Incidental Mutation 'R5155:Mslnl'
| ID |
396697 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Mslnl
|
| Ensembl Gene |
ENSMUSG00000041062 |
| Gene Name |
mesothelin-like |
| Synonyms |
|
| MMRRC Submission |
042737-MU
|
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
R5155 (G1)
|
| Quality Score |
225 |
|
Status
|
Not validated
|
| Chromosome |
17 |
| Chromosomal Location |
25955016-25967304 bp(+) (GRCm39) |
| Type of Mutation |
nonsense |
| DNA Base Change (assembly) |
C to T
at 25957942 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Glutamine to Stop codon
at position 62
(Q62*)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000049020
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000047098]
|
| AlphaFold |
Q8C160 |
| Predicted Effect |
probably null
Transcript: ENSMUST00000047098
AA Change: Q62*
|
| SMART Domains |
Protein: ENSMUSP00000049020
Gene: ENSMUSG00000041062
AA Change: Q62*
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
23 |
N/A |
INTRINSIC |
|
Pfam:Mesothelin
|
29 |
589 |
2.8e-70 |
PFAM |
|
low complexity region
|
633 |
653 |
N/A |
INTRINSIC |
|
| Coding Region Coverage |
- 1x: 99.2%
- 3x: 98.6%
- 10x: 97.0%
- 20x: 94.4%
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 74 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Abca13 |
T |
C |
11: 9,482,447 (GRCm39) |
V4326A |
probably damaging |
Het |
| Actn4 |
A |
G |
7: 28,661,442 (GRCm39) |
|
probably null |
Het |
| Adamts8 |
A |
G |
9: 30,865,844 (GRCm39) |
D464G |
probably benign |
Het |
| Adss1 |
T |
C |
12: 112,604,642 (GRCm39) |
I366T |
probably damaging |
Het |
| Alox12e |
T |
C |
11: 70,207,081 (GRCm39) |
D575G |
possibly damaging |
Het |
| Ankrd44 |
A |
T |
1: 54,817,489 (GRCm39) |
M73K |
probably benign |
Het |
| Ap4e1 |
A |
G |
2: 126,905,289 (GRCm39) |
T987A |
probably benign |
Het |
| Banp |
A |
C |
8: 122,727,759 (GRCm39) |
S318R |
probably damaging |
Het |
| Bcas1 |
T |
C |
2: 170,260,538 (GRCm39) |
H47R |
probably damaging |
Het |
| Brwd1 |
G |
T |
16: 95,803,993 (GRCm39) |
S2524* |
probably null |
Het |
| Btbd8 |
T |
C |
5: 107,638,569 (GRCm39) |
I323T |
probably damaging |
Het |
| Cand2 |
T |
A |
6: 115,769,219 (GRCm39) |
D676E |
probably benign |
Het |
| Cc2d1a |
A |
T |
8: 84,867,755 (GRCm39) |
H224Q |
probably benign |
Het |
| Ccdc138 |
A |
T |
10: 58,343,394 (GRCm39) |
Y83F |
probably benign |
Het |
| Ccdc162 |
A |
T |
10: 41,429,576 (GRCm39) |
|
probably null |
Het |
| Ccdc162 |
A |
C |
10: 41,455,147 (GRCm39) |
S396A |
probably damaging |
Het |
| Ces1e |
A |
T |
8: 93,928,034 (GRCm39) |
*562R |
probably null |
Het |
| Clstn2 |
T |
A |
9: 97,338,484 (GRCm39) |
M892L |
probably benign |
Het |
| Crybg3 |
T |
C |
16: 59,345,264 (GRCm39) |
T2673A |
possibly damaging |
Het |
| Cstf3 |
A |
G |
2: 104,482,830 (GRCm39) |
N326S |
probably benign |
Het |
| Cux1 |
G |
A |
5: 136,594,295 (GRCm39) |
|
probably benign |
Het |
| Cyb5r4 |
T |
G |
9: 86,922,456 (GRCm39) |
M155R |
probably benign |
Het |
| D130043K22Rik |
A |
G |
13: 25,056,273 (GRCm39) |
D535G |
probably damaging |
Het |
| Dnah2 |
G |
A |
11: 69,313,362 (GRCm39) |
P4266S |
probably damaging |
Het |
| Dnah7a |
T |
A |
1: 53,682,654 (GRCm39) |
N272I |
probably benign |
Het |
| Dsg2 |
A |
G |
18: 20,731,715 (GRCm39) |
Y779C |
possibly damaging |
Het |
| Eif4g3 |
T |
A |
4: 137,854,054 (GRCm39) |
N507K |
probably benign |
Het |
| Elavl4 |
T |
C |
4: 110,149,833 (GRCm39) |
Q3R |
probably null |
Het |
| Engase |
T |
G |
11: 118,372,107 (GRCm39) |
I133S |
probably benign |
Het |
| Ercc5 |
T |
C |
1: 44,219,782 (GRCm39) |
V1018A |
probably damaging |
Het |
| Ext1 |
C |
A |
15: 52,939,213 (GRCm39) |
W612L |
probably damaging |
Het |
| Faap100 |
T |
A |
11: 120,268,458 (GRCm39) |
E105V |
possibly damaging |
Het |
| Fam8a1 |
G |
A |
13: 46,827,038 (GRCm39) |
A270T |
probably benign |
Het |
| Fhdc1 |
T |
G |
3: 84,353,457 (GRCm39) |
Q589H |
probably benign |
Het |
| Gatm |
G |
A |
2: 122,440,334 (GRCm39) |
T35I |
probably benign |
Het |
| Gcgr |
T |
C |
11: 120,427,872 (GRCm39) |
I271T |
probably benign |
Het |
| Gm527 |
T |
A |
12: 64,970,381 (GRCm39) |
Y239N |
probably damaging |
Het |
| H2-Ab1 |
A |
G |
17: 34,486,358 (GRCm39) |
H139R |
possibly damaging |
Het |
| Herc2 |
G |
A |
7: 55,877,574 (GRCm39) |
R4547Q |
possibly damaging |
Het |
| Itga1 |
A |
T |
13: 115,171,839 (GRCm39) |
S89T |
probably benign |
Het |
| Kash5 |
C |
A |
7: 44,839,078 (GRCm39) |
E53* |
probably null |
Het |
| Katnip |
A |
G |
7: 125,471,356 (GRCm39) |
T1486A |
probably damaging |
Het |
| Lrba |
A |
G |
3: 86,258,607 (GRCm39) |
M1365V |
probably benign |
Het |
| Lrp1b |
A |
C |
2: 41,618,634 (GRCm39) |
|
probably null |
Het |
| Map1a |
G |
A |
2: 121,132,867 (GRCm39) |
A990T |
probably damaging |
Het |
| Micall2 |
C |
A |
5: 139,695,986 (GRCm39) |
L784F |
probably damaging |
Het |
| Mmp9 |
T |
C |
2: 164,790,986 (GRCm39) |
|
probably null |
Het |
| Mrps7 |
T |
A |
11: 115,495,655 (GRCm39) |
Y64* |
probably null |
Het |
| Nfil3 |
A |
G |
13: 53,122,616 (GRCm39) |
L96P |
probably damaging |
Het |
| Or2f1 |
A |
G |
6: 42,721,748 (GRCm39) |
Y259C |
probably damaging |
Het |
| Phf3 |
T |
C |
1: 30,863,457 (GRCm39) |
D756G |
possibly damaging |
Het |
| Plxnd1 |
C |
T |
6: 115,935,949 (GRCm39) |
|
probably null |
Het |
| Prickle4 |
C |
T |
17: 48,000,982 (GRCm39) |
|
probably null |
Het |
| Prr9 |
T |
A |
3: 92,030,356 (GRCm39) |
T95S |
possibly damaging |
Het |
| Prrc2a |
A |
G |
17: 35,379,067 (GRCm39) |
|
probably null |
Het |
| Prrt3 |
A |
G |
6: 113,474,520 (GRCm39) |
|
probably null |
Het |
| Psme4 |
A |
T |
11: 30,826,806 (GRCm39) |
Y1775F |
probably damaging |
Het |
| Pum2 |
T |
C |
12: 8,763,572 (GRCm39) |
V243A |
possibly damaging |
Het |
| Rnf32 |
T |
C |
5: 29,408,145 (GRCm39) |
S125P |
probably damaging |
Het |
| Rnf8 |
A |
G |
17: 29,845,604 (GRCm39) |
Y65C |
probably damaging |
Het |
| Rph3a |
T |
C |
5: 121,086,833 (GRCm39) |
T456A |
possibly damaging |
Het |
| Scaper |
T |
A |
9: 55,463,370 (GRCm39) |
Q854L |
probably null |
Het |
| Sez6l2 |
T |
C |
7: 126,561,545 (GRCm39) |
S472P |
probably damaging |
Het |
| Spsb3 |
T |
C |
17: 25,105,969 (GRCm39) |
|
probably benign |
Het |
| Srebf2 |
A |
G |
15: 82,080,427 (GRCm39) |
D40G |
probably damaging |
Het |
| Sspo |
A |
G |
6: 48,437,408 (GRCm39) |
N1389D |
probably benign |
Het |
| Taf4b |
G |
T |
18: 14,963,152 (GRCm39) |
A631S |
probably benign |
Het |
| Tcstv1b |
T |
C |
13: 120,635,089 (GRCm39) |
S124P |
probably benign |
Het |
| Tigd4 |
G |
A |
3: 84,501,970 (GRCm39) |
V296M |
possibly damaging |
Het |
| Tsc22d2 |
T |
A |
3: 58,324,737 (GRCm39) |
|
probably benign |
Het |
| Uso1 |
T |
A |
5: 92,315,194 (GRCm39) |
|
probably null |
Het |
| Vmn2r6 |
T |
G |
3: 64,445,935 (GRCm39) |
N597H |
probably benign |
Het |
| Zfc3h1 |
T |
A |
10: 115,248,026 (GRCm39) |
S1076R |
possibly damaging |
Het |
| Zfp64 |
T |
A |
2: 168,748,885 (GRCm39) |
Q44L |
probably benign |
Het |
|
| Other mutations in Mslnl |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01621:Mslnl
|
APN |
17 |
25,962,641 (GRCm39) |
unclassified |
probably benign |
|
|
IGL01629:Mslnl
|
APN |
17 |
25,963,749 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
IGL02084:Mslnl
|
APN |
17 |
25,965,125 (GRCm39) |
missense |
probably benign |
0.07 |
|
IGL02408:Mslnl
|
APN |
17 |
25,966,972 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
IGL02726:Mslnl
|
APN |
17 |
25,963,077 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL03387:Mslnl
|
APN |
17 |
25,963,051 (GRCm39) |
missense |
probably benign |
0.06 |
|
R0561:Mslnl
|
UTSW |
17 |
25,962,177 (GRCm39) |
nonsense |
probably null |
|
|
R0881:Mslnl
|
UTSW |
17 |
25,961,939 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R1295:Mslnl
|
UTSW |
17 |
25,962,214 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1296:Mslnl
|
UTSW |
17 |
25,962,214 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1582:Mslnl
|
UTSW |
17 |
25,961,908 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R1629:Mslnl
|
UTSW |
17 |
25,961,908 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R1630:Mslnl
|
UTSW |
17 |
25,961,908 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R1631:Mslnl
|
UTSW |
17 |
25,961,908 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R1632:Mslnl
|
UTSW |
17 |
25,961,908 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R1794:Mslnl
|
UTSW |
17 |
25,961,908 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R1850:Mslnl
|
UTSW |
17 |
25,961,908 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R1866:Mslnl
|
UTSW |
17 |
25,961,908 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R1876:Mslnl
|
UTSW |
17 |
25,961,908 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R1914:Mslnl
|
UTSW |
17 |
25,961,908 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R2166:Mslnl
|
UTSW |
17 |
25,961,908 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R2241:Mslnl
|
UTSW |
17 |
25,961,908 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R2243:Mslnl
|
UTSW |
17 |
25,961,908 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R2247:Mslnl
|
UTSW |
17 |
25,961,908 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R2282:Mslnl
|
UTSW |
17 |
25,961,908 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R2284:Mslnl
|
UTSW |
17 |
25,961,908 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R2852:Mslnl
|
UTSW |
17 |
25,961,908 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R2867:Mslnl
|
UTSW |
17 |
25,961,908 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R2867:Mslnl
|
UTSW |
17 |
25,961,908 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R2877:Mslnl
|
UTSW |
17 |
25,961,908 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R2878:Mslnl
|
UTSW |
17 |
25,961,908 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R2919:Mslnl
|
UTSW |
17 |
25,961,908 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R2920:Mslnl
|
UTSW |
17 |
25,961,908 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R3026:Mslnl
|
UTSW |
17 |
25,961,908 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R3405:Mslnl
|
UTSW |
17 |
25,965,155 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3406:Mslnl
|
UTSW |
17 |
25,965,155 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3411:Mslnl
|
UTSW |
17 |
25,963,491 (GRCm39) |
missense |
probably benign |
0.05 |
|
R3434:Mslnl
|
UTSW |
17 |
25,961,908 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R3546:Mslnl
|
UTSW |
17 |
25,963,943 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R3612:Mslnl
|
UTSW |
17 |
25,961,908 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R3729:Mslnl
|
UTSW |
17 |
25,961,908 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R3730:Mslnl
|
UTSW |
17 |
25,961,908 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R3802:Mslnl
|
UTSW |
17 |
25,961,908 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R3804:Mslnl
|
UTSW |
17 |
25,961,908 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R3894:Mslnl
|
UTSW |
17 |
25,961,908 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R3895:Mslnl
|
UTSW |
17 |
25,961,908 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R4454:Mslnl
|
UTSW |
17 |
25,961,908 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R4455:Mslnl
|
UTSW |
17 |
25,961,908 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R4456:Mslnl
|
UTSW |
17 |
25,961,908 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R4457:Mslnl
|
UTSW |
17 |
25,961,908 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R4561:Mslnl
|
UTSW |
17 |
25,961,908 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R4562:Mslnl
|
UTSW |
17 |
25,961,908 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R4564:Mslnl
|
UTSW |
17 |
25,961,908 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R4600:Mslnl
|
UTSW |
17 |
25,961,908 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R4601:Mslnl
|
UTSW |
17 |
25,961,908 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R4610:Mslnl
|
UTSW |
17 |
25,961,908 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R4704:Mslnl
|
UTSW |
17 |
25,957,952 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
R5257:Mslnl
|
UTSW |
17 |
25,965,139 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5456:Mslnl
|
UTSW |
17 |
25,962,133 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R5645:Mslnl
|
UTSW |
17 |
25,956,816 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R6007:Mslnl
|
UTSW |
17 |
25,965,749 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6083:Mslnl
|
UTSW |
17 |
25,956,876 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R6142:Mslnl
|
UTSW |
17 |
25,963,531 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6761:Mslnl
|
UTSW |
17 |
25,965,047 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7058:Mslnl
|
UTSW |
17 |
25,962,186 (GRCm39) |
missense |
probably benign |
0.03 |
|
R7156:Mslnl
|
UTSW |
17 |
25,962,184 (GRCm39) |
missense |
probably benign |
0.20 |
|
R7467:Mslnl
|
UTSW |
17 |
25,955,895 (GRCm39) |
start codon destroyed |
probably benign |
0.33 |
|
R7687:Mslnl
|
UTSW |
17 |
25,962,157 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R7807:Mslnl
|
UTSW |
17 |
25,965,751 (GRCm39) |
missense |
probably benign |
0.03 |
|
R8682:Mslnl
|
UTSW |
17 |
25,965,962 (GRCm39) |
missense |
probably benign |
|
|
R8735:Mslnl
|
UTSW |
17 |
25,964,062 (GRCm39) |
missense |
probably benign |
0.09 |
|
R8742:Mslnl
|
UTSW |
17 |
25,964,047 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9208:Mslnl
|
UTSW |
17 |
25,961,694 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R9264:Mslnl
|
UTSW |
17 |
25,961,506 (GRCm39) |
intron |
probably benign |
|
|
RF007:Mslnl
|
UTSW |
17 |
25,962,202 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
| Predicted Primers |
PCR Primer
(F):5'- TGAGAACCTGGCCCTAACAAG -3'
(R):5'- TCCTTGCAAAACTGGCCCTC -3'
Sequencing Primer
(F):5'- TGGCCCTAACAAGGTCCTCTAG -3'
(R):5'- AAACTGGCCCTCCACCTGTG -3'
|
| Posted On |
2016-06-21 |
Incidental Mutation