Incidental Mutation 'R5149:Olfr804'
ID395256
Institutional Source Beutler Lab
Gene Symbol Olfr804
Ensembl Gene ENSMUSG00000095401
Gene Nameolfactory receptor 804
SynonymsMOR110-7, GA_x6K02T2PULF-11383575-11384519
MMRRC Submission 042732-MU
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.097) question?
Stock #R5149 (G1)
Quality Score225
Status Not validated
Chromosome10
Chromosomal Location129703210-129710018 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to C at 129705508 bp
ZygosityHeterozygous
Amino Acid Change Valine to Alanine at position 210 (V210A)
Ref Sequence ENSEMBL: ENSMUSP00000150132 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000077312] [ENSMUST00000213331]
Predicted Effect probably benign
Transcript: ENSMUST00000077312
AA Change: V210A

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
SMART Domains Protein: ENSMUSP00000076540
Gene: ENSMUSG00000095401
AA Change: V210A

DomainStartEndE-ValueType
Pfam:7tm_4 29 306 6e-48 PFAM
Pfam:7tm_1 39 288 3.3e-23 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000213331
AA Change: V210A

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
Predicted Effect noncoding transcript
Transcript: ENSMUST00000216747
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.5%
  • 10x: 96.9%
  • 20x: 94.3%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 44 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Ahsg A G 16: 22,898,923 T245A probably benign Het
Akr1c13 G T 13: 4,194,169 V74L probably benign Het
Amt G A 9: 108,301,451 V389I possibly damaging Het
Ankrd26 T C 6: 118,558,996 N159S probably benign Het
Atp1a4 A G 1: 172,232,005 I840T probably damaging Het
Capn1 T C 19: 5,990,334 probably null Het
Col27a1 T C 4: 63,331,427 probably benign Het
Cyp2j5 A G 4: 96,659,507 L166P probably damaging Het
D6Ertd527e C G 6: 87,111,524 T223S unknown Het
Dchs1 G A 7: 105,755,658 T2559I probably damaging Het
Dnah12 C A 14: 26,850,926 S258* probably null Het
Dpep1 A T 8: 123,200,438 T309S probably benign Het
Epha5 A T 5: 84,150,358 F559L probably damaging Het
Gm3409 T C 5: 146,537,761 I29T possibly damaging Het
Grhl1 CAGAAGAAG CAGAAG 12: 24,612,179 probably benign Het
Gtf3c1 G T 7: 125,668,037 R941S probably damaging Het
Helb C T 10: 120,105,743 E347K probably benign Het
Ighv14-3 A G 12: 114,060,090 S36P probably damaging Het
Klrb1c T A 6: 128,783,707 M211L probably benign Het
Larp7 C T 3: 127,540,811 E510K probably damaging Het
Lrig1 C T 6: 94,628,044 R190Q possibly damaging Het
March6 A G 15: 31,461,994 S863P possibly damaging Het
Mgst2 A G 3: 51,682,537 N132S probably benign Het
Nlgn2 C T 11: 69,825,390 R775H probably damaging Het
Olfr1138 A T 2: 87,737,405 S306R probably benign Het
Olfr135 A C 17: 38,208,317 E24A possibly damaging Het
Papln A T 12: 83,771,882 probably null Het
Poteg C T 8: 27,481,643 S395L possibly damaging Het
Prox1 T A 1: 190,147,053 I643F possibly damaging Het
Sept4 A G 11: 87,589,245 E211G probably damaging Het
Serpinb6e A G 13: 33,832,485 F422L probably damaging Het
Slc22a19 A G 19: 7,711,138 L19P probably damaging Het
Snf8 G T 11: 96,043,460 A136S probably benign Het
Sparcl1 C T 5: 104,085,763 M573I probably damaging Het
Spta1 A G 1: 174,247,434 T2409A probably damaging Het
Tat A G 8: 109,996,818 S313G probably benign Het
Tep1 A T 14: 50,837,398 C1785* probably null Het
Tmem132b A G 5: 125,622,925 S176G probably damaging Het
Tnfrsf8 T C 4: 145,303,105 R42G possibly damaging Het
Trio T C 15: 27,754,029 D2124G possibly damaging Het
Trp53bp1 A T 2: 121,216,117 D1067E probably benign Het
Tspan13 T C 12: 36,024,066 S24G probably damaging Het
Zdbf2 T C 1: 63,304,903 S814P possibly damaging Het
Zfp213 C A 17: 23,561,399 R49L probably damaging Het
Other mutations in Olfr804
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01613:Olfr804 APN 10 129705623 missense probably benign 0.01
IGL02041:Olfr804 APN 10 129705235 missense probably damaging 1.00
IGL02245:Olfr804 APN 10 129705739 missense probably damaging 1.00
IGL02341:Olfr804 APN 10 129705489 missense probably damaging 0.99
IGL02433:Olfr804 APN 10 129705576 missense probably benign 0.01
authen UTSW 10 129705799 missense probably benign 0.00
R0111:Olfr804 UTSW 10 129705277 missense probably damaging 1.00
R0309:Olfr804 UTSW 10 129705139 missense probably benign 0.38
R0326:Olfr804 UTSW 10 129705769 missense possibly damaging 0.69
R0374:Olfr804 UTSW 10 129705647 missense probably benign 0.00
R1573:Olfr804 UTSW 10 129705618 missense probably damaging 1.00
R1663:Olfr804 UTSW 10 129705291 missense probably benign 0.44
R1778:Olfr804 UTSW 10 129705705 missense probably benign 0.01
R1789:Olfr804 UTSW 10 129705607 missense possibly damaging 0.82
R1906:Olfr804 UTSW 10 129705496 missense probably benign 0.00
R2108:Olfr804 UTSW 10 129705621 missense probably benign
R2211:Olfr804 UTSW 10 129705451 missense probably benign
R2432:Olfr804 UTSW 10 129704925 missense possibly damaging 0.91
R2902:Olfr804 UTSW 10 129705451 missense probably benign
R4114:Olfr804 UTSW 10 129705799 missense probably benign 0.00
R5153:Olfr804 UTSW 10 129705157 missense probably benign 0.05
R5846:Olfr804 UTSW 10 129704887 missense probably damaging 0.99
R6553:Olfr804 UTSW 10 129705063 missense probably benign 0.07
R7676:Olfr804 UTSW 10 129705286 missense possibly damaging 0.63
R8161:Olfr804 UTSW 10 129704884 missense not run
Predicted Primers PCR Primer
(F):5'- CAAAGTGTGCCACCAACTCG -3'
(R):5'- GCAGAGCTACACCTTTAGACACAG -3'

Sequencing Primer
(F):5'- CAGCTCCTGGGTGACTGGATTC -3'
(R):5'- AGACACTCTCTCCCTTGCAGATG -3'
Posted On2016-06-21