|Institutional Source||Beutler Lab|
|Gene Name||proline-rich coiled-coil 2A|
|Synonyms||D17H6S51E, G2, 3110039B05Rik, Bat-2, Bat2, Wbp12|
|Is this an essential gene?||Probably essential (E-score: 0.855)|
|Stock #||R5155 (G1)|
|Chromosomal Location||35149076-35164897 bp(-) (GRCm38)|
|Type of Mutation||splice site (6 bp from exon)|
|DNA Base Change (assembly)||A to G at 35160091 bp (GRCm38)|
|Amino Acid Change|
|Ref Sequence||ENSEMBL: ENSMUSP00000133550 (fasta)|
|Gene Model||predicted gene model for transcript(s): [ENSMUST00000025253] [ENSMUST00000174805]|
|Coding Region Coverage||
|MGI Phenotype||FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] A cluster of genes, BAT1-BAT5, has been localized in the vicinity of the genes for TNF alpha and TNF beta. These genes are all within the human major histocompatibility complex class III region. This gene has microsatellite repeats which are associated with the age-at-onset of insulin-dependent diabetes mellitus (IDDM) and possibly thought to be involved with the inflammatory process of pancreatic beta-cell destruction during the development of IDDM. This gene is also a candidate gene for the development of rheumatoid arthritis. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Dec 2010]|
|Allele List at MGI|
|Other mutations in this stock||
|Other mutations in Prrc2a||
(F):5'- AAGGCCGAGCATTCTCTGTC -3'
(R):5'- TGTAGTTCCAGACTATTTGCTGCG -3'
(F):5'- GAGCATTCTCTGTCCAGGCTG -3'
(R):5'- CGTTCTGTGAAGCTATCTGAGAGAG -3'