Incidental Mutation 'R5039:Or8g27'
ID 395707
Institutional Source Beutler Lab
Gene Symbol Or8g27
Ensembl Gene ENSMUSG00000096555
Gene Name olfactory receptor family 8 subfamily G member 27
Synonyms GA_x6K02T2PVTD-32914568-32915503, Olfr944, MOR171-19
MMRRC Submission 042629-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.071) question?
Stock # R5039 (G1)
Quality Score 225
Status Validated
Chromosome 9
Chromosomal Location 39128655-39129590 bp(+) (GRCm39)
Type of Mutation nonsense
DNA Base Change (assembly) T to A at 39129410 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Tyrosine to Stop codon at position 252 (Y252*)
Ref Sequence ENSEMBL: ENSMUSP00000150471 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000079650] [ENSMUST00000213908] [ENSMUST00000215306]
AlphaFold Q9EQ91
Predicted Effect probably null
Transcript: ENSMUST00000079650
AA Change: Y252*
SMART Domains Protein: ENSMUSP00000078595
Gene: ENSMUSG00000096555
AA Change: Y252*

DomainStartEndE-ValueType
Pfam:7tm_4 31 308 2.5e-47 PFAM
Pfam:7tm_1 41 290 2.1e-19 PFAM
Predicted Effect probably null
Transcript: ENSMUST00000213908
AA Change: Y252*
Predicted Effect probably null
Transcript: ENSMUST00000215306
AA Change: Y252*
Meta Mutation Damage Score 0.9755 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.5%
  • 10x: 97.0%
  • 20x: 94.5%
Validation Efficiency 100% (61/61)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 52 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcg4 G A 9: 44,192,863 (GRCm39) A161V probably damaging Het
Anapc2 T C 2: 25,164,808 (GRCm39) I64T possibly damaging Het
Arfgef1 T C 1: 10,269,961 (GRCm39) D396G probably benign Het
Ark2c A G 18: 77,550,608 (GRCm39) S107P probably damaging Het
Axl C T 7: 25,485,340 (GRCm39) V163M probably damaging Het
Blm G A 7: 80,155,621 (GRCm39) P353S possibly damaging Het
Btaf1 T C 19: 36,968,162 (GRCm39) Y1116H probably benign Het
Ccdc18 T A 5: 108,306,514 (GRCm39) probably null Het
Ccdc87 T C 19: 4,890,429 (GRCm39) probably null Het
Cdhr1 T C 14: 36,801,600 (GRCm39) N781S probably benign Het
Ctr9 C A 7: 110,642,064 (GRCm39) H297Q probably benign Het
Cyp2c55 A G 19: 39,026,587 (GRCm39) D398G probably benign Het
Dnase1l1 C T X: 73,320,644 (GRCm39) probably null Het
Dnmt3l T C 10: 77,888,734 (GRCm39) probably null Het
Dock4 C A 12: 40,867,745 (GRCm39) N1440K probably damaging Het
Etnk1 T A 6: 143,141,043 (GRCm39) probably null Het
Fam120a A T 13: 49,063,726 (GRCm39) probably null Het
Fanca T C 8: 124,010,785 (GRCm39) D908G probably benign Het
Gm17535 T A 9: 3,035,786 (GRCm39) L218H probably benign Het
Gm3633 A C 14: 42,461,161 (GRCm39) N42K possibly damaging Het
Gm4781 C A 10: 100,232,851 (GRCm39) noncoding transcript Het
Gm8741 G T 17: 35,555,062 (GRCm39) noncoding transcript Het
Gpr139 A G 7: 118,744,165 (GRCm39) V140A probably benign Het
Ighv1-62-3 G T 12: 115,425,014 (GRCm39) T13K probably benign Het
Itgb2l T C 16: 96,226,205 (GRCm39) T629A possibly damaging Het
Kcnb2 T C 1: 15,779,724 (GRCm39) S199P probably damaging Het
Kdm1b G A 13: 47,230,962 (GRCm39) G663D probably damaging Het
Lama1 A G 17: 68,052,888 (GRCm39) D407G possibly damaging Het
Macf1 T C 4: 123,405,013 (GRCm39) K391R probably damaging Het
Magi3 A T 3: 104,013,107 (GRCm39) S127T probably damaging Het
Map2 A T 1: 66,477,955 (GRCm39) D1759V probably damaging Het
Mllt6 G A 11: 97,560,326 (GRCm39) S210N possibly damaging Het
Myrfl T C 10: 116,658,616 (GRCm39) D447G probably damaging Het
Ndufb7 A G 8: 84,298,094 (GRCm39) probably benign Het
Nt5e T A 9: 88,245,634 (GRCm39) N301K probably benign Het
Or10d4b A T 9: 39,534,856 (GRCm39) T146S possibly damaging Het
Pcdh10 A G 3: 45,336,296 (GRCm39) N870S probably damaging Het
Pcdh18 A G 3: 49,709,305 (GRCm39) V670A probably benign Het
Phf8-ps A C 17: 33,286,734 (GRCm39) C23G probably damaging Het
Polr1c G T 17: 46,558,635 (GRCm39) probably benign Het
Ric3 G C 7: 108,637,930 (GRCm39) S274R probably benign Het
Rimbp3 A G 16: 17,031,195 (GRCm39) T1540A probably damaging Het
Rp1l1 A T 14: 64,268,805 (GRCm39) M1464L probably benign Het
Slc41a3 A G 6: 90,603,399 (GRCm39) Y140C probably damaging Het
Ssb A T 2: 69,696,581 (GRCm39) E38D possibly damaging Het
Syt14 A T 1: 192,709,292 (GRCm39) I16N probably damaging Het
Tet3 T C 6: 83,352,878 (GRCm39) T973A probably damaging Het
Tial1 T C 7: 128,045,692 (GRCm39) probably benign Het
Tnfrsf1a A G 6: 125,337,675 (GRCm39) T89A possibly damaging Het
Trpv5 T C 6: 41,652,879 (GRCm39) Y98C possibly damaging Het
Ylpm1 T A 12: 85,062,267 (GRCm39) S265T probably damaging Het
Ylpm1 A G 12: 85,089,013 (GRCm39) D1006G probably damaging Het
Other mutations in Or8g27
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01096:Or8g27 APN 9 39,129,412 (GRCm39) missense probably damaging 1.00
IGL01529:Or8g27 APN 9 39,129,427 (GRCm39) missense probably benign 0.30
IGL03307:Or8g27 APN 9 39,129,309 (GRCm39) missense probably benign 0.03
R0110:Or8g27 UTSW 9 39,129,024 (GRCm39) missense possibly damaging 0.50
R0413:Or8g27 UTSW 9 39,129,566 (GRCm39) missense probably benign 0.25
R0450:Or8g27 UTSW 9 39,129,024 (GRCm39) missense possibly damaging 0.50
R2108:Or8g27 UTSW 9 39,129,318 (GRCm39) missense probably damaging 0.99
R2112:Or8g27 UTSW 9 39,129,075 (GRCm39) missense probably benign 0.01
R4666:Or8g27 UTSW 9 39,129,142 (GRCm39) missense probably damaging 0.97
R6384:Or8g27 UTSW 9 39,129,274 (GRCm39) missense probably benign 0.06
R8124:Or8g27 UTSW 9 39,128,967 (GRCm39) missense probably benign
R9104:Or8g27 UTSW 9 39,128,831 (GRCm39) missense probably damaging 1.00
R9290:Or8g27 UTSW 9 39,129,531 (GRCm39) missense probably damaging 1.00
R9328:Or8g27 UTSW 9 39,129,175 (GRCm39) missense probably damaging 0.99
Predicted Primers PCR Primer
(F):5'- CACTGGCTTCATGTTTAGGATTC -3'
(R):5'- AAGGGACATCATCTATGATCGTAAC -3'

Sequencing Primer
(F):5'- CTGGCTTCATGTTTAGGATTCAGTTC -3'
(R):5'- TCTGTGGTGAATAATTCTCACATG -3'
Posted On 2016-06-21