Mutagenetix > Incidental Mutation

Incidental Mutation 'R5149:Olfr804'

395256

Institutional Source

Beutler Lab

Gene Symbol

Olfr804

Ensembl Gene

ENSMUSG00000095401

Gene Name

olfactory receptor 804

Synonyms

MOR110-7, GA_x6K02T2PULF-11383575-11384519

MMRRC Submission

042732-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.092) question?

Stock #

R5149 (G1)

Quality Score

225

Status

Not validated

Chromosome

Chromosomal Location

129703210-129710018 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 129705508 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Valine to Alanine at position 210 (V210A)

Ref Sequence

ENSEMBL: ENSMUSP00000150132 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000077312] [ENSMUST00000213331]

AlphaFold

Q7TRH7

Predicted Effect

probably benign
Transcript: ENSMUST00000077312
AA Change: V210A

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)

SMART Domains

Protein: ENSMUSP00000076540
Gene: ENSMUSG00000095401
AA Change: V210A

Domain	Start	End	E-Value	Type
Pfam:7tm_4	29	306	6e-48	PFAM
Pfam:7tm_1	39	288	3.3e-23	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000213331
AA Change: V210A

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000216747

Coding Region Coverage

1x: 99.2%
3x: 98.5%
10x: 96.9%
20x: 94.3%

Validation Efficiency

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 44 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Ahsg	A	G	16: 22,898,923	T245A	probably benign	Het
Akr1c13	G	T	13: 4,194,169	V74L	probably benign	Het
Amt	G	A	9: 108,301,451	V389I	possibly damaging	Het
Ankrd26	T	C	6: 118,558,996	N159S	probably benign	Het
Atp1a4	A	G	1: 172,232,005	I840T	probably damaging	Het
Capn1	T	C	19: 5,990,334		probably null	Het
Col27a1	T	C	4: 63,331,427		probably benign	Het
Cyp2j5	A	G	4: 96,659,507	L166P	probably damaging	Het
D6Ertd527e	C	G	6: 87,111,524	T223S	unknown	Het
Dchs1	G	A	7: 105,755,658	T2559I	probably damaging	Het
Dnah12	C	A	14: 26,850,926	S258*	probably null	Het
Dpep1	A	T	8: 123,200,438	T309S	probably benign	Het
Epha5	A	T	5: 84,150,358	F559L	probably damaging	Het
Gm3409	T	C	5: 146,537,761	I29T	possibly damaging	Het
Grhl1	CAGAAGAAG	CAGAAG	12: 24,612,179		probably benign	Het
Gtf3c1	G	T	7: 125,668,037	R941S	probably damaging	Het
Helb	C	T	10: 120,105,743	E347K	probably benign	Het
Ighv14-3	A	G	12: 114,060,090	S36P	probably damaging	Het
Klrb1c	T	A	6: 128,783,707	M211L	probably benign	Het
Larp7	C	T	3: 127,540,811	E510K	probably damaging	Het
Lrig1	C	T	6: 94,628,044	R190Q	possibly damaging	Het
March6	A	G	15: 31,461,994	S863P	possibly damaging	Het
Mgst2	A	G	3: 51,682,537	N132S	probably benign	Het
Nlgn2	C	T	11: 69,825,390	R775H	probably damaging	Het
Olfr1138	A	T	2: 87,737,405	S306R	probably benign	Het
Olfr135	A	C	17: 38,208,317	E24A	possibly damaging	Het
Papln	A	T	12: 83,771,882		probably null	Het
Poteg	C	T	8: 27,481,643	S395L	possibly damaging	Het
Prox1	T	A	1: 190,147,053	I643F	possibly damaging	Het
Sept4	A	G	11: 87,589,245	E211G	probably damaging	Het
Serpinb6e	A	G	13: 33,832,485	F422L	probably damaging	Het
Slc22a19	A	G	19: 7,711,138	L19P	probably damaging	Het
Snf8	G	T	11: 96,043,460	A136S	probably benign	Het
Sparcl1	C	T	5: 104,085,763	M573I	probably damaging	Het
Spta1	A	G	1: 174,247,434	T2409A	probably damaging	Het
Tat	A	G	8: 109,996,818	S313G	probably benign	Het
Tep1	A	T	14: 50,837,398	C1785*	probably null	Het
Tmem132b	A	G	5: 125,622,925	S176G	probably damaging	Het
Tnfrsf8	T	C	4: 145,303,105	R42G	possibly damaging	Het
Trio	T	C	15: 27,754,029	D2124G	possibly damaging	Het
Trp53bp1	A	T	2: 121,216,117	D1067E	probably benign	Het
Tspan13	T	C	12: 36,024,066	S24G	probably damaging	Het
Zdbf2	T	C	1: 63,304,903	S814P	possibly damaging	Het
Zfp213	C	A	17: 23,561,399	R49L	probably damaging	Het

Other mutations in Olfr804

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01613:Olfr804	APN	10	129705623	missense	probably benign	0.01
IGL02041:Olfr804	APN	10	129705235	missense	probably damaging	1.00
IGL02245:Olfr804	APN	10	129705739	missense	probably damaging	1.00
IGL02341:Olfr804	APN	10	129705489	missense	probably damaging	0.99
IGL02433:Olfr804	APN	10	129705576	missense	probably benign	0.01
authen	UTSW	10	129705799	missense	probably benign	0.00
R0111:Olfr804	UTSW	10	129705277	missense	probably damaging	1.00
R0309:Olfr804	UTSW	10	129705139	missense	probably benign	0.38
R0326:Olfr804	UTSW	10	129705769	missense	possibly damaging	0.69
R0374:Olfr804	UTSW	10	129705647	missense	probably benign	0.00
R1573:Olfr804	UTSW	10	129705618	missense	probably damaging	1.00
R1663:Olfr804	UTSW	10	129705291	missense	probably benign	0.44
R1778:Olfr804	UTSW	10	129705705	missense	probably benign	0.01
R1789:Olfr804	UTSW	10	129705607	missense	possibly damaging	0.82
R1906:Olfr804	UTSW	10	129705496	missense	probably benign	0.00
R2108:Olfr804	UTSW	10	129705621	missense	probably benign
R2211:Olfr804	UTSW	10	129705451	missense	probably benign
R2432:Olfr804	UTSW	10	129704925	missense	possibly damaging	0.91
R2902:Olfr804	UTSW	10	129705451	missense	probably benign
R4114:Olfr804	UTSW	10	129705799	missense	probably benign	0.00
R5153:Olfr804	UTSW	10	129705157	missense	probably benign	0.05
R5846:Olfr804	UTSW	10	129704887	missense	probably damaging	0.99
R6553:Olfr804	UTSW	10	129705063	missense	probably benign	0.07
R7676:Olfr804	UTSW	10	129705286	missense	possibly damaging	0.63
R8161:Olfr804	UTSW	10	129704884	missense	possibly damaging	0.94
R9266:Olfr804	UTSW	10	129705678	missense	probably benign	0.17
R9318:Olfr804	UTSW	10	129705414	missense	probably benign	0.00
R9334:Olfr804	UTSW	10	129705814	missense	probably benign	0.00
R9746:Olfr804	UTSW	10	129705339	missense	probably damaging	0.97

Predicted Primers

PCR Primer
(F):5'- CAAAGTGTGCCACCAACTCG -3'
(R):5'- GCAGAGCTACACCTTTAGACACAG -3'

Sequencing Primer
(F):5'- CAGCTCCTGGGTGACTGGATTC -3'
(R):5'- AGACACTCTCTCCCTTGCAGATG -3'

Posted On

2016-06-21