Incidental Mutation 'R5170:Supt5'
ID 397503
Institutional Source Beutler Lab
Gene Symbol Supt5
Ensembl Gene ENSMUSG00000003435
Gene Name suppressor of Ty 5, DSIF elongation factor subunit
Synonyms Spt5, Supt5h
MMRRC Submission 042750-MU
Accession Numbers
Essential gene? Essential (E-score: 1.000) question?
Stock # R5170 (G1)
Quality Score 225
Status Not validated
Chromosome 7
Chromosomal Location 28014316-28038171 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to A at 28015508 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Proline to Serine at position 910 (P910S)
Ref Sequence ENSEMBL: ENSMUSP00000147164 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000003527] [ENSMUST00000081946] [ENSMUST00000207563] [ENSMUST00000209141]
AlphaFold O55201
Predicted Effect probably benign
Transcript: ENSMUST00000003527
AA Change: P910S

PolyPhen 2 Score 0.046 (Sensitivity: 0.94; Specificity: 0.83)
SMART Domains Protein: ENSMUSP00000003527
Gene: ENSMUSG00000003435
AA Change: P910S

DomainStartEndE-ValueType
low complexity region 2 29 N/A INTRINSIC
coiled coil region 36 63 N/A INTRINSIC
Pfam:Spt5_N 73 170 8.1e-17 PFAM
NGN 174 265 2.2e-14 SMART
KOW 270 297 8.77e0 SMART
KOW 417 444 8.69e-4 SMART
KOW 469 496 9.1e-7 SMART
KOW 591 618 2.46e-3 SMART
low complexity region 677 695 N/A INTRINSIC
KOW 697 724 3.93e-2 SMART
CTD 766 902 2.09e-31 SMART
KOW 1028 1055 9.69e-2 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000081946
SMART Domains Protein: ENSMUSP00000080614
Gene: ENSMUSG00000003438

DomainStartEndE-ValueType
low complexity region 2 16 N/A INTRINSIC
transmembrane domain 66 88 N/A INTRINSIC
CPDc 146 274 1.33e-41 SMART
low complexity region 313 330 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000131849
Predicted Effect noncoding transcript
Transcript: ENSMUST00000135220
Predicted Effect noncoding transcript
Transcript: ENSMUST00000136427
Predicted Effect probably benign
Transcript: ENSMUST00000207563
Predicted Effect probably benign
Transcript: ENSMUST00000209141
AA Change: P910S

PolyPhen 2 Score 0.046 (Sensitivity: 0.94; Specificity: 0.83)
Predicted Effect noncoding transcript
Transcript: ENSMUST00000207649
Predicted Effect noncoding transcript
Transcript: ENSMUST00000207879
Predicted Effect noncoding transcript
Transcript: ENSMUST00000209105
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.3%
  • 20x: 95.4%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 40 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acox3 A G 5: 35,745,969 (GRCm39) I51V probably benign Het
Agbl2 A G 2: 90,633,541 (GRCm39) K559R probably benign Het
Arhgap30 A G 1: 171,235,618 (GRCm39) D664G probably benign Het
BC034090 A G 1: 155,089,396 (GRCm39) V798A probably damaging Het
Bdp1 A T 13: 100,167,302 (GRCm39) C2237* probably null Het
C3 C T 17: 57,530,938 (GRCm39) V388M probably damaging Het
Ccdc170 G A 10: 4,464,200 (GRCm39) E60K probably damaging Het
Cdh8 G A 8: 100,006,182 (GRCm39) T135M probably damaging Het
Cep131 G T 11: 119,961,435 (GRCm39) A572E probably damaging Het
Clec16a A G 16: 10,559,655 (GRCm39) Y976C probably benign Het
Cplx3 G A 9: 57,522,902 (GRCm39) R153* probably null Het
Defa41 A T 8: 21,691,696 (GRCm39) D26V probably damaging Het
Dmpk C G 7: 18,821,944 (GRCm39) L301V probably benign Het
Eno3 A G 11: 70,553,040 (GRCm39) I393V probably benign Het
Fbxo47 A G 11: 97,748,520 (GRCm39) V305A probably benign Het
Fry G A 5: 150,353,319 (GRCm39) V1779M probably benign Het
Gtse1 T C 15: 85,748,465 (GRCm39) probably null Het
Gucy2e A T 11: 69,126,396 (GRCm39) L328Q probably damaging Het
Ifi207 T C 1: 173,558,064 (GRCm39) T225A unknown Het
Igkv4-80 A C 6: 68,993,649 (GRCm39) S81A probably benign Het
Lamc3 A T 2: 31,777,356 (GRCm39) M1L probably benign Het
Myo16 A G 8: 10,619,745 (GRCm39) D1432G probably benign Het
Nwd2 A T 5: 63,963,380 (GRCm39) N988I probably damaging Het
Otx1 C A 11: 21,947,037 (GRCm39) A91S probably damaging Het
Parp14 T C 16: 35,677,649 (GRCm39) E773G probably benign Het
Psen1 T A 12: 83,761,636 (GRCm39) M146K probably damaging Het
Ptx4 G A 17: 25,342,152 (GRCm39) R209Q probably benign Het
Slc13a2 T C 11: 78,291,634 (GRCm39) T340A probably damaging Het
St8sia1 T C 6: 142,909,434 (GRCm39) K21E probably damaging Het
Stxbp1 T C 2: 32,684,686 (GRCm39) D581G probably benign Het
Sumo2 G A 11: 115,425,486 (GRCm39) probably benign Het
Tbc1d30 T C 10: 121,142,743 (GRCm39) Q158R possibly damaging Het
Tenm2 T A 11: 35,915,633 (GRCm39) H1968L probably damaging Het
Trmt1 T C 8: 85,421,861 (GRCm39) Y220H probably damaging Het
Trp73 C T 4: 154,189,295 (GRCm39) E60K possibly damaging Het
Ttn A G 2: 76,617,413 (GRCm39) Y8026H probably damaging Het
Zar1l A G 5: 150,441,050 (GRCm39) probably null Het
Zfp740 T C 15: 102,117,640 (GRCm39) Y117H probably damaging Het
Zfp941 G A 7: 140,392,870 (GRCm39) probably benign Het
Zp1 C A 19: 10,897,918 (GRCm39) V8F possibly damaging Het
Other mutations in Supt5
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00468:Supt5 APN 7 28,014,807 (GRCm39) missense probably benign 0.08
IGL01077:Supt5 APN 7 28,023,213 (GRCm39) nonsense probably null
IGL01477:Supt5 APN 7 28,016,689 (GRCm39) missense possibly damaging 0.94
IGL01813:Supt5 APN 7 28,023,400 (GRCm39) missense probably damaging 0.99
IGL02405:Supt5 APN 7 28,015,249 (GRCm39) missense probably benign 0.00
IGL02525:Supt5 APN 7 28,018,372 (GRCm39) splice site probably benign
IGL02584:Supt5 APN 7 28,025,592 (GRCm39) missense probably benign 0.08
IGL03387:Supt5 APN 7 28,019,508 (GRCm39) missense possibly damaging 0.89
R0420:Supt5 UTSW 7 28,016,754 (GRCm39) splice site probably benign
R0715:Supt5 UTSW 7 28,028,462 (GRCm39) missense probably damaging 1.00
R1226:Supt5 UTSW 7 28,028,172 (GRCm39) missense probably benign 0.03
R1655:Supt5 UTSW 7 28,029,449 (GRCm39) missense probably benign 0.00
R1801:Supt5 UTSW 7 28,016,639 (GRCm39) critical splice donor site probably null
R2424:Supt5 UTSW 7 28,014,590 (GRCm39) missense possibly damaging 0.47
R2883:Supt5 UTSW 7 28,028,745 (GRCm39) missense possibly damaging 0.75
R4280:Supt5 UTSW 7 28,016,498 (GRCm39) missense probably damaging 1.00
R4614:Supt5 UTSW 7 28,025,397 (GRCm39) missense possibly damaging 0.65
R4792:Supt5 UTSW 7 28,015,754 (GRCm39) missense probably benign 0.19
R4997:Supt5 UTSW 7 28,015,462 (GRCm39) missense probably benign 0.05
R5041:Supt5 UTSW 7 28,014,805 (GRCm39) missense probably damaging 1.00
R5062:Supt5 UTSW 7 28,028,440 (GRCm39) splice site probably null
R5119:Supt5 UTSW 7 28,015,795 (GRCm39) missense probably damaging 1.00
R5687:Supt5 UTSW 7 28,017,188 (GRCm39) missense probably benign 0.27
R5720:Supt5 UTSW 7 28,021,993 (GRCm39) missense probably damaging 0.97
R5935:Supt5 UTSW 7 28,028,900 (GRCm39) missense probably benign 0.09
R6032:Supt5 UTSW 7 28,015,600 (GRCm39) missense probably damaging 1.00
R6032:Supt5 UTSW 7 28,015,600 (GRCm39) missense probably damaging 1.00
R6049:Supt5 UTSW 7 28,014,622 (GRCm39) missense probably benign 0.32
R7043:Supt5 UTSW 7 28,019,435 (GRCm39) missense probably benign 0.00
R7085:Supt5 UTSW 7 28,030,914 (GRCm39) missense unknown
R7152:Supt5 UTSW 7 28,023,325 (GRCm39) missense probably benign 0.00
R7201:Supt5 UTSW 7 28,016,213 (GRCm39) missense probably benign 0.03
R7401:Supt5 UTSW 7 28,023,197 (GRCm39) missense probably damaging 0.99
R7959:Supt5 UTSW 7 28,015,224 (GRCm39) missense probably benign 0.43
R8181:Supt5 UTSW 7 28,030,899 (GRCm39) missense unknown
R8998:Supt5 UTSW 7 28,037,848 (GRCm39) missense unknown
R8999:Supt5 UTSW 7 28,037,848 (GRCm39) missense unknown
R9021:Supt5 UTSW 7 28,016,671 (GRCm39) missense probably damaging 0.98
R9314:Supt5 UTSW 7 28,019,799 (GRCm39) missense probably damaging 0.99
R9345:Supt5 UTSW 7 28,016,412 (GRCm39) missense probably benign 0.03
R9477:Supt5 UTSW 7 28,025,500 (GRCm39) missense probably damaging 0.99
R9568:Supt5 UTSW 7 28,014,688 (GRCm39) missense probably damaging 1.00
Z1177:Supt5 UTSW 7 28,016,456 (GRCm39) missense possibly damaging 0.90
Predicted Primers PCR Primer
(F):5'- TGTAACCTCCAGGAGAAGGTGC -3'
(R):5'- CAGCCATGTGAGTCCATCAG -3'

Sequencing Primer
(F):5'- GGTCATTGGACTGTAGCCAAC -3'
(R):5'- TGAGCCCGAAAAGCCCTG -3'
Posted On 2016-07-06