Incidental Mutation 'R5130:Vmn1r225'
| ID |
394977 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Vmn1r225
|
| Ensembl Gene |
ENSMUSG00000043537 |
| Gene Name |
vomeronasal 1 receptor 225 |
| Synonyms |
V1re5 |
| MMRRC Submission |
042718-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.072)
|
| Stock # |
R5130 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
17 |
| Chromosomal Location |
20722561-20723457 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to G
at 20723047 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Arginine to Glycine
at position 163
(R163G)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000056068
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000061660]
|
| AlphaFold |
Q8R2A5 |
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000061660
AA Change: R163G
PolyPhen 2
Score 0.810 (Sensitivity: 0.84; Specificity: 0.93)
|
| SMART Domains |
Protein: ENSMUSP00000056068
Gene: ENSMUSG00000043537
AA Change: R163G
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:TAS2R
|
1 |
287 |
8.9e-15 |
PFAM |
|
Pfam:V1R
|
11 |
291 |
3.1e-24 |
PFAM |
|
| Meta Mutation Damage Score |
0.1795 |
| Coding Region Coverage |
- 1x: 99.2%
- 3x: 98.5%
- 10x: 96.7%
- 20x: 93.4%
|
| Validation Efficiency |
96% (51/53) |
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 45 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 4930558K02Rik |
T |
C |
1: 161,780,184 (GRCm39) |
N110S |
possibly damaging |
Het |
| Acss3 |
T |
C |
10: 106,840,586 (GRCm39) |
I392V |
possibly damaging |
Het |
| Agbl5 |
G |
A |
5: 31,060,403 (GRCm39) |
R141Q |
probably damaging |
Het |
| Arhgef11 |
A |
G |
3: 87,633,321 (GRCm39) |
H696R |
possibly damaging |
Het |
| Baiap3 |
G |
T |
17: 25,464,316 (GRCm39) |
D847E |
probably benign |
Het |
| Cdc27 |
T |
C |
11: 104,425,600 (GRCm39) |
K72R |
probably benign |
Het |
| Cry2 |
T |
C |
2: 92,254,944 (GRCm39) |
E137G |
probably benign |
Het |
| Dhodh |
A |
T |
8: 110,322,388 (GRCm39) |
L237Q |
possibly damaging |
Het |
| Dscam |
A |
T |
16: 96,620,979 (GRCm39) |
N576K |
probably benign |
Het |
| Eng |
A |
G |
2: 32,571,518 (GRCm39) |
N636S |
probably damaging |
Het |
| Ephx2 |
A |
T |
14: 66,345,511 (GRCm39) |
I151K |
probably damaging |
Het |
| Fahd1 |
A |
G |
17: 25,068,733 (GRCm39) |
C115R |
probably damaging |
Het |
| Fer1l4 |
T |
A |
2: 155,891,386 (GRCm39) |
I143F |
possibly damaging |
Het |
| Iqgap3 |
C |
A |
3: 88,016,161 (GRCm39) |
N981K |
probably damaging |
Het |
| Kcna5 |
T |
C |
6: 126,511,496 (GRCm39) |
I211V |
probably benign |
Het |
| Mcm9 |
A |
T |
10: 53,506,495 (GRCm39) |
V14E |
possibly damaging |
Het |
| Mlh1 |
A |
G |
9: 111,058,906 (GRCm39) |
|
probably null |
Het |
| Mylk |
A |
G |
16: 34,809,367 (GRCm39) |
K1775E |
probably damaging |
Het |
| Myo18b |
T |
C |
5: 113,021,769 (GRCm39) |
D541G |
probably benign |
Het |
| Ncapd2 |
A |
T |
6: 125,146,887 (GRCm39) |
M1233K |
possibly damaging |
Het |
| Nf2 |
A |
T |
11: 4,779,862 (GRCm39) |
|
probably benign |
Het |
| Nova2 |
C |
T |
7: 18,660,069 (GRCm39) |
T22I |
unknown |
Het |
| Or3a1d |
A |
T |
11: 74,237,993 (GRCm39) |
M19K |
probably damaging |
Het |
| Or7g28 |
T |
A |
9: 19,272,369 (GRCm39) |
Y94F |
possibly damaging |
Het |
| Or8b12 |
T |
A |
9: 37,657,805 (GRCm39) |
I125N |
probably damaging |
Het |
| Pcdha2 |
A |
T |
18: 37,073,722 (GRCm39) |
N451I |
probably damaging |
Het |
| Pcdhb12 |
T |
A |
18: 37,568,877 (GRCm39) |
F8I |
probably benign |
Het |
| Pdzph1 |
A |
C |
17: 59,229,604 (GRCm39) |
L1018W |
probably damaging |
Het |
| Prdm9 |
T |
C |
17: 15,764,729 (GRCm39) |
R684G |
probably benign |
Het |
| Rabep1 |
T |
A |
11: 70,795,557 (GRCm39) |
V261E |
probably damaging |
Het |
| Ros1 |
T |
A |
10: 52,040,037 (GRCm39) |
Y318F |
possibly damaging |
Het |
| Samd9l |
A |
T |
6: 3,374,548 (GRCm39) |
D904E |
possibly damaging |
Het |
| Siah3 |
A |
T |
14: 75,763,381 (GRCm39) |
K211* |
probably null |
Het |
| Slc5a8 |
T |
A |
10: 88,762,077 (GRCm39) |
N572K |
probably benign |
Het |
| Slfn8 |
A |
G |
11: 82,894,647 (GRCm39) |
F664S |
probably benign |
Het |
| Sowahb |
T |
A |
5: 93,190,630 (GRCm39) |
K696N |
possibly damaging |
Het |
| St7l |
A |
T |
3: 104,803,080 (GRCm39) |
H330L |
probably damaging |
Het |
| Tnrc6c |
T |
A |
11: 117,629,176 (GRCm39) |
|
probably null |
Het |
| Ttc28 |
G |
T |
5: 111,040,722 (GRCm39) |
V37F |
probably benign |
Het |
| Uaca |
C |
A |
9: 60,787,510 (GRCm39) |
Q1409K |
probably damaging |
Het |
| V1rd19 |
T |
A |
7: 23,702,537 (GRCm39) |
M1K |
probably null |
Het |
| Wdr87-ps |
T |
C |
7: 29,228,699 (GRCm39) |
|
noncoding transcript |
Het |
| Zc3h3 |
C |
A |
15: 75,651,139 (GRCm39) |
V694L |
probably damaging |
Het |
| Zfp442 |
G |
T |
2: 150,251,530 (GRCm39) |
T123K |
possibly damaging |
Het |
| Zmym1 |
A |
T |
4: 126,942,451 (GRCm39) |
S646T |
probably damaging |
Het |
|
| Other mutations in Vmn1r225 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01093:Vmn1r225
|
APN |
17 |
20,723,081 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01830:Vmn1r225
|
APN |
17 |
20,722,717 (GRCm39) |
missense |
probably damaging |
0.96 |
|
IGL02943:Vmn1r225
|
APN |
17 |
20,722,567 (GRCm39) |
missense |
possibly damaging |
0.67 |
|
R0544:Vmn1r225
|
UTSW |
17 |
20,722,718 (GRCm39) |
missense |
probably benign |
0.44 |
|
R1126:Vmn1r225
|
UTSW |
17 |
20,722,588 (GRCm39) |
missense |
probably benign |
0.03 |
|
R1809:Vmn1r225
|
UTSW |
17 |
20,722,918 (GRCm39) |
missense |
probably benign |
0.04 |
|
R1928:Vmn1r225
|
UTSW |
17 |
20,723,071 (GRCm39) |
missense |
probably benign |
0.00 |
|
R2044:Vmn1r225
|
UTSW |
17 |
20,722,852 (GRCm39) |
missense |
possibly damaging |
0.50 |
|
R2191:Vmn1r225
|
UTSW |
17 |
20,723,147 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R2206:Vmn1r225
|
UTSW |
17 |
20,722,611 (GRCm39) |
missense |
possibly damaging |
0.56 |
|
R2207:Vmn1r225
|
UTSW |
17 |
20,722,611 (GRCm39) |
missense |
possibly damaging |
0.56 |
|
R2680:Vmn1r225
|
UTSW |
17 |
20,723,055 (GRCm39) |
missense |
probably benign |
0.00 |
|
R3740:Vmn1r225
|
UTSW |
17 |
20,723,261 (GRCm39) |
missense |
possibly damaging |
0.56 |
|
R3807:Vmn1r225
|
UTSW |
17 |
20,723,114 (GRCm39) |
nonsense |
probably null |
|
|
R4196:Vmn1r225
|
UTSW |
17 |
20,723,237 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4970:Vmn1r225
|
UTSW |
17 |
20,722,831 (GRCm39) |
missense |
possibly damaging |
0.74 |
|
R5129:Vmn1r225
|
UTSW |
17 |
20,723,378 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5187:Vmn1r225
|
UTSW |
17 |
20,723,177 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R5580:Vmn1r225
|
UTSW |
17 |
20,723,101 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6563:Vmn1r225
|
UTSW |
17 |
20,722,763 (GRCm39) |
missense |
probably benign |
0.03 |
|
R6674:Vmn1r225
|
UTSW |
17 |
20,723,377 (GRCm39) |
missense |
probably benign |
0.06 |
|
R7003:Vmn1r225
|
UTSW |
17 |
20,723,416 (GRCm39) |
missense |
probably null |
0.01 |
|
R7143:Vmn1r225
|
UTSW |
17 |
20,722,646 (GRCm39) |
missense |
probably benign |
0.22 |
|
R7422:Vmn1r225
|
UTSW |
17 |
20,723,059 (GRCm39) |
missense |
probably benign |
0.25 |
|
R7651:Vmn1r225
|
UTSW |
17 |
20,722,611 (GRCm39) |
missense |
possibly damaging |
0.56 |
|
R7952:Vmn1r225
|
UTSW |
17 |
20,722,589 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R8097:Vmn1r225
|
UTSW |
17 |
20,722,611 (GRCm39) |
missense |
possibly damaging |
0.56 |
|
R8696:Vmn1r225
|
UTSW |
17 |
20,723,419 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8823:Vmn1r225
|
UTSW |
17 |
20,722,823 (GRCm39) |
missense |
probably benign |
0.08 |
|
R9007:Vmn1r225
|
UTSW |
17 |
20,723,449 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R9041:Vmn1r225
|
UTSW |
17 |
20,722,577 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R9147:Vmn1r225
|
UTSW |
17 |
20,722,577 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R9148:Vmn1r225
|
UTSW |
17 |
20,722,577 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R9312:Vmn1r225
|
UTSW |
17 |
20,722,960 (GRCm39) |
missense |
probably benign |
0.39 |
|
R9401:Vmn1r225
|
UTSW |
17 |
20,722,912 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9401:Vmn1r225
|
UTSW |
17 |
20,722,911 (GRCm39) |
nonsense |
probably null |
|
|
R9488:Vmn1r225
|
UTSW |
17 |
20,722,793 (GRCm39) |
missense |
probably damaging |
0.99 |
|
Z1177:Vmn1r225
|
UTSW |
17 |
20,722,753 (GRCm39) |
missense |
possibly damaging |
0.65 |
|
| Predicted Primers |
PCR Primer
(F):5'- ATGTCCATCAGCACCACCTG -3'
(R):5'- AGACATTCGTTGTGAAGCATGTG -3'
Sequencing Primer
(F):5'- GAGTGTCTTTCAGGCAATCAC -3'
(R):5'- GTGTGCTAAGAATACCTTGAACCCTC -3'
|
| Posted On |
2016-06-21 |
Incidental Mutation