Incidental Mutation 'R5170:Supt5'
ID 397503
Institutional Source Beutler Lab
Gene Symbol Supt5
Ensembl Gene ENSMUSG00000003435
Gene Name suppressor of Ty 5
Synonyms Supt5h, Spt5
MMRRC Submission 042750-MU
Accession Numbers
Essential gene? Essential (E-score: 1.000) question?
Stock # R5170 (G1)
Quality Score 225
Status Not validated
Chromosome 7
Chromosomal Location 28314891-28338746 bp(-) (GRCm38)
Type of Mutation missense
DNA Base Change (assembly) G to A at 28316083 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Proline to Serine at position 910 (P910S)
Ref Sequence ENSEMBL: ENSMUSP00000147164 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000003527] [ENSMUST00000081946] [ENSMUST00000207563] [ENSMUST00000209141]
AlphaFold O55201
Predicted Effect probably benign
Transcript: ENSMUST00000003527
AA Change: P910S

PolyPhen 2 Score 0.046 (Sensitivity: 0.94; Specificity: 0.83)
SMART Domains Protein: ENSMUSP00000003527
Gene: ENSMUSG00000003435
AA Change: P910S

DomainStartEndE-ValueType
low complexity region 2 29 N/A INTRINSIC
coiled coil region 36 63 N/A INTRINSIC
Pfam:Spt5_N 73 170 8.1e-17 PFAM
NGN 174 265 2.2e-14 SMART
KOW 270 297 8.77e0 SMART
KOW 417 444 8.69e-4 SMART
KOW 469 496 9.1e-7 SMART
KOW 591 618 2.46e-3 SMART
low complexity region 677 695 N/A INTRINSIC
KOW 697 724 3.93e-2 SMART
CTD 766 902 2.09e-31 SMART
KOW 1028 1055 9.69e-2 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000081946
SMART Domains Protein: ENSMUSP00000080614
Gene: ENSMUSG00000003438

DomainStartEndE-ValueType
low complexity region 2 16 N/A INTRINSIC
transmembrane domain 66 88 N/A INTRINSIC
CPDc 146 274 1.33e-41 SMART
low complexity region 313 330 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000131849
Predicted Effect noncoding transcript
Transcript: ENSMUST00000135220
Predicted Effect noncoding transcript
Transcript: ENSMUST00000136427
Predicted Effect probably benign
Transcript: ENSMUST00000207563
Predicted Effect noncoding transcript
Transcript: ENSMUST00000207649
Predicted Effect noncoding transcript
Transcript: ENSMUST00000207879
Predicted Effect noncoding transcript
Transcript: ENSMUST00000209105
Predicted Effect probably benign
Transcript: ENSMUST00000209141
AA Change: P910S

PolyPhen 2 Score 0.046 (Sensitivity: 0.94; Specificity: 0.83)
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.3%
  • 20x: 95.4%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 40 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acox3 A G 5: 35,588,625 (GRCm38) I51V probably benign Het
Agbl2 A G 2: 90,803,197 (GRCm38) K559R probably benign Het
Arhgap30 A G 1: 171,408,050 (GRCm38) D664G probably benign Het
BC034090 A G 1: 155,213,650 (GRCm38) V798A probably damaging Het
Bdp1 A T 13: 100,030,794 (GRCm38) C2237* probably null Het
C3 C T 17: 57,223,938 (GRCm38) V388M probably damaging Het
Ccdc170 G A 10: 4,514,200 (GRCm38) E60K probably damaging Het
Cdh8 G A 8: 99,279,550 (GRCm38) T135M probably damaging Het
Cep131 G T 11: 120,070,609 (GRCm38) A572E probably damaging Het
Clec16a A G 16: 10,741,791 (GRCm38) Y976C probably benign Het
Dmpk C G 7: 19,088,019 (GRCm38) L301V probably benign Het
Eno3 A G 11: 70,662,214 (GRCm38) I393V probably benign Het
Fbxo47 A G 11: 97,857,694 (GRCm38) V305A probably benign Het
Fry G A 5: 150,429,854 (GRCm38) V1779M probably benign Het
Gm15293 A T 8: 21,201,680 (GRCm38) D26V probably damaging Het
Gtse1 T C 15: 85,864,264 (GRCm38) probably null Het
Gucy2e A T 11: 69,235,570 (GRCm38) L328Q probably damaging Het
Ifi207 T C 1: 173,730,498 (GRCm38) T225A unknown Het
Igkv4-80 A C 6: 69,016,665 (GRCm38) S81A probably benign Het
Lamc3 A T 2: 31,887,344 (GRCm38) M1L probably benign Het
Lman1l G A 9: 57,615,619 (GRCm38) R153* probably null Het
Myo16 A G 8: 10,569,745 (GRCm38) D1432G probably benign Het
Nwd2 A T 5: 63,806,037 (GRCm38) N988I probably damaging Het
Otx1 C A 11: 21,997,037 (GRCm38) A91S probably damaging Het
Parp14 T C 16: 35,857,279 (GRCm38) E773G probably benign Het
Psen1 T A 12: 83,714,862 (GRCm38) M146K probably damaging Het
Ptx4 G A 17: 25,123,178 (GRCm38) R209Q probably benign Het
Slc13a2 T C 11: 78,400,808 (GRCm38) T340A probably damaging Het
St8sia1 T C 6: 142,963,708 (GRCm38) K21E probably damaging Het
Stxbp1 T C 2: 32,794,674 (GRCm38) D581G probably benign Het
Sumo2 G A 11: 115,534,660 (GRCm38) probably benign Het
Tbc1d30 T C 10: 121,306,838 (GRCm38) Q158R possibly damaging Het
Tenm2 T A 11: 36,024,806 (GRCm38) H1968L probably damaging Het
Trmt1 T C 8: 84,695,232 (GRCm38) Y220H probably damaging Het
Trp73 C T 4: 154,104,838 (GRCm38) E60K possibly damaging Het
Ttn A G 2: 76,787,069 (GRCm38) Y8026H probably damaging Het
Zar1l A G 5: 150,517,585 (GRCm38) probably null Het
Zfp740 T C 15: 102,209,205 (GRCm38) Y117H probably damaging Het
Zfp941 G A 7: 140,812,957 (GRCm38) probably benign Het
Zp1 C A 19: 10,920,554 (GRCm38) V8F possibly damaging Het
Other mutations in Supt5
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00468:Supt5 APN 7 28,315,382 (GRCm38) missense probably benign 0.08
IGL01077:Supt5 APN 7 28,323,788 (GRCm38) nonsense probably null
IGL01477:Supt5 APN 7 28,317,264 (GRCm38) missense possibly damaging 0.94
IGL01813:Supt5 APN 7 28,323,975 (GRCm38) missense probably damaging 0.99
IGL02405:Supt5 APN 7 28,315,824 (GRCm38) missense probably benign 0.00
IGL02525:Supt5 APN 7 28,318,947 (GRCm38) splice site probably benign
IGL02584:Supt5 APN 7 28,326,167 (GRCm38) missense probably benign 0.08
IGL03387:Supt5 APN 7 28,320,083 (GRCm38) missense possibly damaging 0.89
R0420:Supt5 UTSW 7 28,317,329 (GRCm38) splice site probably benign
R0715:Supt5 UTSW 7 28,329,037 (GRCm38) missense probably damaging 1.00
R1226:Supt5 UTSW 7 28,328,747 (GRCm38) missense probably benign 0.03
R1655:Supt5 UTSW 7 28,330,024 (GRCm38) missense probably benign 0.00
R1801:Supt5 UTSW 7 28,317,214 (GRCm38) critical splice donor site probably null
R2424:Supt5 UTSW 7 28,315,165 (GRCm38) missense possibly damaging 0.47
R2883:Supt5 UTSW 7 28,329,320 (GRCm38) missense possibly damaging 0.75
R4280:Supt5 UTSW 7 28,317,073 (GRCm38) missense probably damaging 1.00
R4614:Supt5 UTSW 7 28,325,972 (GRCm38) missense possibly damaging 0.65
R4792:Supt5 UTSW 7 28,316,329 (GRCm38) missense probably benign 0.19
R4997:Supt5 UTSW 7 28,316,037 (GRCm38) missense probably benign 0.05
R5041:Supt5 UTSW 7 28,315,380 (GRCm38) missense probably damaging 1.00
R5062:Supt5 UTSW 7 28,329,015 (GRCm38) splice site probably null
R5119:Supt5 UTSW 7 28,316,370 (GRCm38) missense probably damaging 1.00
R5687:Supt5 UTSW 7 28,317,763 (GRCm38) missense probably benign 0.27
R5720:Supt5 UTSW 7 28,322,568 (GRCm38) missense probably damaging 0.97
R5935:Supt5 UTSW 7 28,329,475 (GRCm38) missense probably benign 0.09
R6032:Supt5 UTSW 7 28,316,175 (GRCm38) missense probably damaging 1.00
R6032:Supt5 UTSW 7 28,316,175 (GRCm38) missense probably damaging 1.00
R6049:Supt5 UTSW 7 28,315,197 (GRCm38) missense probably benign 0.32
R7043:Supt5 UTSW 7 28,320,010 (GRCm38) missense probably benign 0.00
R7085:Supt5 UTSW 7 28,331,489 (GRCm38) missense unknown
R7152:Supt5 UTSW 7 28,323,900 (GRCm38) missense probably benign 0.00
R7201:Supt5 UTSW 7 28,316,788 (GRCm38) missense probably benign 0.03
R7401:Supt5 UTSW 7 28,323,772 (GRCm38) missense probably damaging 0.99
R7959:Supt5 UTSW 7 28,315,799 (GRCm38) missense probably benign 0.43
R8181:Supt5 UTSW 7 28,331,474 (GRCm38) missense unknown
R8998:Supt5 UTSW 7 28,338,423 (GRCm38) missense unknown
R8999:Supt5 UTSW 7 28,338,423 (GRCm38) missense unknown
R9021:Supt5 UTSW 7 28,317,246 (GRCm38) missense probably damaging 0.98
R9314:Supt5 UTSW 7 28,320,374 (GRCm38) missense probably damaging 0.99
R9345:Supt5 UTSW 7 28,316,987 (GRCm38) missense probably benign 0.03
R9477:Supt5 UTSW 7 28,326,075 (GRCm38) missense probably damaging 0.99
R9568:Supt5 UTSW 7 28,315,263 (GRCm38) missense probably damaging 1.00
Z1177:Supt5 UTSW 7 28,317,031 (GRCm38) missense possibly damaging 0.90
Predicted Primers PCR Primer
(F):5'- TGTAACCTCCAGGAGAAGGTGC -3'
(R):5'- CAGCCATGTGAGTCCATCAG -3'

Sequencing Primer
(F):5'- GGTCATTGGACTGTAGCCAAC -3'
(R):5'- TGAGCCCGAAAAGCCCTG -3'
Posted On 2016-07-06