Incidental Mutation 'R4707:Mrc2'
| ID |
397237 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Mrc2
|
| Ensembl Gene |
ENSMUSG00000020695 |
| Gene Name |
mannose receptor, C type 2 |
| Synonyms |
Endo180, uPARAP, novel lectin |
| MMRRC Submission |
041955-MU
|
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
R4707 (G1)
|
| Quality Score |
225 |
|
Status
|
Not validated
|
| Chromosome |
11 |
| Chromosomal Location |
105183469-105241965 bp(+) (GRCm39) |
| Type of Mutation |
splice site (5 bp from exon) |
| DNA Base Change (assembly) |
G to A
at 105239257 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000097909
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000021038]
[ENSMUST00000100335]
|
| AlphaFold |
Q64449 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000021038
|
| SMART Domains |
Protein: ENSMUSP00000021038
Gene: ENSMUSG00000020695
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
30 |
N/A |
INTRINSIC |
|
RICIN
|
40 |
160 |
8.49e-12 |
SMART |
|
FN2
|
179 |
227 |
4.83e-27 |
SMART |
|
CLECT
|
234 |
359 |
1.15e-33 |
SMART |
|
CLECT
|
381 |
504 |
1.47e-40 |
SMART |
|
CLECT
|
520 |
644 |
6.82e-27 |
SMART |
|
CLECT
|
668 |
808 |
2.71e-30 |
SMART |
|
CLECT
|
824 |
950 |
6.77e-31 |
SMART |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000100335
|
| SMART Domains |
Protein: ENSMUSP00000097909
Gene: ENSMUSG00000020695
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
30 |
N/A |
INTRINSIC |
|
RICIN
|
40 |
160 |
8.49e-12 |
SMART |
|
FN2
|
179 |
227 |
4.83e-27 |
SMART |
|
CLECT
|
234 |
359 |
1.15e-33 |
SMART |
|
CLECT
|
381 |
504 |
1.47e-40 |
SMART |
|
CLECT
|
520 |
644 |
6.82e-27 |
SMART |
|
CLECT
|
668 |
808 |
2.71e-30 |
SMART |
|
CLECT
|
824 |
950 |
6.77e-31 |
SMART |
|
CLECT
|
971 |
1107 |
3.91e-36 |
SMART |
|
CLECT
|
1124 |
1243 |
1.04e-17 |
SMART |
|
CLECT
|
1259 |
1392 |
9.08e-23 |
SMART |
|
transmembrane domain
|
1412 |
1434 |
N/A |
INTRINSIC |
|
| Meta Mutation Damage Score |
0.9755 |
| Coding Region Coverage |
- 1x: 99.2%
- 3x: 98.5%
- 10x: 97.0%
- 20x: 94.7%
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the mannose receptor family of proteins that contain a fibronectin type II domain and multiple C-type lectin-like domains. The encoded protein plays a role in extracellular matrix remodeling by mediating the internalization and lysosomal degradation of collagen ligands. Expression of this gene may play a role in the tumorigenesis and metastasis of several malignancies including breast cancer, gliomas and metastatic bone disease. [provided by RefSeq, Feb 2012]
PHENOTYPE: Homozygous mice are visibly normal, viable and have no reproductive defects. Mouse embryonic fibroblasts derived from null mice exhibit decreased migration while bone marrow-derived macrophages exhibit increased migration. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 115 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 1700010I14Rik |
A |
G |
17: 9,224,544 (GRCm39) |
K450R |
probably damaging |
Het |
| Abcd2 |
T |
C |
15: 91,043,385 (GRCm39) |
D601G |
probably benign |
Het |
| Abcf3 |
A |
G |
16: 20,367,808 (GRCm39) |
K56E |
possibly damaging |
Het |
| Acaca |
T |
C |
11: 84,203,680 (GRCm39) |
V1477A |
probably damaging |
Het |
| Adamts20 |
G |
A |
15: 94,231,528 (GRCm39) |
P887L |
possibly damaging |
Het |
| Ahnak |
T |
G |
19: 8,994,099 (GRCm39) |
S5128A |
probably benign |
Het |
| Ahsa2 |
C |
A |
11: 23,443,162 (GRCm39) |
V197F |
probably benign |
Het |
| Ak9 |
C |
A |
10: 41,221,456 (GRCm39) |
H402N |
probably benign |
Het |
| Alpk1 |
G |
T |
3: 127,481,241 (GRCm39) |
N175K |
possibly damaging |
Het |
| Als2 |
A |
G |
1: 59,254,472 (GRCm39) |
V295A |
probably benign |
Het |
| Ankrd16 |
A |
G |
2: 11,783,608 (GRCm39) |
D70G |
probably damaging |
Het |
| Apob |
A |
T |
12: 8,056,205 (GRCm39) |
K1562N |
probably damaging |
Het |
| Arfgap2 |
C |
A |
2: 91,100,316 (GRCm39) |
S250R |
probably damaging |
Het |
| Arhgef10l |
C |
T |
4: 140,264,194 (GRCm39) |
M671I |
possibly damaging |
Het |
| Atrnl1 |
A |
G |
19: 57,617,590 (GRCm39) |
I122V |
probably damaging |
Het |
| B4galnt2 |
C |
T |
11: 95,766,923 (GRCm39) |
|
probably null |
Het |
| C8a |
A |
G |
4: 104,713,618 (GRCm39) |
Y171H |
probably damaging |
Het |
| Cacnb4 |
A |
G |
2: 52,364,927 (GRCm39) |
V112A |
probably benign |
Het |
| Capn9 |
G |
T |
8: 125,340,195 (GRCm39) |
C566F |
possibly damaging |
Het |
| Ccdc88a |
T |
A |
11: 29,397,956 (GRCm39) |
S230T |
probably benign |
Het |
| Cd300c2 |
A |
T |
11: 114,887,811 (GRCm39) |
F197Y |
probably benign |
Het |
| Chd5 |
A |
G |
4: 152,445,039 (GRCm39) |
Y340C |
probably damaging |
Het |
| Chrd |
A |
T |
16: 20,557,558 (GRCm39) |
I726F |
possibly damaging |
Het |
| Chrna10 |
G |
A |
7: 101,762,426 (GRCm39) |
P255S |
possibly damaging |
Het |
| Clasp1 |
T |
A |
1: 118,470,927 (GRCm39) |
Y197* |
probably null |
Het |
| Cyp2c69 |
C |
G |
19: 39,837,852 (GRCm39) |
G410A |
probably benign |
Het |
| Cyp2e1 |
G |
A |
7: 140,343,821 (GRCm39) |
V20I |
possibly damaging |
Het |
| Dapp1 |
T |
C |
3: 137,638,928 (GRCm39) |
D225G |
probably benign |
Het |
| Dnah5 |
A |
T |
15: 28,372,521 (GRCm39) |
D2924V |
probably damaging |
Het |
| Efcab12 |
A |
T |
6: 115,791,510 (GRCm39) |
L554Q |
possibly damaging |
Het |
| Emsy |
T |
C |
7: 98,246,311 (GRCm39) |
T228A |
possibly damaging |
Het |
| Evc2 |
G |
A |
5: 37,579,204 (GRCm39) |
V1106I |
probably benign |
Het |
| Exoc8 |
G |
T |
8: 125,624,209 (GRCm39) |
Q53K |
possibly damaging |
Het |
| Fbn2 |
A |
T |
18: 58,189,344 (GRCm39) |
V1594D |
probably damaging |
Het |
| Fer1l4 |
T |
C |
2: 155,887,543 (GRCm39) |
Y551C |
possibly damaging |
Het |
| Fhip1a |
G |
T |
3: 85,595,877 (GRCm39) |
T115K |
probably damaging |
Het |
| Fmnl3 |
A |
G |
15: 99,221,362 (GRCm39) |
M481T |
probably benign |
Het |
| Fras1 |
A |
G |
5: 96,883,097 (GRCm39) |
N2543S |
probably damaging |
Het |
| Fsd2 |
T |
C |
7: 81,209,428 (GRCm39) |
D138G |
probably damaging |
Het |
| Gda |
C |
T |
19: 21,405,992 (GRCm39) |
V5I |
probably benign |
Het |
| Glt8d2 |
A |
T |
10: 82,496,583 (GRCm39) |
D158E |
probably damaging |
Het |
| Gpx6 |
C |
T |
13: 21,496,434 (GRCm39) |
Q3* |
probably null |
Het |
| Greb1l |
A |
G |
18: 10,532,922 (GRCm39) |
M830V |
probably benign |
Het |
| Hnrnpul1 |
A |
C |
7: 25,426,258 (GRCm39) |
V531G |
probably damaging |
Het |
| Ifi206 |
A |
T |
1: 173,308,432 (GRCm39) |
H521Q |
probably benign |
Het |
| Igsf3 |
G |
C |
3: 101,365,410 (GRCm39) |
R1127P |
probably benign |
Het |
| Il1rl1 |
A |
G |
1: 40,489,348 (GRCm39) |
R367G |
probably damaging |
Het |
| Islr |
T |
C |
9: 58,064,970 (GRCm39) |
D179G |
possibly damaging |
Het |
| Jcad |
G |
T |
18: 4,649,338 (GRCm39) |
E70* |
probably null |
Het |
| Kcnd2 |
T |
C |
6: 21,723,211 (GRCm39) |
I467T |
probably benign |
Het |
| Lrrc27 |
A |
G |
7: 138,822,614 (GRCm39) |
T502A |
probably benign |
Het |
| Lrrtm3 |
T |
A |
10: 63,923,781 (GRCm39) |
H462L |
probably benign |
Het |
| Mbd5 |
T |
C |
2: 49,140,168 (GRCm39) |
L44S |
probably damaging |
Het |
| Mccc1 |
C |
A |
3: 36,030,022 (GRCm39) |
M429I |
probably damaging |
Het |
| Mgam |
A |
T |
6: 40,691,566 (GRCm39) |
|
probably null |
Het |
| Mipep |
T |
A |
14: 61,109,552 (GRCm39) |
I643N |
probably damaging |
Het |
| Mmrn1 |
A |
T |
6: 60,965,457 (GRCm39) |
I1162L |
probably benign |
Het |
| Mug1 |
G |
A |
6: 121,861,600 (GRCm39) |
C1354Y |
probably damaging |
Het |
| Nbeal2 |
A |
T |
9: 110,461,123 (GRCm39) |
S1647T |
probably benign |
Het |
| Ndufaf2 |
C |
G |
13: 108,189,314 (GRCm39) |
A145P |
probably damaging |
Het |
| Nedd9 |
A |
T |
13: 41,492,051 (GRCm39) |
|
probably null |
Het |
| Nr4a2 |
T |
A |
2: 57,002,105 (GRCm39) |
H116L |
probably benign |
Het |
| Nwd2 |
A |
G |
5: 63,951,665 (GRCm39) |
Y232C |
probably damaging |
Het |
| Odf4 |
A |
G |
11: 68,817,514 (GRCm39) |
L58P |
probably damaging |
Het |
| Or2a20 |
T |
A |
6: 43,193,883 (GRCm39) |
V12D |
probably benign |
Het |
| Or4a27 |
T |
A |
2: 88,559,056 (GRCm39) |
M296L |
possibly damaging |
Het |
| Or4c116 |
A |
T |
2: 88,942,576 (GRCm39) |
F93L |
probably damaging |
Het |
| Or4g17 |
T |
A |
2: 111,209,990 (GRCm39) |
L215H |
probably damaging |
Het |
| Or7e165 |
C |
T |
9: 19,694,596 (GRCm39) |
H18Y |
probably damaging |
Het |
| Or8g24 |
A |
G |
9: 38,989,558 (GRCm39) |
V161A |
probably benign |
Het |
| Or8s5 |
G |
T |
15: 98,238,659 (GRCm39) |
H70Q |
possibly damaging |
Het |
| Orc6 |
T |
A |
8: 86,029,579 (GRCm39) |
I41K |
probably damaging |
Het |
| Pikfyve |
A |
G |
1: 65,307,005 (GRCm39) |
T1798A |
probably benign |
Het |
| Prdx6b |
T |
C |
2: 80,123,404 (GRCm39) |
L71P |
probably damaging |
Het |
| Prmt2 |
A |
G |
10: 76,062,055 (GRCm39) |
I50T |
probably damaging |
Het |
| Ptdss1 |
T |
C |
13: 67,143,482 (GRCm39) |
|
probably null |
Het |
| Pygl |
T |
C |
12: 70,254,532 (GRCm39) |
T138A |
possibly damaging |
Het |
| Rab3c |
T |
C |
13: 110,198,434 (GRCm39) |
E198G |
probably benign |
Het |
| Rbl2 |
A |
G |
8: 91,812,196 (GRCm39) |
Y255C |
probably damaging |
Het |
| Rev3l |
T |
A |
10: 39,699,393 (GRCm39) |
S1297T |
probably damaging |
Het |
| Rgma |
C |
A |
7: 73,067,564 (GRCm39) |
T367K |
probably damaging |
Het |
| Rps6ka5 |
C |
T |
12: 100,564,144 (GRCm39) |
|
probably null |
Het |
| Rslcan18 |
A |
T |
13: 67,246,590 (GRCm39) |
C217S |
probably damaging |
Het |
| Rtp3 |
A |
G |
9: 110,815,279 (GRCm39) |
|
probably benign |
Het |
| Ryr1 |
A |
T |
7: 28,745,087 (GRCm39) |
N3848K |
probably damaging |
Het |
| Sema6a |
T |
A |
18: 47,381,779 (GRCm39) |
T923S |
probably benign |
Het |
| Serpinb6d |
A |
T |
13: 33,855,336 (GRCm39) |
T337S |
possibly damaging |
Het |
| Sf3b1 |
G |
A |
1: 55,029,666 (GRCm39) |
T1112M |
probably damaging |
Het |
| Shroom3 |
G |
T |
5: 93,090,945 (GRCm39) |
V1151F |
probably damaging |
Het |
| Sidt1 |
A |
T |
16: 44,090,221 (GRCm39) |
Y369* |
probably null |
Het |
| Slc16a6 |
A |
G |
11: 109,354,193 (GRCm39) |
S59P |
probably benign |
Het |
| Slc25a17 |
A |
C |
15: 81,211,527 (GRCm39) |
L163W |
probably damaging |
Het |
| Slc44a3 |
T |
C |
3: 121,320,723 (GRCm39) |
T93A |
possibly damaging |
Het |
| Sptbn1 |
T |
C |
11: 30,087,197 (GRCm39) |
T1081A |
possibly damaging |
Het |
| Sptbn4 |
T |
C |
7: 27,116,431 (GRCm39) |
D456G |
probably benign |
Het |
| Sycp1 |
C |
A |
3: 102,760,805 (GRCm39) |
A703S |
possibly damaging |
Het |
| Tas2r118 |
T |
A |
6: 23,969,225 (GRCm39) |
M279L |
probably benign |
Het |
| Tc2n |
T |
G |
12: 101,660,832 (GRCm39) |
Q133H |
probably benign |
Het |
| Tctn1 |
A |
G |
5: 122,399,468 (GRCm39) |
|
probably null |
Het |
| Tenm4 |
A |
C |
7: 96,423,253 (GRCm39) |
K683Q |
probably damaging |
Het |
| Tex10 |
A |
T |
4: 48,468,984 (GRCm39) |
S64T |
probably benign |
Het |
| Tex15 |
A |
G |
8: 34,072,525 (GRCm39) |
T2691A |
probably benign |
Het |
| Tmem175 |
A |
T |
5: 108,790,016 (GRCm39) |
T123S |
probably damaging |
Het |
| Tsc1 |
C |
A |
2: 28,562,419 (GRCm39) |
S348R |
probably damaging |
Het |
| Ttll4 |
A |
T |
1: 74,718,166 (GRCm39) |
T6S |
possibly damaging |
Het |
| Ttll8 |
A |
T |
15: 88,801,293 (GRCm39) |
I465N |
probably damaging |
Het |
| Ubr3 |
A |
G |
2: 69,768,714 (GRCm39) |
|
probably benign |
Het |
| Ugdh |
A |
T |
5: 65,580,695 (GRCm39) |
|
probably null |
Het |
| Usp34 |
T |
C |
11: 23,437,215 (GRCm39) |
L3326S |
probably damaging |
Het |
| Vmn2r125 |
A |
T |
4: 156,702,276 (GRCm39) |
I21F |
probably damaging |
Het |
| Vps9d1 |
G |
A |
8: 123,975,351 (GRCm39) |
|
probably benign |
Het |
| Xab2 |
G |
A |
8: 3,668,117 (GRCm39) |
R154C |
possibly damaging |
Het |
| Zbtb12 |
T |
C |
17: 35,114,475 (GRCm39) |
S87P |
probably damaging |
Het |
| Zc3h12a |
A |
G |
4: 125,014,686 (GRCm39) |
M266T |
probably damaging |
Het |
| Zfp108 |
G |
A |
7: 23,959,837 (GRCm39) |
A143T |
probably benign |
Het |
|
| Other mutations in Mrc2 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01105:Mrc2
|
APN |
11 |
105,219,567 (GRCm39) |
missense |
probably damaging |
0.96 |
|
IGL01374:Mrc2
|
APN |
11 |
105,238,469 (GRCm39) |
nonsense |
probably null |
|
|
IGL01751:Mrc2
|
APN |
11 |
105,216,560 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL01780:Mrc2
|
APN |
11 |
105,216,547 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01835:Mrc2
|
APN |
11 |
105,227,503 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02350:Mrc2
|
APN |
11 |
105,216,547 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02357:Mrc2
|
APN |
11 |
105,216,547 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02829:Mrc2
|
APN |
11 |
105,227,533 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
IGL02863:Mrc2
|
APN |
11 |
105,224,446 (GRCm39) |
splice site |
probably benign |
|
|
IGL02940:Mrc2
|
APN |
11 |
105,231,997 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02988:Mrc2
|
UTSW |
11 |
105,216,397 (GRCm39) |
missense |
probably benign |
0.04 |
|
R0254:Mrc2
|
UTSW |
11 |
105,238,692 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0634:Mrc2
|
UTSW |
11 |
105,238,518 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1102:Mrc2
|
UTSW |
11 |
105,231,647 (GRCm39) |
missense |
probably benign |
|
|
R1233:Mrc2
|
UTSW |
11 |
105,239,241 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1244:Mrc2
|
UTSW |
11 |
105,239,257 (GRCm39) |
splice site |
probably null |
|
|
R1458:Mrc2
|
UTSW |
11 |
105,228,598 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1500:Mrc2
|
UTSW |
11 |
105,238,551 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1573:Mrc2
|
UTSW |
11 |
105,227,482 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1770:Mrc2
|
UTSW |
11 |
105,229,619 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1842:Mrc2
|
UTSW |
11 |
105,228,546 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R2156:Mrc2
|
UTSW |
11 |
105,238,682 (GRCm39) |
splice site |
probably null |
|
|
R2165:Mrc2
|
UTSW |
11 |
105,239,257 (GRCm39) |
splice site |
probably null |
|
|
R2265:Mrc2
|
UTSW |
11 |
105,239,257 (GRCm39) |
splice site |
probably null |
|
|
R2266:Mrc2
|
UTSW |
11 |
105,239,257 (GRCm39) |
splice site |
probably null |
|
|
R2267:Mrc2
|
UTSW |
11 |
105,239,257 (GRCm39) |
splice site |
probably null |
|
|
R2268:Mrc2
|
UTSW |
11 |
105,239,257 (GRCm39) |
splice site |
probably null |
|
|
R2269:Mrc2
|
UTSW |
11 |
105,239,257 (GRCm39) |
splice site |
probably null |
|
|
R2270:Mrc2
|
UTSW |
11 |
105,239,257 (GRCm39) |
splice site |
probably null |
|
|
R2271:Mrc2
|
UTSW |
11 |
105,239,257 (GRCm39) |
splice site |
probably null |
|
|
R2272:Mrc2
|
UTSW |
11 |
105,239,257 (GRCm39) |
splice site |
probably null |
|
|
R2296:Mrc2
|
UTSW |
11 |
105,239,257 (GRCm39) |
splice site |
probably null |
|
|
R2298:Mrc2
|
UTSW |
11 |
105,239,257 (GRCm39) |
splice site |
probably null |
|
|
R2300:Mrc2
|
UTSW |
11 |
105,239,257 (GRCm39) |
splice site |
probably null |
|
|
R2326:Mrc2
|
UTSW |
11 |
105,239,257 (GRCm39) |
splice site |
probably null |
|
|
R2518:Mrc2
|
UTSW |
11 |
105,239,257 (GRCm39) |
splice site |
probably null |
|
|
R2519:Mrc2
|
UTSW |
11 |
105,239,257 (GRCm39) |
splice site |
probably null |
|
|
R2520:Mrc2
|
UTSW |
11 |
105,239,257 (GRCm39) |
splice site |
probably null |
|
|
R2895:Mrc2
|
UTSW |
11 |
105,239,257 (GRCm39) |
splice site |
probably null |
|
|
R3029:Mrc2
|
UTSW |
11 |
105,239,257 (GRCm39) |
splice site |
probably null |
|
|
R3030:Mrc2
|
UTSW |
11 |
105,239,257 (GRCm39) |
splice site |
probably null |
|
|
R3079:Mrc2
|
UTSW |
11 |
105,227,539 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R3122:Mrc2
|
UTSW |
11 |
105,239,257 (GRCm39) |
splice site |
probably null |
|
|
R3149:Mrc2
|
UTSW |
11 |
105,239,257 (GRCm39) |
splice site |
probably null |
|
|
R3150:Mrc2
|
UTSW |
11 |
105,239,257 (GRCm39) |
splice site |
probably null |
|
|
R3420:Mrc2
|
UTSW |
11 |
105,239,257 (GRCm39) |
splice site |
probably null |
|
|
R3422:Mrc2
|
UTSW |
11 |
105,239,257 (GRCm39) |
splice site |
probably null |
|
|
R3441:Mrc2
|
UTSW |
11 |
105,238,542 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
R3726:Mrc2
|
UTSW |
11 |
105,239,257 (GRCm39) |
splice site |
probably null |
|
|
R3731:Mrc2
|
UTSW |
11 |
105,239,257 (GRCm39) |
splice site |
probably null |
|
|
R3800:Mrc2
|
UTSW |
11 |
105,239,257 (GRCm39) |
splice site |
probably null |
|
|
R3820:Mrc2
|
UTSW |
11 |
105,239,257 (GRCm39) |
splice site |
probably null |
|
|
R3821:Mrc2
|
UTSW |
11 |
105,239,257 (GRCm39) |
splice site |
probably null |
|
|
R3837:Mrc2
|
UTSW |
11 |
105,239,257 (GRCm39) |
splice site |
probably null |
|
|
R3838:Mrc2
|
UTSW |
11 |
105,239,257 (GRCm39) |
splice site |
probably null |
|
|
R3849:Mrc2
|
UTSW |
11 |
105,183,729 (GRCm39) |
critical splice donor site |
probably null |
|
|
R3850:Mrc2
|
UTSW |
11 |
105,183,729 (GRCm39) |
critical splice donor site |
probably null |
|
|
R3914:Mrc2
|
UTSW |
11 |
105,238,058 (GRCm39) |
splice site |
probably benign |
|
|
R3932:Mrc2
|
UTSW |
11 |
105,239,257 (GRCm39) |
splice site |
probably null |
|
|
R3933:Mrc2
|
UTSW |
11 |
105,239,257 (GRCm39) |
splice site |
probably null |
|
|
R3971:Mrc2
|
UTSW |
11 |
105,218,857 (GRCm39) |
missense |
possibly damaging |
0.65 |
|
R4105:Mrc2
|
UTSW |
11 |
105,239,257 (GRCm39) |
splice site |
probably null |
|
|
R4107:Mrc2
|
UTSW |
11 |
105,239,257 (GRCm39) |
splice site |
probably null |
|
|
R4113:Mrc2
|
UTSW |
11 |
105,239,257 (GRCm39) |
splice site |
probably null |
|
|
R4274:Mrc2
|
UTSW |
11 |
105,239,257 (GRCm39) |
splice site |
probably null |
|
|
R4399:Mrc2
|
UTSW |
11 |
105,227,484 (GRCm39) |
nonsense |
probably null |
|
|
R4477:Mrc2
|
UTSW |
11 |
105,239,257 (GRCm39) |
splice site |
probably null |
|
|
R4478:Mrc2
|
UTSW |
11 |
105,239,257 (GRCm39) |
splice site |
probably null |
|
|
R4493:Mrc2
|
UTSW |
11 |
105,239,257 (GRCm39) |
splice site |
probably null |
|
|
R4494:Mrc2
|
UTSW |
11 |
105,239,257 (GRCm39) |
splice site |
probably null |
|
|
R4495:Mrc2
|
UTSW |
11 |
105,239,257 (GRCm39) |
splice site |
probably null |
|
|
R4547:Mrc2
|
UTSW |
11 |
105,227,467 (GRCm39) |
missense |
probably benign |
0.04 |
|
R4600:Mrc2
|
UTSW |
11 |
105,239,257 (GRCm39) |
splice site |
probably null |
|
|
R4601:Mrc2
|
UTSW |
11 |
105,239,257 (GRCm39) |
splice site |
probably null |
|
|
R4602:Mrc2
|
UTSW |
11 |
105,239,257 (GRCm39) |
splice site |
probably null |
|
|
R4603:Mrc2
|
UTSW |
11 |
105,239,257 (GRCm39) |
splice site |
probably null |
|
|
R4610:Mrc2
|
UTSW |
11 |
105,239,257 (GRCm39) |
splice site |
probably null |
|
|
R4611:Mrc2
|
UTSW |
11 |
105,239,257 (GRCm39) |
splice site |
probably null |
|
|
R4637:Mrc2
|
UTSW |
11 |
105,239,257 (GRCm39) |
splice site |
probably null |
|
|
R4672:Mrc2
|
UTSW |
11 |
105,233,923 (GRCm39) |
missense |
probably benign |
0.22 |
|
R4674:Mrc2
|
UTSW |
11 |
105,239,257 (GRCm39) |
splice site |
probably null |
|
|
R4675:Mrc2
|
UTSW |
11 |
105,239,257 (GRCm39) |
splice site |
probably null |
|
|
R4693:Mrc2
|
UTSW |
11 |
105,234,528 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4706:Mrc2
|
UTSW |
11 |
105,239,257 (GRCm39) |
splice site |
probably null |
|
|
R4791:Mrc2
|
UTSW |
11 |
105,239,257 (GRCm39) |
splice site |
probably null |
|
|
R4792:Mrc2
|
UTSW |
11 |
105,239,257 (GRCm39) |
splice site |
probably null |
|
|
R4888:Mrc2
|
UTSW |
11 |
105,232,034 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5523:Mrc2
|
UTSW |
11 |
105,234,408 (GRCm39) |
missense |
probably benign |
|
|
R5600:Mrc2
|
UTSW |
11 |
105,224,492 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5634:Mrc2
|
UTSW |
11 |
105,227,040 (GRCm39) |
nonsense |
probably null |
|
|
R5692:Mrc2
|
UTSW |
11 |
105,227,468 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5706:Mrc2
|
UTSW |
11 |
105,223,169 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5775:Mrc2
|
UTSW |
11 |
105,228,639 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6140:Mrc2
|
UTSW |
11 |
105,237,615 (GRCm39) |
missense |
probably benign |
|
|
R6146:Mrc2
|
UTSW |
11 |
105,216,470 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R6225:Mrc2
|
UTSW |
11 |
105,237,646 (GRCm39) |
missense |
probably benign |
0.01 |
|
R6437:Mrc2
|
UTSW |
11 |
105,240,669 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6618:Mrc2
|
UTSW |
11 |
105,240,708 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6675:Mrc2
|
UTSW |
11 |
105,233,906 (GRCm39) |
splice site |
probably null |
|
|
R6680:Mrc2
|
UTSW |
11 |
105,216,579 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R6868:Mrc2
|
UTSW |
11 |
105,219,244 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6979:Mrc2
|
UTSW |
11 |
105,239,461 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R7038:Mrc2
|
UTSW |
11 |
105,223,062 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R7303:Mrc2
|
UTSW |
11 |
105,216,629 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7320:Mrc2
|
UTSW |
11 |
105,220,061 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R7422:Mrc2
|
UTSW |
11 |
105,183,609 (GRCm39) |
start gained |
probably benign |
|
|
R7537:Mrc2
|
UTSW |
11 |
105,183,623 (GRCm39) |
missense |
probably benign |
|
|
R7640:Mrc2
|
UTSW |
11 |
105,223,121 (GRCm39) |
missense |
possibly damaging |
0.48 |
|
R7709:Mrc2
|
UTSW |
11 |
105,237,285 (GRCm39) |
missense |
probably benign |
0.10 |
|
R7885:Mrc2
|
UTSW |
11 |
105,223,092 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R7976:Mrc2
|
UTSW |
11 |
105,238,829 (GRCm39) |
missense |
possibly damaging |
0.74 |
|
R8042:Mrc2
|
UTSW |
11 |
105,239,181 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R8096:Mrc2
|
UTSW |
11 |
105,234,333 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8353:Mrc2
|
UTSW |
11 |
105,223,137 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R8453:Mrc2
|
UTSW |
11 |
105,223,137 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R8519:Mrc2
|
UTSW |
11 |
105,238,132 (GRCm39) |
missense |
possibly damaging |
0.62 |
|
R8771:Mrc2
|
UTSW |
11 |
105,240,596 (GRCm39) |
missense |
probably benign |
|
|
R8787:Mrc2
|
UTSW |
11 |
105,238,465 (GRCm39) |
missense |
probably benign |
|
|
R8925:Mrc2
|
UTSW |
11 |
105,216,334 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8927:Mrc2
|
UTSW |
11 |
105,216,334 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8991:Mrc2
|
UTSW |
11 |
105,229,740 (GRCm39) |
missense |
probably benign |
|
|
R9017:Mrc2
|
UTSW |
11 |
105,216,711 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9096:Mrc2
|
UTSW |
11 |
105,231,398 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9097:Mrc2
|
UTSW |
11 |
105,231,398 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9223:Mrc2
|
UTSW |
11 |
105,220,093 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9471:Mrc2
|
UTSW |
11 |
105,234,559 (GRCm39) |
missense |
probably benign |
0.03 |
|
R9531:Mrc2
|
UTSW |
11 |
105,240,731 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
T0970:Mrc2
|
UTSW |
11 |
105,238,453 (GRCm39) |
missense |
probably benign |
0.41 |
|
X0004:Mrc2
|
UTSW |
11 |
105,238,453 (GRCm39) |
missense |
probably benign |
0.41 |
|
X0062:Mrc2
|
UTSW |
11 |
105,238,301 (GRCm39) |
critical splice donor site |
probably null |
|
|
Z1176:Mrc2
|
UTSW |
11 |
105,238,186 (GRCm39) |
nonsense |
probably null |
|
|
Z1176:Mrc2
|
UTSW |
11 |
105,232,202 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
| Predicted Primers |
PCR Primer
(F):5'- CTTGAGCTGCCAGAGAAGAG -3'
(R):5'- CTGTGGAAGGAACCCATTGG -3'
Sequencing Primer
(F):5'- GGTCTATCACCATAAGGAGAATCTGC -3'
(R):5'- CCATTGGGAAGGTGTGGGAATG -3'
|
| Posted On |
2016-06-28 |
Incidental Mutation