Incidental Mutation 'R4717:Dapk1'
| ID |
397212 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Dapk1
|
| Ensembl Gene |
ENSMUSG00000021559 |
| Gene Name |
death associated protein kinase 1 |
| Synonyms |
DAP-Kinase, D13Ucla1, 2810425C21Rik, 2310039H24Rik |
| MMRRC Submission |
041984-MU
|
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
R4717 (G1)
|
| Quality Score |
225 |
|
Status
|
Not validated
|
| Chromosome |
13 |
| Chromosomal Location |
60749761-60911005 bp(+) (GRCm39) |
| Type of Mutation |
critical splice donor site (2 bp from exon) |
| DNA Base Change (assembly) |
T to A
at 60874476 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000153607
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000044083]
[ENSMUST00000044083]
[ENSMUST00000077453]
[ENSMUST00000077453]
[ENSMUST00000226059]
|
| AlphaFold |
Q80YE7 |
| Predicted Effect |
probably null
Transcript: ENSMUST00000044083
|
| SMART Domains |
Protein: ENSMUSP00000040825
Gene: ENSMUSG00000021559
| Domain | Start | End | E-Value | Type |
|---|
|
S_TKc
|
13 |
275 |
6.35e-99 |
SMART |
|
low complexity region
|
295 |
306 |
N/A |
INTRINSIC |
|
ANK
|
378 |
407 |
5.09e-2 |
SMART |
|
ANK
|
411 |
440 |
6.61e-1 |
SMART |
|
ANK
|
444 |
473 |
7.64e-6 |
SMART |
|
ANK
|
477 |
506 |
2.13e-4 |
SMART |
|
ANK
|
510 |
539 |
1.31e-4 |
SMART |
|
ANK
|
543 |
572 |
7.83e-3 |
SMART |
|
ANK
|
576 |
605 |
8.52e-4 |
SMART |
|
ANK
|
609 |
638 |
1.85e-4 |
SMART |
|
ANK
|
642 |
671 |
7.29e2 |
SMART |
|
low complexity region
|
711 |
725 |
N/A |
INTRINSIC |
|
DEATH
|
1299 |
1396 |
2.65e-18 |
SMART |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000044083
|
| SMART Domains |
Protein: ENSMUSP00000040825
Gene: ENSMUSG00000021559
| Domain | Start | End | E-Value | Type |
|---|
|
S_TKc
|
13 |
275 |
6.35e-99 |
SMART |
|
low complexity region
|
295 |
306 |
N/A |
INTRINSIC |
|
ANK
|
378 |
407 |
5.09e-2 |
SMART |
|
ANK
|
411 |
440 |
6.61e-1 |
SMART |
|
ANK
|
444 |
473 |
7.64e-6 |
SMART |
|
ANK
|
477 |
506 |
2.13e-4 |
SMART |
|
ANK
|
510 |
539 |
1.31e-4 |
SMART |
|
ANK
|
543 |
572 |
7.83e-3 |
SMART |
|
ANK
|
576 |
605 |
8.52e-4 |
SMART |
|
ANK
|
609 |
638 |
1.85e-4 |
SMART |
|
ANK
|
642 |
671 |
7.29e2 |
SMART |
|
low complexity region
|
711 |
725 |
N/A |
INTRINSIC |
|
DEATH
|
1299 |
1396 |
2.65e-18 |
SMART |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000077453
|
| SMART Domains |
Protein: ENSMUSP00000076666
Gene: ENSMUSG00000021559
| Domain | Start | End | E-Value | Type |
|---|
|
S_TKc
|
13 |
275 |
6.35e-99 |
SMART |
|
low complexity region
|
295 |
306 |
N/A |
INTRINSIC |
|
ANK
|
378 |
407 |
5.09e-2 |
SMART |
|
ANK
|
411 |
440 |
6.61e-1 |
SMART |
|
ANK
|
444 |
473 |
7.64e-6 |
SMART |
|
ANK
|
477 |
506 |
2.13e-4 |
SMART |
|
ANK
|
510 |
539 |
1.31e-4 |
SMART |
|
ANK
|
543 |
572 |
7.83e-3 |
SMART |
|
ANK
|
576 |
605 |
8.52e-4 |
SMART |
|
ANK
|
609 |
638 |
1.85e-4 |
SMART |
|
ANK
|
642 |
671 |
7.29e2 |
SMART |
|
low complexity region
|
711 |
725 |
N/A |
INTRINSIC |
|
Pfam:COR
|
984 |
1176 |
4.2e-10 |
PFAM |
|
DEATH
|
1299 |
1396 |
2.65e-18 |
SMART |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000077453
|
| SMART Domains |
Protein: ENSMUSP00000076666
Gene: ENSMUSG00000021559
| Domain | Start | End | E-Value | Type |
|---|
|
S_TKc
|
13 |
275 |
6.35e-99 |
SMART |
|
low complexity region
|
295 |
306 |
N/A |
INTRINSIC |
|
ANK
|
378 |
407 |
5.09e-2 |
SMART |
|
ANK
|
411 |
440 |
6.61e-1 |
SMART |
|
ANK
|
444 |
473 |
7.64e-6 |
SMART |
|
ANK
|
477 |
506 |
2.13e-4 |
SMART |
|
ANK
|
510 |
539 |
1.31e-4 |
SMART |
|
ANK
|
543 |
572 |
7.83e-3 |
SMART |
|
ANK
|
576 |
605 |
8.52e-4 |
SMART |
|
ANK
|
609 |
638 |
1.85e-4 |
SMART |
|
ANK
|
642 |
671 |
7.29e2 |
SMART |
|
low complexity region
|
711 |
725 |
N/A |
INTRINSIC |
|
Pfam:COR
|
984 |
1176 |
4.2e-10 |
PFAM |
|
DEATH
|
1299 |
1396 |
2.65e-18 |
SMART |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000224340
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000224789
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000226059
|
| Coding Region Coverage |
- 1x: 99.2%
- 3x: 98.6%
- 10x: 97.2%
- 20x: 95.1%
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Death-associated protein kinase 1 is a positive mediator of gamma-interferon induced programmed cell death. DAPK1 encodes a structurally unique 160-kD calmodulin dependent serine-threonine kinase that carries 8 ankyrin repeats and 2 putative P-loop consensus sites. It is a tumor suppressor candidate. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013]
PHENOTYPE: Mice homozygous for a knock-out allele show decreased sensitivity to ER stress-induced cell death and reduced tunicamycin-induced kidney damage. Mice homozygous for a gene trapped allele show decreased infarct size and neuronal death with improved neurological scores after ischemic brain injury. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 86 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 9330159F19Rik |
T |
C |
10: 29,097,783 (GRCm39) |
L60P |
probably damaging |
Het |
| Acsf2 |
T |
G |
11: 94,450,372 (GRCm39) |
M512L |
probably benign |
Het |
| Ahrr |
T |
A |
13: 74,363,885 (GRCm39) |
H312L |
probably benign |
Het |
| Akr1c18 |
T |
C |
13: 4,186,717 (GRCm39) |
M244V |
probably benign |
Het |
| Aldh3b2 |
A |
G |
19: 4,031,128 (GRCm39) |
Y459C |
probably damaging |
Het |
| Arhgap29 |
A |
T |
3: 121,803,607 (GRCm39) |
I796L |
possibly damaging |
Het |
| Arrdc4 |
T |
A |
7: 68,391,406 (GRCm39) |
D287V |
probably damaging |
Het |
| Astn2 |
A |
T |
4: 65,562,991 (GRCm39) |
I930N |
possibly damaging |
Het |
| Bace2 |
T |
A |
16: 97,238,073 (GRCm39) |
L508Q |
probably damaging |
Het |
| Baz2a |
G |
T |
10: 127,960,811 (GRCm39) |
C1537F |
possibly damaging |
Het |
| Cad |
A |
G |
5: 31,224,030 (GRCm39) |
|
probably null |
Het |
| Capn5 |
A |
T |
7: 97,773,126 (GRCm39) |
I626N |
probably benign |
Het |
| Car8 |
A |
T |
4: 8,169,685 (GRCm39) |
N274K |
probably damaging |
Het |
| Casp14 |
T |
C |
10: 78,550,958 (GRCm39) |
I76V |
probably benign |
Het |
| Ccdc88c |
A |
G |
12: 100,882,925 (GRCm39) |
V1649A |
probably benign |
Het |
| Cemip |
A |
T |
7: 83,596,488 (GRCm39) |
I1092N |
probably damaging |
Het |
| Clspn |
A |
G |
4: 126,453,849 (GRCm39) |
N91D |
probably damaging |
Het |
| Cpxm2 |
A |
G |
7: 131,656,574 (GRCm39) |
Y563H |
possibly damaging |
Het |
| Csnk1g2 |
T |
C |
10: 80,473,749 (GRCm39) |
V72A |
probably benign |
Het |
| Cyp46a1 |
T |
C |
12: 108,318,285 (GRCm39) |
|
probably null |
Het |
| Cyp4x1 |
T |
C |
4: 114,978,902 (GRCm39) |
H206R |
probably benign |
Het |
| Ddx1 |
A |
G |
12: 13,290,888 (GRCm39) |
W76R |
probably damaging |
Het |
| Dhx29 |
G |
A |
13: 113,083,469 (GRCm39) |
R508H |
unknown |
Het |
| Dnah2 |
T |
C |
11: 69,320,183 (GRCm39) |
D3962G |
probably benign |
Het |
| Dnajc14 |
T |
A |
10: 128,642,113 (GRCm39) |
C12S |
possibly damaging |
Het |
| Dock1 |
T |
C |
7: 134,449,899 (GRCm39) |
I804T |
probably damaging |
Het |
| Efs |
G |
T |
14: 55,157,801 (GRCm39) |
S170Y |
probably damaging |
Het |
| Eml4 |
G |
T |
17: 83,755,654 (GRCm39) |
W295C |
probably benign |
Het |
| Fkbp15 |
A |
G |
4: 62,226,306 (GRCm39) |
S748P |
probably damaging |
Het |
| Ghr |
T |
G |
15: 3,349,235 (GRCm39) |
I648L |
possibly damaging |
Het |
| Gigyf1 |
T |
A |
5: 137,523,494 (GRCm39) |
I942N |
probably damaging |
Het |
| Gpam |
T |
A |
19: 55,064,046 (GRCm39) |
E682D |
probably benign |
Het |
| Gsr |
A |
T |
8: 34,183,886 (GRCm39) |
K383* |
probably null |
Het |
| Hapln1 |
C |
A |
13: 89,753,579 (GRCm39) |
S248R |
probably benign |
Het |
| Haus2 |
G |
T |
2: 120,449,583 (GRCm39) |
R209L |
probably benign |
Het |
| Hhatl |
A |
G |
9: 121,618,943 (GRCm39) |
F63S |
probably damaging |
Het |
| Hmcn1 |
A |
G |
1: 150,494,816 (GRCm39) |
M4091T |
probably benign |
Het |
| Hspb7 |
A |
G |
4: 141,149,896 (GRCm39) |
D94G |
probably damaging |
Het |
| Irf6 |
T |
A |
1: 192,849,742 (GRCm39) |
|
probably null |
Het |
| Itgb2 |
T |
A |
10: 77,381,878 (GRCm39) |
L60* |
probably null |
Het |
| Jmjd1c |
C |
T |
10: 66,993,830 (GRCm39) |
Q104* |
probably null |
Het |
| Kcnh1 |
A |
G |
1: 191,959,025 (GRCm39) |
D193G |
probably damaging |
Het |
| Klhl25 |
G |
T |
7: 75,516,528 (GRCm39) |
C478F |
probably damaging |
Het |
| Klhl3 |
T |
C |
13: 58,178,330 (GRCm39) |
D267G |
probably damaging |
Het |
| L3mbtl4 |
T |
G |
17: 68,762,708 (GRCm39) |
H80Q |
probably null |
Het |
| Lhcgr |
C |
A |
17: 89,049,895 (GRCm39) |
V544F |
probably benign |
Het |
| Mfsd4a |
T |
C |
1: 131,985,633 (GRCm39) |
N168D |
probably benign |
Het |
| Mmp3 |
A |
G |
9: 7,449,881 (GRCm39) |
Q255R |
possibly damaging |
Het |
| Mrgprb3 |
C |
A |
7: 48,293,000 (GRCm39) |
G184C |
probably benign |
Het |
| Mtpap |
C |
T |
18: 4,396,394 (GRCm39) |
A562V |
possibly damaging |
Het |
| Nid1 |
T |
C |
13: 13,681,086 (GRCm39) |
V1072A |
probably benign |
Het |
| Nsf |
T |
G |
11: 103,714,595 (GRCm39) |
K728T |
probably damaging |
Het |
| Or10ak7 |
T |
C |
4: 118,791,626 (GRCm39) |
N140D |
probably benign |
Het |
| Or12j3 |
T |
C |
7: 139,953,328 (GRCm39) |
N65S |
probably damaging |
Het |
| Or1e17 |
T |
A |
11: 73,831,641 (GRCm39) |
S190T |
possibly damaging |
Het |
| Or2a5 |
T |
C |
6: 42,874,158 (GRCm39) |
Y258H |
probably damaging |
Het |
| Or4k15b |
A |
T |
14: 50,272,821 (GRCm39) |
V13E |
probably damaging |
Het |
| Pcsk5 |
A |
T |
19: 17,502,631 (GRCm39) |
C894S |
probably damaging |
Het |
| Pde2a |
A |
G |
7: 101,143,879 (GRCm39) |
D166G |
probably benign |
Het |
| Pfpl |
G |
A |
19: 12,406,618 (GRCm39) |
E290K |
probably benign |
Het |
| Pi4kb |
A |
C |
3: 94,906,162 (GRCm39) |
I570L |
probably damaging |
Het |
| Plxnb2 |
A |
T |
15: 89,041,622 (GRCm39) |
C1727* |
probably null |
Het |
| Poln |
A |
T |
5: 34,286,792 (GRCm39) |
D125E |
possibly damaging |
Het |
| Pomgnt1 |
A |
G |
4: 116,011,412 (GRCm39) |
D259G |
possibly damaging |
Het |
| Prx |
A |
T |
7: 27,216,152 (GRCm39) |
M218L |
probably benign |
Het |
| Pxn |
A |
T |
5: 115,690,001 (GRCm39) |
Q342L |
probably damaging |
Het |
| Rhpn2 |
A |
G |
7: 35,033,775 (GRCm39) |
D3G |
possibly damaging |
Het |
| Rnase2b |
C |
T |
14: 51,400,174 (GRCm39) |
T85I |
possibly damaging |
Het |
| Rnaseh2b |
C |
A |
14: 62,591,075 (GRCm39) |
T142K |
probably damaging |
Het |
| Sacs |
T |
C |
14: 61,450,304 (GRCm39) |
S4117P |
probably damaging |
Het |
| Sdk2 |
T |
C |
11: 113,745,195 (GRCm39) |
N700S |
probably damaging |
Het |
| Sec62 |
A |
C |
3: 30,864,020 (GRCm39) |
K101Q |
unknown |
Het |
| Sel1l2 |
A |
C |
2: 140,071,943 (GRCm39) |
L659R |
possibly damaging |
Het |
| Septin11 |
A |
G |
5: 93,304,815 (GRCm39) |
I211V |
possibly damaging |
Het |
| Slc25a42 |
C |
T |
8: 70,642,107 (GRCm39) |
E112K |
probably damaging |
Het |
| Spem2 |
T |
C |
11: 69,708,609 (GRCm39) |
N119D |
probably benign |
Het |
| Themis |
G |
A |
10: 28,665,748 (GRCm39) |
E604K |
probably benign |
Het |
| Tie1 |
T |
C |
4: 118,343,414 (GRCm39) |
K150E |
probably damaging |
Het |
| Top6bl |
A |
G |
19: 4,675,901 (GRCm39) |
|
probably benign |
Het |
| Ubap2 |
G |
A |
4: 41,218,333 (GRCm39) |
T258I |
possibly damaging |
Het |
| Ushbp1 |
C |
T |
8: 71,838,313 (GRCm39) |
A664T |
probably damaging |
Het |
| Vmn1r1 |
T |
C |
1: 181,984,774 (GRCm39) |
N297S |
possibly damaging |
Het |
| Vmn1r173 |
A |
C |
7: 23,402,637 (GRCm39) |
I291L |
probably damaging |
Het |
| Yy1 |
A |
G |
12: 108,759,972 (GRCm39) |
I212V |
possibly damaging |
Het |
| Zfp442 |
A |
T |
2: 150,250,149 (GRCm39) |
F527L |
probably damaging |
Het |
| Zyg11b |
T |
A |
4: 108,099,069 (GRCm39) |
H632L |
probably damaging |
Het |
|
| Other mutations in Dapk1 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00089:Dapk1
|
APN |
13 |
60,908,854 (GRCm39) |
missense |
probably benign |
0.23 |
|
IGL00500:Dapk1
|
APN |
13 |
60,908,618 (GRCm39) |
missense |
probably damaging |
0.96 |
|
IGL00801:Dapk1
|
APN |
13 |
60,909,062 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL00903:Dapk1
|
APN |
13 |
60,909,211 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL01468:Dapk1
|
APN |
13 |
60,908,612 (GRCm39) |
missense |
probably benign |
|
|
IGL01535:Dapk1
|
APN |
13 |
60,878,845 (GRCm39) |
splice site |
probably benign |
|
|
IGL01755:Dapk1
|
APN |
13 |
60,908,990 (GRCm39) |
missense |
possibly damaging |
0.63 |
|
IGL01755:Dapk1
|
APN |
13 |
60,908,989 (GRCm39) |
missense |
probably damaging |
0.97 |
|
IGL01862:Dapk1
|
APN |
13 |
60,874,424 (GRCm39) |
missense |
probably benign |
0.39 |
|
IGL01985:Dapk1
|
APN |
13 |
60,884,074 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02124:Dapk1
|
APN |
13 |
60,878,696 (GRCm39) |
missense |
probably benign |
|
|
IGL02376:Dapk1
|
APN |
13 |
60,844,208 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL02449:Dapk1
|
APN |
13 |
60,867,584 (GRCm39) |
splice site |
probably benign |
|
|
IGL02490:Dapk1
|
APN |
13 |
60,897,148 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02503:Dapk1
|
APN |
13 |
60,909,621 (GRCm39) |
nonsense |
probably null |
|
|
IGL02516:Dapk1
|
APN |
13 |
60,844,161 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02544:Dapk1
|
APN |
13 |
60,899,031 (GRCm39) |
missense |
probably benign |
|
|
IGL02604:Dapk1
|
APN |
13 |
60,896,134 (GRCm39) |
missense |
probably benign |
|
|
IGL03035:Dapk1
|
APN |
13 |
60,864,587 (GRCm39) |
missense |
probably damaging |
0.99 |
|
H8562:Dapk1
|
UTSW |
13 |
60,909,126 (GRCm39) |
missense |
probably damaging |
0.98 |
|
P0026:Dapk1
|
UTSW |
13 |
60,865,963 (GRCm39) |
splice site |
probably benign |
|
|
R0116:Dapk1
|
UTSW |
13 |
60,908,914 (GRCm39) |
missense |
probably benign |
|
|
R0165:Dapk1
|
UTSW |
13 |
60,909,407 (GRCm39) |
missense |
probably benign |
0.39 |
|
R0357:Dapk1
|
UTSW |
13 |
60,877,372 (GRCm39) |
nonsense |
probably null |
|
|
R0446:Dapk1
|
UTSW |
13 |
60,873,101 (GRCm39) |
splice site |
probably null |
|
|
R0502:Dapk1
|
UTSW |
13 |
60,878,662 (GRCm39) |
splice site |
probably null |
|
|
R0503:Dapk1
|
UTSW |
13 |
60,878,662 (GRCm39) |
splice site |
probably null |
|
|
R0597:Dapk1
|
UTSW |
13 |
60,909,198 (GRCm39) |
missense |
probably benign |
0.40 |
|
R0614:Dapk1
|
UTSW |
13 |
60,865,946 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0751:Dapk1
|
UTSW |
13 |
60,844,112 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0930:Dapk1
|
UTSW |
13 |
60,905,262 (GRCm39) |
missense |
probably benign |
0.14 |
|
R1023:Dapk1
|
UTSW |
13 |
60,878,799 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1033:Dapk1
|
UTSW |
13 |
60,869,679 (GRCm39) |
critical splice donor site |
probably null |
|
|
R1101:Dapk1
|
UTSW |
13 |
60,864,599 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1184:Dapk1
|
UTSW |
13 |
60,844,112 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1430:Dapk1
|
UTSW |
13 |
60,901,957 (GRCm39) |
missense |
probably benign |
0.28 |
|
R1630:Dapk1
|
UTSW |
13 |
60,877,345 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1681:Dapk1
|
UTSW |
13 |
60,866,278 (GRCm39) |
critical splice donor site |
probably null |
|
|
R1799:Dapk1
|
UTSW |
13 |
60,867,468 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2012:Dapk1
|
UTSW |
13 |
60,869,671 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2068:Dapk1
|
UTSW |
13 |
60,899,022 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2131:Dapk1
|
UTSW |
13 |
60,909,481 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
R2131:Dapk1
|
UTSW |
13 |
60,877,345 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R2154:Dapk1
|
UTSW |
13 |
60,877,317 (GRCm39) |
missense |
probably benign |
0.36 |
|
R2288:Dapk1
|
UTSW |
13 |
60,909,563 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2312:Dapk1
|
UTSW |
13 |
60,905,167 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R2362:Dapk1
|
UTSW |
13 |
60,878,745 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R2400:Dapk1
|
UTSW |
13 |
60,900,030 (GRCm39) |
missense |
probably benign |
0.34 |
|
R2909:Dapk1
|
UTSW |
13 |
60,864,631 (GRCm39) |
critical splice donor site |
probably null |
|
|
R2926:Dapk1
|
UTSW |
13 |
60,867,564 (GRCm39) |
missense |
possibly damaging |
0.58 |
|
R3741:Dapk1
|
UTSW |
13 |
60,896,014 (GRCm39) |
missense |
probably benign |
0.09 |
|
R3810:Dapk1
|
UTSW |
13 |
60,908,503 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R4374:Dapk1
|
UTSW |
13 |
60,867,498 (GRCm39) |
missense |
probably benign |
0.01 |
|
R4375:Dapk1
|
UTSW |
13 |
60,909,403 (GRCm39) |
missense |
probably benign |
|
|
R4377:Dapk1
|
UTSW |
13 |
60,867,498 (GRCm39) |
missense |
probably benign |
0.01 |
|
R4490:Dapk1
|
UTSW |
13 |
60,865,942 (GRCm39) |
missense |
probably benign |
0.26 |
|
R4576:Dapk1
|
UTSW |
13 |
60,869,636 (GRCm39) |
missense |
probably benign |
0.13 |
|
R4599:Dapk1
|
UTSW |
13 |
60,865,861 (GRCm39) |
missense |
probably benign |
0.22 |
|
R4682:Dapk1
|
UTSW |
13 |
60,898,961 (GRCm39) |
missense |
probably benign |
0.41 |
|
R4775:Dapk1
|
UTSW |
13 |
60,897,156 (GRCm39) |
missense |
probably benign |
0.02 |
|
R4790:Dapk1
|
UTSW |
13 |
60,870,919 (GRCm39) |
frame shift |
probably null |
|
|
R4897:Dapk1
|
UTSW |
13 |
60,909,600 (GRCm39) |
missense |
probably benign |
0.01 |
|
R4931:Dapk1
|
UTSW |
13 |
60,908,774 (GRCm39) |
missense |
probably benign |
0.04 |
|
R5113:Dapk1
|
UTSW |
13 |
60,869,592 (GRCm39) |
missense |
probably benign |
0.01 |
|
R5503:Dapk1
|
UTSW |
13 |
60,873,126 (GRCm39) |
missense |
probably benign |
0.15 |
|
R5948:Dapk1
|
UTSW |
13 |
60,877,209 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R6012:Dapk1
|
UTSW |
13 |
60,909,476 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6035:Dapk1
|
UTSW |
13 |
60,909,013 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R6035:Dapk1
|
UTSW |
13 |
60,909,013 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R6268:Dapk1
|
UTSW |
13 |
60,909,580 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R6330:Dapk1
|
UTSW |
13 |
60,909,140 (GRCm39) |
missense |
probably benign |
0.01 |
|
R6331:Dapk1
|
UTSW |
13 |
60,877,256 (GRCm39) |
nonsense |
probably null |
|
|
R6553:Dapk1
|
UTSW |
13 |
60,908,975 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6598:Dapk1
|
UTSW |
13 |
60,909,161 (GRCm39) |
missense |
probably benign |
0.03 |
|
R6602:Dapk1
|
UTSW |
13 |
60,897,018 (GRCm39) |
missense |
probably benign |
0.20 |
|
R6640:Dapk1
|
UTSW |
13 |
60,864,628 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6684:Dapk1
|
UTSW |
13 |
60,908,708 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6747:Dapk1
|
UTSW |
13 |
60,873,154 (GRCm39) |
missense |
probably benign |
0.22 |
|
R6799:Dapk1
|
UTSW |
13 |
60,900,049 (GRCm39) |
missense |
probably benign |
|
|
R6809:Dapk1
|
UTSW |
13 |
60,899,103 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6915:Dapk1
|
UTSW |
13 |
60,844,256 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6949:Dapk1
|
UTSW |
13 |
60,884,138 (GRCm39) |
missense |
probably benign |
0.11 |
|
R6979:Dapk1
|
UTSW |
13 |
60,896,095 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7161:Dapk1
|
UTSW |
13 |
60,844,209 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R7171:Dapk1
|
UTSW |
13 |
60,909,599 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R7199:Dapk1
|
UTSW |
13 |
60,902,024 (GRCm39) |
missense |
probably benign |
0.02 |
|
R7203:Dapk1
|
UTSW |
13 |
60,844,149 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R7404:Dapk1
|
UTSW |
13 |
60,867,455 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7448:Dapk1
|
UTSW |
13 |
60,898,990 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7480:Dapk1
|
UTSW |
13 |
60,905,311 (GRCm39) |
missense |
probably benign |
0.18 |
|
R7532:Dapk1
|
UTSW |
13 |
60,878,700 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7574:Dapk1
|
UTSW |
13 |
60,908,987 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7711:Dapk1
|
UTSW |
13 |
60,909,365 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7753:Dapk1
|
UTSW |
13 |
60,899,007 (GRCm39) |
missense |
possibly damaging |
0.58 |
|
R7804:Dapk1
|
UTSW |
13 |
60,873,153 (GRCm39) |
missense |
probably benign |
0.41 |
|
R7822:Dapk1
|
UTSW |
13 |
60,873,715 (GRCm39) |
missense |
probably benign |
0.05 |
|
R7973:Dapk1
|
UTSW |
13 |
60,909,377 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8103:Dapk1
|
UTSW |
13 |
60,897,009 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R8121:Dapk1
|
UTSW |
13 |
60,909,212 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8245:Dapk1
|
UTSW |
13 |
60,878,710 (GRCm39) |
missense |
probably benign |
|
|
R8401:Dapk1
|
UTSW |
13 |
60,870,904 (GRCm39) |
missense |
probably benign |
0.01 |
|
R8419:Dapk1
|
UTSW |
13 |
60,887,911 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8926:Dapk1
|
UTSW |
13 |
60,908,734 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R9063:Dapk1
|
UTSW |
13 |
60,866,264 (GRCm39) |
missense |
probably benign |
0.06 |
|
R9131:Dapk1
|
UTSW |
13 |
60,909,208 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9176:Dapk1
|
UTSW |
13 |
60,866,262 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9301:Dapk1
|
UTSW |
13 |
60,866,125 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R9407:Dapk1
|
UTSW |
13 |
60,898,991 (GRCm39) |
nonsense |
probably null |
|
|
R9491:Dapk1
|
UTSW |
13 |
60,877,369 (GRCm39) |
missense |
probably benign |
0.44 |
|
R9510:Dapk1
|
UTSW |
13 |
60,910,203 (GRCm39) |
missense |
unknown |
|
|
R9624:Dapk1
|
UTSW |
13 |
60,895,937 (GRCm39) |
missense |
probably benign |
0.31 |
|
R9726:Dapk1
|
UTSW |
13 |
60,898,948 (GRCm39) |
missense |
probably benign |
0.25 |
|
R9794:Dapk1
|
UTSW |
13 |
60,909,082 (GRCm39) |
missense |
probably damaging |
0.98 |
|
Z1176:Dapk1
|
UTSW |
13 |
60,908,618 (GRCm39) |
frame shift |
probably null |
|
|
| Predicted Primers |
PCR Primer
(F):5'- TGTCACCCTATGAGAAGGAAAAC -3'
(R):5'- TAAAAGCTGCACCAGGACATG -3'
Sequencing Primer
(F):5'- ACACTGTGGTTCTAAGGGGAGC -3'
(R):5'- GGACATGGCCAAAAGAACAATAC -3'
|
| Posted On |
2016-06-28 |
Incidental Mutation