Incidental Mutation 'R5163:Odf4'
ID 397111
Institutional Source Beutler Lab
Gene Symbol Odf4
Ensembl Gene ENSMUSG00000032921
Gene Name outer dense fiber of sperm tails 4
Synonyms Oppo1
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R5163 (G1)
Quality Score 225
Status Not validated
Chromosome 11
Chromosomal Location 68812661-68817907 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to A at 68813672 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Cysteine to Phenylalanine at position 133 (C133F)
Gene Model predicted gene model for transcript(s): [ENSMUST00000038932] [ENSMUST00000125134] [ENSMUST00000130271]
AlphaFold Q8VI88
Predicted Effect possibly damaging
Transcript: ENSMUST00000038932
AA Change: C172F

PolyPhen 2 Score 0.856 (Sensitivity: 0.83; Specificity: 0.93)
SMART Domains Protein: ENSMUSP00000040050
Gene: ENSMUSG00000032921
AA Change: C172F

DomainStartEndE-ValueType
Pfam:PMP22_Claudin 42 222 1.1e-8 PFAM
low complexity region 272 287 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000125134
AA Change: C171F

PolyPhen 2 Score 0.033 (Sensitivity: 0.95; Specificity: 0.82)
SMART Domains Protein: ENSMUSP00000133636
Gene: ENSMUSG00000032921
AA Change: C171F

DomainStartEndE-ValueType
transmembrane domain 41 63 N/A INTRINSIC
transmembrane domain 125 147 N/A INTRINSIC
Predicted Effect possibly damaging
Transcript: ENSMUST00000130271
AA Change: C172F

PolyPhen 2 Score 0.856 (Sensitivity: 0.83; Specificity: 0.93)
SMART Domains Protein: ENSMUSP00000134383
Gene: ENSMUSG00000032921
AA Change: C172F

DomainStartEndE-ValueType
transmembrane domain 42 64 N/A INTRINSIC
transmembrane domain 126 148 N/A INTRINSIC
Predicted Effect probably damaging
Transcript: ENSMUST00000156828
AA Change: C133F

PolyPhen 2 Score 0.996 (Sensitivity: 0.55; Specificity: 0.98)
SMART Domains Protein: ENSMUSP00000133569
Gene: ENSMUSG00000032921
AA Change: C133F

DomainStartEndE-ValueType
transmembrane domain 27 49 N/A INTRINSIC
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.6%
  • 10x: 97.2%
  • 20x: 95.1%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a protein that is localized in the outer dense fibers of the tails of mature sperm. This protein is thought to have some important role in the sperm tail. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]
Allele List at MGI
Other mutations in this stock
Total: 43 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2700049A03Rik G T 12: 71,211,320 (GRCm39) E685* probably null Het
2700049A03Rik A T 12: 71,211,321 (GRCm39) E685V possibly damaging Het
Bcor C T X: 11,906,725 (GRCm39) R1551Q probably damaging Het
Btbd19 T G 4: 116,978,628 (GRCm39) I152L probably damaging Het
Dnaaf11 T C 15: 66,314,067 (GRCm39) D311G probably benign Het
Dync2i1 C T 12: 116,219,486 (GRCm39) R152H possibly damaging Het
Ercc6l2 A G 13: 64,046,845 (GRCm39) probably benign Het
Fat4 A G 3: 39,034,946 (GRCm39) D2866G probably damaging Het
Fkbp10 C T 11: 100,313,925 (GRCm39) A311V probably benign Het
Fnbp1l T C 3: 122,338,312 (GRCm39) N511S probably benign Het
Gkn3 C T 6: 87,360,507 (GRCm39) A163T probably damaging Het
Gltp A G 5: 114,812,122 (GRCm39) I147T probably benign Het
Gpr37 A T 6: 25,669,614 (GRCm39) I410N possibly damaging Het
Hivep2 G A 10: 14,015,169 (GRCm39) G1779R probably damaging Het
Ifna14 T C 4: 88,489,599 (GRCm39) Y146C probably damaging Het
Loxhd1 A G 18: 77,449,432 (GRCm39) D662G possibly damaging Het
Lrrc9 A T 12: 72,496,163 (GRCm39) I13F probably damaging Het
Map2k3 T A 11: 60,834,317 (GRCm39) I95N probably damaging Het
Mark1 A G 1: 184,637,807 (GRCm39) I594T probably damaging Het
Mettl14 T C 3: 123,168,474 (GRCm39) I189V possibly damaging Het
Msh2 C A 17: 88,030,841 (GRCm39) A906E probably benign Het
Opa1 A T 16: 29,416,438 (GRCm39) Q106L probably damaging Het
Or10d5j T C 9: 39,868,216 (GRCm39) N5S probably damaging Het
Pax4 T G 6: 28,446,269 (GRCm39) S75R probably damaging Het
Ppfibp1 T A 6: 146,923,629 (GRCm39) probably null Het
Ptpn20 T C 14: 33,353,068 (GRCm39) I269T probably benign Het
Ptprq T C 10: 107,360,192 (GRCm39) Q2161R probably damaging Het
Rab22a A G 2: 173,503,280 (GRCm39) D31G probably damaging Het
Rap1gds1 A T 3: 138,664,817 (GRCm39) M296K probably damaging Het
Rfx1 A G 8: 84,819,840 (GRCm39) T692A probably damaging Het
Sf3b2 A G 19: 5,325,165 (GRCm39) V769A probably damaging Het
Skint5 A T 4: 113,652,762 (GRCm39) F621I unknown Het
Spink5 A C 18: 44,132,924 (GRCm39) R513S possibly damaging Het
Srrm2 C T 17: 24,038,524 (GRCm39) probably benign Het
Srrt A G 5: 137,295,035 (GRCm39) probably null Het
Sun3 T C 11: 8,973,295 (GRCm39) Q134R possibly damaging Het
Tpo A G 12: 30,155,979 (GRCm39) V174A probably benign Het
Ucp1 A G 8: 84,020,832 (GRCm39) R183G possibly damaging Het
Vmn2r66 A G 7: 84,656,017 (GRCm39) V333A probably benign Het
Zfp108 G T 7: 23,960,163 (GRCm39) K251N probably benign Het
Zfp936 A G 7: 42,839,664 (GRCm39) Q377R probably damaging Het
Zkscan2 T C 7: 123,099,090 (GRCm39) E34G probably benign Het
Zup1 T A 10: 33,825,439 (GRCm39) E14D probably damaging Het
Other mutations in Odf4
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01090:Odf4 APN 11 68,812,778 (GRCm39) unclassified probably benign
IGL01782:Odf4 APN 11 68,817,459 (GRCm39) missense probably damaging 0.98
BB006:Odf4 UTSW 11 68,813,759 (GRCm39) missense possibly damaging 0.80
BB016:Odf4 UTSW 11 68,813,759 (GRCm39) missense possibly damaging 0.80
R0030:Odf4 UTSW 11 68,817,767 (GRCm39) missense probably benign 0.33
R0030:Odf4 UTSW 11 68,817,767 (GRCm39) missense probably benign 0.33
R1945:Odf4 UTSW 11 68,812,983 (GRCm39) missense possibly damaging 0.53
R4551:Odf4 UTSW 11 68,812,866 (GRCm39) missense probably benign 0.02
R4552:Odf4 UTSW 11 68,812,866 (GRCm39) missense probably benign 0.02
R4685:Odf4 UTSW 11 68,813,665 (GRCm39) critical splice donor site probably null
R4707:Odf4 UTSW 11 68,817,514 (GRCm39) missense probably damaging 1.00
R6657:Odf4 UTSW 11 68,817,638 (GRCm39) missense probably benign 0.12
R7073:Odf4 UTSW 11 68,817,514 (GRCm39) missense probably damaging 1.00
R7508:Odf4 UTSW 11 68,813,249 (GRCm39) missense possibly damaging 0.71
R7778:Odf4 UTSW 11 68,812,898 (GRCm39) missense probably benign 0.01
R7824:Odf4 UTSW 11 68,812,898 (GRCm39) missense probably benign 0.01
R7929:Odf4 UTSW 11 68,813,759 (GRCm39) missense possibly damaging 0.80
R9425:Odf4 UTSW 11 68,813,810 (GRCm39) missense probably benign
X0025:Odf4 UTSW 11 68,817,616 (GRCm39) missense probably damaging 0.98
Predicted Primers PCR Primer
(F):5'- CACCTAAGAATTGCACAGGGG -3'
(R):5'- CCCCAGACAATTTTAAGATGTGG -3'

Sequencing Primer
(F):5'- TCATCTGCCGAGCCTACAG -3'
(R):5'- GGACAATCCATCCAGTTTTTGG -3'
Posted On 2016-06-21