Incidental Mutation 'R5161:Or5an10'
ID 397027
Institutional Source Beutler Lab
Gene Symbol Or5an10
Ensembl Gene ENSMUSG00000067513
Gene Name olfactory receptor family 5 subfamily AN member 10
Synonyms Olfr1436, GA_x6K02T2RE5P-2634596-2633658, MOR214-2
MMRRC Submission 042743-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.060) question?
Stock # R5161 (G1)
Quality Score 225
Status Validated
Chromosome 19
Chromosomal Location 12275547-12276494 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 12276153 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Serine to Arginine at position 114 (S114R)
Ref Sequence ENSEMBL: ENSMUSP00000085113 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000087812]
AlphaFold A0PK57
Predicted Effect probably damaging
Transcript: ENSMUST00000087812
AA Change: S114R

PolyPhen 2 Score 0.990 (Sensitivity: 0.72; Specificity: 0.97)
SMART Domains Protein: ENSMUSP00000085113
Gene: ENSMUSG00000067513
AA Change: S114R

DomainStartEndE-ValueType
Pfam:7tm_4 35 311 2.4e-54 PFAM
Pfam:7tm_1 45 294 1.3e-19 PFAM
Meta Mutation Damage Score 0.4420 question?
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.6%
  • 10x: 97.3%
  • 20x: 95.2%
Validation Efficiency 98% (56/57)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 55 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
0610040J01Rik G T 5: 64,055,344 (GRCm39) E27* probably null Het
4930407I10Rik G T 15: 81,947,542 (GRCm39) E480* probably null Het
Acad11 T C 9: 104,001,227 (GRCm39) I591T probably benign Het
Acsbg3 A T 17: 57,189,888 (GRCm39) I305F possibly damaging Het
Adamts13 G A 2: 26,883,020 (GRCm39) E857K probably benign Het
Atf2 A C 2: 73,660,134 (GRCm39) probably null Het
Cass4 C A 2: 172,274,244 (GRCm39) A675E probably damaging Het
Coa8 C A 12: 111,689,208 (GRCm39) Q97K possibly damaging Het
Ctsd A T 7: 141,930,881 (GRCm39) L283Q probably damaging Het
Ddrgk1 A T 2: 130,505,296 (GRCm39) M1K probably null Het
Dipk1b C T 2: 26,526,260 (GRCm39) T398M possibly damaging Het
Dock1 G A 7: 134,335,791 (GRCm39) A62T possibly damaging Het
Ehmt1 T C 2: 24,748,207 (GRCm39) D407G possibly damaging Het
Eif1ad17 T A 12: 87,978,887 (GRCm39) D90E possibly damaging Het
Eml6 A G 11: 29,974,467 (GRCm39) V37A probably damaging Het
Fam20a C T 11: 109,564,196 (GRCm39) R519Q probably benign Het
Fat1 A G 8: 45,405,549 (GRCm39) T767A probably benign Het
Fbxl8 A T 8: 105,995,538 (GRCm39) H350L possibly damaging Het
Gm10226 A C 17: 21,910,834 (GRCm39) Q23P possibly damaging Het
Gm38706 A T 6: 130,459,868 (GRCm39) noncoding transcript Het
Gpatch2l G T 12: 86,313,950 (GRCm39) R362L probably benign Het
Hyal5 A T 6: 24,891,602 (GRCm39) D472V probably benign Het
Ighv5-9-1 T C 12: 113,699,777 (GRCm39) S102G possibly damaging Het
Itpripl1 A C 2: 126,983,777 (GRCm39) L115R probably damaging Het
Itsn1 G A 16: 91,705,726 (GRCm39) C169Y possibly damaging Het
Krt88 T A 15: 101,348,349 (GRCm39) C12S probably benign Het
Macroh2a1 T C 13: 56,237,594 (GRCm39) D222G probably benign Het
Muc4 G A 16: 32,582,895 (GRCm39) V2557M probably damaging Het
Myh7b G C 2: 155,474,293 (GRCm39) R1669S possibly damaging Het
Nbeal2 G T 9: 110,458,936 (GRCm39) Q1996K probably benign Het
Obscn T C 11: 58,919,430 (GRCm39) E6205G probably damaging Het
Obscn A G 11: 58,955,136 (GRCm39) Y3926H possibly damaging Het
Or14a259 T C 7: 86,013,546 (GRCm39) probably null Het
P2ry2 A T 7: 100,648,136 (GRCm39) Y56* probably null Het
Pate10 T A 9: 35,652,884 (GRCm39) L42* probably null Het
Pde1a T C 2: 79,708,488 (GRCm39) N242S probably null Het
Pik3cg C T 12: 32,254,977 (GRCm39) E337K possibly damaging Het
Plxna2 A G 1: 194,433,712 (GRCm39) N587S probably benign Het
Pmpca T C 2: 26,285,183 (GRCm39) probably null Het
Ptpn4 C T 1: 119,635,593 (GRCm39) W370* probably null Het
Qki A T 17: 10,434,419 (GRCm39) probably null Het
Rapgef3 A G 15: 97,655,606 (GRCm39) V427A probably damaging Het
Rbbp8 T G 18: 11,855,171 (GRCm39) D465E probably damaging Het
Scn2a A G 2: 65,594,935 (GRCm39) K1928R probably benign Het
Slc5a5 A C 8: 71,341,492 (GRCm39) C346G probably damaging Het
Spata2l A G 8: 123,962,288 (GRCm39) L91P probably damaging Het
Syt3 C A 7: 44,045,439 (GRCm39) H560N possibly damaging Het
Timm23 G A 14: 31,915,882 (GRCm39) P63L probably damaging Het
Tmem191 T C 16: 17,094,743 (GRCm39) S108P possibly damaging Het
Ttc21b A G 2: 66,059,367 (GRCm39) C545R probably damaging Het
Ttc23l G T 15: 10,551,636 (GRCm39) T30K possibly damaging Het
Usp17ld A T 7: 102,899,579 (GRCm39) L451* probably null Het
Vmn1r15 T C 6: 57,235,497 (GRCm39) Y122H probably benign Het
Vxn G T 1: 9,692,902 (GRCm39) G145* probably null Het
Zfp1002 A T 2: 150,097,135 (GRCm39) I98K probably damaging Het
Other mutations in Or5an10
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00975:Or5an10 APN 19 12,276,149 (GRCm39) missense probably damaging 0.99
IGL02129:Or5an10 APN 19 12,275,822 (GRCm39) missense probably damaging 1.00
PIT4378001:Or5an10 UTSW 19 12,276,076 (GRCm39) missense probably damaging 1.00
R0727:Or5an10 UTSW 19 12,276,458 (GRCm39) missense probably benign 0.03
R1244:Or5an10 UTSW 19 12,275,860 (GRCm39) missense probably damaging 0.98
R1647:Or5an10 UTSW 19 12,276,023 (GRCm39) missense probably benign
R1648:Or5an10 UTSW 19 12,276,023 (GRCm39) missense probably benign
R1837:Or5an10 UTSW 19 12,275,740 (GRCm39) missense probably damaging 1.00
R1899:Or5an10 UTSW 19 12,275,707 (GRCm39) missense probably damaging 1.00
R2031:Or5an10 UTSW 19 12,275,740 (GRCm39) missense probably damaging 1.00
R2305:Or5an10 UTSW 19 12,276,451 (GRCm39) missense probably benign 0.01
R4624:Or5an10 UTSW 19 12,276,347 (GRCm39) missense probably benign
R4681:Or5an10 UTSW 19 12,276,413 (GRCm39) missense probably benign 0.05
R4790:Or5an10 UTSW 19 12,276,305 (GRCm39) missense possibly damaging 0.60
R4865:Or5an10 UTSW 19 12,275,944 (GRCm39) missense probably damaging 1.00
R4941:Or5an10 UTSW 19 12,276,260 (GRCm39) missense possibly damaging 0.95
R5138:Or5an10 UTSW 19 12,276,140 (GRCm39) missense possibly damaging 0.56
R5560:Or5an10 UTSW 19 12,276,008 (GRCm39) nonsense probably null
R5983:Or5an10 UTSW 19 12,276,467 (GRCm39) missense probably benign 0.00
R6736:Or5an10 UTSW 19 12,275,936 (GRCm39) nonsense probably null
R6882:Or5an10 UTSW 19 12,275,934 (GRCm39) missense probably damaging 1.00
R6883:Or5an10 UTSW 19 12,275,934 (GRCm39) missense probably damaging 1.00
R7465:Or5an10 UTSW 19 12,275,801 (GRCm39) missense probably benign 0.04
R7500:Or5an10 UTSW 19 12,276,041 (GRCm39) missense probably damaging 0.98
R7529:Or5an10 UTSW 19 12,276,086 (GRCm39) missense probably damaging 1.00
R7565:Or5an10 UTSW 19 12,276,212 (GRCm39) missense probably benign 0.09
R7611:Or5an10 UTSW 19 12,276,242 (GRCm39) missense probably damaging 0.99
R7850:Or5an10 UTSW 19 12,275,996 (GRCm39) missense probably benign
R7956:Or5an10 UTSW 19 12,275,666 (GRCm39) missense probably damaging 1.00
R7991:Or5an10 UTSW 19 12,275,639 (GRCm39) missense probably damaging 1.00
R9770:Or5an10 UTSW 19 12,276,464 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- ACGTTGGGTCCACAGAAGTG -3'
(R):5'- TTACAGCACTGACCTGGAACTTG -3'

Sequencing Primer
(F):5'- TGGAGCTGCAGCATGGC -3'
(R):5'- GGATGGACTCCTATCTCCATACAC -3'
Posted On 2016-06-21