Incidental Mutation 'R5145:Vmn2r10'
ID 395077
Institutional Source Beutler Lab
Gene Symbol Vmn2r10
Ensembl Gene ENSMUSG00000067010
Gene Name vomeronasal 2, receptor 10
Synonyms VR16, V2r16
MMRRC Submission 042729-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.085) question?
Stock # R5145 (G1)
Quality Score 225
Status Validated
Chromosome 5
Chromosomal Location 109141278-109154337 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 109143761 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Alanine at position 730 (T730A)
Ref Sequence ENSEMBL: ENSMUSP00000078162 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000079163] [ENSMUST00000176594]
AlphaFold K7N621
Predicted Effect possibly damaging
Transcript: ENSMUST00000079163
AA Change: T730A

PolyPhen 2 Score 0.638 (Sensitivity: 0.87; Specificity: 0.91)
SMART Domains Protein: ENSMUSP00000078162
Gene: ENSMUSG00000067010
AA Change: T730A

DomainStartEndE-ValueType
signal peptide 1 21 N/A INTRINSIC
Pfam:ANF_receptor 75 464 8.5e-29 PFAM
Pfam:NCD3G 506 560 3.8e-17 PFAM
Pfam:7tm_3 593 828 4e-55 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000176594
SMART Domains Protein: ENSMUSP00000135274
Gene: ENSMUSG00000067010

DomainStartEndE-ValueType
signal peptide 1 21 N/A INTRINSIC
Meta Mutation Damage Score 0.1795 question?
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.6%
  • 10x: 97.2%
  • 20x: 94.8%
Validation Efficiency 100% (37/37)
Allele List at MGI
Other mutations in this stock
Total: 32 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adamts12 G A 15: 11,285,962 (GRCm39) G724R probably damaging Het
Adgrg7 T A 16: 56,562,682 (GRCm39) I552L probably benign Het
Ankrd11 A G 8: 123,617,943 (GRCm39) probably benign Het
Col12a1 T C 9: 79,613,582 (GRCm39) T88A probably benign Het
Col6a5 T G 9: 105,811,444 (GRCm39) I692L unknown Het
Cry2 T C 2: 92,243,405 (GRCm39) I479V probably benign Het
Ddx21 T C 10: 62,423,318 (GRCm39) probably null Het
Efcab12 T A 6: 115,800,238 (GRCm39) I262F probably damaging Het
Eif2ak2 T C 17: 79,183,633 (GRCm39) D72G possibly damaging Het
Fry T C 5: 150,293,689 (GRCm39) F461L probably damaging Het
Gm38706 G A 6: 130,460,731 (GRCm39) noncoding transcript Het
Gm9772 C T 17: 22,226,107 (GRCm39) C59Y probably damaging Het
Meig1 T C 2: 3,410,263 (GRCm39) E79G probably damaging Het
Mfng C T 15: 78,648,588 (GRCm39) R163H probably benign Het
Mfsd2b T A 12: 4,915,908 (GRCm39) probably benign Het
Nfatc2 A C 2: 168,431,987 (GRCm39) I42S probably benign Het
Nlgn3 G A X: 100,361,891 (GRCm39) V287I probably benign Het
Npy6r C T 18: 44,409,686 (GRCm39) T369I probably benign Het
Or7a36 A G 10: 78,820,143 (GRCm39) E173G probably benign Het
Ptprb A G 10: 116,179,820 (GRCm39) T1413A probably benign Het
Ptprc A G 1: 138,017,304 (GRCm39) S624P probably benign Het
Pum3 A G 19: 27,377,169 (GRCm39) V441A probably damaging Het
Ranbp2 T A 10: 58,315,860 (GRCm39) D2193E probably damaging Het
Rbl1 A T 2: 157,017,397 (GRCm39) probably benign Het
Rnf167 T C 11: 70,540,906 (GRCm39) probably benign Het
Sdr9c7 T C 10: 127,738,259 (GRCm39) V179A probably damaging Het
Sema3c A G 5: 17,932,615 (GRCm39) N706S possibly damaging Het
Stt3a T C 9: 36,646,762 (GRCm39) Y617C probably damaging Het
Tdrd6 T A 17: 43,936,966 (GRCm39) S1361C probably damaging Het
Tha1 A C 11: 117,760,502 (GRCm39) S241A probably damaging Het
Tti1 G A 2: 157,850,432 (GRCm39) A269V probably benign Het
Ugt2a1 A G 5: 87,633,886 (GRCm39) probably null Het
Other mutations in Vmn2r10
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00816:Vmn2r10 APN 5 109,150,451 (GRCm39) missense possibly damaging 0.75
IGL01618:Vmn2r10 APN 5 109,150,345 (GRCm39) missense probably damaging 1.00
IGL01624:Vmn2r10 APN 5 109,154,112 (GRCm39) missense possibly damaging 0.83
IGL01941:Vmn2r10 APN 5 109,143,820 (GRCm39) missense probably damaging 1.00
IGL01959:Vmn2r10 APN 5 109,145,571 (GRCm39) missense probably benign 0.00
IGL01973:Vmn2r10 APN 5 109,143,543 (GRCm39) missense probably damaging 1.00
IGL01985:Vmn2r10 APN 5 109,154,125 (GRCm39) missense probably benign 0.21
IGL02451:Vmn2r10 APN 5 109,143,788 (GRCm39) nonsense probably null
IGL02503:Vmn2r10 APN 5 109,151,341 (GRCm39) missense probably damaging 1.00
IGL03275:Vmn2r10 APN 5 109,151,243 (GRCm39) missense probably benign 0.00
R0035:Vmn2r10 UTSW 5 109,145,467 (GRCm39) splice site probably benign
R0395:Vmn2r10 UTSW 5 109,149,859 (GRCm39) missense probably damaging 1.00
R0454:Vmn2r10 UTSW 5 109,151,327 (GRCm39) missense probably benign 0.25
R0648:Vmn2r10 UTSW 5 109,143,782 (GRCm39) missense probably benign 0.00
R1251:Vmn2r10 UTSW 5 109,143,890 (GRCm39) missense probably benign 0.01
R1580:Vmn2r10 UTSW 5 109,154,117 (GRCm39) missense possibly damaging 0.82
R1845:Vmn2r10 UTSW 5 109,149,861 (GRCm39) nonsense probably null
R1986:Vmn2r10 UTSW 5 109,154,120 (GRCm39) nonsense probably null
R2137:Vmn2r10 UTSW 5 109,151,410 (GRCm39) missense possibly damaging 0.87
R2495:Vmn2r10 UTSW 5 109,143,961 (GRCm39) missense probably damaging 1.00
R3932:Vmn2r10 UTSW 5 109,150,088 (GRCm39) missense possibly damaging 0.47
R3933:Vmn2r10 UTSW 5 109,150,088 (GRCm39) missense possibly damaging 0.47
R4899:Vmn2r10 UTSW 5 109,151,324 (GRCm39) missense probably damaging 1.00
R4992:Vmn2r10 UTSW 5 109,145,592 (GRCm39) missense possibly damaging 0.89
R5124:Vmn2r10 UTSW 5 109,154,286 (GRCm39) missense probably benign 0.01
R5156:Vmn2r10 UTSW 5 109,143,466 (GRCm39) missense probably benign 0.11
R5265:Vmn2r10 UTSW 5 109,143,586 (GRCm39) missense probably damaging 1.00
R5311:Vmn2r10 UTSW 5 109,154,121 (GRCm39) missense probably damaging 1.00
R5321:Vmn2r10 UTSW 5 109,143,505 (GRCm39) missense probably damaging 1.00
R5666:Vmn2r10 UTSW 5 109,146,910 (GRCm39) nonsense probably null
R5670:Vmn2r10 UTSW 5 109,146,910 (GRCm39) nonsense probably null
R5872:Vmn2r10 UTSW 5 109,151,377 (GRCm39) missense possibly damaging 0.84
R6004:Vmn2r10 UTSW 5 109,146,944 (GRCm39) missense probably benign 0.30
R6108:Vmn2r10 UTSW 5 109,143,667 (GRCm39) missense probably damaging 1.00
R6332:Vmn2r10 UTSW 5 109,151,328 (GRCm39) missense probably damaging 1.00
R6599:Vmn2r10 UTSW 5 109,143,944 (GRCm39) missense probably benign 0.09
R6651:Vmn2r10 UTSW 5 109,143,488 (GRCm39) missense probably null 0.22
R6891:Vmn2r10 UTSW 5 109,149,845 (GRCm39) missense probably damaging 1.00
R7023:Vmn2r10 UTSW 5 109,149,894 (GRCm39) missense probably damaging 0.96
R7146:Vmn2r10 UTSW 5 109,151,200 (GRCm39) missense probably damaging 1.00
R7941:Vmn2r10 UTSW 5 109,144,306 (GRCm39) missense probably damaging 1.00
R8058:Vmn2r10 UTSW 5 109,149,955 (GRCm39) missense probably benign 0.00
R8478:Vmn2r10 UTSW 5 109,143,636 (GRCm39) missense probably damaging 1.00
R8526:Vmn2r10 UTSW 5 109,145,572 (GRCm39) missense possibly damaging 0.51
R8698:Vmn2r10 UTSW 5 109,151,390 (GRCm39) missense probably benign 0.00
R8796:Vmn2r10 UTSW 5 109,143,917 (GRCm39) missense possibly damaging 0.74
R8854:Vmn2r10 UTSW 5 109,144,126 (GRCm39) missense probably benign 0.20
R8871:Vmn2r10 UTSW 5 109,146,899 (GRCm39) missense possibly damaging 0.67
R8893:Vmn2r10 UTSW 5 109,143,677 (GRCm39) missense probably benign 0.09
R8907:Vmn2r10 UTSW 5 109,149,791 (GRCm39) missense probably benign
R8957:Vmn2r10 UTSW 5 109,149,780 (GRCm39) missense possibly damaging 0.60
R8976:Vmn2r10 UTSW 5 109,145,479 (GRCm39) missense probably damaging 1.00
R9155:Vmn2r10 UTSW 5 109,144,212 (GRCm39) missense probably benign 0.10
R9308:Vmn2r10 UTSW 5 109,145,476 (GRCm39) nonsense probably null
R9800:Vmn2r10 UTSW 5 109,150,404 (GRCm39) missense probably damaging 0.99
Z1088:Vmn2r10 UTSW 5 109,143,979 (GRCm39) missense probably damaging 1.00
Z1176:Vmn2r10 UTSW 5 109,149,854 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- GAAGGTGATCCAGACACTGC -3'
(R):5'- TCCTGCAGCAGACCACATTTG -3'

Sequencing Primer
(F):5'- GGTGATCCAGACACTGCAGAAC -3'
(R):5'- AACTGTGCTCATGGCTTTCAAG -3'
Posted On 2016-06-21