Incidental Mutation 'R0452:Parp4'
| ID |
39719 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Parp4
|
| Ensembl Gene |
ENSMUSG00000054509 |
| Gene Name |
poly (ADP-ribose) polymerase family, member 4 |
| Synonyms |
VPARP, Adprtl1, C030027K23Rik, VAULT3, p193, PH5P, E230037B21Rik |
| MMRRC Submission |
038652-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.146)
|
| Stock # |
R0452 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
14 |
| Chromosomal Location |
56813076-56897251 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to G
at 56886300 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Aspartic acid to Glycine
at position 1793
(D1793G)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000124258
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000161553]
|
| AlphaFold |
E9PYK3 |
| Predicted Effect |
unknown
Transcript: ENSMUST00000161553
AA Change: D1793G
|
| SMART Domains |
Protein: ENSMUSP00000124258
Gene: ENSMUSG00000054509
AA Change: D1793G
| Domain | Start | End | E-Value | Type |
|---|
|
BRCT
|
3 |
84 |
4.32e-9 |
SMART |
|
low complexity region
|
97 |
104 |
N/A |
INTRINSIC |
|
SCOP:d1a26_1
|
252 |
352 |
2e-19 |
SMART |
|
Pfam:PARP
|
371 |
559 |
1.8e-50 |
PFAM |
|
VIT
|
600 |
728 |
1.5e-57 |
SMART |
|
VWA
|
867 |
1030 |
6.08e-13 |
SMART |
|
Blast:14_3_3
|
1149 |
1205 |
5e-10 |
BLAST |
|
low complexity region
|
1255 |
1264 |
N/A |
INTRINSIC |
|
low complexity region
|
1348 |
1362 |
N/A |
INTRINSIC |
|
low complexity region
|
1371 |
1394 |
N/A |
INTRINSIC |
|
internal_repeat_1
|
1395 |
1416 |
4.48e-6 |
PROSPERO |
|
Pfam:Drf_FH1
|
1443 |
1542 |
3.3e-15 |
PFAM |
|
low complexity region
|
1553 |
1587 |
N/A |
INTRINSIC |
|
internal_repeat_2
|
1588 |
1608 |
2.45e-5 |
PROSPERO |
|
low complexity region
|
1695 |
1708 |
N/A |
INTRINSIC |
|
low complexity region
|
1739 |
1750 |
N/A |
INTRINSIC |
|
| Meta Mutation Damage Score |
0.0869 |
| Coding Region Coverage |
- 1x: 99.2%
- 3x: 98.4%
- 10x: 96.6%
- 20x: 93.7%
|
| Validation Efficiency |
99% (93/94) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes poly(ADP-ribosyl)transferase-like 1 protein, which is capable of catalyzing a poly(ADP-ribosyl)ation reaction. This protein has a catalytic domain which is homologous to that of poly (ADP-ribosyl) transferase, but lacks an N-terminal DNA binding domain which activates the C-terminal catalytic domain of poly (ADP-ribosyl) transferase. Since this protein is not capable of binding DNA directly, its transferase activity may be activated by other factors such as protein-protein interaction mediated by the extensive carboxyl terminus. [provided by RefSeq, Jul 2008]
PHENOTYPE: Homozygous null mutants are helathy and fertile. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 90 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 6030452D12Rik |
A |
G |
8: 107,233,822 (GRCm39) |
|
probably benign |
Het |
| Acap3 |
C |
A |
4: 155,986,785 (GRCm39) |
S347* |
probably null |
Het |
| Acvr1 |
G |
A |
2: 58,390,507 (GRCm39) |
P19L |
probably benign |
Het |
| Add2 |
G |
T |
6: 86,081,611 (GRCm39) |
E366* |
probably null |
Het |
| Ankrd28 |
C |
A |
14: 31,470,695 (GRCm39) |
A153S |
probably damaging |
Het |
| Anxa8 |
A |
T |
14: 33,816,727 (GRCm39) |
I206F |
probably damaging |
Het |
| Arhgef4 |
G |
A |
1: 34,771,403 (GRCm39) |
E1237K |
probably damaging |
Het |
| Arid1a |
C |
T |
4: 133,416,416 (GRCm39) |
A1120T |
unknown |
Het |
| Atad5 |
T |
C |
11: 79,997,247 (GRCm39) |
V857A |
probably damaging |
Het |
| Atp2a3 |
T |
A |
11: 72,868,058 (GRCm39) |
|
probably null |
Het |
| Atxn1l |
C |
T |
8: 110,459,027 (GRCm39) |
V412I |
possibly damaging |
Het |
| Card11 |
A |
G |
5: 140,866,125 (GRCm39) |
S923P |
probably benign |
Het |
| Cars1 |
C |
A |
7: 143,146,362 (GRCm39) |
E21* |
probably null |
Het |
| Ccdc115 |
A |
G |
1: 34,476,702 (GRCm39) |
|
probably benign |
Het |
| Ccnj |
T |
A |
19: 40,833,508 (GRCm39) |
|
probably null |
Het |
| Cds2 |
C |
T |
2: 132,140,399 (GRCm39) |
T182I |
probably damaging |
Het |
| Ceacam14 |
A |
G |
7: 17,549,248 (GRCm39) |
H213R |
probably benign |
Het |
| Cfap44 |
A |
T |
16: 44,252,308 (GRCm39) |
M806L |
probably benign |
Het |
| Chd8 |
A |
T |
14: 52,452,044 (GRCm39) |
I1317K |
probably damaging |
Het |
| Cherp |
A |
T |
8: 73,215,366 (GRCm39) |
|
probably benign |
Het |
| Creb5 |
C |
G |
6: 53,581,527 (GRCm39) |
T30S |
possibly damaging |
Het |
| Csf2ra |
A |
G |
19: 61,215,333 (GRCm39) |
M94T |
probably benign |
Het |
| Cyp2b19 |
A |
C |
7: 26,466,187 (GRCm39) |
D330A |
probably benign |
Het |
| Ddost |
G |
A |
4: 138,037,499 (GRCm39) |
V188M |
possibly damaging |
Het |
| Dnah7a |
A |
T |
1: 53,644,978 (GRCm39) |
D1019E |
probably benign |
Het |
| Dtx1 |
A |
T |
5: 120,833,057 (GRCm39) |
I127N |
possibly damaging |
Het |
| Dyrk2 |
T |
C |
10: 118,704,668 (GRCm39) |
T3A |
possibly damaging |
Het |
| Elovl5 |
C |
T |
9: 77,868,193 (GRCm39) |
T35M |
probably damaging |
Het |
| Emc7 |
T |
C |
2: 112,297,314 (GRCm39) |
|
probably benign |
Het |
| Erp27 |
T |
C |
6: 136,886,487 (GRCm39) |
Y182C |
probably damaging |
Het |
| Exoc2 |
T |
A |
13: 31,070,310 (GRCm39) |
|
probably benign |
Het |
| F5 |
A |
C |
1: 164,012,676 (GRCm39) |
D530A |
probably damaging |
Het |
| Fam149a |
A |
T |
8: 45,808,686 (GRCm39) |
V149E |
probably damaging |
Het |
| Fbxo41 |
A |
G |
6: 85,455,164 (GRCm39) |
S614P |
probably damaging |
Het |
| Fmn1 |
T |
A |
2: 113,467,124 (GRCm39) |
Y1342N |
possibly damaging |
Het |
| Gpr22 |
T |
A |
12: 31,758,793 (GRCm39) |
D443V |
possibly damaging |
Het |
| Il17rd |
T |
A |
14: 26,813,888 (GRCm39) |
W56R |
probably damaging |
Het |
| Itga2b |
A |
T |
11: 102,356,779 (GRCm39) |
|
probably null |
Het |
| Jmjd1c |
T |
C |
10: 67,091,261 (GRCm39) |
M2514T |
probably benign |
Het |
| Klk1b9 |
T |
C |
7: 43,443,675 (GRCm39) |
|
probably benign |
Het |
| Krr1 |
T |
C |
10: 111,811,503 (GRCm39) |
Y66H |
probably damaging |
Het |
| Lamb2 |
T |
C |
9: 108,363,553 (GRCm39) |
|
probably benign |
Het |
| Lgals3bp |
A |
T |
11: 118,284,290 (GRCm39) |
Y430N |
probably benign |
Het |
| Lrp10 |
T |
C |
14: 54,705,036 (GRCm39) |
V113A |
probably benign |
Het |
| Mgam |
A |
G |
6: 40,736,024 (GRCm39) |
Y841C |
probably damaging |
Het |
| Nisch |
T |
A |
14: 30,899,421 (GRCm39) |
|
probably benign |
Het |
| Nlrp4d |
G |
A |
7: 10,112,219 (GRCm39) |
T650I |
probably benign |
Het |
| Or4f61 |
T |
A |
2: 111,922,981 (GRCm39) |
K22* |
probably null |
Het |
| Or5p78 |
C |
T |
7: 108,211,577 (GRCm39) |
T21I |
possibly damaging |
Het |
| Pcm1 |
A |
G |
8: 41,778,942 (GRCm39) |
D1850G |
probably benign |
Het |
| Pgap2 |
G |
A |
7: 101,885,669 (GRCm39) |
A145T |
probably damaging |
Het |
| Phc1 |
G |
A |
6: 122,299,995 (GRCm39) |
A583V |
probably damaging |
Het |
| Plcd3 |
G |
A |
11: 102,962,085 (GRCm39) |
|
probably benign |
Het |
| Ppm1m |
T |
A |
9: 106,074,501 (GRCm39) |
Q214L |
probably damaging |
Het |
| Prkg2 |
A |
G |
5: 99,145,379 (GRCm39) |
|
probably benign |
Het |
| Prss3l |
A |
G |
6: 41,422,271 (GRCm39) |
Y45H |
probably benign |
Het |
| Rasal3 |
T |
C |
17: 32,614,791 (GRCm39) |
|
probably benign |
Het |
| Rfc1 |
A |
T |
5: 65,421,640 (GRCm39) |
D1086E |
probably benign |
Het |
| Rnf145 |
T |
A |
11: 44,452,587 (GRCm39) |
L522H |
probably damaging |
Het |
| Setd2 |
T |
A |
9: 110,382,168 (GRCm39) |
|
probably null |
Het |
| Sik1 |
C |
A |
17: 32,068,055 (GRCm39) |
V377F |
possibly damaging |
Het |
| Slc44a4 |
T |
C |
17: 35,147,071 (GRCm39) |
I367T |
possibly damaging |
Het |
| Slfn3 |
A |
G |
11: 83,103,954 (GRCm39) |
D275G |
possibly damaging |
Het |
| Smarcad1 |
A |
T |
6: 65,051,806 (GRCm39) |
N313I |
possibly damaging |
Het |
| Smc4 |
A |
T |
3: 68,915,361 (GRCm39) |
K138* |
probably null |
Het |
| Smg6 |
T |
A |
11: 74,821,039 (GRCm39) |
S437T |
probably benign |
Het |
| Spaca9 |
G |
T |
2: 28,586,005 (GRCm39) |
Q20K |
probably damaging |
Het |
| Spatc1 |
T |
G |
15: 76,152,493 (GRCm39) |
I41S |
probably damaging |
Het |
| Spink5 |
A |
T |
18: 44,096,385 (GRCm39) |
T5S |
possibly damaging |
Het |
| St3gal1 |
C |
A |
15: 66,981,504 (GRCm39) |
|
probably benign |
Het |
| Stat5a |
C |
A |
11: 100,753,961 (GRCm39) |
T97K |
probably benign |
Het |
| Stat5b |
A |
T |
11: 100,689,156 (GRCm39) |
I246N |
probably benign |
Het |
| Supt6 |
G |
T |
11: 78,117,829 (GRCm39) |
D462E |
probably damaging |
Het |
| Swi5 |
A |
T |
2: 32,171,836 (GRCm39) |
|
probably benign |
Het |
| Syne1 |
A |
T |
10: 5,355,435 (GRCm39) |
V375E |
probably damaging |
Het |
| Tcp1 |
T |
C |
17: 13,143,239 (GRCm39) |
F516S |
probably benign |
Het |
| Tdrd7 |
A |
T |
4: 45,965,488 (GRCm39) |
|
probably benign |
Het |
| Tgfbr3 |
A |
T |
5: 107,288,289 (GRCm39) |
N457K |
probably benign |
Het |
| Tmem209 |
A |
G |
6: 30,487,380 (GRCm39) |
M500T |
probably damaging |
Het |
| Tmem44 |
C |
T |
16: 30,336,281 (GRCm39) |
|
probably benign |
Het |
| Ttc21a |
T |
A |
9: 119,768,220 (GRCm39) |
|
probably benign |
Het |
| Ttn |
A |
G |
2: 76,701,454 (GRCm39) |
|
probably benign |
Het |
| Ttn |
T |
A |
2: 76,666,347 (GRCm39) |
I88F |
possibly damaging |
Het |
| Ube2w |
T |
C |
1: 16,672,479 (GRCm39) |
|
probably benign |
Het |
| Ufc1 |
C |
T |
1: 171,117,527 (GRCm39) |
|
probably benign |
Het |
| Uhmk1 |
A |
G |
1: 170,039,971 (GRCm39) |
M132T |
possibly damaging |
Het |
| Usp29 |
A |
G |
7: 6,966,181 (GRCm39) |
N675D |
possibly damaging |
Het |
| Vmn1r23 |
A |
G |
6: 57,903,469 (GRCm39) |
V103A |
possibly damaging |
Het |
| Wdr59 |
G |
T |
8: 112,248,604 (GRCm39) |
R4S |
possibly damaging |
Het |
| Zc3hav1 |
T |
A |
6: 38,284,372 (GRCm39) |
E914D |
probably benign |
Het |
|
| Other mutations in Parp4 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00479:Parp4
|
APN |
14 |
56,853,917 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
IGL00571:Parp4
|
APN |
14 |
56,884,810 (GRCm39) |
missense |
unknown |
|
|
IGL00737:Parp4
|
APN |
14 |
56,821,620 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL00793:Parp4
|
APN |
14 |
56,840,334 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
IGL01108:Parp4
|
APN |
14 |
56,844,897 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL01131:Parp4
|
APN |
14 |
56,823,217 (GRCm39) |
splice site |
probably benign |
|
|
IGL01485:Parp4
|
APN |
14 |
56,859,661 (GRCm39) |
missense |
possibly damaging |
0.54 |
|
IGL01704:Parp4
|
APN |
14 |
56,839,783 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL01993:Parp4
|
APN |
14 |
56,848,245 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
IGL02125:Parp4
|
APN |
14 |
56,827,959 (GRCm39) |
missense |
probably benign |
0.33 |
|
IGL02851:Parp4
|
APN |
14 |
56,886,326 (GRCm39) |
missense |
unknown |
|
|
IGL02863:Parp4
|
APN |
14 |
56,886,243 (GRCm39) |
missense |
unknown |
|
|
IGL03065:Parp4
|
APN |
14 |
56,875,326 (GRCm39) |
missense |
probably benign |
0.09 |
|
IGL03117:Parp4
|
APN |
14 |
56,840,313 (GRCm39) |
missense |
probably benign |
0.17 |
|
IGL03271:Parp4
|
APN |
14 |
56,823,082 (GRCm39) |
missense |
probably benign |
0.10 |
|
IGL03309:Parp4
|
APN |
14 |
56,825,265 (GRCm39) |
missense |
probably benign |
0.11 |
|
IGL03408:Parp4
|
APN |
14 |
56,839,865 (GRCm39) |
missense |
probably damaging |
0.99 |
|
poisonous
|
UTSW |
14 |
56,873,205 (GRCm39) |
missense |
possibly damaging |
0.65 |
|
R0515_Parp4_195
|
UTSW |
14 |
56,851,124 (GRCm39) |
missense |
probably damaging |
1.00 |
|
toxic
|
UTSW |
14 |
56,866,615 (GRCm39) |
missense |
probably benign |
0.28 |
|
venomous
|
UTSW |
14 |
56,827,355 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
virulent
|
UTSW |
14 |
56,825,235 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R0278:Parp4
|
UTSW |
14 |
56,844,980 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0320:Parp4
|
UTSW |
14 |
56,825,953 (GRCm39) |
critical splice donor site |
probably null |
|
|
R0445:Parp4
|
UTSW |
14 |
56,840,205 (GRCm39) |
splice site |
probably null |
|
|
R0511:Parp4
|
UTSW |
14 |
56,873,172 (GRCm39) |
splice site |
probably benign |
|
|
R0515:Parp4
|
UTSW |
14 |
56,851,124 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0608:Parp4
|
UTSW |
14 |
56,839,861 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0800:Parp4
|
UTSW |
14 |
56,827,408 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0959:Parp4
|
UTSW |
14 |
56,885,576 (GRCm39) |
missense |
unknown |
|
|
R1207:Parp4
|
UTSW |
14 |
56,885,339 (GRCm39) |
missense |
unknown |
|
|
R1207:Parp4
|
UTSW |
14 |
56,885,339 (GRCm39) |
missense |
unknown |
|
|
R1342:Parp4
|
UTSW |
14 |
56,827,854 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1520:Parp4
|
UTSW |
14 |
56,835,863 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1565:Parp4
|
UTSW |
14 |
56,827,329 (GRCm39) |
splice site |
probably benign |
|
|
R1574:Parp4
|
UTSW |
14 |
56,839,752 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R1574:Parp4
|
UTSW |
14 |
56,839,752 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R1649:Parp4
|
UTSW |
14 |
56,827,885 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R1666:Parp4
|
UTSW |
14 |
56,861,620 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R1781:Parp4
|
UTSW |
14 |
56,864,838 (GRCm39) |
splice site |
probably null |
|
|
R1799:Parp4
|
UTSW |
14 |
56,885,589 (GRCm39) |
missense |
unknown |
|
|
R1823:Parp4
|
UTSW |
14 |
56,827,329 (GRCm39) |
splice site |
probably benign |
|
|
R1859:Parp4
|
UTSW |
14 |
56,886,372 (GRCm39) |
missense |
unknown |
|
|
R1919:Parp4
|
UTSW |
14 |
56,861,474 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2000:Parp4
|
UTSW |
14 |
56,851,181 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R2032:Parp4
|
UTSW |
14 |
56,866,553 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
R2034:Parp4
|
UTSW |
14 |
56,871,720 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2177:Parp4
|
UTSW |
14 |
56,896,746 (GRCm39) |
missense |
unknown |
|
|
R2291:Parp4
|
UTSW |
14 |
56,851,274 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2865:Parp4
|
UTSW |
14 |
56,851,181 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R3012:Parp4
|
UTSW |
14 |
56,832,873 (GRCm39) |
critical splice donor site |
probably null |
|
|
R3841:Parp4
|
UTSW |
14 |
56,825,235 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R3913:Parp4
|
UTSW |
14 |
56,857,975 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4064:Parp4
|
UTSW |
14 |
56,861,597 (GRCm39) |
missense |
probably benign |
0.06 |
|
R4201:Parp4
|
UTSW |
14 |
56,829,848 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R4288:Parp4
|
UTSW |
14 |
56,844,951 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4360:Parp4
|
UTSW |
14 |
56,866,661 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R4506:Parp4
|
UTSW |
14 |
56,889,761 (GRCm39) |
missense |
unknown |
|
|
R4577:Parp4
|
UTSW |
14 |
56,827,867 (GRCm39) |
missense |
probably benign |
0.33 |
|
R4633:Parp4
|
UTSW |
14 |
56,885,048 (GRCm39) |
missense |
unknown |
|
|
R4762:Parp4
|
UTSW |
14 |
56,848,267 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4836:Parp4
|
UTSW |
14 |
56,823,195 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4974:Parp4
|
UTSW |
14 |
56,827,355 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R5049:Parp4
|
UTSW |
14 |
56,873,188 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
R5479:Parp4
|
UTSW |
14 |
56,861,552 (GRCm39) |
missense |
probably benign |
0.01 |
|
R5683:Parp4
|
UTSW |
14 |
56,884,886 (GRCm39) |
nonsense |
probably null |
|
|
R5884:Parp4
|
UTSW |
14 |
56,852,207 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5965:Parp4
|
UTSW |
14 |
56,861,489 (GRCm39) |
missense |
probably benign |
0.11 |
|
R6001:Parp4
|
UTSW |
14 |
56,878,740 (GRCm39) |
missense |
probably benign |
0.01 |
|
R6027:Parp4
|
UTSW |
14 |
56,866,615 (GRCm39) |
missense |
probably benign |
0.28 |
|
R6230:Parp4
|
UTSW |
14 |
56,844,990 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6242:Parp4
|
UTSW |
14 |
56,832,856 (GRCm39) |
nonsense |
probably null |
|
|
R6355:Parp4
|
UTSW |
14 |
56,839,757 (GRCm39) |
missense |
possibly damaging |
0.61 |
|
R6414:Parp4
|
UTSW |
14 |
56,864,838 (GRCm39) |
splice site |
probably null |
|
|
R6418:Parp4
|
UTSW |
14 |
56,858,108 (GRCm39) |
critical splice donor site |
probably null |
|
|
R6477:Parp4
|
UTSW |
14 |
56,884,694 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6542:Parp4
|
UTSW |
14 |
56,885,339 (GRCm39) |
missense |
unknown |
|
|
R6759:Parp4
|
UTSW |
14 |
56,857,947 (GRCm39) |
missense |
probably benign |
0.10 |
|
R6995:Parp4
|
UTSW |
14 |
56,851,196 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R7002:Parp4
|
UTSW |
14 |
56,839,861 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7026:Parp4
|
UTSW |
14 |
56,858,049 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7062:Parp4
|
UTSW |
14 |
56,852,216 (GRCm39) |
missense |
possibly damaging |
0.48 |
|
R7101:Parp4
|
UTSW |
14 |
56,827,430 (GRCm39) |
missense |
probably benign |
0.02 |
|
R7124:Parp4
|
UTSW |
14 |
56,840,256 (GRCm39) |
missense |
probably benign |
0.11 |
|
R7162:Parp4
|
UTSW |
14 |
56,886,333 (GRCm39) |
missense |
unknown |
|
|
R7293:Parp4
|
UTSW |
14 |
56,885,303 (GRCm39) |
small deletion |
probably benign |
|
|
R7297:Parp4
|
UTSW |
14 |
56,885,138 (GRCm39) |
missense |
not run |
|
|
R7337:Parp4
|
UTSW |
14 |
56,839,852 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7539:Parp4
|
UTSW |
14 |
56,873,212 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7575:Parp4
|
UTSW |
14 |
56,875,375 (GRCm39) |
missense |
probably benign |
0.28 |
|
R7808:Parp4
|
UTSW |
14 |
56,873,205 (GRCm39) |
missense |
possibly damaging |
0.65 |
|
R7854:Parp4
|
UTSW |
14 |
56,896,805 (GRCm39) |
missense |
unknown |
|
|
R7960:Parp4
|
UTSW |
14 |
56,832,708 (GRCm39) |
splice site |
probably null |
|
|
R8152:Parp4
|
UTSW |
14 |
56,884,703 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8344:Parp4
|
UTSW |
14 |
56,886,186 (GRCm39) |
missense |
unknown |
|
|
R8416:Parp4
|
UTSW |
14 |
56,825,271 (GRCm39) |
critical splice donor site |
probably null |
|
|
R8726:Parp4
|
UTSW |
14 |
56,866,556 (GRCm39) |
missense |
probably benign |
0.04 |
|
R8752:Parp4
|
UTSW |
14 |
56,886,073 (GRCm39) |
missense |
unknown |
|
|
R8804:Parp4
|
UTSW |
14 |
56,853,900 (GRCm39) |
nonsense |
probably null |
|
|
R9046:Parp4
|
UTSW |
14 |
56,864,927 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R9176:Parp4
|
UTSW |
14 |
56,873,274 (GRCm39) |
missense |
possibly damaging |
0.54 |
|
R9303:Parp4
|
UTSW |
14 |
56,852,224 (GRCm39) |
critical splice donor site |
probably null |
|
|
R9303:Parp4
|
UTSW |
14 |
56,832,790 (GRCm39) |
frame shift |
probably null |
|
|
R9305:Parp4
|
UTSW |
14 |
56,852,224 (GRCm39) |
critical splice donor site |
probably null |
|
|
R9305:Parp4
|
UTSW |
14 |
56,832,790 (GRCm39) |
frame shift |
probably null |
|
|
R9360:Parp4
|
UTSW |
14 |
56,878,775 (GRCm39) |
critical splice donor site |
probably null |
|
|
R9430:Parp4
|
UTSW |
14 |
56,866,673 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9491:Parp4
|
UTSW |
14 |
56,832,828 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9729:Parp4
|
UTSW |
14 |
56,885,888 (GRCm39) |
missense |
unknown |
|
|
RF020:Parp4
|
UTSW |
14 |
56,884,806 (GRCm39) |
missense |
unknown |
|
|
Z1177:Parp4
|
UTSW |
14 |
56,829,824 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- AAAGTGCCGCAGTGCATCAGAG -3'
(R):5'- TCCCTGAACCACGAGACTGGAAAG -3'
Sequencing Primer
(F):5'- TCAGAGCCCTAATAACAGAGTGTC -3'
(R):5'- ATCCAACTGCCTTGGGAAG -3'
|
| Posted On |
2013-05-23 |
Incidental Mutation