Incidental Mutation 'R5127:Styx'
ID 394837
Institutional Source Beutler Lab
Gene Symbol Styx
Ensembl Gene ENSMUSG00000053205
Gene Name serine/threonine/tyrosine interaction protein
Synonyms 0610039A20Rik, STNS (alternatively spliced intron of Styx)
MMRRC Submission 042715-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.228) question?
Stock # R5127 (G1)
Quality Score 225
Status Validated
Chromosome 14
Chromosomal Location 45588534-45614608 bp(+) (GRCm39)
Type of Mutation splice site
DNA Base Change (assembly) A to G at 45610961 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000153854 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000046191] [ENSMUST00000111835] [ENSMUST00000226276] [ENSMUST00000226303] [ENSMUST00000226603] [ENSMUST00000226785] [ENSMUST00000227468] [ENSMUST00000226873] [ENSMUST00000228311]
AlphaFold Q60969
Predicted Effect probably benign
Transcript: ENSMUST00000046191
SMART Domains Protein: ENSMUSP00000042860
Gene: ENSMUSG00000037722

DomainStartEndE-ValueType
Pfam:Acetyltransf_7 82 172 8e-9 PFAM
Pfam:Acetyltransf_1 91 171 6.3e-11 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000111835
SMART Domains Protein: ENSMUSP00000107466
Gene: ENSMUSG00000053205

DomainStartEndE-ValueType
DSPc 28 173 2.71e-64 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000226276
Predicted Effect probably benign
Transcript: ENSMUST00000226303
Predicted Effect probably benign
Transcript: ENSMUST00000226603
Predicted Effect probably benign
Transcript: ENSMUST00000226785
Predicted Effect noncoding transcript
Transcript: ENSMUST00000228321
Predicted Effect probably benign
Transcript: ENSMUST00000227468
Predicted Effect probably null
Transcript: ENSMUST00000226873
Predicted Effect noncoding transcript
Transcript: ENSMUST00000227538
Predicted Effect probably benign
Transcript: ENSMUST00000228311
Predicted Effect probably benign
Transcript: ENSMUST00000228451
Meta Mutation Damage Score 0.9755 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.5%
  • 10x: 96.9%
  • 20x: 94.2%
Validation Efficiency 93% (42/45)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a pseudophosphatase, able to bind potential substrates but lacking an active catalytic loop. The encoded protein may be involved in spermiogenesis. Two transcript variants encoding the same protein have been found for these genes. [provided by RefSeq, Oct 2011]
PHENOTYPE: Males homozygous for a targeted null mutation are sterile due to a deficiency of germ cells at the immature, round, and elongating spermatid stages. Residual epididymal sperm have head abnormalities. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 41 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2610008E11Rik T C 10: 78,902,826 (GRCm39) K497E probably damaging Het
4933413J09Rik A G 14: 26,097,462 (GRCm39) noncoding transcript Het
Aox1 A T 1: 58,069,185 (GRCm39) I4F probably benign Het
Arhgef5 A T 6: 43,250,148 (GRCm39) N300Y probably damaging Het
B530045E10Rik A G 10: 99,257,983 (GRCm39) noncoding transcript Het
Ccnb1 C G 13: 100,918,283 (GRCm39) Q121H possibly damaging Het
Cdh20 A G 1: 104,875,073 (GRCm39) E285G probably damaging Het
Cfap54 A T 10: 92,722,249 (GRCm39) probably null Het
Col6a3 A G 1: 90,696,067 (GRCm39) C2667R unknown Het
Cts8 C T 13: 61,401,149 (GRCm39) V126M probably damaging Het
Dag1 A T 9: 108,084,771 (GRCm39) I790N possibly damaging Het
Ddit4 A G 10: 59,786,491 (GRCm39) I186T probably damaging Het
Dnajc11 T A 4: 152,054,271 (GRCm39) probably benign Het
Farsa A G 8: 85,595,593 (GRCm39) D495G probably benign Het
Gm1527 T A 3: 28,957,567 (GRCm39) I157N probably damaging Het
Gm5773 T A 3: 93,680,735 (GRCm39) W136R probably benign Het
Hpse C A 5: 100,867,403 (GRCm39) A20S unknown Het
Igfn1 A G 1: 135,887,634 (GRCm39) Y2477H probably damaging Het
Kcnh5 A G 12: 74,944,858 (GRCm39) V797A probably benign Het
Kptn T A 7: 15,859,710 (GRCm39) C311* probably null Het
Lpcat2 A T 8: 93,635,819 (GRCm39) N407I possibly damaging Het
Lrp1 T A 10: 127,375,503 (GRCm39) probably benign Het
Ovol2 C T 2: 144,159,780 (GRCm39) C120Y probably damaging Het
Pcdhac2 G T 18: 37,277,352 (GRCm39) E111* probably null Het
Pknox1 C T 17: 31,809,713 (GRCm39) P106S probably benign Het
Plet1 C T 9: 50,415,595 (GRCm39) T155I probably benign Het
Ppfia2 A G 10: 106,671,621 (GRCm39) K444R probably damaging Het
Prrc2c A T 1: 162,525,415 (GRCm39) I397N unknown Het
Ranbp1 A G 16: 18,065,151 (GRCm39) probably null Het
Raver2 T C 4: 100,960,182 (GRCm39) C221R probably damaging Het
Reps1 A G 10: 17,969,628 (GRCm39) T244A probably benign Het
Slc22a16 G A 10: 40,449,953 (GRCm39) V130I probably benign Het
Stmnd1 G A 13: 46,453,071 (GRCm39) S249N probably benign Het
Sult1b1 T G 5: 87,669,407 (GRCm39) N147T probably damaging Het
Tbc1d2 G A 4: 46,633,639 (GRCm39) probably benign Het
Tm4sf1 T G 3: 57,200,289 (GRCm39) I109L possibly damaging Het
Ufl1 T C 4: 25,256,010 (GRCm39) E423G probably benign Het
Unc13c T C 9: 73,840,654 (GRCm39) I66V probably benign Het
Wfdc10 C T 2: 164,499,060 (GRCm39) Q57* probably null Het
Zeb1os1 T C 18: 5,567,390 (GRCm39) noncoding transcript Het
Zfp369 A T 13: 65,426,847 (GRCm39) probably benign Het
Other mutations in Styx
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02501:Styx APN 14 45,609,922 (GRCm39) missense probably benign
R0464:Styx UTSW 14 45,609,908 (GRCm39) missense probably benign 0.00
R1772:Styx UTSW 14 45,594,215 (GRCm39) missense probably damaging 1.00
R2067:Styx UTSW 14 45,611,020 (GRCm39) missense probably benign 0.01
R2289:Styx UTSW 14 45,592,404 (GRCm39) missense possibly damaging 0.65
R5583:Styx UTSW 14 45,608,483 (GRCm39) missense possibly damaging 0.72
R5755:Styx UTSW 14 45,605,910 (GRCm39) missense probably benign 0.40
R5982:Styx UTSW 14 45,605,909 (GRCm39) missense probably benign 0.43
R7078:Styx UTSW 14 45,609,873 (GRCm39) missense probably benign 0.01
X0023:Styx UTSW 14 45,596,724 (GRCm39) missense probably benign 0.04
Predicted Primers PCR Primer
(F):5'- TGTGTTTCAAGTTCAACAGTGC -3'
(R):5'- GTGTTGCAGAGAAACATGTCTGG -3'

Sequencing Primer
(F):5'- TATACTACGTGCATGCCAGG -3'
(R):5'- CAGAGAAACATGTCTGGAAGCAATG -3'
Posted On 2016-06-21