Mutagenetix > Incidental Mutation

Incidental Mutation 'R5147:Vps13b'

395171

Institutional Source

Beutler Lab

Gene Symbol

Vps13b

Ensembl Gene

ENSMUSG00000037646

Gene Name

vacuolar protein sorting 13B

Synonyms

1810042B05Rik, C330002D13Rik, 2310042E16Rik, Coh1

MMRRC Submission

042731-MU

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

R5147 (G1)

Quality Score

225

Status

Not validated

Chromosome

Chromosomal Location

35371306-35931375 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

C to T at 35456824 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Proline to Serine at position 757 (P757S)

Ref Sequence

ENSEMBL: ENSMUSP00000045490 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000048646]

AlphaFold

no structure available at present

Predicted Effect

probably benign
Transcript: ENSMUST00000048646
AA Change: P757S

PolyPhen 2 Score 0.316 (Sensitivity: 0.90; Specificity: 0.89)

SMART Domains

Protein: ENSMUSP00000045490
Gene: ENSMUSG00000037646
AA Change: P757S

Domain	Start	End	E-Value	Type
Pfam:Chorein_N	2	120	1e-29	PFAM
low complexity region	128	137	N/A	INTRINSIC
low complexity region	143	160	N/A	INTRINSIC
low complexity region	975	984	N/A	INTRINSIC
low complexity region	1007	1018	N/A	INTRINSIC
low complexity region	1876	1883	N/A	INTRINSIC
low complexity region	2042	2054	N/A	INTRINSIC
low complexity region	2414	2423	N/A	INTRINSIC
Pfam:SHR-BD	2601	2700	8.4e-10	PFAM
low complexity region	2954	2964	N/A	INTRINSIC
Pfam:VPS13_C	3539	3706	2.6e-30	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000226579

Coding Region Coverage

1x: 99.2%
3x: 98.6%
10x: 97.1%
20x: 94.5%

Validation Efficiency

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a potential transmembrane protein that may function in vesicle-mediated transport and sorting of proteins within the cell. This protein may play a role in the development and the function of the eye, hematological system, and central nervous system. Mutations in this gene have been associated with Cohen syndrome. Multiple splice variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 37 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abca7	T	C	10: 79,851,149 (GRCm39)	Y2121H	probably benign	Het
Adgrf2	A	G	17: 43,021,574 (GRCm39)	Y417H	probably damaging	Het
Ap5z1	A	C	5: 142,452,265 (GRCm39)	D66A	probably benign	Het
Cachd1	T	A	4: 100,821,688 (GRCm39)	Y422N	probably damaging	Het
Cfap54	C	T	10: 92,773,700 (GRCm39)	G114D	probably benign	Het
Cgref1	C	T	5: 31,091,049 (GRCm39)	G255E	probably benign	Het
Cyp2a22	A	C	7: 26,635,750 (GRCm39)	L271R	probably damaging	Het
Dcp2	G	T	18: 44,550,662 (GRCm39)	E379*	probably null	Het
Fhl3	T	A	4: 124,601,724 (GRCm39)	D277E	probably benign	Het
Gm19684	C	T	17: 36,439,411 (GRCm39)	V190M	probably damaging	Het
Hpse	T	C	5: 100,867,375 (GRCm39)	D29G	probably benign	Het
Il31	T	C	5: 123,620,121 (GRCm39)		probably benign	Het
Ilk	T	C	7: 105,391,774 (GRCm39)	C422R	possibly damaging	Het
Itga1	T	G	13: 115,121,678 (GRCm39)	D777A	possibly damaging	Het
Kank3	A	G	17: 34,041,176 (GRCm39)	D556G	probably damaging	Het
Lrit3	A	G	3: 129,597,574 (GRCm39)	S36P	possibly damaging	Het
Magi1	C	T	6: 93,724,248 (GRCm39)	E256K	probably damaging	Het
Mroh9	C	G	1: 162,888,329 (GRCm39)	G249R	probably damaging	Het
Mymk	C	T	2: 26,952,299 (GRCm39)	M148I	probably benign	Het
Nlrp12	T	A	7: 3,290,003 (GRCm39)	I170F	possibly damaging	Het
Odad3	T	C	9: 21,906,158 (GRCm39)	E260G	probably benign	Het
Or5al7	A	T	2: 85,992,378 (GRCm39)	I305K	possibly damaging	Het
Or5an11	T	A	19: 12,246,268 (GRCm39)	S225T	probably damaging	Het
Pkd1l1	G	A	11: 8,799,003 (GRCm39)	T1803I	possibly damaging	Het
Ppp2r2b	C	T	18: 42,778,942 (GRCm39)	V398I	probably benign	Het
Ppp2r5e	T	A	12: 75,516,544 (GRCm39)	R214S	probably damaging	Het
Prss16	T	C	13: 22,190,264 (GRCm39)	D298G	possibly damaging	Het
Qprt	G	A	7: 126,707,622 (GRCm39)	R189W	probably damaging	Het
Rara	C	T	11: 98,841,550 (GRCm39)	S36F	probably benign	Het
Rasal2	A	G	1: 157,003,264 (GRCm39)	V465A	probably damaging	Het
Slc22a1	C	T	17: 12,869,838 (GRCm39)	G508R	probably damaging	Het
Slco2a1	C	A	9: 102,927,468 (GRCm39)	F120L	probably damaging	Het
Tex15	T	A	8: 34,062,340 (GRCm39)	L864*	probably null	Het
Tssk4	A	G	14: 55,888,430 (GRCm39)	I100V	possibly damaging	Het
Vgll4	A	G	6: 114,867,576 (GRCm39)		probably null	Het
Vmn1r65	T	G	7: 6,011,818 (GRCm39)	I139L	probably benign	Het
Ythdc2	G	A	18: 44,977,359 (GRCm39)	G385E	probably damaging	Het

Other mutations in Vps13b

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00402:Vps13b	APN	15	35,926,372 (GRCm39)	missense	possibly damaging	0.52
IGL00513:Vps13b	APN	15	35,794,030 (GRCm39)	missense	probably damaging	1.00
IGL00516:Vps13b	APN	15	35,640,703 (GRCm39)	missense	probably damaging	1.00
IGL00640:Vps13b	APN	15	35,417,723 (GRCm39)	missense	probably benign
IGL00753:Vps13b	APN	15	35,372,177 (GRCm39)	missense	probably damaging	0.99
IGL00784:Vps13b	APN	15	35,847,046 (GRCm39)	missense	probably damaging	1.00
IGL01138:Vps13b	APN	15	35,446,916 (GRCm39)	splice site	probably benign
IGL01349:Vps13b	APN	15	35,794,091 (GRCm39)	missense	probably benign	0.00
IGL01403:Vps13b	APN	15	35,709,625 (GRCm39)	missense	probably benign	0.00
IGL01535:Vps13b	APN	15	35,455,103 (GRCm39)	missense	possibly damaging	0.67
IGL01571:Vps13b	APN	15	35,877,635 (GRCm39)	splice site	probably benign
IGL01642:Vps13b	APN	15	35,792,218 (GRCm39)	missense	probably benign	0.43
IGL01658:Vps13b	APN	15	35,671,479 (GRCm39)	missense	probably damaging	0.99
IGL01759:Vps13b	APN	15	35,878,935 (GRCm39)	missense	probably damaging	1.00
IGL01763:Vps13b	APN	15	35,709,945 (GRCm39)	missense	possibly damaging	0.72
IGL01906:Vps13b	APN	15	35,639,993 (GRCm39)	splice site	probably benign
IGL01982:Vps13b	APN	15	35,439,050 (GRCm39)	nonsense	probably null
IGL01997:Vps13b	APN	15	35,709,370 (GRCm39)	missense	probably damaging	1.00
IGL02041:Vps13b	APN	15	35,423,391 (GRCm39)	missense	probably damaging	0.98
IGL02073:Vps13b	APN	15	35,875,732 (GRCm39)	missense	possibly damaging	0.52
IGL02077:Vps13b	APN	15	35,910,759 (GRCm39)	missense	possibly damaging	0.68
IGL02141:Vps13b	APN	15	35,572,227 (GRCm39)	missense	probably benign	0.09
IGL02146:Vps13b	APN	15	35,646,479 (GRCm39)	missense	probably benign	0.36
IGL02197:Vps13b	APN	15	35,930,202 (GRCm39)	missense	probably benign	0.02
IGL02311:Vps13b	APN	15	35,709,660 (GRCm39)	missense	probably benign	0.08
IGL02466:Vps13b	APN	15	35,770,887 (GRCm39)	missense	possibly damaging	0.86
IGL02506:Vps13b	APN	15	35,917,308 (GRCm39)	missense	probably damaging	1.00
IGL02550:Vps13b	APN	15	35,572,242 (GRCm39)	missense	probably benign
IGL02553:Vps13b	APN	15	35,646,447 (GRCm39)	missense	probably benign	0.00
IGL02674:Vps13b	APN	15	35,640,104 (GRCm39)	missense	probably benign	0.41
IGL02690:Vps13b	APN	15	35,917,288 (GRCm39)	missense	probably damaging	1.00
IGL02731:Vps13b	APN	15	35,917,274 (GRCm39)	missense	probably benign	0.00
IGL02739:Vps13b	APN	15	35,880,046 (GRCm39)	missense	probably damaging	1.00
IGL02868:Vps13b	APN	15	35,884,665 (GRCm39)	missense	probably benign	0.03
IGL03081:Vps13b	APN	15	35,875,966 (GRCm39)	missense	probably damaging	0.97
IGL03178:Vps13b	APN	15	35,869,446 (GRCm39)	missense	probably damaging	1.00
IGL03343:Vps13b	APN	15	35,917,316 (GRCm39)	missense	possibly damaging	0.76
IGL03407:Vps13b	APN	15	35,640,012 (GRCm39)	missense	possibly damaging	0.95
IGL03410:Vps13b	APN	15	35,910,486 (GRCm39)	missense	probably benign
omlette	UTSW	15	35,671,546 (GRCm39)	missense	probably benign	0.13
swiss	UTSW	15	35,709,819 (GRCm39)	missense	possibly damaging	0.80
FR4449:Vps13b	UTSW	15	35,847,103 (GRCm39)	missense	probably damaging	1.00
FR4548:Vps13b	UTSW	15	35,847,103 (GRCm39)	missense	probably damaging	1.00
FR4737:Vps13b	UTSW	15	35,847,103 (GRCm39)	missense	probably damaging	1.00
FR4976:Vps13b	UTSW	15	35,847,103 (GRCm39)	missense	probably damaging	1.00
LCD18:Vps13b	UTSW	15	35,847,103 (GRCm39)	missense	probably damaging	1.00
PIT4531001:Vps13b	UTSW	15	35,878,971 (GRCm39)	missense	probably damaging	1.00
PIT4581001:Vps13b	UTSW	15	35,534,409 (GRCm39)	missense	probably damaging	1.00
PIT4618001:Vps13b	UTSW	15	35,709,386 (GRCm39)	missense	probably damaging	1.00
R0026:Vps13b	UTSW	15	35,923,447 (GRCm39)	missense	possibly damaging	0.62
R0026:Vps13b	UTSW	15	35,923,447 (GRCm39)	missense	possibly damaging	0.62
R0108:Vps13b	UTSW	15	35,572,265 (GRCm39)	missense	probably benign	0.20
R0109:Vps13b	UTSW	15	35,572,265 (GRCm39)	missense	probably benign	0.20
R0109:Vps13b	UTSW	15	35,572,265 (GRCm39)	missense	probably benign	0.20
R0116:Vps13b	UTSW	15	35,423,301 (GRCm39)	missense	probably damaging	0.99
R0123:Vps13b	UTSW	15	35,887,407 (GRCm39)	missense	probably benign	0.01
R0124:Vps13b	UTSW	15	35,576,674 (GRCm39)	critical splice donor site	probably null
R0134:Vps13b	UTSW	15	35,887,407 (GRCm39)	missense	probably benign	0.01
R0137:Vps13b	UTSW	15	35,926,365 (GRCm39)	missense	probably benign	0.06
R0195:Vps13b	UTSW	15	35,472,045 (GRCm39)	missense	probably benign	0.00
R0225:Vps13b	UTSW	15	35,887,407 (GRCm39)	missense	probably benign	0.01
R0320:Vps13b	UTSW	15	35,674,974 (GRCm39)	missense	probably damaging	0.98
R0333:Vps13b	UTSW	15	35,879,949 (GRCm39)	missense	probably damaging	1.00
R0336:Vps13b	UTSW	15	35,455,279 (GRCm39)	nonsense	probably null
R0463:Vps13b	UTSW	15	35,597,555 (GRCm39)	missense	probably damaging	0.98
R0466:Vps13b	UTSW	15	35,445,748 (GRCm39)	nonsense	probably null
R0472:Vps13b	UTSW	15	35,417,779 (GRCm39)	critical splice donor site	probably null
R0523:Vps13b	UTSW	15	35,472,196 (GRCm39)	missense	probably benign	0.20
R0602:Vps13b	UTSW	15	35,422,514 (GRCm39)	missense	probably damaging	1.00
R0612:Vps13b	UTSW	15	35,623,803 (GRCm39)	missense	probably benign	0.12
R0627:Vps13b	UTSW	15	35,372,145 (GRCm39)	nonsense	probably null
R0679:Vps13b	UTSW	15	35,709,849 (GRCm39)	missense	possibly damaging	0.73
R0742:Vps13b	UTSW	15	35,794,507 (GRCm39)	missense	probably benign	0.22
R1053:Vps13b	UTSW	15	35,652,509 (GRCm39)	missense	probably damaging	1.00
R1355:Vps13b	UTSW	15	35,422,600 (GRCm39)	missense	probably damaging	1.00
R1386:Vps13b	UTSW	15	35,923,458 (GRCm39)	missense	probably damaging	0.99
R1403:Vps13b	UTSW	15	35,709,268 (GRCm39)	splice site	probably benign
R1453:Vps13b	UTSW	15	35,422,590 (GRCm39)	missense	probably damaging	0.97
R1464:Vps13b	UTSW	15	35,709,630 (GRCm39)	missense	probably benign	0.14
R1464:Vps13b	UTSW	15	35,709,630 (GRCm39)	missense	probably benign	0.14
R1511:Vps13b	UTSW	15	35,841,719 (GRCm39)	missense	probably benign	0.00
R1511:Vps13b	UTSW	15	35,840,121 (GRCm39)	missense	probably damaging	0.99
R1513:Vps13b	UTSW	15	35,438,876 (GRCm39)	nonsense	probably null
R1536:Vps13b	UTSW	15	35,875,712 (GRCm39)	missense	probably damaging	0.98
R1537:Vps13b	UTSW	15	35,792,327 (GRCm39)	missense	possibly damaging	0.62
R1558:Vps13b	UTSW	15	35,534,465 (GRCm39)	missense	probably damaging	1.00
R1601:Vps13b	UTSW	15	35,642,582 (GRCm39)	missense	probably benign	0.11
R1653:Vps13b	UTSW	15	35,607,418 (GRCm39)	nonsense	probably null
R1695:Vps13b	UTSW	15	35,576,667 (GRCm39)	missense	probably benign	0.05
R1760:Vps13b	UTSW	15	35,884,765 (GRCm39)	missense	possibly damaging	0.54
R1785:Vps13b	UTSW	15	35,879,937 (GRCm39)	missense	probably damaging	1.00
R1786:Vps13b	UTSW	15	35,879,937 (GRCm39)	missense	probably damaging	1.00
R1803:Vps13b	UTSW	15	35,430,351 (GRCm39)	nonsense	probably null
R1804:Vps13b	UTSW	15	35,917,283 (GRCm39)	missense	probably damaging	1.00
R1808:Vps13b	UTSW	15	35,792,205 (GRCm39)	missense	probably benign	0.00
R1817:Vps13b	UTSW	15	35,910,788 (GRCm39)	missense	possibly damaging	0.86
R1818:Vps13b	UTSW	15	35,877,723 (GRCm39)	missense	probably benign	0.00
R1836:Vps13b	UTSW	15	35,910,378 (GRCm39)	missense	probably damaging	0.99
R1850:Vps13b	UTSW	15	35,675,105 (GRCm39)	splice site	probably benign
R1884:Vps13b	UTSW	15	35,430,437 (GRCm39)	splice site	probably benign
R1938:Vps13b	UTSW	15	35,709,653 (GRCm39)	missense	probably damaging	1.00
R1955:Vps13b	UTSW	15	35,925,554 (GRCm39)	critical splice donor site	probably null
R1956:Vps13b	UTSW	15	35,869,553 (GRCm39)	missense	probably damaging	1.00
R1958:Vps13b	UTSW	15	35,878,835 (GRCm39)	missense	probably damaging	0.99
R2013:Vps13b	UTSW	15	35,607,288 (GRCm39)	missense	probably damaging	0.99
R2014:Vps13b	UTSW	15	35,607,288 (GRCm39)	missense	probably damaging	0.99
R2015:Vps13b	UTSW	15	35,607,288 (GRCm39)	missense	probably damaging	0.99
R2038:Vps13b	UTSW	15	35,884,887 (GRCm39)	missense	probably damaging	1.00
R2058:Vps13b	UTSW	15	35,841,593 (GRCm39)	missense	probably damaging	1.00
R2082:Vps13b	UTSW	15	35,910,892 (GRCm39)	missense	possibly damaging	0.70
R2087:Vps13b	UTSW	15	35,597,639 (GRCm39)	missense	probably damaging	0.99
R2124:Vps13b	UTSW	15	35,646,226 (GRCm39)	missense	probably benign	0.08
R2130:Vps13b	UTSW	15	35,671,546 (GRCm39)	missense	probably benign	0.13
R2168:Vps13b	UTSW	15	35,792,334 (GRCm39)	missense	probably damaging	1.00
R2168:Vps13b	UTSW	15	35,792,335 (GRCm39)	missense	probably damaging	1.00
R2171:Vps13b	UTSW	15	35,887,343 (GRCm39)	missense	probably benign	0.44
R2221:Vps13b	UTSW	15	35,884,743 (GRCm39)	missense	probably benign
R2263:Vps13b	UTSW	15	35,646,327 (GRCm39)	missense	probably benign	0.02
R2289:Vps13b	UTSW	15	35,572,251 (GRCm39)	missense	probably damaging	1.00
R2316:Vps13b	UTSW	15	35,675,045 (GRCm39)	nonsense	probably null
R2351:Vps13b	UTSW	15	35,869,457 (GRCm39)	missense	probably damaging	1.00
R2512:Vps13b	UTSW	15	35,884,701 (GRCm39)	missense	probably benign	0.35
R3054:Vps13b	UTSW	15	35,646,507 (GRCm39)	missense	probably damaging	0.99
R3055:Vps13b	UTSW	15	35,646,507 (GRCm39)	missense	probably damaging	0.99
R3196:Vps13b	UTSW	15	35,869,541 (GRCm39)	missense	probably damaging	1.00
R3236:Vps13b	UTSW	15	35,910,450 (GRCm39)	missense	probably benign	0.40
R3404:Vps13b	UTSW	15	35,926,200 (GRCm39)	missense	probably damaging	1.00
R3722:Vps13b	UTSW	15	35,671,528 (GRCm39)	missense	probably damaging	0.99
R4077:Vps13b	UTSW	15	35,455,274 (GRCm39)	missense	probably damaging	0.99
R4153:Vps13b	UTSW	15	35,792,173 (GRCm39)	splice site	probably null
R4224:Vps13b	UTSW	15	35,876,565 (GRCm39)	missense	probably damaging	0.99
R4408:Vps13b	UTSW	15	35,709,440 (GRCm39)	missense	probably damaging	0.98
R4431:Vps13b	UTSW	15	35,770,899 (GRCm39)	missense	probably damaging	1.00
R4449:Vps13b	UTSW	15	35,876,939 (GRCm39)	missense	possibly damaging	0.86
R4508:Vps13b	UTSW	15	35,709,819 (GRCm39)	missense	possibly damaging	0.80
R4631:Vps13b	UTSW	15	35,646,278 (GRCm39)	missense	possibly damaging	0.95
R4655:Vps13b	UTSW	15	35,770,835 (GRCm39)	missense	probably benign
R4666:Vps13b	UTSW	15	35,640,690 (GRCm39)	missense	probably benign	0.13
R4684:Vps13b	UTSW	15	35,879,967 (GRCm39)	missense	probably benign
R4684:Vps13b	UTSW	15	35,841,487 (GRCm39)	missense	probably benign
R4684:Vps13b	UTSW	15	35,646,324 (GRCm39)	missense	probably damaging	0.98
R4721:Vps13b	UTSW	15	35,910,864 (GRCm39)	nonsense	probably null
R4771:Vps13b	UTSW	15	35,910,946 (GRCm39)	missense	probably damaging	1.00
R4830:Vps13b	UTSW	15	35,452,370 (GRCm39)	missense	possibly damaging	0.94
R4835:Vps13b	UTSW	15	35,869,518 (GRCm39)	missense	probably damaging	1.00
R4835:Vps13b	UTSW	15	35,910,439 (GRCm39)	missense	probably benign
R4857:Vps13b	UTSW	15	35,456,800 (GRCm39)	missense	probably benign	0.01
R4891:Vps13b	UTSW	15	35,640,661 (GRCm39)	splice site	probably null
R5095:Vps13b	UTSW	15	35,923,348 (GRCm39)	missense	probably damaging	1.00
R5110:Vps13b	UTSW	15	35,770,955 (GRCm39)	missense	probably damaging	0.99
R5153:Vps13b	UTSW	15	35,422,599 (GRCm39)	missense	probably damaging	0.99
R5257:Vps13b	UTSW	15	35,794,567 (GRCm39)	missense	possibly damaging	0.75
R5258:Vps13b	UTSW	15	35,794,567 (GRCm39)	missense	possibly damaging	0.75
R5296:Vps13b	UTSW	15	35,876,559 (GRCm39)	missense	probably damaging	1.00
R5386:Vps13b	UTSW	15	35,640,674 (GRCm39)	critical splice acceptor site	probably null
R5396:Vps13b	UTSW	15	35,887,094 (GRCm39)	missense	probably damaging	0.99
R5412:Vps13b	UTSW	15	35,533,531 (GRCm39)	missense	probably damaging	1.00
R5488:Vps13b	UTSW	15	35,770,688 (GRCm39)	missense	probably benign
R5489:Vps13b	UTSW	15	35,770,688 (GRCm39)	missense	probably benign
R5503:Vps13b	UTSW	15	35,452,312 (GRCm39)	missense	probably damaging	0.97
R5575:Vps13b	UTSW	15	35,930,065 (GRCm39)	missense	probably damaging	1.00
R5781:Vps13b	UTSW	15	35,794,181 (GRCm39)	missense	probably damaging	0.97
R5872:Vps13b	UTSW	15	35,869,497 (GRCm39)	missense	possibly damaging	0.56
R5876:Vps13b	UTSW	15	35,917,207 (GRCm39)	missense	probably damaging	0.99
R5994:Vps13b	UTSW	15	35,875,918 (GRCm39)	missense	probably damaging	1.00
R6031:Vps13b	UTSW	15	35,472,114 (GRCm39)	missense	probably damaging	1.00
R6031:Vps13b	UTSW	15	35,472,114 (GRCm39)	missense	probably damaging	1.00
R6045:Vps13b	UTSW	15	35,671,462 (GRCm39)	missense	probably damaging	0.99
R6143:Vps13b	UTSW	15	35,668,884 (GRCm39)	missense	probably damaging	0.99
R6147:Vps13b	UTSW	15	35,930,177 (GRCm39)	missense	probably benign	0.16
R6218:Vps13b	UTSW	15	35,770,610 (GRCm39)	missense	probably benign	0.00
R6447:Vps13b	UTSW	15	35,572,272 (GRCm39)	missense	probably benign	0.02
R6555:Vps13b	UTSW	15	35,846,993 (GRCm39)	missense	probably damaging	1.00
R6578:Vps13b	UTSW	15	35,446,247 (GRCm39)	missense	probably damaging	0.99
R6640:Vps13b	UTSW	15	35,617,842 (GRCm39)	missense	possibly damaging	0.93
R6645:Vps13b	UTSW	15	35,910,451 (GRCm39)	missense	probably benign	0.25
R6711:Vps13b	UTSW	15	35,887,395 (GRCm39)	missense	probably damaging	1.00
R6727:Vps13b	UTSW	15	35,770,829 (GRCm39)	missense	probably benign	0.19
R6737:Vps13b	UTSW	15	35,910,757 (GRCm39)	missense	probably damaging	1.00
R6844:Vps13b	UTSW	15	35,877,736 (GRCm39)	missense	probably benign	0.06
R6849:Vps13b	UTSW	15	35,905,455 (GRCm39)	missense	probably damaging	1.00
R6861:Vps13b	UTSW	15	35,576,541 (GRCm39)	missense	probably damaging	0.99
R6938:Vps13b	UTSW	15	35,423,344 (GRCm39)	missense	probably damaging	0.99
R6943:Vps13b	UTSW	15	35,448,835 (GRCm39)	missense	possibly damaging	0.95
R6989:Vps13b	UTSW	15	35,448,727 (GRCm39)	missense	probably benign	0.02
R7092:Vps13b	UTSW	15	35,640,780 (GRCm39)	missense	probably damaging	1.00
R7232:Vps13b	UTSW	15	35,877,703 (GRCm39)	missense	probably damaging	1.00
R7307:Vps13b	UTSW	15	35,841,691 (GRCm39)	missense	probably benign
R7400:Vps13b	UTSW	15	35,379,046 (GRCm39)	missense	probably damaging	1.00
R7414:Vps13b	UTSW	15	35,910,973 (GRCm39)	missense	probably damaging	1.00
R7497:Vps13b	UTSW	15	35,876,843 (GRCm39)	missense	probably benign	0.38
R7500:Vps13b	UTSW	15	35,910,670 (GRCm39)	missense	possibly damaging	0.74
R7603:Vps13b	UTSW	15	35,576,585 (GRCm39)	missense	probably damaging	0.98
R7605:Vps13b	UTSW	15	35,770,792 (GRCm39)	missense	probably damaging	0.97
R7849:Vps13b	UTSW	15	35,423,378 (GRCm39)	missense	probably damaging	0.99
R7984:Vps13b	UTSW	15	35,880,059 (GRCm39)	missense	probably benign
R8094:Vps13b	UTSW	15	35,669,052 (GRCm39)	critical splice donor site	probably null
R8097:Vps13b	UTSW	15	35,709,492 (GRCm39)	missense	probably benign	0.38
R8131:Vps13b	UTSW	15	35,372,255 (GRCm39)	critical splice donor site	probably null
R8139:Vps13b	UTSW	15	35,607,418 (GRCm39)	nonsense	probably null
R8174:Vps13b	UTSW	15	35,709,456 (GRCm39)	nonsense	probably null
R8225:Vps13b	UTSW	15	35,794,528 (GRCm39)	missense	probably damaging	0.99
R8239:Vps13b	UTSW	15	35,597,550 (GRCm39)	missense	probably damaging	1.00
R8244:Vps13b	UTSW	15	35,917,349 (GRCm39)	missense	probably damaging	1.00
R8303:Vps13b	UTSW	15	35,640,063 (GRCm39)	missense	probably damaging	1.00
R8311:Vps13b	UTSW	15	35,887,100 (GRCm39)	missense	probably benign	0.37
R8443:Vps13b	UTSW	15	35,455,246 (GRCm39)	missense	probably benign
R8494:Vps13b	UTSW	15	35,422,594 (GRCm39)	missense	probably damaging	0.99
R8499:Vps13b	UTSW	15	35,841,466 (GRCm39)	missense	probably damaging	1.00
R8506:Vps13b	UTSW	15	35,446,891 (GRCm39)	missense	probably benign	0.31
R8559:Vps13b	UTSW	15	35,876,788 (GRCm39)	missense	probably damaging	1.00
R8686:Vps13b	UTSW	15	35,925,535 (GRCm39)	missense	probably damaging	0.99
R8782:Vps13b	UTSW	15	35,422,483 (GRCm39)	missense	possibly damaging	0.93
R8806:Vps13b	UTSW	15	35,472,212 (GRCm39)	critical splice donor site	probably benign
R8824:Vps13b	UTSW	15	35,533,445 (GRCm39)	missense	probably damaging	0.99
R9024:Vps13b	UTSW	15	35,923,470 (GRCm39)	missense	probably damaging	0.97
R9038:Vps13b	UTSW	15	35,875,931 (GRCm39)	missense	possibly damaging	0.70
R9054:Vps13b	UTSW	15	35,422,537 (GRCm39)	missense	probably damaging	1.00
R9091:Vps13b	UTSW	15	35,770,919 (GRCm39)	missense	probably benign	0.13
R9129:Vps13b	UTSW	15	35,448,793 (GRCm39)	missense	probably damaging	1.00
R9214:Vps13b	UTSW	15	35,623,892 (GRCm39)	missense	probably damaging	0.99
R9237:Vps13b	UTSW	15	35,841,479 (GRCm39)	missense	probably damaging	1.00
R9256:Vps13b	UTSW	15	35,623,925 (GRCm39)	missense	possibly damaging	0.95
R9270:Vps13b	UTSW	15	35,770,919 (GRCm39)	missense	probably benign	0.13
R9279:Vps13b	UTSW	15	35,572,290 (GRCm39)	missense	probably damaging	0.97
R9291:Vps13b	UTSW	15	35,847,059 (GRCm39)	missense	probably damaging	1.00
R9342:Vps13b	UTSW	15	35,455,200 (GRCm39)	missense	possibly damaging	0.94
R9404:Vps13b	UTSW	15	35,876,565 (GRCm39)	missense	probably damaging	1.00
R9488:Vps13b	UTSW	15	35,447,880 (GRCm39)	missense	possibly damaging	0.77
R9509:Vps13b	UTSW	15	35,841,457 (GRCm39)	missense	possibly damaging	0.79
R9610:Vps13b	UTSW	15	35,642,555 (GRCm39)	missense	possibly damaging	0.85
R9611:Vps13b	UTSW	15	35,642,555 (GRCm39)	missense	possibly damaging	0.85
R9658:Vps13b	UTSW	15	35,623,774 (GRCm39)	missense	probably benign	0.00
R9674:Vps13b	UTSW	15	35,607,380 (GRCm39)	missense	probably damaging	0.98
R9696:Vps13b	UTSW	15	35,675,033 (GRCm39)	missense	possibly damaging	0.56
R9767:Vps13b	UTSW	15	35,910,403 (GRCm39)	missense	probably damaging	1.00
R9797:Vps13b	UTSW	15	35,675,022 (GRCm39)	missense	probably damaging	1.00
RF020:Vps13b	UTSW	15	35,925,552 (GRCm39)	missense	probably null	1.00
X0026:Vps13b	UTSW	15	35,910,792 (GRCm39)	missense	probably damaging	1.00
X0028:Vps13b	UTSW	15	35,709,577 (GRCm39)	missense	probably benign	0.00
Z1177:Vps13b	UTSW	15	35,669,031 (GRCm39)	nonsense	probably null

Predicted Primers

PCR Primer
(F):5'- GCCCTGCTCTCAGTTTATAAATTGG -3'
(R):5'- TCCTTCCACACATGTGCAATAG -3'

Sequencing Primer
(F):5'- ACTATTGTCAAACCATCTCAAACTG -3'
(R):5'- TGAATGCACATACATAGCACATG -3'

Posted On

2016-06-21