Mutagenetix > Incidental Mutation

Incidental Mutation 'R5135:Naip2'

396162

Institutional Source

Beutler Lab

Gene Symbol

Naip2

Ensembl Gene

ENSMUSG00000078945

Gene Name

NLR family, apoptosis inhibitory protein 2

Synonyms

Naip-rs6, Birc1b, Naip2

MMRRC Submission

043261-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.069) question?

Stock #

R5135 (G1)

Quality Score

225

Status

Validated

Chromosome

Chromosomal Location

100280571-100338600 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to T at 100315948 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Asparagine to Lysine at position 277 (N277K)

Ref Sequence

ENSEMBL: ENSMUSP00000113890 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000067975] [ENSMUST00000117913] [ENSMUST00000167986]

AlphaFold

Q9QUK4

Predicted Effect

probably damaging
Transcript: ENSMUST00000067975
AA Change: N277K

PolyPhen 2 Score 0.980 (Sensitivity: 0.75; Specificity: 0.96)

SMART Domains

Protein: ENSMUSP00000070827
Gene: ENSMUSG00000078945
AA Change: N277K

Domain	Start	End	E-Value	Type
BIR	58	129	7.95e-18	SMART
BIR	157	229	5.31e-37	SMART
BIR	276	347	4.22e-31	SMART
Pfam:NACHT	508	662	1.9e-36	PFAM
low complexity region	954	964	N/A	INTRINSIC
low complexity region	1116	1126	N/A	INTRINSIC

Predicted Effect

probably damaging
Transcript: ENSMUST00000117913
AA Change: N277K

PolyPhen 2 Score 0.980 (Sensitivity: 0.75; Specificity: 0.96)

SMART Domains

Protein: ENSMUSP00000113890
Gene: ENSMUSG00000078945
AA Change: N277K

Domain	Start	End	E-Value	Type
BIR	58	129	7.95e-18	SMART
BIR	157	229	5.31e-37	SMART
BIR	276	347	4.22e-31	SMART
Pfam:NACHT	508	662	1.9e-36	PFAM
low complexity region	954	964	N/A	INTRINSIC
low complexity region	1116	1126	N/A	INTRINSIC

Predicted Effect

probably damaging
Transcript: ENSMUST00000167986
AA Change: N277K

PolyPhen 2 Score 0.976 (Sensitivity: 0.76; Specificity: 0.96)

SMART Domains

Protein: ENSMUSP00000125852
Gene: ENSMUSG00000078945
AA Change: N277K

Domain	Start	End	E-Value	Type
BIR	58	129	7.95e-18	SMART
BIR	157	229	5.31e-37	SMART
BIR	276	347	4.22e-31	SMART
Pfam:NACHT	508	662	8.6e-35	PFAM
low complexity region	954	964	N/A	INTRINSIC
low complexity region	1116	1126	N/A	INTRINSIC

Meta Mutation Damage Score

0.6467

Coding Region Coverage

1x: 99.3%
3x: 98.7%
10x: 97.3%
20x: 95.1%

Validation Efficiency

98% (82/84)

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene is part of a 500 kb inverted duplication on chromosome 5q13. This duplicated region contains at least four genes and repetitive elements which make it prone to rearrangements and deletions. The repetitiveness and complexity of the sequence have also caused difficulty in determining the organization of this genomic region. This copy of the gene is full length; additional copies with truncations and internal deletions are also present in this region of chromosome 5q13. It is thought that this gene is a modifier of spinal muscular atrophy caused by mutations in a neighboring gene, SMN1. The protein encoded by this gene contains regions of homology to two baculovirus inhibitor of apoptosis proteins, and it is able to suppress apoptosis induced by various signals. Alternative splicing and the use of alternative promoters results in multiple transcript variants. [provided by RefSeq, Nov 2016]

Allele List at MGI

Other mutations in this stock

Total: 80 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1700056E22Rik	T	C	1: 183,765,703 (GRCm39)	S119G	probably benign	Het
4930553M12Rik	G	T	4: 88,786,508 (GRCm39)	H37N	unknown	Het
Adam10	T	A	9: 70,673,356 (GRCm39)	C496S	probably damaging	Het
Aldh18a1	A	C	19: 40,543,261 (GRCm39)		probably benign	Het
Alox5	A	G	6: 116,390,747 (GRCm39)	F468S	probably benign	Het
Ankrd50	T	C	3: 38,509,952 (GRCm39)	H805R	probably damaging	Het
Ap2s1	T	A	7: 16,481,248 (GRCm39)	D72E	probably damaging	Het
Apaf1	T	C	10: 90,895,956 (GRCm39)	Y372C	probably damaging	Het
Apob	C	T	12: 8,060,086 (GRCm39)	T2823I	probably damaging	Het
Bhmt	A	G	13: 93,763,831 (GRCm39)	V70A	probably damaging	Het
Bltp3b	T	C	10: 89,625,217 (GRCm39)	I48T	probably damaging	Het
Cdc42bpg	T	A	19: 6,370,648 (GRCm39)	L1247H	probably damaging	Het
Cel	A	G	2: 28,449,435 (GRCm39)	V264A	probably benign	Het
Celsr2	T	C	3: 108,305,975 (GRCm39)	N2043S	probably damaging	Het
Clca4a	A	T	3: 144,660,707 (GRCm39)	W706R	probably damaging	Het
Col22a1	G	T	15: 71,671,186 (GRCm39)	P1058Q	unknown	Het
Cyp4a14	A	G	4: 115,347,157 (GRCm39)		probably null	Het
Dhx30	T	G	9: 109,927,863 (GRCm39)	R55S	probably damaging	Het
Dlgap5	C	T	14: 47,637,122 (GRCm39)	R452H	probably damaging	Het
Dnah12	T	A	14: 26,492,434 (GRCm39)	D1191E	probably damaging	Het
Dock3	A	T	9: 106,810,196 (GRCm39)	I164N	probably damaging	Het
Edrf1	T	A	7: 133,252,773 (GRCm39)	M436K	probably benign	Het
Eif2ak2	T	A	17: 79,173,774 (GRCm39)	Y268F	probably damaging	Het
Evi2a	G	A	11: 79,418,277 (GRCm39)	T111M	possibly damaging	Het
Fzd4	A	G	7: 89,056,709 (GRCm39)	E252G	probably damaging	Het
Gcm2	A	G	13: 41,256,435 (GRCm39)	V438A	probably benign	Het
Gm10722	T	C	9: 3,000,937 (GRCm39)	C6R	probably benign	Het
Gm4787	G	C	12: 81,424,604 (GRCm39)	T518S	probably benign	Het
Gm4846	T	C	1: 166,311,551 (GRCm39)	D436G	probably damaging	Het
Gm5414	T	A	15: 101,536,203 (GRCm39)	I141F	probably damaging	Het
Gm6185	T	A	1: 161,025,801 (GRCm39)		noncoding transcript	Het
Grip2	T	C	6: 91,750,897 (GRCm39)	E776G	possibly damaging	Het
H2-Ob	T	A	17: 34,462,490 (GRCm39)	V160E	probably benign	Het
Hormad1	T	C	3: 95,492,531 (GRCm39)		probably benign	Het
Ighv2-1	A	T	12: 113,538,082 (GRCm39)		probably benign	Het
Igkv4-92	A	T	6: 68,732,538 (GRCm39)	C14S	probably benign	Het
Iqsec3	T	C	6: 121,360,878 (GRCm39)	I993M	probably damaging	Het
Kdm5b	T	A	1: 134,516,484 (GRCm39)		probably benign	Het
Kitl	T	C	10: 99,924,084 (GRCm39)		probably null	Het
Klhl26	G	T	8: 70,905,368 (GRCm39)	R100S	probably benign	Het
Kpna4	C	T	3: 69,000,142 (GRCm39)		probably null	Het
Lama5	T	A	2: 179,844,013 (GRCm39)	N383Y	possibly damaging	Het
Large1	T	G	8: 73,544,724 (GRCm39)	I685L	probably benign	Het
Larp4b	A	G	13: 9,220,773 (GRCm39)	E590G	probably damaging	Het
Liph	A	T	16: 21,774,915 (GRCm39)	C425*	probably null	Het
Lrrc31	A	T	3: 30,739,039 (GRCm39)	C327*	probably null	Het
Lrrc36	T	C	8: 106,190,530 (GRCm39)	V733A	probably benign	Het
Mmel1	T	A	4: 154,966,781 (GRCm39)	I83K	probably benign	Het
Myo16	G	T	8: 10,526,114 (GRCm39)	V885L	probably benign	Het
Ncapg2	T	A	12: 116,391,406 (GRCm39)	I485N	possibly damaging	Het
Npc1l1	A	T	11: 6,174,245 (GRCm39)	Y687N	possibly damaging	Het
Obscn	A	T	11: 59,020,479 (GRCm39)	V922E	probably damaging	Het
Oc90	A	G	15: 65,755,679 (GRCm39)	S223P	probably benign	Het
Or1e16	AGCGGTCGTAGGC	AGC	11: 73,286,480 (GRCm39)		probably null	Het
Or4a80	A	T	2: 89,582,239 (GRCm39)	L311H	possibly damaging	Het
Or4e1	T	C	14: 52,701,311 (GRCm39)	I52V	probably benign	Het
Pakap	G	T	4: 57,855,912 (GRCm39)	A414S	probably benign	Het
Pdlim5	C	T	3: 142,010,126 (GRCm39)	R174H	probably benign	Het
Pex5l	G	T	3: 33,009,980 (GRCm39)	A386E	probably damaging	Het
Plcxd1	T	A	5: 110,249,229 (GRCm39)		probably benign	Het
Pramel12	T	G	4: 143,145,579 (GRCm39)	S349R	probably benign	Het
Prl8a1	A	T	13: 27,763,802 (GRCm39)		probably null	Het
Ryr2	G	T	13: 11,677,016 (GRCm39)	N3278K	probably benign	Het
Sacm1l	A	G	9: 123,406,090 (GRCm39)	M324V	probably benign	Het
Sdad1	T	C	5: 92,451,793 (GRCm39)	T143A	probably benign	Het
Sec11a	A	T	7: 80,572,812 (GRCm39)		probably benign	Het
Sema6a	A	G	18: 47,424,239 (GRCm39)	V223A	probably damaging	Het
Serpinb6c	A	G	13: 34,064,080 (GRCm39)	V325A	probably damaging	Het
Slc4a2	G	A	5: 24,635,125 (GRCm39)	A177T	possibly damaging	Het
Slc5a4a	A	G	10: 75,983,428 (GRCm39)	N22D	unknown	Het
Stard13	C	T	5: 150,986,232 (GRCm39)	W308*	probably null	Het
Tanc2	C	T	11: 105,748,379 (GRCm39)	L504F	possibly damaging	Het
Tfap2e	G	T	4: 126,614,337 (GRCm39)	N282K	probably damaging	Het
Usp36	G	T	11: 118,155,731 (GRCm39)	T682K	possibly damaging	Het
Zc3h11a	T	C	1: 133,561,527 (GRCm39)	T315A	probably benign	Het
Zfa-ps	T	A	10: 52,419,118 (GRCm39)		noncoding transcript	Het
Zfp1002	A	T	2: 150,097,410 (GRCm39)	Y34*	probably null	Het
Zfp663	A	T	2: 165,195,590 (GRCm39)	C210S	possibly damaging	Het
Zfp747	T	C	7: 126,973,566 (GRCm39)	I201M	probably damaging	Het
Zic4	C	T	9: 91,266,205 (GRCm39)	T276M	probably damaging	Het

Other mutations in Naip2

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00515:Naip2	APN	13	100,291,395 (GRCm39)	missense	probably benign	0.00
IGL00676:Naip2	APN	13	100,289,140 (GRCm39)	missense	probably damaging	1.00
IGL00870:Naip2	APN	13	100,288,568 (GRCm39)	splice site	probably benign
IGL00908:Naip2	APN	13	100,297,157 (GRCm39)	missense	probably benign	0.01
IGL00916:Naip2	APN	13	100,297,939 (GRCm39)	missense	probably damaging	0.97
IGL00949:Naip2	APN	13	100,298,099 (GRCm39)	missense	probably damaging	1.00
IGL01010:Naip2	APN	13	100,291,446 (GRCm39)	missense	probably damaging	0.99
IGL01642:Naip2	APN	13	100,297,445 (GRCm39)	missense	probably damaging	0.97
IGL01884:Naip2	APN	13	100,325,329 (GRCm39)	splice site	probably benign
IGL01917:Naip2	APN	13	100,298,591 (GRCm39)	missense	probably benign	0.00
IGL02015:Naip2	APN	13	100,298,115 (GRCm39)	missense	possibly damaging	0.57
IGL02315:Naip2	APN	13	100,297,744 (GRCm39)	missense	probably damaging	1.00
IGL02328:Naip2	APN	13	100,297,877 (GRCm39)	missense	probably damaging	1.00
IGL02735:Naip2	APN	13	100,296,722 (GRCm39)	missense	probably damaging	0.99
IGL02738:Naip2	APN	13	100,325,685 (GRCm39)	missense	probably benign	0.01
IGL02887:Naip2	APN	13	100,298,020 (GRCm39)	missense	possibly damaging	0.90
IGL02894:Naip2	APN	13	100,320,297 (GRCm39)	missense	probably benign
IGL02894:Naip2	APN	13	100,297,505 (GRCm39)	missense	probably damaging	1.00
IGL02974:Naip2	APN	13	100,298,186 (GRCm39)	missense	probably damaging	1.00
IGL03024:Naip2	APN	13	100,325,862 (GRCm39)	missense	possibly damaging	0.50
IGL03056:Naip2	APN	13	100,298,795 (GRCm39)	missense	possibly damaging	0.90
IGL03281:Naip2	APN	13	100,298,128 (GRCm39)	missense	probably damaging	0.99
R0131:Naip2	UTSW	13	100,320,296 (GRCm39)	missense	probably benign	0.01
R0131:Naip2	UTSW	13	100,320,296 (GRCm39)	missense	probably benign	0.01
R0132:Naip2	UTSW	13	100,320,296 (GRCm39)	missense	probably benign	0.01
R0310:Naip2	UTSW	13	100,285,350 (GRCm39)	missense	probably damaging	1.00
R0367:Naip2	UTSW	13	100,298,290 (GRCm39)	missense	probably benign	0.01
R0368:Naip2	UTSW	13	100,298,290 (GRCm39)	missense	probably benign	0.01
R0422:Naip2	UTSW	13	100,297,621 (GRCm39)	missense	probably benign	0.10
R0441:Naip2	UTSW	13	100,298,290 (GRCm39)	missense	probably benign	0.01
R0445:Naip2	UTSW	13	100,298,395 (GRCm39)	missense	possibly damaging	0.91
R0446:Naip2	UTSW	13	100,298,290 (GRCm39)	missense	probably benign	0.01
R0464:Naip2	UTSW	13	100,298,290 (GRCm39)	missense	probably benign	0.01
R0466:Naip2	UTSW	13	100,298,290 (GRCm39)	missense	probably benign	0.01
R0467:Naip2	UTSW	13	100,298,290 (GRCm39)	missense	probably benign	0.01
R0486:Naip2	UTSW	13	100,298,290 (GRCm39)	missense	probably benign	0.01
R0533:Naip2	UTSW	13	100,298,290 (GRCm39)	missense	probably benign	0.01
R0853:Naip2	UTSW	13	100,298,362 (GRCm39)	missense	probably benign
R0853:Naip2	UTSW	13	100,298,368 (GRCm39)	missense	probably benign	0.00
R0855:Naip2	UTSW	13	100,298,368 (GRCm39)	missense	probably benign	0.00
R0855:Naip2	UTSW	13	100,298,362 (GRCm39)	missense	probably benign
R0904:Naip2	UTSW	13	100,298,368 (GRCm39)	missense	probably benign	0.00
R0904:Naip2	UTSW	13	100,298,362 (GRCm39)	missense	probably benign
R0906:Naip2	UTSW	13	100,298,368 (GRCm39)	missense	probably benign	0.00
R0906:Naip2	UTSW	13	100,298,362 (GRCm39)	missense	probably benign
R0908:Naip2	UTSW	13	100,298,368 (GRCm39)	missense	probably benign	0.00
R0908:Naip2	UTSW	13	100,298,362 (GRCm39)	missense	probably benign
R0959:Naip2	UTSW	13	100,291,419 (GRCm39)	missense	probably benign	0.03
R0959:Naip2	UTSW	13	100,291,386 (GRCm39)	missense	probably benign	0.01
R0962:Naip2	UTSW	13	100,315,893 (GRCm39)	missense	probably damaging	1.00
R1024:Naip2	UTSW	13	100,298,368 (GRCm39)	missense	probably benign	0.00
R1024:Naip2	UTSW	13	100,298,362 (GRCm39)	missense	probably benign
R1186:Naip2	UTSW	13	100,298,545 (GRCm39)	frame shift	probably null
R1186:Naip2	UTSW	13	100,298,489 (GRCm39)	missense	possibly damaging	0.63
R1217:Naip2	UTSW	13	100,298,368 (GRCm39)	missense	probably benign	0.00
R1217:Naip2	UTSW	13	100,298,362 (GRCm39)	missense	probably benign
R1340:Naip2	UTSW	13	100,325,630 (GRCm39)	missense	possibly damaging	0.80
R1342:Naip2	UTSW	13	100,298,368 (GRCm39)	missense	probably benign	0.00
R1342:Naip2	UTSW	13	100,298,362 (GRCm39)	missense	probably benign
R1404:Naip2	UTSW	13	100,298,362 (GRCm39)	missense	probably benign
R1423:Naip2	UTSW	13	100,291,355 (GRCm39)	intron	probably benign
R1423:Naip2	UTSW	13	100,298,368 (GRCm39)	missense	probably benign	0.00
R1423:Naip2	UTSW	13	100,291,386 (GRCm39)	missense	probably benign	0.01
R1423:Naip2	UTSW	13	100,291,380 (GRCm39)	missense	possibly damaging	0.59
R1426:Naip2	UTSW	13	100,298,368 (GRCm39)	missense	probably benign	0.00
R1426:Naip2	UTSW	13	100,298,362 (GRCm39)	missense	probably benign
R1472:Naip2	UTSW	13	100,298,368 (GRCm39)	missense	probably benign	0.00
R1575:Naip2	UTSW	13	100,291,537 (GRCm39)	intron	probably benign
R1575:Naip2	UTSW	13	100,291,529 (GRCm39)	missense	probably benign	0.00
R1576:Naip2	UTSW	13	100,291,529 (GRCm39)	missense	probably benign	0.00
R1576:Naip2	UTSW	13	100,291,537 (GRCm39)	intron	probably benign
R1599:Naip2	UTSW	13	100,298,489 (GRCm39)	missense	possibly damaging	0.63
R1640:Naip2	UTSW	13	100,298,489 (GRCm39)	missense	possibly damaging	0.63
R1641:Naip2	UTSW	13	100,298,489 (GRCm39)	missense	possibly damaging	0.63
R1642:Naip2	UTSW	13	100,298,489 (GRCm39)	missense	possibly damaging	0.63
R1643:Naip2	UTSW	13	100,298,489 (GRCm39)	missense	possibly damaging	0.63
R1644:Naip2	UTSW	13	100,319,437 (GRCm39)	missense	possibly damaging	0.83
R1681:Naip2	UTSW	13	100,298,368 (GRCm39)	missense	probably benign	0.00
R1681:Naip2	UTSW	13	100,298,362 (GRCm39)	missense	probably benign
R1891:Naip2	UTSW	13	100,291,395 (GRCm39)	missense	probably benign	0.00
R1913:Naip2	UTSW	13	100,288,665 (GRCm39)	critical splice acceptor site	probably null
R1937:Naip2	UTSW	13	100,298,368 (GRCm39)	missense	probably benign	0.00
R1937:Naip2	UTSW	13	100,298,362 (GRCm39)	missense	probably benign
R1993:Naip2	UTSW	13	100,298,515 (GRCm39)	missense	probably benign	0.03
R2001:Naip2	UTSW	13	100,281,096 (GRCm39)	missense	probably damaging	1.00
R2055:Naip2	UTSW	13	100,315,880 (GRCm39)	missense	probably benign	0.07
R2198:Naip2	UTSW	13	100,289,100 (GRCm39)	missense	probably damaging	1.00
R2906:Naip2	UTSW	13	100,298,504 (GRCm39)	missense	probably damaging	1.00
R2931:Naip2	UTSW	13	100,291,529 (GRCm39)	missense	probably benign	0.00
R3014:Naip2	UTSW	13	100,298,290 (GRCm39)	missense	probably benign	0.01
R3016:Naip2	UTSW	13	100,298,290 (GRCm39)	missense	probably benign	0.01
R3037:Naip2	UTSW	13	100,291,457 (GRCm39)	missense	probably benign	0.08
R3414:Naip2	UTSW	13	100,325,771 (GRCm39)	nonsense	probably null
R3437:Naip2	UTSW	13	100,291,419 (GRCm39)	missense	probably benign	0.03
R3713:Naip2	UTSW	13	100,298,410 (GRCm39)	missense	probably damaging	1.00
R3806:Naip2	UTSW	13	100,289,142 (GRCm39)	missense	possibly damaging	0.92
R3847:Naip2	UTSW	13	100,315,940 (GRCm39)	missense	probably damaging	1.00
R3847:Naip2	UTSW	13	100,315,941 (GRCm39)	missense	probably damaging	1.00
R3848:Naip2	UTSW	13	100,315,940 (GRCm39)	missense	probably damaging	1.00
R3848:Naip2	UTSW	13	100,315,941 (GRCm39)	missense	probably damaging	1.00
R3849:Naip2	UTSW	13	100,315,940 (GRCm39)	missense	probably damaging	1.00
R3849:Naip2	UTSW	13	100,315,941 (GRCm39)	missense	probably damaging	1.00
R3850:Naip2	UTSW	13	100,315,940 (GRCm39)	missense	probably damaging	1.00
R3850:Naip2	UTSW	13	100,315,941 (GRCm39)	missense	probably damaging	1.00
R3891:Naip2	UTSW	13	100,297,606 (GRCm39)	missense	probably damaging	0.99
R4419:Naip2	UTSW	13	100,297,133 (GRCm39)	missense	probably benign	0.03
R4456:Naip2	UTSW	13	100,291,419 (GRCm39)	missense	probably benign	0.03
R4458:Naip2	UTSW	13	100,291,419 (GRCm39)	missense	probably benign	0.03
R4689:Naip2	UTSW	13	100,285,320 (GRCm39)	missense	probably damaging	1.00
R4797:Naip2	UTSW	13	100,298,243 (GRCm39)	missense	probably damaging	1.00
R4852:Naip2	UTSW	13	100,298,044 (GRCm39)	missense	probably benign
R4922:Naip2	UTSW	13	100,291,468 (GRCm39)	missense	probably benign
R5185:Naip2	UTSW	13	100,325,859 (GRCm39)	missense	probably damaging	1.00
R5265:Naip2	UTSW	13	100,289,068 (GRCm39)	missense	probably damaging	1.00
R5451:Naip2	UTSW	13	100,325,368 (GRCm39)	missense	probably benign	0.12
R5521:Naip2	UTSW	13	100,291,422 (GRCm39)	missense	probably damaging	1.00
R5737:Naip2	UTSW	13	100,298,362 (GRCm39)	missense	probably benign	0.38
R6244:Naip2	UTSW	13	100,288,645 (GRCm39)	missense	probably damaging	1.00
R6478:Naip2	UTSW	13	100,298,549 (GRCm39)	missense	probably benign
R6480:Naip2	UTSW	13	100,298,549 (GRCm39)	missense	probably benign
R6481:Naip2	UTSW	13	100,298,549 (GRCm39)	missense	probably benign
R6490:Naip2	UTSW	13	100,297,193 (GRCm39)	missense	probably benign
R6653:Naip2	UTSW	13	100,288,644 (GRCm39)	missense	probably benign	0.00
R6653:Naip2	UTSW	13	100,298,352 (GRCm39)	missense	probably benign
R6768:Naip2	UTSW	13	100,314,832 (GRCm39)	nonsense	probably null
R6791:Naip2	UTSW	13	100,291,468 (GRCm39)	missense	probably benign
R6793:Naip2	UTSW	13	100,291,468 (GRCm39)	missense	probably benign
R6890:Naip2	UTSW	13	100,298,549 (GRCm39)	missense	probably benign
R7036:Naip2	UTSW	13	100,291,529 (GRCm39)	missense	probably benign	0.00
R7213:Naip2	UTSW	13	100,323,991 (GRCm39)	missense	probably damaging	1.00
R7342:Naip2	UTSW	13	100,325,864 (GRCm39)	missense	probably benign	0.09
R7445:Naip2	UTSW	13	100,298,290 (GRCm39)	missense	probably benign	0.01
R7572:Naip2	UTSW	13	100,291,468 (GRCm39)	missense	probably benign
R7699:Naip2	UTSW	13	100,296,877 (GRCm39)	missense	probably benign	0.00
R7840:Naip2	UTSW	13	100,280,917 (GRCm39)	missense	probably benign	0.14
R7874:Naip2	UTSW	13	100,291,468 (GRCm39)	missense	probably benign
R7874:Naip2	UTSW	13	100,291,459 (GRCm39)	missense	probably benign	0.00
R8038:Naip2	UTSW	13	100,298,570 (GRCm39)	missense	probably benign	0.00
R8065:Naip2	UTSW	13	100,325,730 (GRCm39)	missense	probably damaging	1.00
R8094:Naip2	UTSW	13	100,298,290 (GRCm39)	missense	probably benign	0.01
R8166:Naip2	UTSW	13	100,298,515 (GRCm39)	missense	probably benign	0.03
R8378:Naip2	UTSW	13	100,298,290 (GRCm39)	missense	probably benign	0.01
R8669:Naip2	UTSW	13	100,325,477 (GRCm39)	missense	probably benign	0.05
R8691:Naip2	UTSW	13	100,297,676 (GRCm39)	missense	probably damaging	1.00
R8716:Naip2	UTSW	13	100,280,914 (GRCm39)	missense	probably benign
R8720:Naip2	UTSW	13	100,298,630 (GRCm39)	missense	probably benign	0.04
R8888:Naip2	UTSW	13	100,325,644 (GRCm39)	missense	probably benign	0.01
R8895:Naip2	UTSW	13	100,325,644 (GRCm39)	missense	probably benign	0.01
R9031:Naip2	UTSW	13	100,314,776 (GRCm39)	missense	possibly damaging	0.55
R9072:Naip2	UTSW	13	100,291,468 (GRCm39)	missense	probably benign
R9072:Naip2	UTSW	13	100,291,459 (GRCm39)	missense	probably benign	0.00
R9074:Naip2	UTSW	13	100,291,468 (GRCm39)	missense	probably benign
R9074:Naip2	UTSW	13	100,291,459 (GRCm39)	missense	probably benign	0.00
R9077:Naip2	UTSW	13	100,291,468 (GRCm39)	missense	probably benign
R9077:Naip2	UTSW	13	100,291,459 (GRCm39)	missense	probably benign	0.00
R9176:Naip2	UTSW	13	100,298,707 (GRCm39)	missense	probably damaging	1.00
R9219:Naip2	UTSW	13	100,297,213 (GRCm39)	missense	probably benign	0.06
R9358:Naip2	UTSW	13	100,298,080 (GRCm39)	missense	probably damaging	1.00
R9371:Naip2	UTSW	13	100,298,354 (GRCm39)	nonsense	probably null
R9414:Naip2	UTSW	13	100,298,243 (GRCm39)	missense	probably damaging	1.00
R9415:Naip2	UTSW	13	100,298,243 (GRCm39)	missense	probably damaging	1.00
R9416:Naip2	UTSW	13	100,298,243 (GRCm39)	missense	probably damaging	1.00
R9708:Naip2	UTSW	13	100,298,087 (GRCm39)	missense	probably damaging	0.99
V5622:Naip2	UTSW	13	100,291,537 (GRCm39)	intron	probably benign
V5622:Naip2	UTSW	13	100,291,529 (GRCm39)	missense	probably benign	0.00
V5622:Naip2	UTSW	13	100,291,529 (GRCm39)	missense	probably benign	0.00
X0063:Naip2	UTSW	13	100,298,266 (GRCm39)	missense	probably damaging	1.00
Y5405:Naip2	UTSW	13	100,291,468 (GRCm39)	missense	probably benign
Z1088:Naip2	UTSW	13	100,298,417 (GRCm39)	missense	probably benign
Z1176:Naip2	UTSW	13	100,298,417 (GRCm39)	missense	probably benign
Z1176:Naip2	UTSW	13	100,298,101 (GRCm39)	missense	probably benign	0.02
Z1177:Naip2	UTSW	13	100,298,417 (GRCm39)	missense	probably benign
Z1177:Naip2	UTSW	13	100,289,137 (GRCm39)	missense	possibly damaging	0.65
Z1177:Naip2	UTSW	13	100,299,373 (GRCm39)	missense	probably benign	0.01

Predicted Primers

PCR Primer
(F):5'- AGGATTCGAATATGTGGTCCAC -3'
(R):5'- GATCATCAGATCTGCACCCC -3'

Sequencing Primer
(F):5'- ATGTTCAGCCTGAGAGCACTGAC -3'
(R):5'- ACACACACAGACACACACACTC -3'

Posted On

2016-06-21