Mutagenetix > Incidental Mutations

Incidental Mutation 'R5053:Olfr1211'

394724

Institutional Source

Beutler Lab

Gene Symbol

Olfr1211

Ensembl Gene

ENSMUSG00000075112

Gene Name

olfactory receptor 1211

Synonyms

MOR233-21, MOR233-16P, GA_x6K02T2Q125-50409367-50408432

MMRRC Submission

042643-MU

Accession Numbers

Is this an essential gene?

Probably non essential (E-score: 0.073) question?

Stock #

R5053 (G1)

Quality Score

225

Status

Not validated

Chromosome

Chromosomal Location

88926876-88938111 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

C to A at 88930253 bp

Zygosity

Heterozygous

Amino Acid Change

Valine to Phenylalanine at position 21 (V21F)

Ref Sequence

ENSEMBL: ENSMUSP00000150571 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000099808] [ENSMUST00000213412] [ENSMUST00000215205]

Predicted Effect

probably benign
Transcript: ENSMUST00000099808
AA Change: V21F

PolyPhen 2 Score 0.019 (Sensitivity: 0.95; Specificity: 0.80)

SMART Domains

Protein: ENSMUSP00000097396
Gene: ENSMUSG00000075112
AA Change: V21F

Domain	Start	End	E-Value	Type
Pfam:7tm_4	29	303	9.5e-49	PFAM
Pfam:7tm_1	39	286	2.5e-14	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000141958

Predicted Effect

probably benign
Transcript: ENSMUST00000213412
AA Change: V21F

PolyPhen 2 Score 0.019 (Sensitivity: 0.95; Specificity: 0.80)

Predicted Effect

probably benign
Transcript: ENSMUST00000215205
AA Change: V21F

PolyPhen 2 Score 0.019 (Sensitivity: 0.95; Specificity: 0.80)

Coding Region Coverage

1x: 99.3%
3x: 98.3%
10x: 95.9%
20x: 90.6%

Validation Efficiency

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 62 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Acvrl1	A	T	15: 101,137,369	I259F	probably damaging	Het
Adgrf2	A	G	17: 42,710,443	S497P	probably damaging	Het
Adsl	T	C	15: 80,960,450	C180R	probably damaging	Het
Ahctf1	A	G	1: 179,786,784	I448T	possibly damaging	Het
Alg9	G	T	9: 50,788,172	G200W	probably damaging	Het
Amhr2	G	A	15: 102,447,258	V213I	probably damaging	Het
Ankrd44	A	T	1: 54,735,089	L200*	probably null	Het
As3mt	A	G	19: 46,709,054	Y87C	probably damaging	Het
Bcl11a	C	A	11: 24,164,068	F470L	probably benign	Het
Cacna2d2	A	T	9: 107,514,864	Y468F	probably damaging	Het
Cep250	A	G	2: 155,962,928	D71G	possibly damaging	Het
Clca4b	T	C	3: 144,911,121	T923A	probably benign	Het
Clec16a	T	C	16: 10,576,597	L273P	probably damaging	Het
Comtd1	T	C	14: 21,847,696	D123G	probably damaging	Het
Cpa5	A	T	6: 30,623,272	E144V	probably damaging	Het
Cyp2c37	G	A	19: 40,001,887	S343N	probably benign	Het
Dennd6a	C	A	14: 26,608,583	T103K	probably damaging	Het
Ect2l	A	G	10: 18,140,345	L733P	probably damaging	Het
Erg	T	A	16: 95,524,534	H11L	probably benign	Het
Ero1lb	T	C	13: 12,599,906	L253P	probably damaging	Het
Etfbkmt	T	A	6: 149,147,268	L135*	probably null	Het
Frmd4a	A	T	2: 4,603,921	T867S	probably damaging	Het
Gm815	C	T	19: 26,886,413	A18V	unknown	Het
Gna12	C	A	5: 140,760,727	R321L	probably benign	Het
Herc1	A	T	9: 66,470,326	K3458M	possibly damaging	Het
Irs1	A	G	1: 82,286,922	L1191P	probably benign	Het
Kcp	G	T	6: 29,496,958	Q551K	probably benign	Het
Klhl11	C	T	11: 100,472,200	V177M	probably damaging	Het
Klk14	G	A	7: 43,692,077	C51Y	probably damaging	Het
Llcfc1	A	G	6: 41,685,335	H91R	possibly damaging	Het
Lmnb2	A	T	10: 80,904,655	M223K	probably damaging	Het
Mbd6	C	T	10: 127,286,441	V173I	probably benign	Het
Mme	T	A	3: 63,364,849	V623E	probably damaging	Het
Ndc1	T	C	4: 107,374,218	S119P	probably damaging	Het
Nfs1	A	C	2: 156,126,398	C383G	probably damaging	Het
Nphp4	A	G	4: 152,544,462		probably null	Het
Oca2	C	A	7: 56,323,580	Q411K	probably benign	Het
Olfr1061	A	G	2: 86,413,338	F238S	probably damaging	Het
Olfr1377	G	A	11: 50,985,310	G203D	probably damaging	Het
Olfr479	A	G	7: 108,055,534	H184R	probably benign	Het
Olfr748	T	A	14: 50,710,511	Y60*	probably null	Het
Pcdh7	A	T	5: 57,721,601	T493S	probably damaging	Het
Phf20	T	C	2: 156,273,862	S368P	probably benign	Het
Pla2g2e	T	G	4: 138,880,375	V22G	possibly damaging	Het
Plxna1	A	T	6: 89,322,460	H1736Q	probably damaging	Het
Prlr	C	A	15: 10,325,385	Q215K	probably benign	Het
Prpf6	T	C	2: 181,649,453	V687A	probably benign	Het
Ptprq	T	A	10: 107,563,202	T1951S	probably damaging	Het
Sec31a	G	T	5: 100,393,214	Q345K	possibly damaging	Het
Serpina3k	T	C	12: 104,343,214		probably null	Het
Sertad3	T	A	7: 27,476,522	V127E	probably benign	Het
Sf3b1	A	T	1: 54,997,177	N912K	probably benign	Het
Shq1	A	G	6: 100,655,259	L202P	probably damaging	Het
Sp8	C	T	12: 118,849,604	T398M	probably damaging	Het
Tmem150c	A	T	5: 100,083,740	D125E	probably benign	Het
Trim3	G	T	7: 105,617,761	D470E	probably damaging	Het
Ubap1	T	A	4: 41,387,315	C88*	probably null	Het
Unc79	T	A	12: 103,104,748	D1124E	probably damaging	Het
Usf3	T	C	16: 44,217,187	S677P	probably benign	Het
Vmn1r76	T	C	7: 11,930,314		probably null	Het
Zfp819	C	T	7: 43,617,146	T275I	probably damaging	Het
Zranb2	T	A	3: 157,541,159	D161E	probably damaging	Het

Other mutations in Olfr1211

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL02724:Olfr1211	APN	2	88929448	missense	probably damaging	1.00
IGL02936:Olfr1211	APN	2	88929784	missense	probably benign	0.01
IGL02960:Olfr1211	APN	2	88929784	missense	possibly damaging	0.80
IGL02989:Olfr1211	APN	2	88929704	missense	possibly damaging	0.72
R0193:Olfr1211	UTSW	2	88930283	missense	probably benign	0.01
R0413:Olfr1211	UTSW	2	88929562	missense	probably benign	0.16
R1644:Olfr1211	UTSW	2	88929387	missense	probably benign	0.01
R3715:Olfr1211	UTSW	2	88929413	missense	probably benign	0.07
R4019:Olfr1211	UTSW	2	88929736	missense	probably benign	0.02
R4722:Olfr1211	UTSW	2	88929980	missense	possibly damaging	0.91
R4751:Olfr1211	UTSW	2	88929914	missense	probably damaging	1.00
R4859:Olfr1211	UTSW	2	88930283	missense	probably benign	0.01
R6148:Olfr1211	UTSW	2	88930253	missense	probably benign	0.00
R7064:Olfr1211	UTSW	2	88929509	missense	probably benign	0.00
R7527:Olfr1211	UTSW	2	88930090	missense	probably benign	0.00
R7584:Olfr1211	UTSW	2	88929805	missense	probably damaging	1.00
R7989:Olfr1211	UTSW	2	88929514	missense	probably damaging	0.99

Predicted Primers

PCR Primer
(F):5'- CCATCTTTGGTGTGATGACAGAAG -3'
(R):5'- TATGTACATGTGTTGGGCAAAGC -3'

Sequencing Primer
(F):5'- TGACAGAAGAGAAGCATGCATCC -3'
(R):5'- TTGGGCAAAGCACTGTTTTC -3'

Posted On

2016-06-15