Incidental Mutation 'R5148:Or5d14'
ID 395186
Institutional Source Beutler Lab
Gene Symbol Or5d14
Ensembl Gene ENSMUSG00000075139
Gene Name olfactory receptor family 5 subfamily D member 14
Synonyms MOR174-14, Olfr1162, GA_x6K02T2Q125-49542541-49541597
MMRRC Submission 043262-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.066) question?
Stock # R5148 (G1)
Quality Score 225
Status Validated
Chromosome 2
Chromosomal Location 87880022-87880966 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to A at 87880737 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Isoleucine at position 77 (T77I)
Ref Sequence ENSEMBL: ENSMUSP00000139068 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000099837] [ENSMUST00000183862]
AlphaFold Q7TR28
Predicted Effect probably benign
Transcript: ENSMUST00000099837
AA Change: T77I

PolyPhen 2 Score 0.081 (Sensitivity: 0.93; Specificity: 0.85)
SMART Domains Protein: ENSMUSP00000097425
Gene: ENSMUSG00000075139
AA Change: T77I

DomainStartEndE-ValueType
Pfam:7tm_4 33 310 2.9e-46 PFAM
Pfam:7tm_1 43 292 1.5e-14 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000183862
AA Change: T77I

PolyPhen 2 Score 0.081 (Sensitivity: 0.93; Specificity: 0.85)
SMART Domains Protein: ENSMUSP00000139068
Gene: ENSMUSG00000075139
AA Change: T77I

DomainStartEndE-ValueType
Pfam:7tm_1 43 292 4.2e-27 PFAM
Pfam:7tm_4 141 285 3.1e-37 PFAM
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.7%
  • 10x: 97.3%
  • 20x: 95.2%
Validation Efficiency 100% (48/48)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 43 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Ank2 A T 3: 126,819,285 (GRCm39) probably null Het
Atf7 A G 15: 102,455,608 (GRCm39) M252T probably benign Het
Cacna1h C A 17: 25,606,519 (GRCm39) D1027Y probably damaging Het
Cngb1 A G 8: 95,992,611 (GRCm39) V667A probably benign Het
Cntf T C 19: 12,741,368 (GRCm39) E164G probably damaging Het
Dbt T C 3: 116,321,893 (GRCm39) probably benign Het
Egfem1 G A 3: 29,511,972 (GRCm39) probably benign Het
Gm12790 C T 4: 101,825,268 (GRCm39) V49I possibly damaging Het
Gm5444 C T 13: 4,884,314 (GRCm39) noncoding transcript Het
Gpcpd1 A T 2: 132,376,110 (GRCm39) Y574* probably null Het
Gss G T 2: 155,415,029 (GRCm39) N225K possibly damaging Het
Il17rc G T 6: 113,459,958 (GRCm39) A635S probably benign Het
Lhfpl5 T A 17: 28,798,942 (GRCm39) D150E probably damaging Het
Lin9 T A 1: 180,496,763 (GRCm39) L351I probably benign Het
Lrrc40 T G 3: 157,760,206 (GRCm39) probably null Het
Ly6f A G 15: 75,143,646 (GRCm39) T118A probably benign Het
Malrd1 A G 2: 16,147,037 (GRCm39) N1960D unknown Het
Map3k14 T C 11: 103,130,158 (GRCm39) H253R probably benign Het
Morc2a T C 11: 3,639,084 (GRCm39) L1025P probably damaging Het
Nlrc5 G T 8: 95,203,321 (GRCm39) G474W probably damaging Het
Olr1 G T 6: 129,470,572 (GRCm39) D198E probably benign Het
Or5b123 C A 19: 13,596,874 (GRCm39) S116* probably null Het
Or8c16 T C 9: 38,130,317 (GRCm39) I66T probably benign Het
Pafah1b1 A T 11: 74,575,278 (GRCm39) S209T probably damaging Het
Phf14 A T 6: 11,961,641 (GRCm39) Y426F possibly damaging Het
Phldb1 A G 9: 44,615,455 (GRCm39) V855A probably benign Het
Pira2 T G 7: 3,847,592 (GRCm39) R32S possibly damaging Het
Pnldc1 T C 17: 13,111,676 (GRCm39) I344V probably benign Het
Prss29 T C 17: 25,539,881 (GRCm39) V93A probably benign Het
Ptpn13 C T 5: 103,640,098 (GRCm39) L186F probably damaging Het
Ralgps1 A C 2: 33,048,999 (GRCm39) C303W probably damaging Het
Sdr42e1 T A 8: 118,390,342 (GRCm39) N100Y probably damaging Het
Serpina11 A T 12: 103,952,503 (GRCm39) L96Q probably damaging Het
Slc12a8 G A 16: 33,445,288 (GRCm39) R448H probably benign Het
Snrpd1 T A 18: 10,626,892 (GRCm39) V53E probably benign Het
Ssbp1 T C 6: 40,454,883 (GRCm39) V114A possibly damaging Het
T A G 17: 8,655,037 (GRCm39) E47G probably damaging Het
Tmem156 T C 5: 65,231,111 (GRCm39) K189R probably benign Het
Trim47 G T 11: 115,998,678 (GRCm39) Q314K possibly damaging Het
Vmn2r3 G T 3: 64,186,247 (GRCm39) P146Q probably damaging Het
Vmn2r6 A C 3: 64,464,015 (GRCm39) V273G probably damaging Het
Wrnip1 G T 13: 32,990,839 (GRCm39) R366L probably damaging Het
Zfp981 A T 4: 146,621,357 (GRCm39) H94L possibly damaging Het
Other mutations in Or5d14
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01669:Or5d14 APN 2 87,880,128 (GRCm39) missense possibly damaging 0.63
IGL01965:Or5d14 APN 2 87,880,780 (GRCm39) missense probably benign 0.14
IGL02183:Or5d14 APN 2 87,880,333 (GRCm39) missense possibly damaging 0.96
R0281:Or5d14 UTSW 2 87,880,756 (GRCm39) missense possibly damaging 0.96
R0501:Or5d14 UTSW 2 87,880,815 (GRCm39) missense probably damaging 1.00
R4254:Or5d14 UTSW 2 87,880,123 (GRCm39) missense possibly damaging 0.62
R4589:Or5d14 UTSW 2 87,880,823 (GRCm39) missense probably benign 0.12
R4824:Or5d14 UTSW 2 87,880,432 (GRCm39) missense probably damaging 1.00
R5580:Or5d14 UTSW 2 87,880,668 (GRCm39) missense possibly damaging 0.79
R6174:Or5d14 UTSW 2 87,880,646 (GRCm39) nonsense probably null
R6888:Or5d14 UTSW 2 87,880,608 (GRCm39) missense probably damaging 1.00
R7935:Or5d14 UTSW 2 87,880,290 (GRCm39) missense probably damaging 1.00
R7951:Or5d14 UTSW 2 87,880,601 (GRCm39) nonsense probably null
R9123:Or5d14 UTSW 2 87,880,294 (GRCm39) missense probably damaging 0.99
R9125:Or5d14 UTSW 2 87,880,294 (GRCm39) missense probably damaging 0.99
R9133:Or5d14 UTSW 2 87,880,782 (GRCm39) missense probably damaging 1.00
R9280:Or5d14 UTSW 2 87,880,458 (GRCm39) missense probably damaging 1.00
R9374:Or5d14 UTSW 2 87,880,509 (GRCm39) nonsense probably null
R9552:Or5d14 UTSW 2 87,880,509 (GRCm39) nonsense probably null
Z1177:Or5d14 UTSW 2 87,880,648 (GRCm39) missense probably benign 0.00
Predicted Primers PCR Primer
(F):5'- ATATGACCCAGTCACAAGCAGG -3'
(R):5'- TTGGGCTTCACAGACTACCCTG -3'

Sequencing Primer
(F):5'- CTTGGTGACATGGCCACAGTATAC -3'
(R):5'- TTCACAGACTACCCTGAGCTTCAG -3'
Posted On 2016-06-21