Incidental Mutation 'R5168:Gvin3'
| ID |
397397 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Gvin3
|
| Ensembl Gene |
ENSMUSG00000073902 |
| Gene Name |
GTPase, very large interferon inducible, family member 3 |
| Synonyms |
Gm1966 |
| MMRRC Submission |
042748-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.098)
|
| Stock # |
R5168 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
7 |
| Chromosomal Location |
106195950-106203242 bp(-) (GRCm39) |
| Type of Mutation |
exon |
| DNA Base Change (assembly) |
T to C
at 106196054 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
|
| Gene Model |
predicted gene model for transcript(s):
|
| AlphaFold |
no structure available at present |
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000184540
|
| Coding Region Coverage |
- 1x: 99.3%
- 3x: 98.7%
- 10x: 97.3%
- 20x: 95.5%
|
| Validation Efficiency |
96% (47/49) |
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 41 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Abca1 |
T |
C |
4: 53,086,070 (GRCm39) |
N478D |
probably benign |
Het |
| Acsl1 |
T |
A |
8: 46,966,303 (GRCm39) |
|
probably benign |
Het |
| Aox1 |
T |
A |
1: 58,088,561 (GRCm39) |
C116S |
probably damaging |
Het |
| Bag6 |
T |
C |
17: 35,363,671 (GRCm39) |
L785P |
probably damaging |
Het |
| Calcr |
T |
C |
6: 3,708,610 (GRCm39) |
N192S |
probably benign |
Het |
| Cntrl |
T |
A |
2: 35,047,667 (GRCm39) |
L1414H |
probably damaging |
Het |
| Cntrob |
T |
A |
11: 69,190,816 (GRCm39) |
I849F |
possibly damaging |
Het |
| Col6a3 |
C |
T |
1: 90,701,361 (GRCm39) |
W2518* |
probably null |
Het |
| Cxcl15 |
T |
A |
5: 90,943,142 (GRCm39) |
I48K |
probably damaging |
Het |
| Dab2 |
T |
C |
15: 6,365,924 (GRCm39) |
|
probably benign |
Het |
| Ddx54 |
A |
G |
5: 120,755,097 (GRCm39) |
E82G |
probably benign |
Het |
| Dock1 |
T |
C |
7: 134,720,637 (GRCm39) |
W1249R |
probably damaging |
Het |
| Fras1 |
A |
C |
5: 96,856,616 (GRCm39) |
M2000L |
probably benign |
Het |
| Gpr31b |
A |
T |
17: 13,270,326 (GRCm39) |
I281N |
probably damaging |
Het |
| Haus5 |
T |
C |
7: 30,357,136 (GRCm39) |
T432A |
possibly damaging |
Het |
| Hecw2 |
A |
G |
1: 53,952,459 (GRCm39) |
S925P |
probably damaging |
Het |
| Katnal1 |
A |
G |
5: 148,858,132 (GRCm39) |
M26T |
possibly damaging |
Het |
| Mccc1 |
C |
T |
3: 36,044,929 (GRCm39) |
W71* |
probably null |
Het |
| Muc6 |
G |
A |
7: 141,223,981 (GRCm39) |
|
probably benign |
Het |
| Nrbp1 |
T |
A |
5: 31,407,481 (GRCm39) |
V397D |
probably damaging |
Het |
| Nt5dc1 |
T |
A |
10: 34,273,236 (GRCm39) |
E187D |
probably benign |
Het |
| Or1e19 |
T |
A |
11: 73,316,669 (GRCm39) |
I47F |
probably benign |
Het |
| Or51f23 |
C |
T |
7: 102,453,528 (GRCm39) |
A281V |
probably benign |
Het |
| Polr1c |
G |
T |
17: 46,558,635 (GRCm39) |
|
probably benign |
Het |
| Pramel27 |
T |
C |
4: 143,579,768 (GRCm39) |
V451A |
probably benign |
Het |
| Ralgapa1 |
A |
G |
12: 55,804,817 (GRCm39) |
V493A |
probably benign |
Het |
| Ryr2 |
T |
C |
13: 11,767,207 (GRCm39) |
T1228A |
probably benign |
Het |
| Slc26a3 |
G |
A |
12: 31,518,553 (GRCm39) |
V674I |
possibly damaging |
Het |
| Spata31f1a |
C |
T |
4: 42,851,488 (GRCm39) |
V223I |
probably damaging |
Het |
| Srp68 |
C |
A |
11: 116,156,300 (GRCm39) |
E147D |
probably damaging |
Het |
| Tacr3 |
T |
C |
3: 134,535,320 (GRCm39) |
I96T |
probably damaging |
Het |
| Tmem236 |
T |
C |
2: 14,197,139 (GRCm39) |
|
probably null |
Het |
| Tmem62 |
T |
A |
2: 120,824,088 (GRCm39) |
N254K |
probably benign |
Het |
| Tmem79 |
A |
T |
3: 88,240,651 (GRCm39) |
L99Q |
probably damaging |
Het |
| Trav6-5 |
A |
T |
14: 53,728,973 (GRCm39) |
N78Y |
probably benign |
Het |
| Trim33 |
C |
T |
3: 103,248,997 (GRCm39) |
Q807* |
probably null |
Het |
| Ugt1a10 |
A |
G |
1: 87,983,531 (GRCm39) |
T110A |
probably benign |
Het |
| Vcl |
C |
T |
14: 21,060,170 (GRCm39) |
T603I |
probably damaging |
Het |
| Vps8 |
A |
T |
16: 21,276,195 (GRCm39) |
T243S |
probably damaging |
Het |
| Vps8 |
A |
C |
16: 21,351,849 (GRCm39) |
I323L |
probably benign |
Het |
| Zfp746 |
G |
C |
6: 48,041,329 (GRCm39) |
Q465E |
possibly damaging |
Het |
|
| Other mutations in Gvin3 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01400:Gvin3
|
APN |
7 |
106,201,242 (GRCm39) |
missense |
probably benign |
0.10 |
|
IGL01410:Gvin3
|
APN |
7 |
106,202,258 (GRCm39) |
exon |
noncoding transcript |
|
|
IGL01415:Gvin3
|
APN |
7 |
106,202,258 (GRCm39) |
exon |
noncoding transcript |
|
|
IGL01538:Gvin3
|
APN |
7 |
106,201,744 (GRCm39) |
missense |
probably damaging |
0.96 |
|
IGL01751:Gvin3
|
APN |
7 |
106,201,516 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
IGL01916:Gvin3
|
APN |
7 |
106,201,033 (GRCm39) |
missense |
probably benign |
0.28 |
|
IGL02171:Gvin3
|
APN |
7 |
106,200,548 (GRCm39) |
exon |
noncoding transcript |
|
|
IGL02550:Gvin3
|
APN |
7 |
106,200,846 (GRCm39) |
exon |
noncoding transcript |
|
|
H8562:Gvin3
|
UTSW |
7 |
106,202,356 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0016:Gvin3
|
UTSW |
7 |
106,202,453 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0178:Gvin3
|
UTSW |
7 |
106,201,028 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0420:Gvin3
|
UTSW |
7 |
106,203,090 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0658:Gvin3
|
UTSW |
7 |
106,202,093 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R1378:Gvin3
|
UTSW |
7 |
106,201,373 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R1506:Gvin3
|
UTSW |
7 |
106,200,788 (GRCm39) |
missense |
probably benign |
0.08 |
|
R1628:Gvin3
|
UTSW |
7 |
106,202,476 (GRCm39) |
nonsense |
probably null |
|
|
R1834:Gvin3
|
UTSW |
7 |
106,202,983 (GRCm39) |
missense |
possibly damaging |
0.79 |
|
R1888:Gvin3
|
UTSW |
7 |
106,196,630 (GRCm39) |
exon |
noncoding transcript |
|
|
R2145:Gvin3
|
UTSW |
7 |
106,202,215 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
R4056:Gvin3
|
UTSW |
7 |
106,203,216 (GRCm39) |
missense |
possibly damaging |
0.59 |
|
R4067:Gvin3
|
UTSW |
7 |
106,198,772 (GRCm39) |
exon |
noncoding transcript |
|
|
R4631:Gvin3
|
UTSW |
7 |
106,198,730 (GRCm39) |
exon |
noncoding transcript |
|
|
R4817:Gvin3
|
UTSW |
7 |
106,200,437 (GRCm39) |
exon |
noncoding transcript |
|
|
R4900:Gvin3
|
UTSW |
7 |
106,197,793 (GRCm39) |
exon |
noncoding transcript |
|
|
R4970:Gvin3
|
UTSW |
7 |
106,199,864 (GRCm39) |
exon |
noncoding transcript |
|
|
R5009:Gvin3
|
UTSW |
7 |
106,200,767 (GRCm39) |
exon |
noncoding transcript |
|
|
R5050:Gvin3
|
UTSW |
7 |
106,196,179 (GRCm39) |
exon |
noncoding transcript |
|
|
R5086:Gvin3
|
UTSW |
7 |
106,197,234 (GRCm39) |
exon |
noncoding transcript |
|
|
R5090:Gvin3
|
UTSW |
7 |
106,200,109 (GRCm39) |
exon |
noncoding transcript |
|
|
R5260:Gvin3
|
UTSW |
7 |
106,198,411 (GRCm39) |
exon |
noncoding transcript |
|
|
R5331:Gvin3
|
UTSW |
7 |
106,197,958 (GRCm39) |
exon |
noncoding transcript |
|
|
R5389:Gvin3
|
UTSW |
7 |
106,197,442 (GRCm39) |
exon |
noncoding transcript |
|
|
R5433:Gvin3
|
UTSW |
7 |
106,199,314 (GRCm39) |
exon |
noncoding transcript |
|
|
R5488:Gvin3
|
UTSW |
7 |
106,200,797 (GRCm39) |
exon |
noncoding transcript |
|
|
R5489:Gvin3
|
UTSW |
7 |
106,200,797 (GRCm39) |
exon |
noncoding transcript |
|
|
R5504:Gvin3
|
UTSW |
7 |
106,201,951 (GRCm39) |
exon |
noncoding transcript |
|
|
R5956:Gvin3
|
UTSW |
7 |
106,200,677 (GRCm39) |
exon |
noncoding transcript |
|
|
| Predicted Primers |
PCR Primer
(F):5'- TAGGCTGCCTTGGCTAAAG -3'
(R):5'- GGAAACAGTGTCCCTTTTGTAATG -3'
Sequencing Primer
(F):5'- GGCTAAAGTAAAACTTCTGTGGCCTG -3'
(R):5'- AGACCACTTCGTCACTGATG -3'
|
| Posted On |
2016-07-06 |
Incidental Mutation