Incidental Mutation 'R5139:Zfp853'
ID 396345
Institutional Source Beutler Lab
Gene Symbol Zfp853
Ensembl Gene ENSMUSG00000093910
Gene Name zinc finger protein 853
Synonyms LOC330230
MMRRC Submission 042725-MU
Accession Numbers
Essential gene? Possibly non essential (E-score: 0.306) question?
Stock # R5139 (G1)
Quality Score 121
Status Not validated
Chromosome 5
Chromosomal Location 143272793-143279378 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 143274570 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Glutamine to Arginine at position 350 (Q350R)
Ref Sequence ENSEMBL: ENSMUSP00000148846 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000180336] [ENSMUST00000212355] [ENSMUST00000212715]
AlphaFold A0A1D5RM95
Predicted Effect unknown
Transcript: ENSMUST00000180336
AA Change: Q299R
SMART Domains Protein: ENSMUSP00000137494
Gene: ENSMUSG00000093910
AA Change: Q299R

DomainStartEndE-ValueType
low complexity region 43 62 N/A INTRINSIC
low complexity region 80 87 N/A INTRINSIC
low complexity region 102 145 N/A INTRINSIC
coiled coil region 280 408 N/A INTRINSIC
low complexity region 412 424 N/A INTRINSIC
low complexity region 435 458 N/A INTRINSIC
low complexity region 488 499 N/A INTRINSIC
ZnF_C2H2 501 523 7.78e-3 SMART
ZnF_C2H2 529 551 4.87e-4 SMART
ZnF_C2H2 557 579 2.57e-3 SMART
ZnF_C2H2 585 607 2.24e-3 SMART
ZnF_C2H2 613 636 4.17e-3 SMART
low complexity region 639 651 N/A INTRINSIC
Predicted Effect unknown
Transcript: ENSMUST00000212355
AA Change: Q365R
Predicted Effect unknown
Transcript: ENSMUST00000212715
AA Change: Q350R
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 96.9%
  • 20x: 94.0%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 42 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2510039O18Rik T C 4: 148,029,905 (GRCm39) L625P probably damaging Het
Agtpbp1 A G 13: 59,648,027 (GRCm39) S598P probably damaging Het
Ahnak A C 19: 8,982,019 (GRCm39) D1101A probably damaging Het
Aoah T C 13: 21,207,407 (GRCm39) V542A possibly damaging Het
Aox1 T C 1: 58,100,456 (GRCm39) S418P probably benign Het
Appl1 A G 14: 26,669,112 (GRCm39) I354T probably benign Het
BC035947 T C 1: 78,475,884 (GRCm39) E216G possibly damaging Het
Bnip3l A G 14: 67,237,064 (GRCm39) S63P probably damaging Het
Cckar T C 5: 53,860,265 (GRCm39) N188S probably benign Het
Ccl24 C T 5: 135,601,775 (GRCm39) A18T probably benign Het
Cmya5 A G 13: 93,232,569 (GRCm39) C840R probably benign Het
Copa C T 1: 171,948,896 (GRCm39) R1183W probably damaging Het
Dnah10 T C 5: 124,876,024 (GRCm39) V2621A probably damaging Het
Fryl A G 5: 73,248,061 (GRCm39) Y1019H probably damaging Het
Hira T C 16: 18,773,508 (GRCm39) Y943H probably damaging Het
Ighv3-8 T C 12: 114,285,994 (GRCm39) Y116C probably damaging Het
Igkv4-70 G A 6: 69,245,089 (GRCm39) T44I probably damaging Het
Lce3c G A 3: 92,852,778 (GRCm39) G80S unknown Het
Ldhb A T 6: 142,439,921 (GRCm39) N206K probably damaging Het
Mical1 T A 10: 41,354,411 (GRCm39) probably null Het
Myh2 T C 11: 67,070,174 (GRCm39) L402P probably damaging Het
Naa15 T A 3: 51,351,261 (GRCm39) L144I probably damaging Het
Nbea T A 3: 55,534,384 (GRCm39) I2918F possibly damaging Het
Or5w11 C A 2: 87,459,000 (GRCm39) H64Q probably benign Het
Pdcd11 C A 19: 47,095,554 (GRCm39) S625R probably benign Het
Pdlim7 A G 13: 55,654,869 (GRCm39) S214P probably damaging Het
Polg T C 7: 79,099,773 (GRCm39) D49G probably damaging Het
Polr2f C A 15: 79,035,858 (GRCm39) D106E possibly damaging Het
Ppp6r3 A C 19: 3,514,610 (GRCm39) N766K probably damaging Het
Prl8a1 T A 13: 27,758,049 (GRCm39) D220V probably damaging Het
Qrfprl A T 6: 65,433,203 (GRCm39) N341I probably damaging Het
Septin9 A G 11: 117,247,511 (GRCm39) K497E possibly damaging Het
Sfswap T G 5: 129,648,073 (GRCm39) M927R possibly damaging Het
Smad9 T G 3: 54,704,827 (GRCm39) W400G possibly damaging Het
St13 G C 15: 81,283,786 (GRCm39) R4G probably benign Het
Tcaf3 A G 6: 42,573,867 (GRCm39) V115A probably benign Het
Tesmin A G 19: 3,456,934 (GRCm39) I238V probably damaging Het
Trf C T 9: 103,100,133 (GRCm39) probably null Het
Trpc3 A T 3: 36,725,706 (GRCm39) M90K possibly damaging Het
Tshz3 C T 7: 36,470,450 (GRCm39) T813I probably benign Het
Tub T A 7: 108,610,309 (GRCm39) M1K probably null Het
Wdfy3 A T 5: 101,997,133 (GRCm39) probably null Het
Other mutations in Zfp853
AlleleSourceChrCoordTypePredicted EffectPPH Score
R1656:Zfp853 UTSW 5 143,274,840 (GRCm39) splice site probably benign
R2072:Zfp853 UTSW 5 143,275,137 (GRCm39) missense unknown
R2915:Zfp853 UTSW 5 143,275,332 (GRCm39) missense unknown
R4862:Zfp853 UTSW 5 143,275,416 (GRCm39) missense unknown
R4869:Zfp853 UTSW 5 143,274,048 (GRCm39) missense probably damaging 0.99
R4945:Zfp853 UTSW 5 143,274,584 (GRCm39) missense unknown
R5335:Zfp853 UTSW 5 143,274,318 (GRCm39) missense unknown
R5426:Zfp853 UTSW 5 143,274,624 (GRCm39) missense unknown
R5844:Zfp853 UTSW 5 143,274,424 (GRCm39) missense unknown
R5845:Zfp853 UTSW 5 143,274,424 (GRCm39) missense unknown
R5847:Zfp853 UTSW 5 143,274,424 (GRCm39) missense unknown
R6039:Zfp853 UTSW 5 143,274,529 (GRCm39) nonsense probably null
R6039:Zfp853 UTSW 5 143,274,529 (GRCm39) nonsense probably null
R7124:Zfp853 UTSW 5 143,275,362 (GRCm39) missense unknown
R7283:Zfp853 UTSW 5 143,273,493 (GRCm39) missense unknown
R7323:Zfp853 UTSW 5 143,275,110 (GRCm39) missense unknown
R8026:Zfp853 UTSW 5 143,274,280 (GRCm39) missense unknown
R8121:Zfp853 UTSW 5 143,274,018 (GRCm39) missense probably damaging 0.99
R8290:Zfp853 UTSW 5 143,274,826 (GRCm39) nonsense probably null
R8347:Zfp853 UTSW 5 143,274,702 (GRCm39) missense unknown
R9017:Zfp853 UTSW 5 143,274,243 (GRCm39) missense unknown
R9110:Zfp853 UTSW 5 143,275,320 (GRCm39) missense unknown
R9123:Zfp853 UTSW 5 143,274,496 (GRCm39) nonsense probably null
R9560:Zfp853 UTSW 5 143,275,080 (GRCm39) missense unknown
Predicted Primers PCR Primer
(F):5'- ACAGAGGTCAGCTCCAGTTG -3'
(R):5'- CAACAGGAGCAGTTTCAGCAG -3'

Sequencing Primer
(F):5'- GTCAGCTCCAGTTGCAGCTC -3'
(R):5'- CAGCAGGGACAGTTGCAAC -3'
Posted On 2016-06-21