Incidental Mutation 'R5152:Or8g21'
ID 395452
Institutional Source Beutler Lab
Gene Symbol Or8g21
Ensembl Gene ENSMUSG00000059595
Gene Name olfactory receptor family 8 subfamily G member 21
Synonyms MOR171-11, GA_x6K02T2PVTD-32691280-32690354, Olfr935
MMRRC Submission 042734-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.064) question?
Stock # R5152 (G1)
Quality Score 225
Status Validated
Chromosome 9
Chromosomal Location 38905803-38906729 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 38906473 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Glutamic Acid at position 86 (V86E)
Ref Sequence ENSEMBL: ENSMUSP00000149193 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000080748] [ENSMUST00000214157]
AlphaFold Q8VG16
Predicted Effect possibly damaging
Transcript: ENSMUST00000080748
AA Change: V86E

PolyPhen 2 Score 0.883 (Sensitivity: 0.82; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000079572
Gene: ENSMUSG00000059595
AA Change: V86E

DomainStartEndE-ValueType
Pfam:7tm_4 31 308 4e-53 PFAM
Pfam:7tm_1 41 290 1.2e-22 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000214157
AA Change: V86E

PolyPhen 2 Score 0.883 (Sensitivity: 0.82; Specificity: 0.94)
Meta Mutation Damage Score 0.0952 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.0%
  • 20x: 94.4%
Validation Efficiency 99% (83/84)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 77 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca16 T C 7: 120,139,846 (GRCm39) S1503P probably benign Het
Actn3 C A 19: 4,913,572 (GRCm39) V620F probably damaging Het
Adamtsl3 A G 7: 82,223,752 (GRCm39) K252E probably benign Het
Adgrg1 A G 8: 95,736,373 (GRCm39) Y509C probably damaging Het
Arhgef2 G A 3: 88,536,875 (GRCm39) probably null Het
Bod1l T C 5: 41,973,886 (GRCm39) E2476G probably benign Het
Capn3 T C 2: 120,331,811 (GRCm39) probably benign Het
Catsperz T C 19: 6,900,705 (GRCm39) T147A probably benign Het
Cc2d1b C A 4: 108,483,283 (GRCm39) A289E probably benign Het
Ccdc170 A C 10: 4,511,107 (GRCm39) H722P probably damaging Het
Cdk13 C A 13: 17,893,110 (GRCm39) A1358S probably benign Het
Cntn6 T A 6: 104,546,074 (GRCm39) probably benign Het
Coch A G 12: 51,642,225 (GRCm39) N66D probably benign Het
Col12a1 A G 9: 79,564,030 (GRCm39) S1732P probably damaging Het
Copa T A 1: 171,945,628 (GRCm39) V917E probably benign Het
Csmd2 C A 4: 128,445,828 (GRCm39) N3299K probably benign Het
Cyp2c67 A T 19: 39,627,132 (GRCm39) F233I probably benign Het
D630039A03Rik T A 4: 57,910,434 (GRCm39) H126L probably damaging Het
Ddx46 T C 13: 55,806,843 (GRCm39) L492P probably damaging Het
Dpysl3 C T 18: 43,571,145 (GRCm39) G43D probably benign Het
Enpp5 C T 17: 44,392,024 (GRCm39) P151L probably damaging Het
Exoc3l4 T C 12: 111,397,327 (GRCm39) probably benign Het
Faap100 T A 11: 120,268,458 (GRCm39) E105V possibly damaging Het
Flg2 C A 3: 93,122,284 (GRCm39) P1485T unknown Het
Fmo5 A G 3: 97,549,078 (GRCm39) Y242C probably benign Het
Fsip2 C A 2: 82,808,916 (GRCm39) T1745N probably benign Het
Gata4 T A 14: 63,478,570 (GRCm39) N10Y probably damaging Het
Gm10722 A C 9: 3,001,041 (GRCm39) Y39S probably benign Het
Gm4787 A C 12: 81,425,451 (GRCm39) S236A probably benign Het
Golga7 A C 8: 23,735,965 (GRCm39) S94A probably benign Het
Gpbp1 A G 13: 111,589,815 (GRCm39) probably benign Het
Grm1 A G 10: 10,955,619 (GRCm39) Y222H probably benign Het
Gstcd A G 3: 132,790,717 (GRCm39) Y17H possibly damaging Het
Hephl1 C A 9: 14,991,481 (GRCm39) D586Y probably damaging Het
Hpn C A 7: 30,799,261 (GRCm39) V35L probably damaging Het
Il23r T A 6: 67,400,725 (GRCm39) N535I probably damaging Het
Inpp4a T C 1: 37,397,616 (GRCm39) I45T possibly damaging Het
Itgae G C 11: 73,021,821 (GRCm39) G901R probably damaging Het
Kif28 T C 1: 179,530,103 (GRCm39) D686G probably damaging Het
Kit A G 5: 75,781,507 (GRCm39) E312G probably benign Het
Lamb2 C A 9: 108,364,937 (GRCm39) S1230R probably benign Het
Lars1 A T 18: 42,361,842 (GRCm39) D588E possibly damaging Het
Lgr4 T A 2: 109,830,948 (GRCm39) F292I probably damaging Het
Lmf1 C T 17: 25,874,493 (GRCm39) S458L probably damaging Het
Lpin2 T A 17: 71,552,154 (GRCm39) C787S probably damaging Het
Ms4a4a A C 19: 11,365,676 (GRCm39) I138L probably benign Het
Mterf1a A T 5: 3,940,984 (GRCm39) F295I probably damaging Het
Muc4 A T 16: 32,577,432 (GRCm39) K241* probably null Het
Muc5b T C 7: 141,419,268 (GRCm39) F4017S possibly damaging Het
Nfkbil1 T C 17: 35,440,384 (GRCm39) probably benign Het
Or10d5j T C 9: 39,868,202 (GRCm39) T22A probably benign Het
Or4x6 A G 2: 89,949,465 (GRCm39) L159P probably damaging Het
Osgep T C 14: 51,155,315 (GRCm39) D81G probably damaging Het
Otos A G 1: 92,572,116 (GRCm39) F70S probably damaging Het
Pcdhb2 T A 18: 37,429,179 (GRCm39) V384D probably damaging Het
Ppp1r10 C T 17: 36,240,144 (GRCm39) P514S probably damaging Het
Pramel14 G A 4: 143,720,830 (GRCm39) P37L probably damaging Het
Prdm16 A G 4: 154,430,559 (GRCm39) Y309H probably damaging Het
Rap1gds1 A T 3: 138,661,962 (GRCm39) D382E probably damaging Het
Reln A G 5: 22,153,627 (GRCm39) F2226L probably damaging Het
Rmi2 C T 16: 10,657,765 (GRCm39) T125M probably damaging Het
Setd1a C T 7: 127,383,197 (GRCm39) T231I probably benign Het
Sftpa1 G A 14: 40,856,309 (GRCm39) G218D probably damaging Het
Shcbp1 A T 8: 4,786,138 (GRCm39) F655I probably damaging Het
Slc5a7 T C 17: 54,585,861 (GRCm39) I319V possibly damaging Het
Sp140l2 G A 1: 85,239,581 (GRCm39) P19S probably benign Het
Spata31d1c C T 13: 65,183,409 (GRCm39) T317I probably damaging Het
Speg C T 1: 75,404,742 (GRCm39) P2845S possibly damaging Het
Synpo2 A G 3: 123,029,550 (GRCm39) probably null Het
Tdpoz9 T C 3: 93,957,451 (GRCm39) probably benign Het
Tdrd7 T A 4: 46,013,191 (GRCm39) S644T probably damaging Het
Tmem182 T A 1: 40,877,460 (GRCm39) Y112N probably damaging Het
Usp45 T A 4: 21,824,815 (GRCm39) N522K probably benign Het
Vnn3 A T 10: 23,740,237 (GRCm39) Y180F probably benign Het
Wnk1 C T 6: 119,979,241 (GRCm39) R282Q possibly damaging Het
Xrn1 A T 9: 95,846,118 (GRCm39) D57V probably benign Het
Zfp831 T C 2: 174,486,357 (GRCm39) V344A probably benign Het
Other mutations in Or8g21
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01522:Or8g21 APN 9 38,906,396 (GRCm39) missense probably benign 0.08
IGL01671:Or8g21 APN 9 38,906,149 (GRCm39) missense probably benign 0.05
IGL02331:Or8g21 APN 9 38,906,402 (GRCm39) missense probably damaging 0.99
IGL03069:Or8g21 APN 9 38,906,728 (GRCm39) start codon destroyed probably null 0.98
IGL03143:Or8g21 APN 9 38,906,732 (GRCm39) utr 5 prime probably benign
R0149:Or8g21 UTSW 9 38,905,880 (GRCm39) missense probably benign 0.05
R0400:Or8g21 UTSW 9 38,906,494 (GRCm39) missense probably damaging 1.00
R1818:Or8g21 UTSW 9 38,905,902 (GRCm39) missense possibly damaging 0.61
R2092:Or8g21 UTSW 9 38,906,485 (GRCm39) missense probably damaging 1.00
R2151:Or8g21 UTSW 9 38,906,012 (GRCm39) missense probably damaging 1.00
R2166:Or8g21 UTSW 9 38,906,513 (GRCm39) nonsense probably null
R2347:Or8g21 UTSW 9 38,905,805 (GRCm39) makesense probably null
R4404:Or8g21 UTSW 9 38,905,865 (GRCm39) missense possibly damaging 0.77
R4406:Or8g21 UTSW 9 38,905,865 (GRCm39) missense possibly damaging 0.77
R5467:Or8g21 UTSW 9 38,906,200 (GRCm39) missense probably benign 0.14
R5509:Or8g21 UTSW 9 38,905,924 (GRCm39) missense probably benign 0.03
R5954:Or8g21 UTSW 9 38,906,711 (GRCm39) missense probably damaging 1.00
R6647:Or8g21 UTSW 9 38,906,210 (GRCm39) missense possibly damaging 0.55
R6680:Or8g21 UTSW 9 38,905,954 (GRCm39) missense probably damaging 1.00
R6928:Or8g21 UTSW 9 38,905,928 (GRCm39) missense probably benign 0.03
R7242:Or8g21 UTSW 9 38,906,437 (GRCm39) missense probably benign 0.31
R7271:Or8g21 UTSW 9 38,905,953 (GRCm39) nonsense probably null
R7309:Or8g21 UTSW 9 38,906,576 (GRCm39) missense probably damaging 1.00
R7775:Or8g21 UTSW 9 38,906,203 (GRCm39) missense probably damaging 1.00
R7778:Or8g21 UTSW 9 38,906,203 (GRCm39) missense probably damaging 1.00
R7866:Or8g21 UTSW 9 38,906,027 (GRCm39) missense not run
R8280:Or8g21 UTSW 9 38,906,075 (GRCm39) missense probably benign
R8334:Or8g21 UTSW 9 38,905,889 (GRCm39) missense probably benign 0.00
R8841:Or8g21 UTSW 9 38,905,879 (GRCm39) missense possibly damaging 0.95
R9161:Or8g21 UTSW 9 38,905,816 (GRCm39) missense possibly damaging 0.70
R9169:Or8g21 UTSW 9 38,906,573 (GRCm39) missense probably benign 0.23
R9659:Or8g21 UTSW 9 38,906,296 (GRCm39) missense possibly damaging 0.64
R9739:Or8g21 UTSW 9 38,906,302 (GRCm39) nonsense probably null
R9788:Or8g21 UTSW 9 38,906,296 (GRCm39) missense possibly damaging 0.64
Predicted Primers PCR Primer
(F):5'- GCTGATGCACAAACTATGCC -3'
(R):5'- AACTACAGCTGCCACTCTTC -3'

Sequencing Primer
(F):5'- CTGATGCACAAACTATGCCTATAATG -3'
(R):5'- CCTCCTCTTTCTTGGAATCTACCTG -3'
Posted On 2016-06-21