Incidental Mutation 'R5150:Fam210b'
ID 395291
Institutional Source Beutler Lab
Gene Symbol Fam210b
Ensembl Gene ENSMUSG00000027495
Gene Name family with sequence similarity 210, member B
Synonyms 2010011I20Rik
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R5150 (G1)
Quality Score 225
Status Validated
Chromosome 2
Chromosomal Location 172187485-172197669 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 172193468 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Tyrosine to Histidine at position 94 (Y94H)
Ref Sequence ENSEMBL: ENSMUSP00000028995 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000028995] [ENSMUST00000028997] [ENSMUST00000109139] [ENSMUST00000109140]
AlphaFold Q9D8B6
Predicted Effect probably damaging
Transcript: ENSMUST00000028995
AA Change: Y94H

PolyPhen 2 Score 0.981 (Sensitivity: 0.75; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000028995
Gene: ENSMUSG00000027495
AA Change: Y94H

DomainStartEndE-ValueType
Pfam:DUF1279 85 172 4e-30 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000028997
SMART Domains Protein: ENSMUSP00000028997
Gene: ENSMUSG00000027496

DomainStartEndE-ValueType
S_TKc 146 396 2.25e-99 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000109139
SMART Domains Protein: ENSMUSP00000104767
Gene: ENSMUSG00000027496

DomainStartEndE-ValueType
S_TKc 124 374 2.25e-99 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000109140
SMART Domains Protein: ENSMUSP00000104768
Gene: ENSMUSG00000027496

DomainStartEndE-ValueType
S_TKc 124 374 2.25e-99 SMART
Meta Mutation Damage Score 0.9574 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.5%
  • 10x: 96.8%
  • 20x: 93.9%
Validation Efficiency 93% (57/61)
Allele List at MGI
Other mutations in this stock
Total: 51 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adam33 T C 2: 130,895,117 (GRCm39) probably benign Het
Ahnak T C 19: 8,988,268 (GRCm39) V3184A possibly damaging Het
Aoc1 A G 6: 48,883,084 (GRCm39) N320S possibly damaging Het
Bin2 T C 15: 100,543,244 (GRCm39) E313G probably damaging Het
Brd10 C A 19: 29,782,950 (GRCm39) A109S probably damaging Het
C9orf72 A G 4: 35,193,270 (GRCm39) S228P possibly damaging Het
Ccdc47 T C 11: 106,096,265 (GRCm39) D253G possibly damaging Het
Ccdc73 A G 2: 104,822,384 (GRCm39) T778A probably benign Het
Cops3 C A 11: 59,710,839 (GRCm39) D377Y probably damaging Het
Cyp4a14 A C 4: 115,350,806 (GRCm39) V156G probably damaging Het
D6Ertd527e C G 6: 87,088,506 (GRCm39) T223S unknown Het
Disp1 C A 1: 182,871,063 (GRCm39) M452I probably damaging Het
Fbxo45 C A 16: 32,065,524 (GRCm39) probably benign Het
Flrt2 T A 12: 95,745,977 (GRCm39) M105K possibly damaging Het
Gm26558 G A 2: 70,491,656 (GRCm39) probably benign Het
Gpr83 T G 9: 14,772,101 (GRCm39) L91R probably damaging Het
Greb1l TTTAATAACTT TTT 18: 10,555,950 (GRCm39) probably null Het
Hmces T A 6: 87,910,217 (GRCm39) probably null Het
Itgb4 C T 11: 115,874,983 (GRCm39) R447W probably benign Het
Ksr2 A C 5: 117,693,074 (GRCm39) E174A probably damaging Het
Lats1 A G 10: 7,588,415 (GRCm39) T1011A probably benign Het
Lrrc46 T C 11: 96,926,957 (GRCm39) D120G probably damaging Het
Ncstn C A 1: 171,895,151 (GRCm39) probably benign Het
Neb T C 2: 52,059,130 (GRCm39) T6118A probably benign Het
Nipsnap2 A C 5: 129,834,175 (GRCm39) M272L probably benign Het
Nlgn2 C T 11: 69,716,216 (GRCm39) R775H probably damaging Het
Or13c7c A G 4: 43,836,301 (GRCm39) L63P probably damaging Het
Or2n1c A C 17: 38,519,208 (GRCm39) E24A possibly damaging Het
Or4f15 T A 2: 111,814,366 (GRCm39) T18S probably benign Het
Or4f61 T A 2: 111,922,880 (GRCm39) L55F possibly damaging Het
Or4g17 T A 2: 111,209,598 (GRCm39) D84E probably damaging Het
Or5b118 A T 19: 13,448,794 (GRCm39) Q153H probably benign Het
Pold1 A G 7: 44,185,256 (GRCm39) V750A possibly damaging Het
Prdm11 C T 2: 92,805,817 (GRCm39) E378K probably damaging Het
Ptpn9 A G 9: 56,943,954 (GRCm39) D276G probably benign Het
Rlf A T 4: 121,005,369 (GRCm39) F1204I probably damaging Het
Robo1 C A 16: 72,769,192 (GRCm39) T537K possibly damaging Het
Sec31b T A 19: 44,508,970 (GRCm39) M670L probably benign Het
Sephs1 T A 2: 4,904,321 (GRCm39) V233E possibly damaging Het
Serpinb2 T C 1: 107,450,939 (GRCm39) probably null Het
Sf3b3 T C 8: 111,550,008 (GRCm39) Q670R possibly damaging Het
Slc8a2 A C 7: 15,879,101 (GRCm39) D529A possibly damaging Het
Sva A G 6: 42,019,093 (GRCm39) N88D probably benign Het
Tcf15 G T 2: 151,986,051 (GRCm39) R169L probably damaging Het
Tfr2 A G 5: 137,572,752 (GRCm39) T188A probably benign Het
Tshz1 T A 18: 84,031,340 (GRCm39) K1023* probably null Het
Ttc28 A G 5: 111,373,555 (GRCm39) N966S probably damaging Het
Unc5c T A 3: 141,463,554 (GRCm39) I225N probably damaging Het
Ush2a T C 1: 188,184,067 (GRCm39) L1457S possibly damaging Het
Zbtb34 G T 2: 33,301,133 (GRCm39) H469Q probably damaging Het
Zfp692 T C 11: 58,198,413 (GRCm39) M1T probably null Het
Other mutations in Fam210b
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01636:Fam210b APN 2 172,193,460 (GRCm39) missense probably damaging 0.99
IGL02142:Fam210b APN 2 172,194,497 (GRCm39) unclassified probably benign
IGL02152:Fam210b APN 2 172,193,423 (GRCm39) missense probably benign 0.02
IGL02531:Fam210b APN 2 172,194,675 (GRCm39) missense probably damaging 0.99
IGL03051:Fam210b APN 2 172,194,612 (GRCm39) missense probably benign 0.21
R0597:Fam210b UTSW 2 172,187,773 (GRCm39) splice site probably benign
R4117:Fam210b UTSW 2 172,193,486 (GRCm39) missense probably benign 0.25
R4281:Fam210b UTSW 2 172,193,468 (GRCm39) missense probably damaging 0.98
R4978:Fam210b UTSW 2 172,187,585 (GRCm39) missense probably damaging 0.99
R4983:Fam210b UTSW 2 172,187,585 (GRCm39) missense probably damaging 0.99
R9544:Fam210b UTSW 2 172,194,633 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- GTCACTGACATCTGAGGAGG -3'
(R):5'- CCACACATTAGCTTAGCTTACAGC -3'

Sequencing Primer
(F):5'- CTGACATCTGAGGAGGAGGCAG -3'
(R):5'- TGGGCAAGTGATTCTACCGAC -3'
Posted On 2016-06-21