Incidental Mutation 'R5170:Nwd2'
ID 397494
Institutional Source Beutler Lab
Gene Symbol Nwd2
Ensembl Gene ENSMUSG00000090061
Gene Name NACHT and WD repeat domain containing 2
Synonyms 3110047P20Rik, B830017A01Rik
MMRRC Submission 042750-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.120) question?
Stock # R5170 (G1)
Quality Score 225
Status Not validated
Chromosome 5
Chromosomal Location 63806446-63967889 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 63963380 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Asparagine to Isoleucine at position 988 (N988I)
Ref Sequence ENSEMBL: ENSMUSP00000124712 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000159584]
AlphaFold Q6P5U7
Predicted Effect probably damaging
Transcript: ENSMUST00000159584
AA Change: N988I

PolyPhen 2 Score 0.991 (Sensitivity: 0.71; Specificity: 0.97)
SMART Domains Protein: ENSMUSP00000124712
Gene: ENSMUSG00000090061
AA Change: N988I

DomainStartEndE-ValueType
Pfam:DUF4062 42 145 1.5e-8 PFAM
Blast:AAA 408 691 3e-29 BLAST
WD40 939 995 1.06e2 SMART
WD40 998 1037 8.96e-2 SMART
Blast:WD40 1091 1126 9e-19 BLAST
Blast:WD40 1129 1170 1e-17 BLAST
Blast:WD40 1220 1260 3e-16 BLAST
WD40 1263 1302 3.4e-2 SMART
WD40 1347 1385 2.65e1 SMART
WD40 1386 1425 1.58e2 SMART
Blast:WD40 1466 1507 3e-19 BLAST
Blast:WD40 1606 1644 4e-18 BLAST
Blast:KR 1686 1730 2e-16 BLAST
Predicted Effect probably benign
Transcript: ENSMUST00000162757
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.3%
  • 20x: 95.4%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 40 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acox3 A G 5: 35,745,969 (GRCm39) I51V probably benign Het
Agbl2 A G 2: 90,633,541 (GRCm39) K559R probably benign Het
Arhgap30 A G 1: 171,235,618 (GRCm39) D664G probably benign Het
BC034090 A G 1: 155,089,396 (GRCm39) V798A probably damaging Het
Bdp1 A T 13: 100,167,302 (GRCm39) C2237* probably null Het
C3 C T 17: 57,530,938 (GRCm39) V388M probably damaging Het
Ccdc170 G A 10: 4,464,200 (GRCm39) E60K probably damaging Het
Cdh8 G A 8: 100,006,182 (GRCm39) T135M probably damaging Het
Cep131 G T 11: 119,961,435 (GRCm39) A572E probably damaging Het
Clec16a A G 16: 10,559,655 (GRCm39) Y976C probably benign Het
Cplx3 G A 9: 57,522,902 (GRCm39) R153* probably null Het
Defa41 A T 8: 21,691,696 (GRCm39) D26V probably damaging Het
Dmpk C G 7: 18,821,944 (GRCm39) L301V probably benign Het
Eno3 A G 11: 70,553,040 (GRCm39) I393V probably benign Het
Fbxo47 A G 11: 97,748,520 (GRCm39) V305A probably benign Het
Fry G A 5: 150,353,319 (GRCm39) V1779M probably benign Het
Gtse1 T C 15: 85,748,465 (GRCm39) probably null Het
Gucy2e A T 11: 69,126,396 (GRCm39) L328Q probably damaging Het
Ifi207 T C 1: 173,558,064 (GRCm39) T225A unknown Het
Igkv4-80 A C 6: 68,993,649 (GRCm39) S81A probably benign Het
Lamc3 A T 2: 31,777,356 (GRCm39) M1L probably benign Het
Myo16 A G 8: 10,619,745 (GRCm39) D1432G probably benign Het
Otx1 C A 11: 21,947,037 (GRCm39) A91S probably damaging Het
Parp14 T C 16: 35,677,649 (GRCm39) E773G probably benign Het
Psen1 T A 12: 83,761,636 (GRCm39) M146K probably damaging Het
Ptx4 G A 17: 25,342,152 (GRCm39) R209Q probably benign Het
Slc13a2 T C 11: 78,291,634 (GRCm39) T340A probably damaging Het
St8sia1 T C 6: 142,909,434 (GRCm39) K21E probably damaging Het
Stxbp1 T C 2: 32,684,686 (GRCm39) D581G probably benign Het
Sumo2 G A 11: 115,425,486 (GRCm39) probably benign Het
Supt5 G A 7: 28,015,508 (GRCm39) P910S probably benign Het
Tbc1d30 T C 10: 121,142,743 (GRCm39) Q158R possibly damaging Het
Tenm2 T A 11: 35,915,633 (GRCm39) H1968L probably damaging Het
Trmt1 T C 8: 85,421,861 (GRCm39) Y220H probably damaging Het
Trp73 C T 4: 154,189,295 (GRCm39) E60K possibly damaging Het
Ttn A G 2: 76,617,413 (GRCm39) Y8026H probably damaging Het
Zar1l A G 5: 150,441,050 (GRCm39) probably null Het
Zfp740 T C 15: 102,117,640 (GRCm39) Y117H probably damaging Het
Zfp941 G A 7: 140,392,870 (GRCm39) probably benign Het
Zp1 C A 19: 10,897,918 (GRCm39) V8F possibly damaging Het
Other mutations in Nwd2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00325:Nwd2 APN 5 63,962,818 (GRCm39) missense probably benign
IGL01111:Nwd2 APN 5 63,964,643 (GRCm39) missense probably damaging 1.00
IGL01152:Nwd2 APN 5 63,963,872 (GRCm39) missense possibly damaging 0.74
IGL01307:Nwd2 APN 5 63,965,626 (GRCm39) missense possibly damaging 0.95
IGL01449:Nwd2 APN 5 63,962,937 (GRCm39) missense probably damaging 1.00
IGL01624:Nwd2 APN 5 63,964,153 (GRCm39) missense probably damaging 1.00
IGL01997:Nwd2 APN 5 63,961,938 (GRCm39) missense probably damaging 0.99
IGL02007:Nwd2 APN 5 63,962,042 (GRCm39) missense possibly damaging 0.87
IGL02143:Nwd2 APN 5 63,948,996 (GRCm39) splice site probably null
IGL02184:Nwd2 APN 5 63,963,020 (GRCm39) missense probably damaging 1.00
IGL02379:Nwd2 APN 5 63,962,644 (GRCm39) missense probably damaging 1.00
IGL02489:Nwd2 APN 5 63,962,570 (GRCm39) missense probably damaging 1.00
IGL02580:Nwd2 APN 5 63,965,512 (GRCm39) missense probably damaging 0.99
IGL02682:Nwd2 APN 5 63,962,021 (GRCm39) missense probably damaging 1.00
IGL02682:Nwd2 APN 5 63,962,020 (GRCm39) missense probably benign 0.03
IGL02891:Nwd2 APN 5 63,882,570 (GRCm39) missense possibly damaging 0.91
IGL03135:Nwd2 APN 5 63,963,338 (GRCm39) missense probably damaging 1.00
IGL03149:Nwd2 APN 5 63,963,338 (GRCm39) missense probably damaging 1.00
R0113:Nwd2 UTSW 5 63,965,241 (GRCm39) missense probably damaging 1.00
R0172:Nwd2 UTSW 5 63,963,712 (GRCm39) missense probably benign 0.44
R0196:Nwd2 UTSW 5 63,963,694 (GRCm39) missense probably benign 0.37
R0239:Nwd2 UTSW 5 63,957,467 (GRCm39) missense probably benign 0.01
R0239:Nwd2 UTSW 5 63,957,467 (GRCm39) missense probably benign 0.01
R0309:Nwd2 UTSW 5 63,964,561 (GRCm39) missense probably damaging 1.00
R0311:Nwd2 UTSW 5 63,962,341 (GRCm39) missense probably damaging 0.99
R0335:Nwd2 UTSW 5 63,962,116 (GRCm39) missense probably benign 0.00
R0384:Nwd2 UTSW 5 63,963,025 (GRCm39) missense probably benign 0.11
R0496:Nwd2 UTSW 5 63,963,686 (GRCm39) missense probably damaging 0.99
R0497:Nwd2 UTSW 5 63,963,686 (GRCm39) missense probably damaging 0.99
R0498:Nwd2 UTSW 5 63,963,686 (GRCm39) missense probably damaging 0.99
R0505:Nwd2 UTSW 5 63,962,454 (GRCm39) missense probably damaging 1.00
R0655:Nwd2 UTSW 5 63,948,928 (GRCm39) missense possibly damaging 0.73
R0762:Nwd2 UTSW 5 63,957,757 (GRCm39) missense probably benign 0.33
R0835:Nwd2 UTSW 5 63,957,473 (GRCm39) missense probably damaging 0.99
R0926:Nwd2 UTSW 5 63,965,234 (GRCm39) missense probably damaging 0.99
R0948:Nwd2 UTSW 5 63,964,655 (GRCm39) missense probably damaging 1.00
R1015:Nwd2 UTSW 5 63,964,154 (GRCm39) missense probably damaging 1.00
R1086:Nwd2 UTSW 5 63,963,917 (GRCm39) missense probably damaging 1.00
R1186:Nwd2 UTSW 5 63,807,367 (GRCm39) utr 5 prime probably benign
R1305:Nwd2 UTSW 5 63,902,540 (GRCm39) missense probably damaging 0.97
R1542:Nwd2 UTSW 5 63,964,318 (GRCm39) missense probably damaging 1.00
R1548:Nwd2 UTSW 5 63,957,525 (GRCm39) missense probably benign 0.00
R1553:Nwd2 UTSW 5 63,957,848 (GRCm39) missense probably benign 0.00
R1636:Nwd2 UTSW 5 63,964,900 (GRCm39) missense probably damaging 1.00
R1658:Nwd2 UTSW 5 63,964,589 (GRCm39) missense probably damaging 1.00
R1763:Nwd2 UTSW 5 63,965,614 (GRCm39) missense probably benign
R1800:Nwd2 UTSW 5 63,962,917 (GRCm39) missense probably benign 0.15
R1813:Nwd2 UTSW 5 63,962,753 (GRCm39) missense probably benign 0.00
R1861:Nwd2 UTSW 5 63,962,197 (GRCm39) missense probably damaging 0.96
R1889:Nwd2 UTSW 5 63,965,009 (GRCm39) missense possibly damaging 0.49
R1896:Nwd2 UTSW 5 63,962,753 (GRCm39) missense probably benign 0.00
R1919:Nwd2 UTSW 5 63,963,523 (GRCm39) missense probably damaging 1.00
R1922:Nwd2 UTSW 5 63,951,585 (GRCm39) missense probably benign
R2258:Nwd2 UTSW 5 63,962,499 (GRCm39) missense probably benign 0.00
R2292:Nwd2 UTSW 5 63,962,917 (GRCm39) missense probably benign 0.15
R2504:Nwd2 UTSW 5 63,961,717 (GRCm39) missense probably benign 0.02
R2869:Nwd2 UTSW 5 63,957,671 (GRCm39) missense probably benign 0.00
R2869:Nwd2 UTSW 5 63,957,671 (GRCm39) missense probably benign 0.00
R2958:Nwd2 UTSW 5 63,963,325 (GRCm39) missense probably benign 0.01
R3034:Nwd2 UTSW 5 63,957,446 (GRCm39) missense probably damaging 1.00
R3422:Nwd2 UTSW 5 63,882,536 (GRCm39) missense possibly damaging 0.46
R3423:Nwd2 UTSW 5 63,957,504 (GRCm39) missense probably damaging 1.00
R3439:Nwd2 UTSW 5 63,961,895 (GRCm39) missense probably benign 0.00
R4193:Nwd2 UTSW 5 63,964,808 (GRCm39) missense probably damaging 1.00
R4254:Nwd2 UTSW 5 63,963,889 (GRCm39) missense possibly damaging 0.74
R4384:Nwd2 UTSW 5 63,963,914 (GRCm39) missense probably damaging 1.00
R4707:Nwd2 UTSW 5 63,951,665 (GRCm39) missense probably damaging 1.00
R4713:Nwd2 UTSW 5 63,961,803 (GRCm39) missense probably benign 0.00
R4735:Nwd2 UTSW 5 63,965,594 (GRCm39) missense probably benign 0.34
R4744:Nwd2 UTSW 5 63,964,310 (GRCm39) missense probably damaging 1.00
R4795:Nwd2 UTSW 5 63,962,776 (GRCm39) missense probably benign 0.21
R4835:Nwd2 UTSW 5 63,965,189 (GRCm39) missense probably benign 0.00
R4839:Nwd2 UTSW 5 63,962,893 (GRCm39) missense possibly damaging 0.92
R4896:Nwd2 UTSW 5 63,962,151 (GRCm39) missense probably damaging 1.00
R5017:Nwd2 UTSW 5 63,807,484 (GRCm39) utr 5 prime probably benign
R5312:Nwd2 UTSW 5 63,963,415 (GRCm39) nonsense probably null
R5330:Nwd2 UTSW 5 63,963,859 (GRCm39) missense probably benign 0.02
R5331:Nwd2 UTSW 5 63,963,859 (GRCm39) missense probably benign 0.02
R5419:Nwd2 UTSW 5 63,965,051 (GRCm39) missense probably benign 0.11
R5434:Nwd2 UTSW 5 63,964,991 (GRCm39) missense probably benign 0.00
R5445:Nwd2 UTSW 5 63,962,681 (GRCm39) missense probably damaging 1.00
R5761:Nwd2 UTSW 5 63,882,573 (GRCm39) missense probably damaging 1.00
R5788:Nwd2 UTSW 5 63,965,114 (GRCm39) missense probably benign 0.00
R5907:Nwd2 UTSW 5 63,963,326 (GRCm39) missense probably damaging 0.99
R5959:Nwd2 UTSW 5 63,965,413 (GRCm39) missense probably benign 0.32
R6002:Nwd2 UTSW 5 63,962,143 (GRCm39) missense probably benign
R6027:Nwd2 UTSW 5 63,965,563 (GRCm39) missense possibly damaging 0.65
R6082:Nwd2 UTSW 5 63,962,374 (GRCm39) missense possibly damaging 0.96
R6163:Nwd2 UTSW 5 63,963,131 (GRCm39) missense probably benign 0.00
R6172:Nwd2 UTSW 5 63,964,249 (GRCm39) missense probably damaging 0.98
R6334:Nwd2 UTSW 5 63,957,596 (GRCm39) missense possibly damaging 0.95
R6447:Nwd2 UTSW 5 63,964,898 (GRCm39) missense probably benign 0.41
R6649:Nwd2 UTSW 5 63,882,527 (GRCm39) missense possibly damaging 0.89
R6855:Nwd2 UTSW 5 63,961,794 (GRCm39) missense probably benign 0.00
R7034:Nwd2 UTSW 5 63,962,258 (GRCm39) missense probably damaging 1.00
R7168:Nwd2 UTSW 5 63,964,837 (GRCm39) missense probably benign 0.04
R7326:Nwd2 UTSW 5 63,957,752 (GRCm39) missense probably damaging 1.00
R7561:Nwd2 UTSW 5 63,964,434 (GRCm39) nonsense probably null
R7576:Nwd2 UTSW 5 63,964,736 (GRCm39) missense probably benign 0.00
R7580:Nwd2 UTSW 5 63,965,624 (GRCm39) missense probably benign 0.05
R7723:Nwd2 UTSW 5 63,965,347 (GRCm39) missense possibly damaging 0.69
R7769:Nwd2 UTSW 5 63,961,847 (GRCm39) missense probably damaging 0.99
R8293:Nwd2 UTSW 5 63,962,663 (GRCm39) missense probably benign 0.05
R8517:Nwd2 UTSW 5 63,948,925 (GRCm39) missense probably damaging 1.00
R8782:Nwd2 UTSW 5 63,882,540 (GRCm39) missense probably damaging 1.00
R8792:Nwd2 UTSW 5 63,963,047 (GRCm39) missense probably damaging 0.97
R8888:Nwd2 UTSW 5 63,963,241 (GRCm39) missense probably damaging 1.00
R8895:Nwd2 UTSW 5 63,963,241 (GRCm39) missense probably damaging 1.00
R8901:Nwd2 UTSW 5 63,963,685 (GRCm39) missense probably damaging 1.00
R8913:Nwd2 UTSW 5 63,963,440 (GRCm39) missense possibly damaging 0.80
R8920:Nwd2 UTSW 5 63,948,863 (GRCm39) missense probably damaging 1.00
R9052:Nwd2 UTSW 5 63,961,773 (GRCm39) missense probably damaging 1.00
R9362:Nwd2 UTSW 5 63,961,747 (GRCm39) missense probably benign 0.23
R9368:Nwd2 UTSW 5 63,962,306 (GRCm39) missense probably damaging 0.99
R9377:Nwd2 UTSW 5 63,957,740 (GRCm39) missense probably damaging 1.00
R9430:Nwd2 UTSW 5 63,964,665 (GRCm39) missense probably damaging 1.00
R9655:Nwd2 UTSW 5 63,964,568 (GRCm39) nonsense probably null
R9661:Nwd2 UTSW 5 63,957,780 (GRCm39) missense probably damaging 0.97
R9736:Nwd2 UTSW 5 63,951,600 (GRCm39) missense probably damaging 1.00
R9793:Nwd2 UTSW 5 63,964,232 (GRCm39) missense probably damaging 1.00
R9795:Nwd2 UTSW 5 63,964,232 (GRCm39) missense probably damaging 1.00
RF020:Nwd2 UTSW 5 63,963,066 (GRCm39) nonsense probably null
X0023:Nwd2 UTSW 5 63,964,306 (GRCm39) missense probably damaging 0.99
Z1176:Nwd2 UTSW 5 63,963,500 (GRCm39) missense probably damaging 1.00
Z1176:Nwd2 UTSW 5 63,882,540 (GRCm39) missense probably damaging 1.00
Z1177:Nwd2 UTSW 5 63,964,669 (GRCm39) nonsense probably null
Z1177:Nwd2 UTSW 5 63,962,327 (GRCm39) missense possibly damaging 0.60
Predicted Primers PCR Primer
(F):5'- AGTTCCCTGCCCAAACTCAG -3'
(R):5'- ATTGATGTAGGTGGAGCCGC -3'

Sequencing Primer
(F):5'- CAGACACCTCCTTTTAGAATGTGAC -3'
(R):5'- TAGGTGGAGCCGCTTCCATG -3'
Posted On 2016-07-06