Incidental Mutation 'R5135:Kdm5b'
| ID |
396093 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Kdm5b
|
| Ensembl Gene |
ENSMUSG00000042207 |
| Gene Name |
lysine (K)-specific demethylase 5B |
| Synonyms |
Jarid1b, Plu1, Rb-Bp2, 2210016I17Rik, 2010009J12Rik, PLU-1, D1Ertd202e |
| MMRRC Submission |
043261-MU
|
| Accession Numbers |
|
| Essential gene? |
Possibly non essential
(E-score: 0.268)
|
| Stock # |
R5135 (G1)
|
| Quality Score |
219 |
|
Status
|
Validated
|
| Chromosome |
1 |
| Chromosomal Location |
134560171-134635285 bp(+) (GRCm38) |
| Type of Mutation |
intron |
| DNA Base Change (assembly) |
T to A
at 134588746 bp (GRCm38)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000107817
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000047714]
[ENSMUST00000112198]
|
| AlphaFold |
Q80Y84 |
| PDB Structure |
Solution structure of the ARID domain of Jarid1b protein [SOLUTION NMR]
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000047714
|
| SMART Domains |
Protein: ENSMUSP00000038138
Gene: ENSMUSG00000042207
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
7 |
30 |
N/A |
INTRINSIC |
|
JmjN
|
31 |
72 |
2.87e-20 |
SMART |
|
ARID
|
94 |
183 |
7.39e-32 |
SMART |
|
BRIGHT
|
98 |
188 |
1.51e-35 |
SMART |
|
low complexity region
|
228 |
239 |
N/A |
INTRINSIC |
|
PHD
|
311 |
357 |
6.15e-14 |
SMART |
|
JmjC
|
453 |
619 |
2.33e-67 |
SMART |
|
Pfam:zf-C5HC2
|
692 |
744 |
2.2e-17 |
PFAM |
|
Pfam:PLU-1
|
757 |
1088 |
5.6e-92 |
PFAM |
|
low complexity region
|
1097 |
1109 |
N/A |
INTRINSIC |
|
PHD
|
1178 |
1222 |
6.2e-10 |
SMART |
|
low complexity region
|
1225 |
1236 |
N/A |
INTRINSIC |
|
low complexity region
|
1406 |
1417 |
N/A |
INTRINSIC |
|
low complexity region
|
1470 |
1484 |
N/A |
INTRINSIC |
|
PHD
|
1486 |
1536 |
1.18e-6 |
SMART |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000112197
|
| SMART Domains |
Protein: ENSMUSP00000107816
Gene: ENSMUSG00000042207
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
7 |
30 |
N/A |
INTRINSIC |
|
JmjN
|
31 |
72 |
2.87e-20 |
SMART |
|
ARID
|
94 |
183 |
7.39e-32 |
SMART |
|
BRIGHT
|
98 |
188 |
1.51e-35 |
SMART |
|
low complexity region
|
225 |
236 |
N/A |
INTRINSIC |
|
PHD
|
308 |
354 |
6.15e-14 |
SMART |
|
JmjC
|
450 |
595 |
2.6e-24 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000112198
|
| SMART Domains |
Protein: ENSMUSP00000107817
Gene: ENSMUSG00000042207
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
7 |
30 |
N/A |
INTRINSIC |
|
JmjN
|
31 |
72 |
2.87e-20 |
SMART |
|
ARID
|
94 |
183 |
7.39e-32 |
SMART |
|
BRIGHT
|
98 |
188 |
1.51e-35 |
SMART |
|
low complexity region
|
228 |
239 |
N/A |
INTRINSIC |
|
PHD
|
311 |
357 |
6.15e-14 |
SMART |
|
JmjC
|
453 |
619 |
2.33e-67 |
SMART |
|
Pfam:zf-C5HC2
|
692 |
745 |
6.7e-21 |
PFAM |
|
Pfam:PLU-1
|
756 |
1088 |
6e-94 |
PFAM |
|
low complexity region
|
1097 |
1109 |
N/A |
INTRINSIC |
|
PHD
|
1178 |
1222 |
6.2e-10 |
SMART |
|
low complexity region
|
1225 |
1236 |
N/A |
INTRINSIC |
|
low complexity region
|
1406 |
1417 |
N/A |
INTRINSIC |
|
low complexity region
|
1470 |
1484 |
N/A |
INTRINSIC |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000186128
|
| Meta Mutation Damage Score |
0.0898 |
| Coding Region Coverage |
- 1x: 99.3%
- 3x: 98.7%
- 10x: 97.3%
- 20x: 95.1%
|
| Validation Efficiency |
98% (82/84) |
| MGI Phenotype |
FUNCTION: This gene encodes a lysine-specific histone demethylase that belongs to the jumonji/ARID domain-containing family of histone demethylases. The encoded protein is capable of demethylating tri-, di- and monomethylated lysine 4 of histone H3. This protein plays a role in the transcriptional repression or certain tumor suppressor genes and is upregulated in certain cancer cells. This protein may also play a role in genome stability and DNA repair. Homozygous mutant mice display decreased body weight, decreased female fertility, lower uterine weight, and a delay in mammary development. Knockout of this gene has also been associated with embryonic lethality. [provided by RefSeq, Dec 2016]
PHENOTYPE: Mice homozygous for a gene trapped allele exhibit decreased body weight, background-sensitive premature mortality, decreased female fertility, delayed mammary gland development, decreased serum estradiol levels, and reduced mammary epithelial cell proliferation in early puberty. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 80 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 1700056E22Rik |
T |
C |
1: 184,033,506 (GRCm38) |
S119G |
probably benign |
Het |
| 4930553M12Rik |
G |
T |
4: 88,868,271 (GRCm38) |
H37N |
unknown |
Het |
| Adam10 |
T |
A |
9: 70,766,074 (GRCm38) |
C496S |
probably damaging |
Het |
| Akap2 |
G |
T |
4: 57,855,912 (GRCm38) |
A414S |
probably benign |
Het |
| Aldh18a1 |
A |
C |
19: 40,554,817 (GRCm38) |
|
probably benign |
Het |
| Alox5 |
A |
G |
6: 116,413,786 (GRCm38) |
F468S |
probably benign |
Het |
| Ankrd50 |
T |
C |
3: 38,455,803 (GRCm38) |
H805R |
probably damaging |
Het |
| Ap2s1 |
T |
A |
7: 16,747,323 (GRCm38) |
D72E |
probably damaging |
Het |
| Apaf1 |
T |
C |
10: 91,060,094 (GRCm38) |
Y372C |
probably damaging |
Het |
| Apob |
C |
T |
12: 8,010,086 (GRCm38) |
T2823I |
probably damaging |
Het |
| Bhmt |
A |
G |
13: 93,627,323 (GRCm38) |
V70A |
probably damaging |
Het |
| Cdc42bpg |
T |
A |
19: 6,320,618 (GRCm38) |
L1247H |
probably damaging |
Het |
| Cel |
A |
G |
2: 28,559,423 (GRCm38) |
V264A |
probably benign |
Het |
| Celsr2 |
T |
C |
3: 108,398,659 (GRCm38) |
N2043S |
probably damaging |
Het |
| Clca4a |
A |
T |
3: 144,954,946 (GRCm38) |
W706R |
probably damaging |
Het |
| Col22a1 |
G |
T |
15: 71,799,337 (GRCm38) |
P1058Q |
unknown |
Het |
| Cyp4a14 |
A |
G |
4: 115,489,960 (GRCm38) |
|
probably null |
Het |
| Dhx30 |
T |
G |
9: 110,098,795 (GRCm38) |
R55S |
probably damaging |
Het |
| Dlgap5 |
C |
T |
14: 47,399,665 (GRCm38) |
R452H |
probably damaging |
Het |
| Dnah12 |
T |
A |
14: 26,770,477 (GRCm38) |
D1191E |
probably damaging |
Het |
| Dock3 |
A |
T |
9: 106,932,997 (GRCm38) |
I164N |
probably damaging |
Het |
| Edrf1 |
T |
A |
7: 133,651,044 (GRCm38) |
M436K |
probably benign |
Het |
| Eif2ak2 |
T |
A |
17: 78,866,345 (GRCm38) |
Y268F |
probably damaging |
Het |
| Evi2a |
G |
A |
11: 79,527,451 (GRCm38) |
T111M |
possibly damaging |
Het |
| Fzd4 |
A |
G |
7: 89,407,501 (GRCm38) |
E252G |
probably damaging |
Het |
| Gcm2 |
A |
G |
13: 41,102,959 (GRCm38) |
V438A |
probably benign |
Het |
| Gm10722 |
T |
C |
9: 3,000,937 (GRCm38) |
C6R |
probably benign |
Het |
| Gm21994 |
A |
T |
2: 150,255,490 (GRCm38) |
Y34* |
probably null |
Het |
| Gm4787 |
G |
C |
12: 81,377,830 (GRCm38) |
T518S |
probably benign |
Het |
| Gm4846 |
T |
C |
1: 166,483,982 (GRCm38) |
D436G |
probably damaging |
Het |
| Gm5414 |
T |
A |
15: 101,627,768 (GRCm38) |
I141F |
probably damaging |
Het |
| Gm6185 |
T |
A |
1: 161,198,231 (GRCm38) |
|
noncoding transcript |
Het |
| Grip2 |
T |
C |
6: 91,773,916 (GRCm38) |
E776G |
possibly damaging |
Het |
| H2-Ob |
T |
A |
17: 34,243,516 (GRCm38) |
V160E |
probably benign |
Het |
| Hormad1 |
T |
C |
3: 95,585,220 (GRCm38) |
|
probably benign |
Het |
| Ighv2-1 |
A |
T |
12: 113,574,462 (GRCm38) |
|
probably benign |
Het |
| Igkv4-92 |
A |
T |
6: 68,755,554 (GRCm38) |
C14S |
probably benign |
Het |
| Iqsec3 |
T |
C |
6: 121,383,919 (GRCm38) |
I993M |
probably damaging |
Het |
| Kitl |
T |
C |
10: 100,088,222 (GRCm38) |
|
probably null |
Het |
| Klhl26 |
G |
T |
8: 70,452,718 (GRCm38) |
R100S |
probably benign |
Het |
| Kpna4 |
C |
T |
3: 69,092,809 (GRCm38) |
|
probably null |
Het |
| Lama5 |
T |
A |
2: 180,202,220 (GRCm38) |
N383Y |
possibly damaging |
Het |
| Large1 |
T |
G |
8: 72,818,096 (GRCm38) |
I685L |
probably benign |
Het |
| Larp4b |
A |
G |
13: 9,170,737 (GRCm38) |
E590G |
probably damaging |
Het |
| Liph |
A |
T |
16: 21,956,165 (GRCm38) |
C425* |
probably null |
Het |
| Lrrc31 |
A |
T |
3: 30,684,890 (GRCm38) |
C327* |
probably null |
Het |
| Lrrc36 |
T |
C |
8: 105,463,898 (GRCm38) |
V733A |
probably benign |
Het |
| Mmel1 |
T |
A |
4: 154,882,324 (GRCm38) |
I83K |
probably benign |
Het |
| Myo16 |
G |
T |
8: 10,476,114 (GRCm38) |
V885L |
probably benign |
Het |
| Naip2 |
A |
T |
13: 100,179,440 (GRCm38) |
N277K |
probably damaging |
Het |
| Ncapg2 |
T |
A |
12: 116,427,786 (GRCm38) |
I485N |
possibly damaging |
Het |
| Npc1l1 |
A |
T |
11: 6,224,245 (GRCm38) |
Y687N |
possibly damaging |
Het |
| Obscn |
A |
T |
11: 59,129,653 (GRCm38) |
V922E |
probably damaging |
Het |
| Oc90 |
A |
G |
15: 65,883,830 (GRCm38) |
S223P |
probably benign |
Het |
| Olfr1 |
AGCGGTCGTAGGC |
AGC |
11: 73,395,654 (GRCm38) |
|
probably null |
Het |
| Olfr1253 |
A |
T |
2: 89,751,895 (GRCm38) |
L311H |
possibly damaging |
Het |
| Olfr1508 |
T |
C |
14: 52,463,854 (GRCm38) |
I52V |
probably benign |
Het |
| Pdlim5 |
C |
T |
3: 142,304,365 (GRCm38) |
R174H |
probably benign |
Het |
| Pex5l |
G |
T |
3: 32,955,831 (GRCm38) |
A386E |
probably damaging |
Het |
| Plcxd1 |
T |
A |
5: 110,101,363 (GRCm38) |
|
probably benign |
Het |
| Pramef8 |
T |
G |
4: 143,419,009 (GRCm38) |
S349R |
probably benign |
Het |
| Prl8a1 |
A |
T |
13: 27,579,819 (GRCm38) |
|
probably null |
Het |
| Ryr2 |
G |
T |
13: 11,662,130 (GRCm38) |
N3278K |
probably benign |
Het |
| Sacm1l |
A |
G |
9: 123,577,025 (GRCm38) |
M324V |
probably benign |
Het |
| Sdad1 |
T |
C |
5: 92,303,934 (GRCm38) |
T143A |
probably benign |
Het |
| Sec11a |
A |
T |
7: 80,923,064 (GRCm38) |
|
probably benign |
Het |
| Sema6a |
A |
G |
18: 47,291,172 (GRCm38) |
V223A |
probably damaging |
Het |
| Serpinb6c |
A |
G |
13: 33,880,097 (GRCm38) |
V325A |
probably damaging |
Het |
| Slc4a2 |
G |
A |
5: 24,430,127 (GRCm38) |
A177T |
possibly damaging |
Het |
| Slc5a4a |
A |
G |
10: 76,147,594 (GRCm38) |
N22D |
unknown |
Het |
| Stard13 |
C |
T |
5: 151,062,767 (GRCm38) |
W308* |
probably null |
Het |
| Tanc2 |
C |
T |
11: 105,857,553 (GRCm38) |
L504F |
possibly damaging |
Het |
| Tfap2e |
G |
T |
4: 126,720,544 (GRCm38) |
N282K |
probably damaging |
Het |
| Uhrf1bp1l |
T |
C |
10: 89,789,355 (GRCm38) |
I48T |
probably damaging |
Het |
| Usp36 |
G |
T |
11: 118,264,905 (GRCm38) |
T682K |
possibly damaging |
Het |
| Zc3h11a |
T |
C |
1: 133,633,789 (GRCm38) |
T315A |
probably benign |
Het |
| Zfa-ps |
T |
A |
10: 52,543,022 (GRCm38) |
|
noncoding transcript |
Het |
| Zfp663 |
A |
T |
2: 165,353,670 (GRCm38) |
C210S |
possibly damaging |
Het |
| Zfp747 |
T |
C |
7: 127,374,394 (GRCm38) |
I201M |
probably damaging |
Het |
| Zic4 |
C |
T |
9: 91,384,152 (GRCm38) |
T276M |
probably damaging |
Het |
|
| Other mutations in Kdm5b |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00230:Kdm5b
|
APN |
1 |
134,620,955 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL01458:Kdm5b
|
APN |
1 |
134,621,986 (GRCm38) |
missense |
possibly damaging |
0.53 |
|
IGL01567:Kdm5b
|
APN |
1 |
134,602,540 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL01625:Kdm5b
|
APN |
1 |
134,617,968 (GRCm38) |
missense |
possibly damaging |
0.74 |
|
IGL01970:Kdm5b
|
APN |
1 |
134,600,727 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL02183:Kdm5b
|
APN |
1 |
134,624,931 (GRCm38) |
missense |
probably benign |
0.09 |
|
IGL02592:Kdm5b
|
APN |
1 |
134,624,853 (GRCm38) |
missense |
probably damaging |
0.99 |
|
IGL02695:Kdm5b
|
APN |
1 |
134,604,485 (GRCm38) |
missense |
possibly damaging |
0.94 |
|
IGL02697:Kdm5b
|
APN |
1 |
134,588,773 (GRCm38) |
splice site |
probably benign |
|
|
IGL03036:Kdm5b
|
APN |
1 |
134,608,937 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL03056:Kdm5b
|
APN |
1 |
134,587,979 (GRCm38) |
missense |
probably damaging |
0.99 |
|
IGL03206:Kdm5b
|
APN |
1 |
134,627,317 (GRCm38) |
missense |
probably benign |
|
|
IGL03342:Kdm5b
|
APN |
1 |
134,602,576 (GRCm38) |
missense |
probably benign |
0.00 |
|
IGL03388:Kdm5b
|
APN |
1 |
134,627,322 (GRCm38) |
missense |
probably benign |
|
|
amaryllis
|
UTSW |
1 |
134,609,061 (GRCm38) |
critical splice donor site |
probably null |
|
|
PIT4486001:Kdm5b
|
UTSW |
1 |
134,628,685 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R0233:Kdm5b
|
UTSW |
1 |
134,604,634 (GRCm38) |
splice site |
probably benign |
|
|
R0334:Kdm5b
|
UTSW |
1 |
134,604,522 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R0504:Kdm5b
|
UTSW |
1 |
134,621,023 (GRCm38) |
critical splice donor site |
probably null |
|
|
R0505:Kdm5b
|
UTSW |
1 |
134,602,571 (GRCm38) |
missense |
probably damaging |
0.96 |
|
R0521:Kdm5b
|
UTSW |
1 |
134,618,033 (GRCm38) |
missense |
possibly damaging |
0.65 |
|
R1004:Kdm5b
|
UTSW |
1 |
134,588,904 (GRCm38) |
missense |
possibly damaging |
0.71 |
|
R1087:Kdm5b
|
UTSW |
1 |
134,600,637 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1126:Kdm5b
|
UTSW |
1 |
134,613,991 (GRCm38) |
missense |
possibly damaging |
0.90 |
|
R1221:Kdm5b
|
UTSW |
1 |
134,599,091 (GRCm38) |
missense |
probably damaging |
0.98 |
|
R1230:Kdm5b
|
UTSW |
1 |
134,613,254 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1345:Kdm5b
|
UTSW |
1 |
134,630,550 (GRCm38) |
missense |
possibly damaging |
0.94 |
|
R1482:Kdm5b
|
UTSW |
1 |
134,624,897 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1582:Kdm5b
|
UTSW |
1 |
134,624,853 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R1653:Kdm5b
|
UTSW |
1 |
134,602,481 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1693:Kdm5b
|
UTSW |
1 |
134,597,576 (GRCm38) |
splice site |
probably benign |
|
|
R1721:Kdm5b
|
UTSW |
1 |
134,613,181 (GRCm38) |
splice site |
probably benign |
|
|
R1741:Kdm5b
|
UTSW |
1 |
134,618,017 (GRCm38) |
missense |
possibly damaging |
0.82 |
|
R1762:Kdm5b
|
UTSW |
1 |
134,604,467 (GRCm38) |
nonsense |
probably null |
|
|
R1820:Kdm5b
|
UTSW |
1 |
134,597,670 (GRCm38) |
missense |
possibly damaging |
0.87 |
|
R1872:Kdm5b
|
UTSW |
1 |
134,624,994 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1966:Kdm5b
|
UTSW |
1 |
134,613,873 (GRCm38) |
splice site |
probably null |
|
|
R2056:Kdm5b
|
UTSW |
1 |
134,613,214 (GRCm38) |
missense |
probably benign |
0.05 |
|
R2059:Kdm5b
|
UTSW |
1 |
134,613,214 (GRCm38) |
missense |
probably benign |
0.05 |
|
R2405:Kdm5b
|
UTSW |
1 |
134,609,016 (GRCm38) |
missense |
probably damaging |
0.97 |
|
R3417:Kdm5b
|
UTSW |
1 |
134,587,977 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R3771:Kdm5b
|
UTSW |
1 |
134,613,345 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R3783:Kdm5b
|
UTSW |
1 |
134,630,542 (GRCm38) |
missense |
probably benign |
|
|
R3803:Kdm5b
|
UTSW |
1 |
134,615,941 (GRCm38) |
missense |
probably benign |
0.07 |
|
R3980:Kdm5b
|
UTSW |
1 |
134,619,670 (GRCm38) |
missense |
probably benign |
0.11 |
|
R3983:Kdm5b
|
UTSW |
1 |
134,631,304 (GRCm38) |
missense |
possibly damaging |
0.91 |
|
R4013:Kdm5b
|
UTSW |
1 |
134,627,329 (GRCm38) |
missense |
possibly damaging |
0.86 |
|
R4162:Kdm5b
|
UTSW |
1 |
134,625,161 (GRCm38) |
missense |
probably benign |
0.01 |
|
R4701:Kdm5b
|
UTSW |
1 |
134,606,012 (GRCm38) |
intron |
probably benign |
|
|
R4791:Kdm5b
|
UTSW |
1 |
134,630,800 (GRCm38) |
missense |
possibly damaging |
0.82 |
|
R4836:Kdm5b
|
UTSW |
1 |
134,593,315 (GRCm38) |
splice site |
probably null |
|
|
R4924:Kdm5b
|
UTSW |
1 |
134,631,351 (GRCm38) |
missense |
probably benign |
0.00 |
|
R5248:Kdm5b
|
UTSW |
1 |
134,620,997 (GRCm38) |
missense |
probably benign |
0.11 |
|
R5290:Kdm5b
|
UTSW |
1 |
134,622,099 (GRCm38) |
splice site |
probably null |
|
|
R5358:Kdm5b
|
UTSW |
1 |
134,607,694 (GRCm38) |
nonsense |
probably null |
|
|
R5388:Kdm5b
|
UTSW |
1 |
134,608,897 (GRCm38) |
nonsense |
probably null |
|
|
R5396:Kdm5b
|
UTSW |
1 |
134,622,098 (GRCm38) |
splice site |
probably null |
|
|
R5397:Kdm5b
|
UTSW |
1 |
134,622,098 (GRCm38) |
splice site |
probably null |
|
|
R5398:Kdm5b
|
UTSW |
1 |
134,622,098 (GRCm38) |
splice site |
probably null |
|
|
R5399:Kdm5b
|
UTSW |
1 |
134,622,098 (GRCm38) |
splice site |
probably null |
|
|
R5529:Kdm5b
|
UTSW |
1 |
134,588,003 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5540:Kdm5b
|
UTSW |
1 |
134,631,241 (GRCm38) |
missense |
probably damaging |
0.98 |
|
R5661:Kdm5b
|
UTSW |
1 |
134,599,073 (GRCm38) |
missense |
probably benign |
0.01 |
|
R5663:Kdm5b
|
UTSW |
1 |
134,630,635 (GRCm38) |
missense |
probably benign |
|
|
R5822:Kdm5b
|
UTSW |
1 |
134,588,773 (GRCm38) |
splice site |
probably benign |
|
|
R6226:Kdm5b
|
UTSW |
1 |
134,608,878 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R6368:Kdm5b
|
UTSW |
1 |
134,599,207 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6681:Kdm5b
|
UTSW |
1 |
134,613,269 (GRCm38) |
missense |
possibly damaging |
0.90 |
|
R6715:Kdm5b
|
UTSW |
1 |
134,609,061 (GRCm38) |
critical splice donor site |
probably null |
|
|
R7132:Kdm5b
|
UTSW |
1 |
134,599,106 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7202:Kdm5b
|
UTSW |
1 |
134,624,759 (GRCm38) |
missense |
probably benign |
|
|
R7258:Kdm5b
|
UTSW |
1 |
134,621,021 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7335:Kdm5b
|
UTSW |
1 |
134,560,439 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7420:Kdm5b
|
UTSW |
1 |
134,604,497 (GRCm38) |
missense |
probably benign |
0.14 |
|
R7426:Kdm5b
|
UTSW |
1 |
134,595,833 (GRCm38) |
missense |
probably benign |
0.02 |
|
R7452:Kdm5b
|
UTSW |
1 |
134,624,948 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7595:Kdm5b
|
UTSW |
1 |
134,608,966 (GRCm38) |
missense |
probably benign |
0.00 |
|
R7612:Kdm5b
|
UTSW |
1 |
134,624,918 (GRCm38) |
nonsense |
probably null |
|
|
R7704:Kdm5b
|
UTSW |
1 |
134,587,931 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7846:Kdm5b
|
UTSW |
1 |
134,617,840 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8115:Kdm5b
|
UTSW |
1 |
134,619,673 (GRCm38) |
missense |
possibly damaging |
0.83 |
|
R8146:Kdm5b
|
UTSW |
1 |
134,625,126 (GRCm38) |
missense |
probably benign |
0.05 |
|
R8160:Kdm5b
|
UTSW |
1 |
134,613,919 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8527:Kdm5b
|
UTSW |
1 |
134,605,774 (GRCm38) |
missense |
possibly damaging |
0.78 |
|
R8542:Kdm5b
|
UTSW |
1 |
134,605,774 (GRCm38) |
missense |
possibly damaging |
0.78 |
|
R8930:Kdm5b
|
UTSW |
1 |
134,616,272 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8932:Kdm5b
|
UTSW |
1 |
134,616,272 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8950:Kdm5b
|
UTSW |
1 |
134,613,926 (GRCm38) |
missense |
possibly damaging |
0.84 |
|
R9089:Kdm5b
|
UTSW |
1 |
134,607,768 (GRCm38) |
missense |
probably damaging |
0.98 |
|
R9109:Kdm5b
|
UTSW |
1 |
134,600,755 (GRCm38) |
critical splice donor site |
probably null |
|
|
R9133:Kdm5b
|
UTSW |
1 |
134,602,585 (GRCm38) |
missense |
probably benign |
|
|
R9298:Kdm5b
|
UTSW |
1 |
134,600,755 (GRCm38) |
critical splice donor site |
probably null |
|
|
R9423:Kdm5b
|
UTSW |
1 |
134,587,967 (GRCm38) |
missense |
possibly damaging |
0.85 |
|
R9630:Kdm5b
|
UTSW |
1 |
134,585,233 (GRCm38) |
critical splice donor site |
probably null |
|
|
R9670:Kdm5b
|
UTSW |
1 |
134,630,502 (GRCm38) |
nonsense |
probably null |
|
|
X0063:Kdm5b
|
UTSW |
1 |
134,588,876 (GRCm38) |
missense |
probably benign |
0.07 |
|
Z1176:Kdm5b
|
UTSW |
1 |
134,625,035 (GRCm38) |
missense |
probably damaging |
1.00 |
|
Z1177:Kdm5b
|
UTSW |
1 |
134,595,798 (GRCm38) |
frame shift |
probably null |
|
|
| Predicted Primers |
PCR Primer
(F):5'- CACTGTCAAAGGTGCTGTTC -3'
(R):5'- GGTAGCTCCAATACTCACCCTC -3'
Sequencing Primer
(F):5'- ACCTTCAAATTAATAGCTTAGCTGG -3'
(R):5'- ACCCTCAGACTGTCTCCAG -3'
|
| Posted On |
2016-06-21 |
Incidental Mutation