Incidental Mutation 'R5152:Wnk1'
ID 395442
Institutional Source Beutler Lab
Gene Symbol Wnk1
Ensembl Gene ENSMUSG00000045962
Gene Name WNK lysine deficient protein kinase 1
Synonyms Prkwnk1, 6430573H23Rik, EG406236, Hsn2
MMRRC Submission 042734-MU
Accession Numbers
Essential gene? Essential (E-score: 1.000) question?
Stock # R5152 (G1)
Quality Score 225
Status Validated
Chromosome 6
Chromosomal Location 119900930-120015633 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to T at 119979241 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Arginine to Glutamine at position 282 (R282Q)
Ref Sequence ENSEMBL: ENSMUSP00000145304 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000060043] [ENSMUST00000088644] [ENSMUST00000088646] [ENSMUST00000177761] [ENSMUST00000203030]
AlphaFold P83741
Predicted Effect possibly damaging
Transcript: ENSMUST00000060043
AA Change: R282Q

PolyPhen 2 Score 0.876 (Sensitivity: 0.83; Specificity: 0.93)
SMART Domains Protein: ENSMUSP00000063001
Gene: ENSMUSG00000045962
AA Change: R282Q

DomainStartEndE-ValueType
low complexity region 101 115 N/A INTRINSIC
low complexity region 127 141 N/A INTRINSIC
low complexity region 171 193 N/A INTRINSIC
Pfam:Pkinase_Tyr 221 477 1.5e-44 PFAM
Pfam:Pkinase 221 479 4.4e-58 PFAM
Pfam:OSR1_C 500 537 2e-22 PFAM
coiled coil region 563 597 N/A INTRINSIC
low complexity region 734 746 N/A INTRINSIC
low complexity region 865 876 N/A INTRINSIC
low complexity region 1018 1028 N/A INTRINSIC
low complexity region 1042 1058 N/A INTRINSIC
internal_repeat_1 1136 1178 2.15e-5 PROSPERO
low complexity region 1289 1305 N/A INTRINSIC
low complexity region 1345 1357 N/A INTRINSIC
low complexity region 1379 1396 N/A INTRINSIC
low complexity region 1398 1428 N/A INTRINSIC
low complexity region 1429 1454 N/A INTRINSIC
low complexity region 1496 1515 N/A INTRINSIC
low complexity region 1542 1556 N/A INTRINSIC
low complexity region 1586 1609 N/A INTRINSIC
low complexity region 1670 1691 N/A INTRINSIC
low complexity region 1698 1712 N/A INTRINSIC
low complexity region 1738 1764 N/A INTRINSIC
low complexity region 1882 1900 N/A INTRINSIC
coiled coil region 2065 2092 N/A INTRINSIC
low complexity region 2103 2114 N/A INTRINSIC
low complexity region 2116 2140 N/A INTRINSIC
low complexity region 2208 2232 N/A INTRINSIC
Predicted Effect possibly damaging
Transcript: ENSMUST00000088644
AA Change: R282Q

PolyPhen 2 Score 0.876 (Sensitivity: 0.83; Specificity: 0.93)
SMART Domains Protein: ENSMUSP00000086017
Gene: ENSMUSG00000045962
AA Change: R282Q

DomainStartEndE-ValueType
low complexity region 101 115 N/A INTRINSIC
low complexity region 127 141 N/A INTRINSIC
low complexity region 171 193 N/A INTRINSIC
Pfam:Pkinase_Tyr 221 477 5.5e-44 PFAM
Pfam:Pkinase 221 479 4.3e-56 PFAM
Pfam:OSR1_C 500 537 1.9e-22 PFAM
coiled coil region 563 597 N/A INTRINSIC
low complexity region 742 753 N/A INTRINSIC
low complexity region 919 935 N/A INTRINSIC
low complexity region 1050 1063 N/A INTRINSIC
low complexity region 1067 1076 N/A INTRINSIC
low complexity region 1146 1158 N/A INTRINSIC
low complexity region 1276 1286 N/A INTRINSIC
low complexity region 1300 1316 N/A INTRINSIC
internal_repeat_1 1394 1436 2.19e-5 PROSPERO
low complexity region 1547 1563 N/A INTRINSIC
low complexity region 1603 1615 N/A INTRINSIC
low complexity region 1637 1654 N/A INTRINSIC
low complexity region 1656 1686 N/A INTRINSIC
low complexity region 1687 1712 N/A INTRINSIC
low complexity region 1754 1773 N/A INTRINSIC
low complexity region 1800 1814 N/A INTRINSIC
low complexity region 1844 1867 N/A INTRINSIC
low complexity region 1928 1949 N/A INTRINSIC
low complexity region 1956 1970 N/A INTRINSIC
low complexity region 1996 2022 N/A INTRINSIC
low complexity region 2140 2158 N/A INTRINSIC
coiled coil region 2323 2350 N/A INTRINSIC
low complexity region 2361 2372 N/A INTRINSIC
low complexity region 2374 2398 N/A INTRINSIC
low complexity region 2466 2490 N/A INTRINSIC
Predicted Effect possibly damaging
Transcript: ENSMUST00000088646
AA Change: R282Q

PolyPhen 2 Score 0.876 (Sensitivity: 0.83; Specificity: 0.93)
SMART Domains Protein: ENSMUSP00000086019
Gene: ENSMUSG00000045962
AA Change: R282Q

DomainStartEndE-ValueType
low complexity region 101 115 N/A INTRINSIC
low complexity region 127 141 N/A INTRINSIC
low complexity region 171 193 N/A INTRINSIC
Pfam:Pkinase_Tyr 221 477 1.3e-44 PFAM
Pfam:Pkinase 221 479 4e-58 PFAM
Pfam:OSR1_C 500 537 1.8e-22 PFAM
coiled coil region 563 597 N/A INTRINSIC
low complexity region 734 746 N/A INTRINSIC
low complexity region 864 874 N/A INTRINSIC
low complexity region 888 904 N/A INTRINSIC
internal_repeat_1 982 1024 7.56e-6 PROSPERO
low complexity region 1135 1151 N/A INTRINSIC
low complexity region 1191 1203 N/A INTRINSIC
low complexity region 1225 1242 N/A INTRINSIC
low complexity region 1244 1274 N/A INTRINSIC
low complexity region 1275 1300 N/A INTRINSIC
low complexity region 1342 1361 N/A INTRINSIC
low complexity region 1388 1402 N/A INTRINSIC
low complexity region 1432 1455 N/A INTRINSIC
low complexity region 1516 1537 N/A INTRINSIC
low complexity region 1544 1558 N/A INTRINSIC
low complexity region 1584 1610 N/A INTRINSIC
low complexity region 1700 1718 N/A INTRINSIC
coiled coil region 1883 1910 N/A INTRINSIC
low complexity region 1921 1932 N/A INTRINSIC
low complexity region 1934 1958 N/A INTRINSIC
low complexity region 2026 2050 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000159397
Predicted Effect noncoding transcript
Transcript: ENSMUST00000160032
Predicted Effect possibly damaging
Transcript: ENSMUST00000177761
AA Change: R282Q

PolyPhen 2 Score 0.876 (Sensitivity: 0.83; Specificity: 0.93)
SMART Domains Protein: ENSMUSP00000136777
Gene: ENSMUSG00000045962
AA Change: R282Q

DomainStartEndE-ValueType
low complexity region 101 115 N/A INTRINSIC
low complexity region 127 141 N/A INTRINSIC
low complexity region 171 193 N/A INTRINSIC
Pfam:Pkinase_Tyr 221 477 1.7e-44 PFAM
Pfam:Pkinase 221 479 5.1e-58 PFAM
Pfam:OSR1_C 500 537 2.2e-22 PFAM
coiled coil region 563 597 N/A INTRINSIC
low complexity region 710 722 N/A INTRINSIC
low complexity region 828 839 N/A INTRINSIC
low complexity region 1005 1021 N/A INTRINSIC
low complexity region 1136 1149 N/A INTRINSIC
low complexity region 1153 1162 N/A INTRINSIC
low complexity region 1232 1244 N/A INTRINSIC
low complexity region 1291 1307 N/A INTRINSIC
internal_repeat_1 1385 1427 1.91e-5 PROSPERO
low complexity region 1538 1554 N/A INTRINSIC
low complexity region 1594 1606 N/A INTRINSIC
low complexity region 1628 1645 N/A INTRINSIC
low complexity region 1647 1677 N/A INTRINSIC
low complexity region 1678 1703 N/A INTRINSIC
low complexity region 1745 1764 N/A INTRINSIC
low complexity region 1791 1805 N/A INTRINSIC
low complexity region 1835 1858 N/A INTRINSIC
low complexity region 1919 1940 N/A INTRINSIC
low complexity region 1947 1961 N/A INTRINSIC
low complexity region 1987 2013 N/A INTRINSIC
low complexity region 2131 2149 N/A INTRINSIC
coiled coil region 2314 2341 N/A INTRINSIC
low complexity region 2352 2363 N/A INTRINSIC
low complexity region 2365 2389 N/A INTRINSIC
low complexity region 2457 2481 N/A INTRINSIC
Predicted Effect possibly damaging
Transcript: ENSMUST00000203030
AA Change: R282Q

PolyPhen 2 Score 0.876 (Sensitivity: 0.83; Specificity: 0.93)
SMART Domains Protein: ENSMUSP00000145304
Gene: ENSMUSG00000045962
AA Change: R282Q

DomainStartEndE-ValueType
low complexity region 101 115 N/A INTRINSIC
low complexity region 127 141 N/A INTRINSIC
low complexity region 171 193 N/A INTRINSIC
Pfam:Pkinase_Tyr 221 477 4.1e-44 PFAM
Pfam:Pkinase 221 479 3.2e-56 PFAM
Pfam:OSR1_C 500 537 1.5e-22 PFAM
coiled coil region 563 597 N/A INTRINSIC
low complexity region 734 746 N/A INTRINSIC
low complexity region 793 809 N/A INTRINSIC
internal_repeat_1 887 929 5.8e-6 PROSPERO
low complexity region 1040 1056 N/A INTRINSIC
low complexity region 1096 1108 N/A INTRINSIC
low complexity region 1130 1147 N/A INTRINSIC
low complexity region 1149 1179 N/A INTRINSIC
low complexity region 1180 1205 N/A INTRINSIC
low complexity region 1247 1266 N/A INTRINSIC
low complexity region 1293 1307 N/A INTRINSIC
low complexity region 1337 1360 N/A INTRINSIC
low complexity region 1421 1442 N/A INTRINSIC
low complexity region 1449 1463 N/A INTRINSIC
low complexity region 1489 1515 N/A INTRINSIC
low complexity region 1633 1651 N/A INTRINSIC
coiled coil region 1816 1843 N/A INTRINSIC
low complexity region 1854 1865 N/A INTRINSIC
low complexity region 1867 1891 N/A INTRINSIC
low complexity region 1959 1983 N/A INTRINSIC
Meta Mutation Damage Score 0.1795 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.0%
  • 20x: 94.4%
Validation Efficiency 99% (83/84)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the WNK subfamily of serine/threonine protein kinases. The encoded protein may be a key regulator of blood pressure by controlling the transport of sodium and chloride ions. Mutations in this gene have been associated with pseudohypoaldosteronism type II and hereditary sensory neuropathy type II. Alternatively spliced transcript variants encoding different isoforms have been described but the full-length nature of all of them has yet to be determined.[provided by RefSeq, May 2010]
PHENOTYPE: Homozygous mutant mice die before birth, whereas heterozygotes survive and exhibit decreased blood pressure. Mice homozygous for an allele that does not produce the kidney isoform exhibit a slight increase in systemic arterial diastolic blood pressure and reduced sensitivity to amiloride. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 77 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca16 T C 7: 120,139,846 (GRCm39) S1503P probably benign Het
Actn3 C A 19: 4,913,572 (GRCm39) V620F probably damaging Het
Adamtsl3 A G 7: 82,223,752 (GRCm39) K252E probably benign Het
Adgrg1 A G 8: 95,736,373 (GRCm39) Y509C probably damaging Het
Arhgef2 G A 3: 88,536,875 (GRCm39) probably null Het
Bod1l T C 5: 41,973,886 (GRCm39) E2476G probably benign Het
Capn3 T C 2: 120,331,811 (GRCm39) probably benign Het
Catsperz T C 19: 6,900,705 (GRCm39) T147A probably benign Het
Cc2d1b C A 4: 108,483,283 (GRCm39) A289E probably benign Het
Ccdc170 A C 10: 4,511,107 (GRCm39) H722P probably damaging Het
Cdk13 C A 13: 17,893,110 (GRCm39) A1358S probably benign Het
Cntn6 T A 6: 104,546,074 (GRCm39) probably benign Het
Coch A G 12: 51,642,225 (GRCm39) N66D probably benign Het
Col12a1 A G 9: 79,564,030 (GRCm39) S1732P probably damaging Het
Copa T A 1: 171,945,628 (GRCm39) V917E probably benign Het
Csmd2 C A 4: 128,445,828 (GRCm39) N3299K probably benign Het
Cyp2c67 A T 19: 39,627,132 (GRCm39) F233I probably benign Het
D630039A03Rik T A 4: 57,910,434 (GRCm39) H126L probably damaging Het
Ddx46 T C 13: 55,806,843 (GRCm39) L492P probably damaging Het
Dpysl3 C T 18: 43,571,145 (GRCm39) G43D probably benign Het
Enpp5 C T 17: 44,392,024 (GRCm39) P151L probably damaging Het
Exoc3l4 T C 12: 111,397,327 (GRCm39) probably benign Het
Faap100 T A 11: 120,268,458 (GRCm39) E105V possibly damaging Het
Flg2 C A 3: 93,122,284 (GRCm39) P1485T unknown Het
Fmo5 A G 3: 97,549,078 (GRCm39) Y242C probably benign Het
Fsip2 C A 2: 82,808,916 (GRCm39) T1745N probably benign Het
Gata4 T A 14: 63,478,570 (GRCm39) N10Y probably damaging Het
Gm10722 A C 9: 3,001,041 (GRCm39) Y39S probably benign Het
Gm4787 A C 12: 81,425,451 (GRCm39) S236A probably benign Het
Golga7 A C 8: 23,735,965 (GRCm39) S94A probably benign Het
Gpbp1 A G 13: 111,589,815 (GRCm39) probably benign Het
Grm1 A G 10: 10,955,619 (GRCm39) Y222H probably benign Het
Gstcd A G 3: 132,790,717 (GRCm39) Y17H possibly damaging Het
Hephl1 C A 9: 14,991,481 (GRCm39) D586Y probably damaging Het
Hpn C A 7: 30,799,261 (GRCm39) V35L probably damaging Het
Il23r T A 6: 67,400,725 (GRCm39) N535I probably damaging Het
Inpp4a T C 1: 37,397,616 (GRCm39) I45T possibly damaging Het
Itgae G C 11: 73,021,821 (GRCm39) G901R probably damaging Het
Kif28 T C 1: 179,530,103 (GRCm39) D686G probably damaging Het
Kit A G 5: 75,781,507 (GRCm39) E312G probably benign Het
Lamb2 C A 9: 108,364,937 (GRCm39) S1230R probably benign Het
Lars1 A T 18: 42,361,842 (GRCm39) D588E possibly damaging Het
Lgr4 T A 2: 109,830,948 (GRCm39) F292I probably damaging Het
Lmf1 C T 17: 25,874,493 (GRCm39) S458L probably damaging Het
Lpin2 T A 17: 71,552,154 (GRCm39) C787S probably damaging Het
Ms4a4a A C 19: 11,365,676 (GRCm39) I138L probably benign Het
Mterf1a A T 5: 3,940,984 (GRCm39) F295I probably damaging Het
Muc4 A T 16: 32,577,432 (GRCm39) K241* probably null Het
Muc5b T C 7: 141,419,268 (GRCm39) F4017S possibly damaging Het
Nfkbil1 T C 17: 35,440,384 (GRCm39) probably benign Het
Or10d5j T C 9: 39,868,202 (GRCm39) T22A probably benign Het
Or4x6 A G 2: 89,949,465 (GRCm39) L159P probably damaging Het
Or8g21 A T 9: 38,906,473 (GRCm39) V86E possibly damaging Het
Osgep T C 14: 51,155,315 (GRCm39) D81G probably damaging Het
Otos A G 1: 92,572,116 (GRCm39) F70S probably damaging Het
Pcdhb2 T A 18: 37,429,179 (GRCm39) V384D probably damaging Het
Ppp1r10 C T 17: 36,240,144 (GRCm39) P514S probably damaging Het
Pramel14 G A 4: 143,720,830 (GRCm39) P37L probably damaging Het
Prdm16 A G 4: 154,430,559 (GRCm39) Y309H probably damaging Het
Rap1gds1 A T 3: 138,661,962 (GRCm39) D382E probably damaging Het
Reln A G 5: 22,153,627 (GRCm39) F2226L probably damaging Het
Rmi2 C T 16: 10,657,765 (GRCm39) T125M probably damaging Het
Setd1a C T 7: 127,383,197 (GRCm39) T231I probably benign Het
Sftpa1 G A 14: 40,856,309 (GRCm39) G218D probably damaging Het
Shcbp1 A T 8: 4,786,138 (GRCm39) F655I probably damaging Het
Slc5a7 T C 17: 54,585,861 (GRCm39) I319V possibly damaging Het
Sp140l2 G A 1: 85,239,581 (GRCm39) P19S probably benign Het
Spata31d1c C T 13: 65,183,409 (GRCm39) T317I probably damaging Het
Speg C T 1: 75,404,742 (GRCm39) P2845S possibly damaging Het
Synpo2 A G 3: 123,029,550 (GRCm39) probably null Het
Tdpoz9 T C 3: 93,957,451 (GRCm39) probably benign Het
Tdrd7 T A 4: 46,013,191 (GRCm39) S644T probably damaging Het
Tmem182 T A 1: 40,877,460 (GRCm39) Y112N probably damaging Het
Usp45 T A 4: 21,824,815 (GRCm39) N522K probably benign Het
Vnn3 A T 10: 23,740,237 (GRCm39) Y180F probably benign Het
Xrn1 A T 9: 95,846,118 (GRCm39) D57V probably benign Het
Zfp831 T C 2: 174,486,357 (GRCm39) V344A probably benign Het
Other mutations in Wnk1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00901:Wnk1 APN 6 119,937,669 (GRCm39) missense probably damaging 1.00
IGL01364:Wnk1 APN 6 119,914,372 (GRCm39) missense probably damaging 1.00
IGL01715:Wnk1 APN 6 119,925,358 (GRCm39) missense probably damaging 1.00
IGL01951:Wnk1 APN 6 119,940,446 (GRCm39) missense probably damaging 0.99
IGL02043:Wnk1 APN 6 119,926,039 (GRCm39) unclassified probably benign
IGL02268:Wnk1 APN 6 119,914,334 (GRCm39) nonsense probably null
IGL02348:Wnk1 APN 6 119,940,289 (GRCm39) missense probably damaging 0.98
IGL02425:Wnk1 APN 6 119,940,415 (GRCm39) missense probably damaging 1.00
IGL02850:Wnk1 APN 6 119,914,823 (GRCm39) missense probably benign 0.26
IGL03160:Wnk1 APN 6 119,903,594 (GRCm39) missense probably damaging 1.00
IGL03387:Wnk1 APN 6 119,931,148 (GRCm39) missense possibly damaging 0.76
IGL03405:Wnk1 APN 6 119,930,856 (GRCm39) missense probably benign 0.41
Actor UTSW 6 119,947,939 (GRCm39) missense probably damaging 1.00
Bad UTSW 6 119,942,639 (GRCm39) intron probably benign
Blink UTSW 6 119,979,234 (GRCm39) nonsense probably null
Knock UTSW 6 119,920,839 (GRCm39) splice site probably null
Narrow UTSW 6 119,969,369 (GRCm39) missense probably damaging 1.00
nictitate UTSW 6 119,979,241 (GRCm39) missense possibly damaging 0.88
opportunity UTSW 6 119,928,029 (GRCm39) missense probably damaging 1.00
path UTSW 6 120,014,110 (GRCm39) missense probably damaging 0.99
Stormy UTSW 6 119,969,408 (GRCm39) missense probably damaging 1.00
tear UTSW 6 119,940,431 (GRCm39) missense probably damaging 0.98
Tic UTSW 6 119,927,044 (GRCm39) missense probably damaging 1.00
Unforgiving UTSW 6 119,925,243 (GRCm39) missense probably damaging 1.00
Window UTSW 6 119,969,414 (GRCm39) missense probably damaging 1.00
Woke UTSW 6 119,939,916 (GRCm39) missense probably benign 0.12
IGL03052:Wnk1 UTSW 6 119,921,760 (GRCm39) splice site probably benign
PIT4480001:Wnk1 UTSW 6 119,940,328 (GRCm39) nonsense probably null
R0044:Wnk1 UTSW 6 120,014,110 (GRCm39) missense probably damaging 0.99
R0207:Wnk1 UTSW 6 119,929,694 (GRCm39) missense probably damaging 1.00
R0333:Wnk1 UTSW 6 119,905,124 (GRCm39) intron probably benign
R0453:Wnk1 UTSW 6 119,940,112 (GRCm39) missense probably damaging 0.99
R0457:Wnk1 UTSW 6 119,946,293 (GRCm39) missense probably damaging 1.00
R0501:Wnk1 UTSW 6 119,939,764 (GRCm39) missense probably damaging 1.00
R0525:Wnk1 UTSW 6 119,903,525 (GRCm39) missense probably damaging 1.00
R0526:Wnk1 UTSW 6 119,928,953 (GRCm39) missense probably damaging 0.99
R0606:Wnk1 UTSW 6 119,903,644 (GRCm39) missense probably damaging 1.00
R0658:Wnk1 UTSW 6 119,925,466 (GRCm39) missense probably damaging 0.98
R1148:Wnk1 UTSW 6 119,928,967 (GRCm39) splice site probably benign
R1188:Wnk1 UTSW 6 119,925,670 (GRCm39) nonsense probably null
R1245:Wnk1 UTSW 6 119,925,418 (GRCm39) missense probably benign 0.26
R1449:Wnk1 UTSW 6 119,929,779 (GRCm39) missense probably damaging 1.00
R1469:Wnk1 UTSW 6 119,927,645 (GRCm39) splice site probably benign
R1869:Wnk1 UTSW 6 119,928,050 (GRCm39) missense probably damaging 1.00
R1871:Wnk1 UTSW 6 119,928,050 (GRCm39) missense probably damaging 1.00
R1928:Wnk1 UTSW 6 119,929,884 (GRCm39) missense probably damaging 1.00
R1959:Wnk1 UTSW 6 119,946,208 (GRCm39) missense probably damaging 0.98
R1961:Wnk1 UTSW 6 119,946,208 (GRCm39) missense probably damaging 0.98
R1964:Wnk1 UTSW 6 119,911,343 (GRCm39) missense possibly damaging 0.86
R1983:Wnk1 UTSW 6 119,914,539 (GRCm39) missense probably damaging 1.00
R2062:Wnk1 UTSW 6 119,905,118 (GRCm39) splice site probably null
R2144:Wnk1 UTSW 6 119,925,949 (GRCm39) unclassified probably benign
R2186:Wnk1 UTSW 6 119,925,528 (GRCm39) missense probably benign 0.26
R2281:Wnk1 UTSW 6 119,940,601 (GRCm39) splice site probably null
R2338:Wnk1 UTSW 6 119,946,495 (GRCm39) missense probably benign 0.42
R2420:Wnk1 UTSW 6 119,913,328 (GRCm39) critical splice donor site probably null
R3727:Wnk1 UTSW 6 119,969,414 (GRCm39) missense probably damaging 1.00
R3773:Wnk1 UTSW 6 119,979,241 (GRCm39) missense possibly damaging 0.88
R3836:Wnk1 UTSW 6 119,927,004 (GRCm39) missense probably damaging 1.00
R3837:Wnk1 UTSW 6 119,927,004 (GRCm39) missense probably damaging 1.00
R3847:Wnk1 UTSW 6 119,946,315 (GRCm39) missense possibly damaging 0.70
R3903:Wnk1 UTSW 6 119,926,012 (GRCm39) missense probably damaging 1.00
R4031:Wnk1 UTSW 6 119,928,029 (GRCm39) missense probably damaging 1.00
R4095:Wnk1 UTSW 6 119,925,087 (GRCm39) missense probably damaging 1.00
R4232:Wnk1 UTSW 6 119,926,222 (GRCm39) missense possibly damaging 0.90
R4422:Wnk1 UTSW 6 119,930,856 (GRCm39) missense probably benign 0.41
R4423:Wnk1 UTSW 6 119,903,387 (GRCm39) missense probably damaging 1.00
R4572:Wnk1 UTSW 6 119,928,872 (GRCm39) missense possibly damaging 0.49
R4704:Wnk1 UTSW 6 119,942,705 (GRCm39) missense possibly damaging 0.83
R4755:Wnk1 UTSW 6 119,940,431 (GRCm39) missense probably damaging 0.98
R4812:Wnk1 UTSW 6 119,929,732 (GRCm39) missense probably benign 0.16
R4822:Wnk1 UTSW 6 119,939,399 (GRCm39) missense probably benign 0.02
R4879:Wnk1 UTSW 6 119,926,338 (GRCm39) missense probably damaging 1.00
R4970:Wnk1 UTSW 6 119,942,696 (GRCm39) intron probably benign
R5002:Wnk1 UTSW 6 119,914,924 (GRCm39) missense probably benign 0.13
R5037:Wnk1 UTSW 6 119,942,696 (GRCm39) intron probably benign
R5257:Wnk1 UTSW 6 120,014,149 (GRCm39) missense probably benign 0.00
R5354:Wnk1 UTSW 6 119,945,484 (GRCm39) missense probably benign 0.01
R5421:Wnk1 UTSW 6 119,929,779 (GRCm39) missense probably damaging 1.00
R5564:Wnk1 UTSW 6 119,925,852 (GRCm39) unclassified probably benign
R5600:Wnk1 UTSW 6 119,926,319 (GRCm39) missense probably damaging 1.00
R5847:Wnk1 UTSW 6 119,969,369 (GRCm39) missense probably damaging 1.00
R6083:Wnk1 UTSW 6 120,014,562 (GRCm39) missense probably damaging 0.99
R6110:Wnk1 UTSW 6 119,949,958 (GRCm39) intron probably benign
R6128:Wnk1 UTSW 6 119,940,747 (GRCm39) splice site probably null
R6237:Wnk1 UTSW 6 119,929,728 (GRCm39) missense probably damaging 1.00
R6341:Wnk1 UTSW 6 119,925,546 (GRCm39) missense probably damaging 1.00
R6467:Wnk1 UTSW 6 119,939,916 (GRCm39) missense probably benign 0.12
R6696:Wnk1 UTSW 6 119,925,243 (GRCm39) missense probably damaging 1.00
R6888:Wnk1 UTSW 6 119,925,742 (GRCm39) missense probably benign 0.26
R6923:Wnk1 UTSW 6 119,942,639 (GRCm39) intron probably benign
R7024:Wnk1 UTSW 6 119,942,687 (GRCm39) intron probably benign
R7072:Wnk1 UTSW 6 119,914,822 (GRCm39) missense unknown
R7087:Wnk1 UTSW 6 120,014,491 (GRCm39) missense possibly damaging 0.94
R7102:Wnk1 UTSW 6 119,925,268 (GRCm39) missense unknown
R7134:Wnk1 UTSW 6 119,903,389 (GRCm39) missense unknown
R7137:Wnk1 UTSW 6 120,015,173 (GRCm39) unclassified probably benign
R7142:Wnk1 UTSW 6 119,926,240 (GRCm39) missense probably benign 0.09
R7174:Wnk1 UTSW 6 119,947,939 (GRCm39) missense probably damaging 1.00
R7205:Wnk1 UTSW 6 119,920,839 (GRCm39) splice site probably null
R7218:Wnk1 UTSW 6 119,979,234 (GRCm39) nonsense probably null
R7498:Wnk1 UTSW 6 119,904,157 (GRCm39) missense unknown
R7599:Wnk1 UTSW 6 119,906,789 (GRCm39) missense possibly damaging 0.83
R7615:Wnk1 UTSW 6 119,909,699 (GRCm39) missense probably benign 0.27
R7799:Wnk1 UTSW 6 119,926,137 (GRCm39) missense probably benign 0.04
R7979:Wnk1 UTSW 6 120,014,409 (GRCm39) missense probably damaging 1.00
R8075:Wnk1 UTSW 6 119,909,675 (GRCm39) missense probably damaging 0.99
R8331:Wnk1 UTSW 6 119,930,794 (GRCm39) missense probably benign 0.09
R8343:Wnk1 UTSW 6 119,940,454 (GRCm39) missense probably damaging 0.99
R8348:Wnk1 UTSW 6 119,906,960 (GRCm39) splice site probably null
R8359:Wnk1 UTSW 6 119,969,408 (GRCm39) missense probably damaging 1.00
R8424:Wnk1 UTSW 6 119,911,388 (GRCm39) missense unknown
R8519:Wnk1 UTSW 6 119,927,044 (GRCm39) missense probably damaging 1.00
R8930:Wnk1 UTSW 6 119,940,226 (GRCm39) missense probably damaging 0.99
R8932:Wnk1 UTSW 6 119,940,226 (GRCm39) missense probably damaging 0.99
R8933:Wnk1 UTSW 6 120,013,959 (GRCm39) missense probably damaging 1.00
R9005:Wnk1 UTSW 6 119,939,393 (GRCm39) missense probably damaging 1.00
R9147:Wnk1 UTSW 6 119,925,631 (GRCm39) missense unknown
R9148:Wnk1 UTSW 6 119,925,631 (GRCm39) missense unknown
R9354:Wnk1 UTSW 6 119,942,660 (GRCm39) missense unknown
R9379:Wnk1 UTSW 6 119,928,678 (GRCm39) missense probably damaging 1.00
X0064:Wnk1 UTSW 6 120,013,993 (GRCm39) missense possibly damaging 0.93
Z1177:Wnk1 UTSW 6 119,925,166 (GRCm39) missense unknown
Predicted Primers PCR Primer
(F):5'- GTTTATTCAGCAACAAACTCATCCC -3'
(R):5'- CATGTGCCATCTTGACCAGC -3'

Sequencing Primer
(F):5'- TGTGGGTAGTAAAAACACATTGGTTG -3'
(R):5'- GTGCCATCTTGACCAGCTTATTTAG -3'
Posted On 2016-06-21