Incidental Mutation 'R5139:Ccl24'
ID 396344
Institutional Source Beutler Lab
Gene Symbol Ccl24
Ensembl Gene ENSMUSG00000004814
Gene Name C-C motif chemokine ligand 24
Synonyms MPIF-2, CKb-6, Scya24, eotaxin-2
MMRRC Submission 042725-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R5139 (G1)
Quality Score 225
Status Not validated
Chromosome 5
Chromosomal Location 135598791-135601903 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to T at 135601775 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Alanine to Threonine at position 18 (A18T)
Ref Sequence ENSEMBL: ENSMUSP00000144002 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000004936] [ENSMUST00000201401]
AlphaFold Q9JKC0
Predicted Effect probably benign
Transcript: ENSMUST00000004936
AA Change: A18T

PolyPhen 2 Score 0.016 (Sensitivity: 0.95; Specificity: 0.79)
SMART Domains Protein: ENSMUSP00000004936
Gene: ENSMUSG00000004814
AA Change: A18T

DomainStartEndE-ValueType
low complexity region 8 20 N/A INTRINSIC
SCY 30 89 3.57e-24 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000201401
AA Change: A18T

PolyPhen 2 Score 0.016 (Sensitivity: 0.95; Specificity: 0.79)
SMART Domains Protein: ENSMUSP00000144002
Gene: ENSMUSG00000004814
AA Change: A18T

DomainStartEndE-ValueType
low complexity region 8 20 N/A INTRINSIC
SCY 30 89 3.57e-24 SMART
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 96.9%
  • 20x: 94.0%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene belongs to the subfamily of small cytokine CC genes. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity on resting T lymphocytes, a minimal activity on neutrophils, and is negative on monocytes and activated T lymphocytes. The protein is also a strong suppressor of colony formation by a multipotential hematopoietic progenitor cell line. [provided by RefSeq, Jul 2008]
PHENOTYPE: Mutant mice are born at the expected Mendelian frequency and appear healthy and normal. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 42 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2510039O18Rik T C 4: 148,029,905 (GRCm39) L625P probably damaging Het
Agtpbp1 A G 13: 59,648,027 (GRCm39) S598P probably damaging Het
Ahnak A C 19: 8,982,019 (GRCm39) D1101A probably damaging Het
Aoah T C 13: 21,207,407 (GRCm39) V542A possibly damaging Het
Aox1 T C 1: 58,100,456 (GRCm39) S418P probably benign Het
Appl1 A G 14: 26,669,112 (GRCm39) I354T probably benign Het
BC035947 T C 1: 78,475,884 (GRCm39) E216G possibly damaging Het
Bnip3l A G 14: 67,237,064 (GRCm39) S63P probably damaging Het
Cckar T C 5: 53,860,265 (GRCm39) N188S probably benign Het
Cmya5 A G 13: 93,232,569 (GRCm39) C840R probably benign Het
Copa C T 1: 171,948,896 (GRCm39) R1183W probably damaging Het
Dnah10 T C 5: 124,876,024 (GRCm39) V2621A probably damaging Het
Fryl A G 5: 73,248,061 (GRCm39) Y1019H probably damaging Het
Hira T C 16: 18,773,508 (GRCm39) Y943H probably damaging Het
Ighv3-8 T C 12: 114,285,994 (GRCm39) Y116C probably damaging Het
Igkv4-70 G A 6: 69,245,089 (GRCm39) T44I probably damaging Het
Lce3c G A 3: 92,852,778 (GRCm39) G80S unknown Het
Ldhb A T 6: 142,439,921 (GRCm39) N206K probably damaging Het
Mical1 T A 10: 41,354,411 (GRCm39) probably null Het
Myh2 T C 11: 67,070,174 (GRCm39) L402P probably damaging Het
Naa15 T A 3: 51,351,261 (GRCm39) L144I probably damaging Het
Nbea T A 3: 55,534,384 (GRCm39) I2918F possibly damaging Het
Or5w11 C A 2: 87,459,000 (GRCm39) H64Q probably benign Het
Pdcd11 C A 19: 47,095,554 (GRCm39) S625R probably benign Het
Pdlim7 A G 13: 55,654,869 (GRCm39) S214P probably damaging Het
Polg T C 7: 79,099,773 (GRCm39) D49G probably damaging Het
Polr2f C A 15: 79,035,858 (GRCm39) D106E possibly damaging Het
Ppp6r3 A C 19: 3,514,610 (GRCm39) N766K probably damaging Het
Prl8a1 T A 13: 27,758,049 (GRCm39) D220V probably damaging Het
Qrfprl A T 6: 65,433,203 (GRCm39) N341I probably damaging Het
Septin9 A G 11: 117,247,511 (GRCm39) K497E possibly damaging Het
Sfswap T G 5: 129,648,073 (GRCm39) M927R possibly damaging Het
Smad9 T G 3: 54,704,827 (GRCm39) W400G possibly damaging Het
St13 G C 15: 81,283,786 (GRCm39) R4G probably benign Het
Tcaf3 A G 6: 42,573,867 (GRCm39) V115A probably benign Het
Tesmin A G 19: 3,456,934 (GRCm39) I238V probably damaging Het
Trf C T 9: 103,100,133 (GRCm39) probably null Het
Trpc3 A T 3: 36,725,706 (GRCm39) M90K possibly damaging Het
Tshz3 C T 7: 36,470,450 (GRCm39) T813I probably benign Het
Tub T A 7: 108,610,309 (GRCm39) M1K probably null Het
Wdfy3 A T 5: 101,997,133 (GRCm39) probably null Het
Zfp853 T C 5: 143,274,570 (GRCm39) Q350R unknown Het
Other mutations in Ccl24
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL03302:Ccl24 APN 5 135,599,732 (GRCm39) missense probably benign 0.00
R4779:Ccl24 UTSW 5 135,601,811 (GRCm39) missense possibly damaging 0.74
R7391:Ccl24 UTSW 5 135,599,676 (GRCm39) missense possibly damaging 0.67
Predicted Primers PCR Primer
(F):5'- GCTCAACTGCAGACACAGAG -3'
(R):5'- CGATTTTCGAGGAAGTCCGTGG -3'

Sequencing Primer
(F):5'- TGCAGACACAGAGCCTGTC -3'
(R):5'- GAGGGACACCAGAGCCTCTATC -3'
Posted On 2016-06-21