GRCm39)		probably benign	Het
Zdhhc13	A	G	7: 48,474,479 (GRCm39)	N577S	possibly damaging	Het
Zmym6	A	G	4: 127,017,767 (GRCm39)	N1183D	possibly damaging	Het

Other mutations in Gm5866

Allele	Source	Chr	Coord	Type	Predicted Effect
IGL02693:Gm5866	APN	5	52,740,558 (GRCm39)	unclassified	noncoding transcript
R3771:Gm5866	UTSW	5	52,740,088 (GRCm39)	exon	noncoding transcript
R3772:Gm5866	UTSW	5	52,740,088 (GRCm39)	exon	noncoding transcript
R4657:Gm5866	UTSW	5	52,740,262 (GRCm39)	exon	noncoding transcript
R5120:Gm5866	UTSW	5	52,740,224 (GRCm39)	exon	noncoding transcript
R5874:Gm5866	UTSW	5	52,739,956 (GRCm39)	exon	noncoding transcript

Predicted Primers

PCR Primer
(F):5'- TCACTCCACTGGGACTTCTG -3'
(R):5'- TGGCGTGGTCAAGGACTTAG -3'

Sequencing Primer
(F):5'- TCCGTGTACACAGAGCTGATCATG -3'
(R):5'- CTTAGGGGCTACCATAGTACAAGC -3'

Posted On

2016-06-15