|Institutional Source||Beutler Lab|
|Gene Name||asparaginyl-tRNA synthetase 2 (mitochondrial)(putative)|
|Essential gene?||Essential (E-score: 1.000)|
|Stock #||R5162 (G1)|
|Chromosomal Location||96951505-97064758 bp(+) (GRCm38)|
|Type of Mutation||utr 3 prime|
|DNA Base Change (assembly)||T to C at 97059820 bp (GRCm38)|
|Amino Acid Change|
|Ref Sequence||ENSEMBL: ENSMUSP00000146169 (fasta)|
|Gene Model||predicted gene model for transcript(s): [ENSMUST00000044466] [ENSMUST00000150681]|
|Coding Region Coverage||
|Validation Efficiency||98% (61/62)|
|MGI Phenotype||FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a putative member of the class II family of aminoacyl-tRNA synthetases. These enzymes play a critical role in protein biosynthesis by charging tRNAs with their cognate amino acids. This protein is encoded by the nuclear genome but is likely to be imported to the mitochondrion where it is thought to catalyze the ligation of asparagine to tRNA molecules. Mutations in this gene have been associated with combined oxidative phosphorylation deficiency 24 (COXPD24). [provided by RefSeq, Mar 2015]|
|Allele List at MGI|
|Other mutations in this stock||
|Other mutations in Nars2||
(F):5'- TCCTGCTGCATTGATTGGCG -3'
(R):5'- ATACTCAGCTCACGTGCCAAG -3'
(F):5'- GGGCACAGGCTTCATTCACTATG -3'
(R):5'- TGGATGACAGCACTATCTACCTC -3'