Incidental Mutation 'R5168:Or51f23'
ID 397396
Institutional Source Beutler Lab
Gene Symbol Or51f23
Ensembl Gene ENSMUSG00000048469
Gene Name olfactory receptor family 51 subfamily F member 23
Synonyms GA_x6K02T2PBJ9-5513635-5514627, MOR14-10, Olfr564
MMRRC Submission 042748-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.087) question?
Stock # R5168 (G1)
Quality Score 225
Status Validated
Chromosome 7
Chromosomal Location 102452687-102453637 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to T at 102453528 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Alanine to Valine at position 281 (A281V)
Ref Sequence ENSEMBL: ENSMUSP00000129376 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000061096]
AlphaFold E9PWA8
Predicted Effect probably benign
Transcript: ENSMUST00000061096
AA Change: A281V

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000129376
Gene: ENSMUSG00000048469
AA Change: A281V

DomainStartEndE-ValueType
Pfam:7tm_4 33 312 3.6e-117 PFAM
Pfam:7TM_GPCR_Srsx 38 256 4.7e-8 PFAM
Pfam:7tm_1 43 294 2.5e-20 PFAM
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.7%
  • 10x: 97.3%
  • 20x: 95.5%
Validation Efficiency 96% (47/49)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 41 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca1 T C 4: 53,086,070 (GRCm39) N478D probably benign Het
Acsl1 T A 8: 46,966,303 (GRCm39) probably benign Het
Aox1 T A 1: 58,088,561 (GRCm39) C116S probably damaging Het
Bag6 T C 17: 35,363,671 (GRCm39) L785P probably damaging Het
Calcr T C 6: 3,708,610 (GRCm39) N192S probably benign Het
Cntrl T A 2: 35,047,667 (GRCm39) L1414H probably damaging Het
Cntrob T A 11: 69,190,816 (GRCm39) I849F possibly damaging Het
Col6a3 C T 1: 90,701,361 (GRCm39) W2518* probably null Het
Cxcl15 T A 5: 90,943,142 (GRCm39) I48K probably damaging Het
Dab2 T C 15: 6,365,924 (GRCm39) probably benign Het
Ddx54 A G 5: 120,755,097 (GRCm39) E82G probably benign Het
Dock1 T C 7: 134,720,637 (GRCm39) W1249R probably damaging Het
Fras1 A C 5: 96,856,616 (GRCm39) M2000L probably benign Het
Gpr31b A T 17: 13,270,326 (GRCm39) I281N probably damaging Het
Gvin3 T C 7: 106,196,054 (GRCm39) noncoding transcript Het
Haus5 T C 7: 30,357,136 (GRCm39) T432A possibly damaging Het
Hecw2 A G 1: 53,952,459 (GRCm39) S925P probably damaging Het
Katnal1 A G 5: 148,858,132 (GRCm39) M26T possibly damaging Het
Mccc1 C T 3: 36,044,929 (GRCm39) W71* probably null Het
Muc6 G A 7: 141,223,981 (GRCm39) probably benign Het
Nrbp1 T A 5: 31,407,481 (GRCm39) V397D probably damaging Het
Nt5dc1 T A 10: 34,273,236 (GRCm39) E187D probably benign Het
Or1e19 T A 11: 73,316,669 (GRCm39) I47F probably benign Het
Polr1c G T 17: 46,558,635 (GRCm39) probably benign Het
Pramel27 T C 4: 143,579,768 (GRCm39) V451A probably benign Het
Ralgapa1 A G 12: 55,804,817 (GRCm39) V493A probably benign Het
Ryr2 T C 13: 11,767,207 (GRCm39) T1228A probably benign Het
Slc26a3 G A 12: 31,518,553 (GRCm39) V674I possibly damaging Het
Spata31f1a C T 4: 42,851,488 (GRCm39) V223I probably damaging Het
Srp68 C A 11: 116,156,300 (GRCm39) E147D probably damaging Het
Tacr3 T C 3: 134,535,320 (GRCm39) I96T probably damaging Het
Tmem236 T C 2: 14,197,139 (GRCm39) probably null Het
Tmem62 T A 2: 120,824,088 (GRCm39) N254K probably benign Het
Tmem79 A T 3: 88,240,651 (GRCm39) L99Q probably damaging Het
Trav6-5 A T 14: 53,728,973 (GRCm39) N78Y probably benign Het
Trim33 C T 3: 103,248,997 (GRCm39) Q807* probably null Het
Ugt1a10 A G 1: 87,983,531 (GRCm39) T110A probably benign Het
Vcl C T 14: 21,060,170 (GRCm39) T603I probably damaging Het
Vps8 A T 16: 21,276,195 (GRCm39) T243S probably damaging Het
Vps8 A C 16: 21,351,849 (GRCm39) I323L probably benign Het
Zfp746 G C 6: 48,041,329 (GRCm39) Q465E possibly damaging Het
Other mutations in Or51f23
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01392:Or51f23 APN 7 102,453,061 (GRCm39) nonsense probably null
IGL03248:Or51f23 APN 7 102,452,846 (GRCm39) nonsense probably null
R1108:Or51f23 UTSW 7 102,453,057 (GRCm39) missense probably benign 0.08
R1395:Or51f23 UTSW 7 102,453,414 (GRCm39) missense possibly damaging 0.90
R1422:Or51f23 UTSW 7 102,453,057 (GRCm39) missense probably benign 0.08
R4032:Or51f23 UTSW 7 102,453,396 (GRCm39) missense probably benign 0.00
R5269:Or51f23 UTSW 7 102,453,327 (GRCm39) missense probably benign
R5639:Or51f23 UTSW 7 102,453,200 (GRCm39) missense probably benign
R5930:Or51f23 UTSW 7 102,453,481 (GRCm39) missense probably damaging 1.00
R6019:Or51f23 UTSW 7 102,453,491 (GRCm39) nonsense probably null
R7206:Or51f23 UTSW 7 102,452,891 (GRCm39) missense probably damaging 1.00
R7254:Or51f23 UTSW 7 102,452,765 (GRCm39) missense probably benign
R7845:Or51f23 UTSW 7 102,453,492 (GRCm39) missense not run
R8036:Or51f23 UTSW 7 102,452,763 (GRCm39) missense possibly damaging 0.87
R8730:Or51f23 UTSW 7 102,453,348 (GRCm39) missense probably benign 0.00
R9156:Or51f23 UTSW 7 102,453,339 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- CAGAACTGTCCTCAGCATTGC -3'
(R):5'- TGCCTTCTTGCTTAAACCTGAAG -3'

Sequencing Primer
(F):5'- TCAGCATTGCTTCCCCAG -3'
(R):5'- TTGCAACATGAGCATCAATCTAC -3'
Posted On 2016-07-06