Incidental Mutation 'R5159:Tmprss15'
ID 396903
Institutional Source Beutler Lab
Gene Symbol Tmprss15
Ensembl Gene ENSMUSG00000022857
Gene Name transmembrane protease, serine 15
Synonyms Prss7, enterokinase, enteropeptidase, A130097D21Rik
MMRRC Submission 042741-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R5159 (G1)
Quality Score 225
Status Validated
Chromosome 16
Chromosomal Location 78749896-78887985 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 78800298 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Glutamine to Arginine at position 595 (Q595R)
Ref Sequence ENSEMBL: ENSMUSP00000052034 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000023566] [ENSMUST00000060402]
AlphaFold P97435
Predicted Effect probably benign
Transcript: ENSMUST00000023566
AA Change: Q610R

PolyPhen 2 Score 0.026 (Sensitivity: 0.95; Specificity: 0.81)
SMART Domains Protein: ENSMUSP00000023566
Gene: ENSMUSG00000022857
AA Change: Q610R

DomainStartEndE-ValueType
transmembrane domain 21 43 N/A INTRINSIC
SEA 52 172 1.62e-22 SMART
LDLa 228 268 1.74e-4 SMART
CUB 270 379 1.54e-11 SMART
MAM 387 549 7.33e-54 SMART
low complexity region 551 567 N/A INTRINSIC
CUB 569 679 1.72e-32 SMART
LDLa 687 724 7.32e-12 SMART
SR 723 813 3.12e-5 SMART
Tryp_SPc 829 1064 1.48e-95 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000060402
AA Change: Q595R

PolyPhen 2 Score 0.258 (Sensitivity: 0.91; Specificity: 0.88)
SMART Domains Protein: ENSMUSP00000052034
Gene: ENSMUSG00000022857
AA Change: Q595R

DomainStartEndE-ValueType
transmembrane domain 21 43 N/A INTRINSIC
SEA 52 172 1.62e-22 SMART
LDLa 213 253 1.74e-4 SMART
CUB 255 364 1.54e-11 SMART
MAM 372 534 7.33e-54 SMART
low complexity region 536 552 N/A INTRINSIC
CUB 554 664 1.72e-32 SMART
LDLa 672 709 7.32e-12 SMART
SR 708 798 3.12e-5 SMART
Tryp_SPc 814 1049 1.48e-95 SMART
Meta Mutation Damage Score 0.0753 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.1%
  • 20x: 94.7%
Validation Efficiency 100% (63/63)
MGI Phenotype FUNCTION: This gene encodes an enzyme that proteolytically activates the pancreatic proenzyme trypsinogen, converting it into trypsin. The encoded protein is cleaved into two chains that form a heterodimer linked by a disulfide bond. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2013]
Allele List at MGI
Other mutations in this stock
Total: 58 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
9930111J21Rik1 T C 11: 48,839,352 (GRCm39) T412A probably benign Het
Aldh5a1 T A 13: 25,097,776 (GRCm39) M420L possibly damaging Het
Armc2 A G 10: 41,884,711 (GRCm39) S77P probably damaging Het
Avil A G 10: 126,856,317 (GRCm39) probably null Het
Bltp3a A G 17: 28,100,530 (GRCm39) H323R probably damaging Het
Bmp5 T A 9: 75,801,035 (GRCm39) F388L probably damaging Het
Brca2 T G 5: 150,465,573 (GRCm39) V1779G possibly damaging Het
Cblb T A 16: 51,932,483 (GRCm39) S147T probably damaging Het
Cblc T C 7: 19,519,233 (GRCm39) E409G probably benign Het
Cdc34b C T 11: 94,632,886 (GRCm39) R29W probably damaging Het
Clic6 T A 16: 92,324,954 (GRCm39) Y371N probably benign Het
Col5a2 A G 1: 45,425,991 (GRCm39) probably null Het
Coro1a A T 7: 126,302,221 (GRCm39) V42D probably damaging Het
Cpa3 C T 3: 20,281,387 (GRCm39) C173Y probably damaging Het
Crb1 A C 1: 139,170,756 (GRCm39) V817G probably damaging Het
Cyp2c39 A G 19: 39,549,378 (GRCm39) T299A possibly damaging Het
Dock5 G A 14: 68,029,738 (GRCm39) R1019C probably benign Het
Exoc8 T C 8: 125,622,952 (GRCm39) T472A probably benign Het
Fancc A G 13: 63,469,679 (GRCm39) probably null Het
Fcgbpl1 T A 7: 27,852,733 (GRCm39) M1340K probably benign Het
Inpp5d T C 1: 87,604,064 (GRCm39) L244P probably damaging Het
Ireb2 A G 9: 54,799,831 (GRCm39) N424S probably benign Het
Krt35 T C 11: 99,984,875 (GRCm39) D261G probably damaging Het
Lipc T A 9: 70,720,192 (GRCm39) I272L probably benign Het
Lpcat3 A G 6: 124,676,357 (GRCm39) probably benign Het
Lzts1 T C 8: 69,591,236 (GRCm39) D304G probably benign Het
Mdn1 A G 4: 32,774,008 (GRCm39) I5540V possibly damaging Het
Msln T C 17: 25,970,563 (GRCm39) S231G probably benign Het
Mup8 G A 4: 60,221,062 (GRCm39) T101M probably benign Het
Myh8 T C 11: 67,179,179 (GRCm39) I524T probably damaging Het
Pappa2 A G 1: 158,589,189 (GRCm39) C1679R probably damaging Het
Pcdhb1 T C 18: 37,399,416 (GRCm39) S456P possibly damaging Het
Pcdhga5 A G 18: 37,828,719 (GRCm39) N389S probably benign Het
Pitrm1 C A 13: 6,617,507 (GRCm39) S620R probably benign Het
Plod3 T A 5: 137,023,932 (GRCm39) probably benign Het
Por A T 5: 135,759,771 (GRCm39) Q194L probably benign Het
Prkag3 A T 1: 74,780,646 (GRCm39) Y396N probably damaging Het
R3hcc1 T C 14: 69,935,053 (GRCm39) probably null Het
Rcan3 C T 4: 135,152,592 (GRCm39) S43N probably damaging Het
Rhot1 A G 11: 80,111,098 (GRCm39) T31A probably damaging Het
Rnps1 T G 17: 24,637,486 (GRCm39) S43A unknown Het
Rp1 T C 1: 4,416,426 (GRCm39) D1562G possibly damaging Het
Rps19-ps13 A G 18: 40,859,428 (GRCm39) noncoding transcript Het
Serpina3c A T 12: 104,115,771 (GRCm39) S258T possibly damaging Het
Smc2 G A 4: 52,460,181 (GRCm39) R519Q possibly damaging Het
Sorbs2 A T 8: 46,248,767 (GRCm39) T593S probably benign Het
Sptbn2 A G 19: 4,787,885 (GRCm39) T955A probably benign Het
Stfa3 T C 16: 36,272,581 (GRCm39) K40E probably damaging Het
Tmem87b A G 2: 128,666,378 (GRCm39) E75G probably benign Het
Trak1 A T 9: 121,289,478 (GRCm39) I597F probably damaging Het
Trat1 T C 16: 48,555,300 (GRCm39) D144G probably damaging Het
Trim25 T C 11: 88,890,358 (GRCm39) V15A probably benign Het
Tulp1 A C 17: 28,578,034 (GRCm39) probably null Het
Txndc15 T A 13: 55,865,734 (GRCm39) M66K probably benign Het
Vmn1r206 T A 13: 22,804,775 (GRCm39) N144I probably damaging Het
Wwc2 T C 8: 48,353,796 (GRCm39) T113A probably benign Het
Xpo5 A C 17: 46,528,535 (GRCm39) E313D probably damaging Het
Zfp790 C T 7: 29,529,192 (GRCm39) H626Y probably benign Het
Other mutations in Tmprss15
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00331:Tmprss15 APN 16 78,782,882 (GRCm39) missense possibly damaging 0.87
IGL00477:Tmprss15 APN 16 78,818,301 (GRCm39) missense probably damaging 1.00
IGL01583:Tmprss15 APN 16 78,868,149 (GRCm39) missense probably benign
IGL01896:Tmprss15 APN 16 78,887,678 (GRCm39) missense probably benign 0.22
IGL02052:Tmprss15 APN 16 78,884,394 (GRCm39) missense probably damaging 1.00
IGL02374:Tmprss15 APN 16 78,832,056 (GRCm39) missense probably benign 0.00
IGL02505:Tmprss15 APN 16 78,784,629 (GRCm39) missense probably benign 0.00
IGL02632:Tmprss15 APN 16 78,782,790 (GRCm39) missense probably damaging 0.98
IGL02674:Tmprss15 APN 16 78,798,682 (GRCm39) missense possibly damaging 0.72
beached UTSW 16 78,821,736 (GRCm39) missense possibly damaging 0.62
Cellulite UTSW 16 78,754,259 (GRCm39) missense probably damaging 1.00
lolling UTSW 16 78,800,298 (GRCm39) missense probably benign 0.26
miniature UTSW 16 78,854,497 (GRCm39) critical splice donor site probably null
PIT1430001:Tmprss15 UTSW 16 78,821,640 (GRCm39) critical splice donor site probably null
R0106:Tmprss15 UTSW 16 78,800,277 (GRCm39) missense probably damaging 0.99
R0106:Tmprss15 UTSW 16 78,800,277 (GRCm39) missense probably damaging 0.99
R0195:Tmprss15 UTSW 16 78,831,222 (GRCm39) missense probably benign 0.05
R0335:Tmprss15 UTSW 16 78,821,630 (GRCm39) splice site probably benign
R0514:Tmprss15 UTSW 16 78,765,155 (GRCm39) missense probably benign 0.05
R0552:Tmprss15 UTSW 16 78,821,637 (GRCm39) splice site probably null
R0675:Tmprss15 UTSW 16 78,782,838 (GRCm39) missense probably damaging 0.98
R0739:Tmprss15 UTSW 16 78,821,736 (GRCm39) missense possibly damaging 0.62
R1435:Tmprss15 UTSW 16 78,818,342 (GRCm39) missense probably benign 0.03
R1446:Tmprss15 UTSW 16 78,875,846 (GRCm39) missense probably benign 0.01
R1572:Tmprss15 UTSW 16 78,887,717 (GRCm39) missense probably benign 0.00
R1708:Tmprss15 UTSW 16 78,850,958 (GRCm39) missense possibly damaging 0.95
R1893:Tmprss15 UTSW 16 78,868,306 (GRCm39) missense probably benign
R2403:Tmprss15 UTSW 16 78,854,578 (GRCm39) missense probably damaging 1.00
R2866:Tmprss15 UTSW 16 78,832,121 (GRCm39) missense possibly damaging 0.65
R2913:Tmprss15 UTSW 16 78,759,078 (GRCm39) missense probably benign 0.45
R2914:Tmprss15 UTSW 16 78,759,078 (GRCm39) missense probably benign 0.45
R3425:Tmprss15 UTSW 16 78,800,321 (GRCm39) missense possibly damaging 0.83
R3703:Tmprss15 UTSW 16 78,851,030 (GRCm39) critical splice acceptor site probably null
R3916:Tmprss15 UTSW 16 78,782,884 (GRCm39) missense probably damaging 1.00
R3950:Tmprss15 UTSW 16 78,870,074 (GRCm39) missense probably benign 0.04
R4332:Tmprss15 UTSW 16 78,831,222 (GRCm39) missense probably benign 0.15
R4392:Tmprss15 UTSW 16 78,821,326 (GRCm39) missense probably damaging 1.00
R4515:Tmprss15 UTSW 16 78,754,244 (GRCm39) missense probably benign 0.00
R4619:Tmprss15 UTSW 16 78,818,358 (GRCm39) missense probably damaging 1.00
R4620:Tmprss15 UTSW 16 78,818,358 (GRCm39) missense probably damaging 1.00
R4754:Tmprss15 UTSW 16 78,851,012 (GRCm39) missense probably damaging 0.98
R4853:Tmprss15 UTSW 16 78,757,479 (GRCm39) missense probably benign
R5441:Tmprss15 UTSW 16 78,868,335 (GRCm39) critical splice acceptor site probably null
R5824:Tmprss15 UTSW 16 78,831,201 (GRCm39) missense probably damaging 0.99
R5970:Tmprss15 UTSW 16 78,854,547 (GRCm39) missense probably benign 0.00
R6224:Tmprss15 UTSW 16 78,821,266 (GRCm39) missense probably benign 0.08
R6257:Tmprss15 UTSW 16 78,769,113 (GRCm39) missense probably damaging 1.00
R6313:Tmprss15 UTSW 16 78,759,058 (GRCm39) missense probably benign 0.16
R6368:Tmprss15 UTSW 16 78,802,945 (GRCm39) splice site probably null
R6525:Tmprss15 UTSW 16 78,800,266 (GRCm39) missense probably damaging 0.97
R6587:Tmprss15 UTSW 16 78,868,317 (GRCm39) missense probably benign
R6894:Tmprss15 UTSW 16 78,872,702 (GRCm39) nonsense probably null
R7018:Tmprss15 UTSW 16 78,821,741 (GRCm39) missense possibly damaging 0.78
R7180:Tmprss15 UTSW 16 78,764,886 (GRCm39) missense probably damaging 0.97
R7324:Tmprss15 UTSW 16 78,758,907 (GRCm39) missense probably damaging 1.00
R7337:Tmprss15 UTSW 16 78,868,164 (GRCm39) missense probably benign 0.01
R7558:Tmprss15 UTSW 16 78,800,302 (GRCm39) missense possibly damaging 0.55
R7732:Tmprss15 UTSW 16 78,800,308 (GRCm39) missense probably benign 0.11
R7792:Tmprss15 UTSW 16 78,800,275 (GRCm39) missense probably damaging 1.00
R7829:Tmprss15 UTSW 16 78,784,538 (GRCm39) missense probably benign 0.02
R7998:Tmprss15 UTSW 16 78,798,731 (GRCm39) missense possibly damaging 0.79
R8009:Tmprss15 UTSW 16 78,887,751 (GRCm39) missense probably damaging 0.96
R8145:Tmprss15 UTSW 16 78,757,473 (GRCm39) missense probably damaging 1.00
R8183:Tmprss15 UTSW 16 78,884,400 (GRCm39) missense probably benign 0.04
R8221:Tmprss15 UTSW 16 78,821,223 (GRCm39) missense probably damaging 0.99
R8294:Tmprss15 UTSW 16 78,868,176 (GRCm39) missense probably benign
R8537:Tmprss15 UTSW 16 78,884,403 (GRCm39) missense probably damaging 0.99
R8735:Tmprss15 UTSW 16 78,798,702 (GRCm39) missense possibly damaging 0.88
R8858:Tmprss15 UTSW 16 78,854,497 (GRCm39) critical splice donor site probably null
R8869:Tmprss15 UTSW 16 78,750,834 (GRCm39) nonsense probably null
R8884:Tmprss15 UTSW 16 78,821,657 (GRCm39) missense probably benign 0.00
R9014:Tmprss15 UTSW 16 78,872,691 (GRCm39) missense probably benign 0.04
R9075:Tmprss15 UTSW 16 78,754,259 (GRCm39) missense probably damaging 1.00
R9351:Tmprss15 UTSW 16 78,832,086 (GRCm39) missense probably damaging 1.00
R9393:Tmprss15 UTSW 16 78,754,211 (GRCm39) missense probably benign 0.01
R9747:Tmprss15 UTSW 16 78,884,400 (GRCm39) missense probably benign 0.04
R9767:Tmprss15 UTSW 16 78,875,977 (GRCm39) missense probably damaging 1.00
R9783:Tmprss15 UTSW 16 78,887,890 (GRCm39) start gained probably benign
RF005:Tmprss15 UTSW 16 78,750,689 (GRCm39) makesense probably null
Predicted Primers PCR Primer
(F):5'- GTAAAGTGCTCCCATCTGCG -3'
(R):5'- ACTGTGGAAAGATCATCCCAG -3'

Sequencing Primer
(F):5'- CCATCTGCGTCAGTGTGCTG -3'
(R):5'- TGTGGAAAGATCATCCCAGTCACAC -3'
Posted On 2016-06-21