Incidental Mutation 'R4700:Celsr2'
| ID |
394785 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Celsr2
|
| Ensembl Gene |
ENSMUSG00000068740 |
| Gene Name |
cadherin, EGF LAG seven-pass G-type receptor 2 |
| Synonyms |
EGFL2, Adgrc2, flamingo, mfmi1 |
| MMRRC Submission |
041948-MU
|
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
R4700 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
3 |
| Chromosomal Location |
108298167-108323383 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to C
at 108304547 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Arginine to Glycine
at position 2271
(R2271G)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000088046
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000090558]
|
| AlphaFold |
no structure available at present |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000090558
AA Change: R2271G
PolyPhen 2
Score 0.243 (Sensitivity: 0.91; Specificity: 0.88)
|
| SMART Domains |
Protein: ENSMUSP00000088046
Gene: ENSMUSG00000068740
AA Change: R2271G
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
31 |
N/A |
INTRINSIC |
|
low complexity region
|
35 |
53 |
N/A |
INTRINSIC |
|
CA
|
203 |
287 |
1.36e-26 |
SMART |
|
CA
|
311 |
397 |
1.33e-29 |
SMART |
|
CA
|
421 |
503 |
2.59e-27 |
SMART |
|
CA
|
527 |
608 |
3.33e-30 |
SMART |
|
CA
|
632 |
710 |
5.18e-18 |
SMART |
|
CA
|
734 |
813 |
1.08e-29 |
SMART |
|
CA
|
837 |
919 |
8.08e-29 |
SMART |
|
low complexity region
|
920 |
932 |
N/A |
INTRINSIC |
|
CA
|
943 |
1021 |
4.3e-24 |
SMART |
|
CA
|
1049 |
1125 |
1.87e-1 |
SMART |
|
low complexity region
|
1188 |
1198 |
N/A |
INTRINSIC |
|
EGF
|
1231 |
1286 |
1.81e-3 |
SMART |
|
EGF_CA
|
1288 |
1324 |
2.24e-8 |
SMART |
|
EGF
|
1331 |
1366 |
6.65e-2 |
SMART |
|
LamG
|
1387 |
1554 |
8.4e-30 |
SMART |
|
EGF
|
1577 |
1610 |
8e-5 |
SMART |
|
LamG
|
1636 |
1770 |
1.56e-24 |
SMART |
|
EGF
|
1796 |
1829 |
2.35e-2 |
SMART |
|
EGF
|
1831 |
1867 |
3.88e-3 |
SMART |
|
TNFR
|
1908 |
1943 |
1.35e-1 |
SMART |
|
EGF_Lam
|
1924 |
1969 |
9.54e-12 |
SMART |
|
HormR
|
1972 |
2034 |
1.57e-20 |
SMART |
|
Pfam:GAIN
|
2046 |
2289 |
3e-62 |
PFAM |
|
GPS
|
2315 |
2368 |
1.86e-25 |
SMART |
|
Pfam:7tm_2
|
2373 |
2605 |
1.1e-48 |
PFAM |
|
low complexity region
|
2715 |
2733 |
N/A |
INTRINSIC |
|
low complexity region
|
2857 |
2873 |
N/A |
INTRINSIC |
|
low complexity region
|
2874 |
2881 |
N/A |
INTRINSIC |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000126349
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000126935
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000130941
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000133216
|
| Predicted Effect |
unknown
Transcript: ENSMUST00000147251
AA Change: R259G
|
| SMART Domains |
Protein: ENSMUSP00000122329
Gene: ENSMUSG00000068740
AA Change: R259G
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:GAIN
|
35 |
278 |
5.1e-63 |
PFAM |
|
GPS
|
304 |
357 |
1.86e-25 |
SMART |
|
Pfam:7tm_2
|
362 |
594 |
2e-49 |
PFAM |
|
low complexity region
|
704 |
722 |
N/A |
INTRINSIC |
|
low complexity region
|
846 |
862 |
N/A |
INTRINSIC |
|
low complexity region
|
863 |
870 |
N/A |
INTRINSIC |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000147565
|
| SMART Domains |
Protein: ENSMUSP00000122516
Gene: ENSMUSG00000068740
| Domain | Start | End | E-Value | Type |
|---|
|
EGF
|
13 |
46 |
8e-5 |
SMART |
|
LamG
|
72 |
206 |
1.56e-24 |
SMART |
|
| Meta Mutation Damage Score |
0.2872 |
| Coding Region Coverage |
- 1x: 99.1%
- 3x: 98.4%
- 10x: 96.8%
- 20x: 94.0%
|
| Validation Efficiency |
97% (127/131) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a member of the flamingo subfamily, part of the cadherin superfamily. The flamingo subfamily consists of nonclassic-type cadherins; a subpopulation that does not interact with catenins. The flamingo cadherins are located at the plasma membrane and have nine cadherin domains, seven epidermal growth factor-like repeats and two laminin A G-type repeats in their ectodomain. They also have seven transmembrane domains, a characteristic unique to this subfamily. It is postulated that these proteins are receptors involved in contact-mediated communication, with cadherin domains acting as homophilic binding regions and the EGF-like domains involved in cell adhesion and receptor-ligand interactions. The specific function of this particular member has not been determined. [provided by RefSeq, Jul 2008]
PHENOTYPE: Mice homozygous for disruptions in this allele have mild to moderately dilated lateral ventricles in the brain but are otherwise normal. [provided by MGI curators]
|
| Allele List at MGI |
All alleles(4) : Targeted, knock-out(1) Targeted, other(3)
|
| Other mutations in this stock |
Total: 112 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| A530084C06Rik |
A |
G |
13: 31,742,795 (GRCm39) |
|
probably benign |
Het |
| Abca13 |
A |
G |
11: 9,242,306 (GRCm39) |
T1390A |
possibly damaging |
Het |
| Abca14 |
T |
A |
7: 119,911,928 (GRCm39) |
|
probably null |
Het |
| Abca8a |
A |
C |
11: 109,961,308 (GRCm39) |
V538G |
probably damaging |
Het |
| Acy1 |
C |
T |
9: 106,310,782 (GRCm39) |
G329R |
probably benign |
Het |
| Adamts17 |
T |
C |
7: 66,691,636 (GRCm39) |
C607R |
probably damaging |
Het |
| Adamts20 |
A |
T |
15: 94,292,503 (GRCm39) |
C202* |
probably null |
Het |
| Adcy5 |
A |
G |
16: 35,099,586 (GRCm39) |
N712S |
possibly damaging |
Het |
| Ahnak |
A |
G |
19: 8,982,045 (GRCm39) |
K1110E |
probably benign |
Het |
| Anks6 |
T |
A |
4: 47,033,127 (GRCm39) |
H578L |
possibly damaging |
Het |
| Appl1 |
C |
A |
14: 26,647,928 (GRCm39) |
L626F |
probably benign |
Het |
| Arl1 |
A |
G |
10: 88,566,499 (GRCm39) |
|
probably benign |
Het |
| Atf4 |
T |
A |
15: 80,141,618 (GRCm39) |
I336K |
probably damaging |
Het |
| Atp7b |
A |
T |
8: 22,490,137 (GRCm39) |
S1044T |
probably benign |
Het |
| Carm1 |
A |
G |
9: 21,498,480 (GRCm39) |
N466S |
probably benign |
Het |
| Cbl |
A |
G |
9: 44,084,677 (GRCm39) |
S153P |
probably damaging |
Het |
| Ccdc159 |
A |
G |
9: 21,839,027 (GRCm39) |
|
probably null |
Het |
| Cd109 |
CATTTATTTATTTATTTATTTATTTATTTATTTAT |
CATTTATTTATTTATTTATTTATTTATTTATTTATTTAT |
9: 78,619,782 (GRCm39) |
|
probably benign |
Het |
| Cdc7 |
T |
C |
5: 107,121,707 (GRCm39) |
F207L |
probably benign |
Het |
| Cep162 |
T |
C |
9: 87,088,915 (GRCm39) |
Q989R |
probably damaging |
Het |
| Cep89 |
A |
G |
7: 35,137,862 (GRCm39) |
T749A |
probably benign |
Het |
| Clcn5 |
T |
C |
X: 7,032,591 (GRCm39) |
|
probably null |
Het |
| Clu |
A |
T |
14: 66,217,313 (GRCm39) |
Y382F |
probably benign |
Het |
| Cnih4 |
A |
G |
1: 180,993,808 (GRCm39) |
|
probably benign |
Het |
| Crb1 |
A |
G |
1: 139,126,509 (GRCm39) |
L1340P |
probably damaging |
Het |
| Ddx4 |
T |
C |
13: 112,750,269 (GRCm39) |
T421A |
probably damaging |
Het |
| Dennd5a |
T |
C |
7: 109,520,405 (GRCm39) |
E484G |
probably benign |
Het |
| Dsg4 |
G |
T |
18: 20,589,965 (GRCm39) |
V372L |
possibly damaging |
Het |
| Dyrk2 |
T |
C |
10: 118,704,191 (GRCm39) |
D21G |
probably benign |
Het |
| E2f1 |
C |
G |
2: 154,405,942 (GRCm39) |
G144R |
probably damaging |
Het |
| Epb41l4a |
A |
T |
18: 33,935,560 (GRCm39) |
|
probably null |
Het |
| F10 |
G |
T |
8: 13,089,621 (GRCm39) |
V67F |
possibly damaging |
Het |
| Fat3 |
A |
G |
9: 15,942,469 (GRCm39) |
I1301T |
probably damaging |
Het |
| Filip1l |
A |
G |
16: 57,391,058 (GRCm39) |
T549A |
probably benign |
Het |
| Flt4 |
C |
A |
11: 49,517,271 (GRCm39) |
|
probably benign |
Het |
| Fndc1 |
G |
A |
17: 7,990,312 (GRCm39) |
T1128I |
unknown |
Het |
| Fos |
T |
C |
12: 85,522,936 (GRCm39) |
S283P |
probably benign |
Het |
| Fryl |
T |
C |
5: 73,222,881 (GRCm39) |
Y1900C |
possibly damaging |
Het |
| Fsip2 |
C |
A |
2: 82,817,373 (GRCm39) |
Q4369K |
probably benign |
Het |
| Gad2 |
A |
T |
2: 22,563,982 (GRCm39) |
H395L |
probably damaging |
Het |
| Grm2 |
T |
A |
9: 106,531,130 (GRCm39) |
I120F |
probably benign |
Het |
| Hjurp |
GT |
GTT |
1: 88,194,246 (GRCm39) |
|
probably null |
Het |
| Igsf10 |
A |
T |
3: 59,227,751 (GRCm39) |
I1974N |
probably damaging |
Het |
| Il23r |
T |
C |
6: 67,450,834 (GRCm39) |
N215S |
probably damaging |
Het |
| Jph1 |
T |
A |
1: 17,161,928 (GRCm39) |
M245L |
possibly damaging |
Het |
| Loxl4 |
G |
A |
19: 42,596,052 (GRCm39) |
H147Y |
probably benign |
Het |
| Lsg1 |
A |
G |
16: 30,384,267 (GRCm39) |
I521T |
probably damaging |
Het |
| Ltc4s |
C |
T |
11: 50,127,908 (GRCm39) |
G83R |
probably damaging |
Het |
| Map2 |
A |
G |
1: 66,449,796 (GRCm39) |
E173G |
probably damaging |
Het |
| Med29 |
T |
A |
7: 28,086,352 (GRCm39) |
D152V |
possibly damaging |
Het |
| Megf8 |
A |
G |
7: 25,062,940 (GRCm39) |
D2432G |
probably damaging |
Het |
| Mrpl38 |
G |
A |
11: 116,025,978 (GRCm39) |
|
probably benign |
Het |
| Myh7 |
A |
G |
14: 55,225,778 (GRCm39) |
I521T |
possibly damaging |
Het |
| Mylk |
G |
T |
16: 34,742,805 (GRCm39) |
V1106L |
probably benign |
Het |
| Myo15b |
A |
T |
11: 115,752,761 (GRCm39) |
D753V |
possibly damaging |
Het |
| Myo1g |
T |
C |
11: 6,466,785 (GRCm39) |
|
probably null |
Het |
| Myrfl |
A |
G |
10: 116,613,247 (GRCm39) |
|
probably null |
Het |
| Naip5 |
A |
G |
13: 100,359,922 (GRCm39) |
V438A |
possibly damaging |
Het |
| Nav3 |
A |
G |
10: 109,600,796 (GRCm39) |
V1277A |
probably benign |
Het |
| Nek10 |
T |
A |
14: 14,842,841 (GRCm38) |
V182E |
possibly damaging |
Het |
| Ngly1 |
T |
C |
14: 16,281,809 (GRCm38) |
V355A |
probably benign |
Het |
| Nol6 |
T |
C |
4: 41,118,944 (GRCm39) |
E683G |
possibly damaging |
Het |
| Obsl1 |
A |
T |
1: 75,480,085 (GRCm39) |
V487E |
probably damaging |
Het |
| Oc90 |
T |
A |
15: 65,753,354 (GRCm39) |
R322W |
possibly damaging |
Het |
| Or1q1 |
C |
A |
2: 36,887,515 (GRCm39) |
A231D |
probably benign |
Het |
| Or4f60 |
A |
G |
2: 111,902,097 (GRCm39) |
V277A |
possibly damaging |
Het |
| Or52e4 |
A |
T |
7: 104,705,483 (GRCm39) |
H10L |
possibly damaging |
Het |
| Or8b4 |
A |
G |
9: 37,830,217 (GRCm39) |
E93G |
possibly damaging |
Het |
| Osbp2 |
T |
C |
11: 3,662,160 (GRCm39) |
H231R |
probably damaging |
Het |
| Pate6 |
A |
T |
9: 35,701,021 (GRCm39) |
C22S |
probably damaging |
Het |
| Pdzph1 |
T |
C |
17: 59,281,541 (GRCm39) |
H247R |
probably damaging |
Het |
| Pidd1 |
T |
C |
7: 141,022,162 (GRCm39) |
N209S |
probably damaging |
Het |
| Pknox1 |
C |
T |
17: 31,822,286 (GRCm39) |
A351V |
probably damaging |
Het |
| Plxnd1 |
C |
A |
6: 115,935,576 (GRCm39) |
V1737F |
probably damaging |
Het |
| Prkdc |
A |
T |
16: 15,519,976 (GRCm39) |
K1138M |
probably damaging |
Het |
| Rad54l2 |
T |
C |
9: 106,631,224 (GRCm39) |
D21G |
possibly damaging |
Het |
| Recql4 |
C |
T |
15: 76,592,785 (GRCm39) |
C302Y |
probably damaging |
Het |
| Scgb2b6 |
T |
C |
7: 31,318,908 (GRCm39) |
|
noncoding transcript |
Het |
| Sdc1 |
A |
G |
12: 8,840,541 (GRCm39) |
E106G |
possibly damaging |
Het |
| Slc10a5 |
T |
G |
3: 10,400,360 (GRCm39) |
Q100P |
probably damaging |
Het |
| Slc10a5 |
C |
A |
3: 10,400,359 (GRCm39) |
Q100H |
probably damaging |
Het |
| Slc5a9 |
A |
T |
4: 111,748,134 (GRCm39) |
L226Q |
possibly damaging |
Het |
| Slfn1 |
T |
C |
11: 83,012,475 (GRCm39) |
V197A |
probably benign |
Het |
| Spire1 |
T |
C |
18: 67,645,935 (GRCm39) |
M244V |
probably benign |
Het |
| St3gal3 |
C |
T |
4: 117,817,232 (GRCm39) |
V141I |
probably benign |
Het |
| St6galnac4 |
G |
T |
2: 32,477,172 (GRCm39) |
|
probably benign |
Het |
| Svep1 |
T |
C |
4: 58,097,323 (GRCm39) |
K1407E |
possibly damaging |
Het |
| Tbc1d32 |
A |
G |
10: 56,100,745 (GRCm39) |
C78R |
probably damaging |
Het |
| Tcstv5 |
T |
C |
13: 120,411,378 (GRCm39) |
Y76C |
probably benign |
Het |
| Tln2 |
A |
G |
9: 67,253,809 (GRCm39) |
V754A |
probably benign |
Het |
| Tmeff1 |
A |
T |
4: 48,636,869 (GRCm39) |
Y189F |
possibly damaging |
Het |
| Tmem131l |
C |
T |
3: 83,806,519 (GRCm39) |
A1433T |
probably benign |
Het |
| Tnfrsf8 |
T |
C |
4: 145,029,692 (GRCm39) |
Y36C |
probably damaging |
Het |
| Trp53i11 |
G |
T |
2: 93,030,245 (GRCm39) |
R184L |
probably damaging |
Het |
| Trpv1 |
A |
T |
11: 73,142,110 (GRCm39) |
M214L |
possibly damaging |
Het |
| Tsnax |
T |
A |
8: 125,755,533 (GRCm39) |
S132T |
probably benign |
Het |
| Ttc28 |
T |
C |
5: 111,424,909 (GRCm39) |
L1547P |
probably damaging |
Het |
| Ttc3 |
A |
G |
16: 94,240,100 (GRCm39) |
|
probably null |
Het |
| Tubal3 |
T |
A |
13: 3,983,514 (GRCm39) |
D431E |
probably damaging |
Het |
| Ugt2b36 |
A |
T |
5: 87,240,301 (GRCm39) |
|
probably null |
Het |
| Vmn1r23 |
A |
T |
6: 57,903,190 (GRCm39) |
I196K |
probably benign |
Het |
| Vmn1r55 |
A |
C |
7: 5,149,586 (GRCm39) |
L279R |
probably damaging |
Het |
| Vmn1r55 |
G |
T |
7: 5,149,587 (GRCm39) |
L279M |
probably damaging |
Het |
| Vmn2r89 |
G |
A |
14: 51,694,942 (GRCm39) |
G474E |
probably damaging |
Het |
| Vps26b |
T |
C |
9: 26,926,511 (GRCm39) |
K163E |
probably damaging |
Het |
| Zfp142 |
A |
G |
1: 74,609,431 (GRCm39) |
F1352L |
probably damaging |
Het |
| Zfp422 |
C |
T |
6: 116,603,844 (GRCm39) |
E52K |
possibly damaging |
Het |
| Zfp423 |
T |
A |
8: 88,508,338 (GRCm39) |
|
probably null |
Het |
| Zfp493 |
T |
C |
13: 67,934,736 (GRCm39) |
F230L |
probably damaging |
Het |
| Zfp760 |
T |
C |
17: 21,941,388 (GRCm39) |
C188R |
probably benign |
Het |
| Zfyve28 |
G |
T |
5: 34,375,189 (GRCm39) |
T275K |
probably damaging |
Het |
| Znhit3 |
T |
C |
11: 84,807,155 (GRCm39) |
N5D |
probably benign |
Het |
|
| Other mutations in Celsr2 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00898:Celsr2
|
APN |
3 |
108,321,195 (GRCm39) |
missense |
possibly damaging |
0.49 |
|
IGL01020:Celsr2
|
APN |
3 |
108,310,586 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL01420:Celsr2
|
APN |
3 |
108,301,079 (GRCm39) |
missense |
probably benign |
0.13 |
|
IGL01448:Celsr2
|
APN |
3 |
108,300,555 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL01559:Celsr2
|
APN |
3 |
108,314,183 (GRCm39) |
missense |
possibly damaging |
0.75 |
|
IGL01674:Celsr2
|
APN |
3 |
108,322,159 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01863:Celsr2
|
APN |
3 |
108,301,338 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL02309:Celsr2
|
APN |
3 |
108,303,327 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02325:Celsr2
|
APN |
3 |
108,320,187 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02409:Celsr2
|
APN |
3 |
108,321,271 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02514:Celsr2
|
APN |
3 |
108,304,826 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL02812:Celsr2
|
APN |
3 |
108,321,429 (GRCm39) |
missense |
probably benign |
0.25 |
|
IGL02894:Celsr2
|
APN |
3 |
108,302,526 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03281:Celsr2
|
APN |
3 |
108,320,256 (GRCm39) |
missense |
probably damaging |
1.00 |
|
barrow
|
UTSW |
3 |
108,302,281 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
goldeneye
|
UTSW |
3 |
108,302,235 (GRCm39) |
missense |
probably damaging |
1.00 |
|
1mM(1):Celsr2
|
UTSW |
3 |
108,308,154 (GRCm39) |
missense |
probably benign |
0.01 |
|
ANU74:Celsr2
|
UTSW |
3 |
108,319,815 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02799:Celsr2
|
UTSW |
3 |
108,321,378 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0011:Celsr2
|
UTSW |
3 |
108,320,718 (GRCm39) |
missense |
probably benign |
0.19 |
|
R0031:Celsr2
|
UTSW |
3 |
108,320,379 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0049:Celsr2
|
UTSW |
3 |
108,304,570 (GRCm39) |
missense |
probably benign |
0.12 |
|
R0049:Celsr2
|
UTSW |
3 |
108,304,570 (GRCm39) |
missense |
probably benign |
0.12 |
|
R0090:Celsr2
|
UTSW |
3 |
108,300,643 (GRCm39) |
splice site |
probably benign |
|
|
R0140:Celsr2
|
UTSW |
3 |
108,305,249 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0524:Celsr2
|
UTSW |
3 |
108,308,903 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0607:Celsr2
|
UTSW |
3 |
108,311,211 (GRCm39) |
critical splice donor site |
probably null |
|
|
R0662:Celsr2
|
UTSW |
3 |
108,305,836 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0690:Celsr2
|
UTSW |
3 |
108,322,293 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0691:Celsr2
|
UTSW |
3 |
108,319,939 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0710:Celsr2
|
UTSW |
3 |
108,320,028 (GRCm39) |
missense |
probably benign |
0.42 |
|
R0730:Celsr2
|
UTSW |
3 |
108,305,922 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0815:Celsr2
|
UTSW |
3 |
108,308,617 (GRCm39) |
missense |
possibly damaging |
0.56 |
|
R0848:Celsr2
|
UTSW |
3 |
108,321,654 (GRCm39) |
missense |
probably benign |
|
|
R0989:Celsr2
|
UTSW |
3 |
108,310,588 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1185:Celsr2
|
UTSW |
3 |
108,307,025 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R1185:Celsr2
|
UTSW |
3 |
108,307,025 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R1185:Celsr2
|
UTSW |
3 |
108,307,025 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R1469:Celsr2
|
UTSW |
3 |
108,321,424 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1469:Celsr2
|
UTSW |
3 |
108,321,424 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1474:Celsr2
|
UTSW |
3 |
108,301,055 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R1608:Celsr2
|
UTSW |
3 |
108,309,799 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1653:Celsr2
|
UTSW |
3 |
108,320,836 (GRCm39) |
missense |
possibly damaging |
0.52 |
|
R1659:Celsr2
|
UTSW |
3 |
108,321,411 (GRCm39) |
missense |
probably benign |
|
|
R1689:Celsr2
|
UTSW |
3 |
108,314,620 (GRCm39) |
missense |
possibly damaging |
0.63 |
|
R1848:Celsr2
|
UTSW |
3 |
108,308,626 (GRCm39) |
missense |
probably benign |
0.35 |
|
R1859:Celsr2
|
UTSW |
3 |
108,303,946 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1918:Celsr2
|
UTSW |
3 |
108,305,966 (GRCm39) |
missense |
probably benign |
0.05 |
|
R1974:Celsr2
|
UTSW |
3 |
108,321,530 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2042:Celsr2
|
UTSW |
3 |
108,309,811 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R2167:Celsr2
|
UTSW |
3 |
108,320,509 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R2333:Celsr2
|
UTSW |
3 |
108,305,921 (GRCm39) |
missense |
probably benign |
0.16 |
|
R2434:Celsr2
|
UTSW |
3 |
108,311,795 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2504:Celsr2
|
UTSW |
3 |
108,320,907 (GRCm39) |
missense |
probably benign |
0.11 |
|
R3420:Celsr2
|
UTSW |
3 |
108,321,732 (GRCm39) |
missense |
probably benign |
0.03 |
|
R3712:Celsr2
|
UTSW |
3 |
108,308,155 (GRCm39) |
missense |
probably benign |
|
|
R3723:Celsr2
|
UTSW |
3 |
108,304,731 (GRCm39) |
splice site |
probably benign |
|
|
R3809:Celsr2
|
UTSW |
3 |
108,310,555 (GRCm39) |
missense |
possibly damaging |
0.67 |
|
R4018:Celsr2
|
UTSW |
3 |
108,302,281 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R4126:Celsr2
|
UTSW |
3 |
108,309,413 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
R4177:Celsr2
|
UTSW |
3 |
108,321,294 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R4232:Celsr2
|
UTSW |
3 |
108,321,088 (GRCm39) |
missense |
probably benign |
0.02 |
|
R4293:Celsr2
|
UTSW |
3 |
108,300,993 (GRCm39) |
missense |
probably benign |
0.01 |
|
R4458:Celsr2
|
UTSW |
3 |
108,302,313 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R4621:Celsr2
|
UTSW |
3 |
108,302,532 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R4645:Celsr2
|
UTSW |
3 |
108,303,285 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4732:Celsr2
|
UTSW |
3 |
108,306,268 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4733:Celsr2
|
UTSW |
3 |
108,306,268 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4901:Celsr2
|
UTSW |
3 |
108,314,303 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
R4932:Celsr2
|
UTSW |
3 |
108,310,074 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4989:Celsr2
|
UTSW |
3 |
108,319,945 (GRCm39) |
missense |
possibly damaging |
0.62 |
|
R5052:Celsr2
|
UTSW |
3 |
108,319,674 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5093:Celsr2
|
UTSW |
3 |
108,320,689 (GRCm39) |
missense |
possibly damaging |
0.66 |
|
R5114:Celsr2
|
UTSW |
3 |
108,301,312 (GRCm39) |
missense |
probably benign |
0.05 |
|
R5120:Celsr2
|
UTSW |
3 |
108,300,436 (GRCm39) |
missense |
probably benign |
0.02 |
|
R5135:Celsr2
|
UTSW |
3 |
108,305,975 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5247:Celsr2
|
UTSW |
3 |
108,304,946 (GRCm39) |
missense |
probably benign |
0.34 |
|
R5381:Celsr2
|
UTSW |
3 |
108,310,073 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5412:Celsr2
|
UTSW |
3 |
108,307,311 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5445:Celsr2
|
UTSW |
3 |
108,299,974 (GRCm39) |
missense |
probably benign |
0.01 |
|
R5528:Celsr2
|
UTSW |
3 |
108,320,610 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5598:Celsr2
|
UTSW |
3 |
108,310,119 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R5652:Celsr2
|
UTSW |
3 |
108,304,051 (GRCm39) |
missense |
probably null |
0.49 |
|
R5697:Celsr2
|
UTSW |
3 |
108,311,237 (GRCm39) |
nonsense |
probably null |
|
|
R5718:Celsr2
|
UTSW |
3 |
108,300,674 (GRCm39) |
missense |
probably benign |
|
|
R5869:Celsr2
|
UTSW |
3 |
108,321,225 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5876:Celsr2
|
UTSW |
3 |
108,321,259 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R6021:Celsr2
|
UTSW |
3 |
108,308,561 (GRCm39) |
missense |
probably benign |
|
|
R6054:Celsr2
|
UTSW |
3 |
108,314,279 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R6244:Celsr2
|
UTSW |
3 |
108,300,444 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R6313:Celsr2
|
UTSW |
3 |
108,308,530 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6322:Celsr2
|
UTSW |
3 |
108,319,890 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6555:Celsr2
|
UTSW |
3 |
108,302,235 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6682:Celsr2
|
UTSW |
3 |
108,307,817 (GRCm39) |
critical splice donor site |
probably null |
|
|
R7062:Celsr2
|
UTSW |
3 |
108,309,826 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R7110:Celsr2
|
UTSW |
3 |
108,305,181 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7139:Celsr2
|
UTSW |
3 |
108,322,675 (GRCm39) |
missense |
unknown |
|
|
R7326:Celsr2
|
UTSW |
3 |
108,302,311 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R7425:Celsr2
|
UTSW |
3 |
108,309,773 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7452:Celsr2
|
UTSW |
3 |
108,320,406 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R7461:Celsr2
|
UTSW |
3 |
108,302,956 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7502:Celsr2
|
UTSW |
3 |
108,306,218 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7613:Celsr2
|
UTSW |
3 |
108,302,956 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7644:Celsr2
|
UTSW |
3 |
108,320,806 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7666:Celsr2
|
UTSW |
3 |
108,305,904 (GRCm39) |
missense |
probably benign |
|
|
R7687:Celsr2
|
UTSW |
3 |
108,305,085 (GRCm39) |
missense |
probably benign |
0.27 |
|
R7695:Celsr2
|
UTSW |
3 |
108,310,069 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8002:Celsr2
|
UTSW |
3 |
108,311,285 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8052:Celsr2
|
UTSW |
3 |
108,319,971 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8283:Celsr2
|
UTSW |
3 |
108,303,771 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8356:Celsr2
|
UTSW |
3 |
108,320,847 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R8381:Celsr2
|
UTSW |
3 |
108,302,952 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8427:Celsr2
|
UTSW |
3 |
108,299,949 (GRCm39) |
makesense |
probably null |
|
|
R8435:Celsr2
|
UTSW |
3 |
108,321,715 (GRCm39) |
missense |
probably benign |
|
|
R8438:Celsr2
|
UTSW |
3 |
108,301,139 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8458:Celsr2
|
UTSW |
3 |
108,306,218 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8460:Celsr2
|
UTSW |
3 |
108,304,093 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
R8462:Celsr2
|
UTSW |
3 |
108,320,167 (GRCm39) |
nonsense |
probably null |
|
|
R8479:Celsr2
|
UTSW |
3 |
108,306,218 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8480:Celsr2
|
UTSW |
3 |
108,306,218 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8512:Celsr2
|
UTSW |
3 |
108,321,154 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8694:Celsr2
|
UTSW |
3 |
108,314,176 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8772:Celsr2
|
UTSW |
3 |
108,304,389 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
R8843:Celsr2
|
UTSW |
3 |
108,303,443 (GRCm39) |
splice site |
probably benign |
|
|
R8888:Celsr2
|
UTSW |
3 |
108,320,880 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R8895:Celsr2
|
UTSW |
3 |
108,320,880 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R8917:Celsr2
|
UTSW |
3 |
108,303,882 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9119:Celsr2
|
UTSW |
3 |
108,309,288 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R9169:Celsr2
|
UTSW |
3 |
108,309,862 (GRCm39) |
missense |
probably benign |
0.04 |
|
R9209:Celsr2
|
UTSW |
3 |
108,321,349 (GRCm39) |
missense |
probably benign |
0.02 |
|
R9342:Celsr2
|
UTSW |
3 |
108,320,442 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9416:Celsr2
|
UTSW |
3 |
108,322,084 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R9493:Celsr2
|
UTSW |
3 |
108,301,074 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9564:Celsr2
|
UTSW |
3 |
108,321,834 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9598:Celsr2
|
UTSW |
3 |
108,322,578 (GRCm39) |
missense |
possibly damaging |
0.72 |
|
R9629:Celsr2
|
UTSW |
3 |
108,308,915 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9691:Celsr2
|
UTSW |
3 |
108,301,551 (GRCm39) |
missense |
probably damaging |
1.00 |
|
X0020:Celsr2
|
UTSW |
3 |
108,303,426 (GRCm39) |
missense |
probably damaging |
1.00 |
|
X0050:Celsr2
|
UTSW |
3 |
108,308,588 (GRCm39) |
missense |
probably benign |
0.09 |
|
Z1088:Celsr2
|
UTSW |
3 |
108,321,433 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1176:Celsr2
|
UTSW |
3 |
108,319,657 (GRCm39) |
missense |
probably benign |
0.07 |
|
Z1176:Celsr2
|
UTSW |
3 |
108,300,447 (GRCm39) |
missense |
probably benign |
0.10 |
|
Z1177:Celsr2
|
UTSW |
3 |
108,320,887 (GRCm39) |
missense |
probably benign |
0.32 |
|
Z1177:Celsr2
|
UTSW |
3 |
108,319,536 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1191:Celsr2
|
UTSW |
3 |
108,321,865 (GRCm39) |
missense |
possibly damaging |
0.68 |
|
| Predicted Primers |
PCR Primer
(F):5'- TCGTGAACGCTGATGCTCAC -3'
(R):5'- AACACAGATGTGGTAACGGC -3'
Sequencing Primer
(F):5'- CCACAGGGGTGTTGATGAC -3'
(R):5'- GCAGCATTTACTTCCAGAGATGC -3'
|
| Posted On |
2016-06-17 |
Incidental Mutation