Mutagenetix > Incidental Mutation

Incidental Mutation 'R5170:Zfp941'

397504

Institutional Source

Beutler Lab

Gene Symbol

Zfp941

Ensembl Gene

ENSMUSG00000060314

Gene Name

zinc finger protein 941

Synonyms

BC066028

MMRRC Submission

042750-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.068) question?

Stock #

R5170 (G1)

Quality Score

225

Status

Not validated

Chromosome

Chromosomal Location

140807449-140822178 bp(-) (GRCm38)

Type of Mutation

unclassified

DNA Base Change (assembly)

G to A at 140812957 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000147965 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000080651] [ENSMUST00000106052] [ENSMUST00000150053]

AlphaFold

Q3URY5

Predicted Effect

unknown
Transcript: ENSMUST00000080651
AA Change: P163L

SMART Domains

Protein: ENSMUSP00000079482
Gene: ENSMUSG00000060314
AA Change: P163L

Domain	Start	End	E-Value	Type
KRAB	4	65	3.88e-21	SMART
ZnF_C2H2	339	361	1.26e-2	SMART
ZnF_C2H2	367	389	1.12e-3	SMART
ZnF_C2H2	395	417	7.78e-3	SMART
ZnF_C2H2	423	445	1.12e-3	SMART
ZnF_C2H2	451	471	1.16e1	SMART
ZnF_C2H2	500	522	2.57e-3	SMART
ZnF_C2H2	528	550	7.9e-4	SMART
ZnF_C2H2	556	578	6.42e-4	SMART
ZnF_C2H2	584	606	1.38e-3	SMART
ZnF_C2H2	612	634	3.69e-4	SMART

Predicted Effect

unknown
Transcript: ENSMUST00000106052
AA Change: P163L

SMART Domains

Protein: ENSMUSP00000101667
Gene: ENSMUSG00000060314
AA Change: P163L

Domain	Start	End	E-Value	Type
KRAB	4	65	3.88e-21	SMART
ZnF_C2H2	339	361	1.26e-2	SMART
ZnF_C2H2	367	389	1.12e-3	SMART
ZnF_C2H2	395	417	7.78e-3	SMART
ZnF_C2H2	423	445	1.12e-3	SMART
ZnF_C2H2	451	471	1.16e1	SMART
ZnF_C2H2	500	522	2.57e-3	SMART
ZnF_C2H2	528	550	7.9e-4	SMART
ZnF_C2H2	556	578	6.42e-4	SMART
ZnF_C2H2	584	606	1.38e-3	SMART
ZnF_C2H2	612	634	3.69e-4	SMART
ZnF_C2H2	640	662	2.99e-4	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000150053

Coding Region Coverage

1x: 99.2%
3x: 98.6%
10x: 97.3%
20x: 95.4%

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 40 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Acox3	A	G	5: 35,588,625 (GRCm38)	I51V	probably benign	Het
Agbl2	A	G	2: 90,803,197 (GRCm38)	K559R	probably benign	Het
Arhgap30	A	G	1: 171,408,050 (GRCm38)	D664G	probably benign	Het
BC034090	A	G	1: 155,213,650 (GRCm38)	V798A	probably damaging	Het
Bdp1	A	T	13: 100,030,794 (GRCm38)	C2237*	probably null	Het
C3	C	T	17: 57,223,938 (GRCm38)	V388M	probably damaging	Het
Ccdc170	G	A	10: 4,514,200 (GRCm38)	E60K	probably damaging	Het
Cdh8	G	A	8: 99,279,550 (GRCm38)	T135M	probably damaging	Het
Cep131	G	T	11: 120,070,609 (GRCm38)	A572E	probably damaging	Het
Clec16a	A	G	16: 10,741,791 (GRCm38)	Y976C	probably benign	Het
Dmpk	C	G	7: 19,088,019 (GRCm38)	L301V	probably benign	Het
Eno3	A	G	11: 70,662,214 (GRCm38)	I393V	probably benign	Het
Fbxo47	A	G	11: 97,857,694 (GRCm38)	V305A	probably benign	Het
Fry	G	A	5: 150,429,854 (GRCm38)	V1779M	probably benign	Het
Gm15293	A	T	8: 21,201,680 (GRCm38)	D26V	probably damaging	Het
Gtse1	T	C	15: 85,864,264 (GRCm38)		probably null	Het
Gucy2e	A	T	11: 69,235,570 (GRCm38)	L328Q	probably damaging	Het
Ifi207	T	C	1: 173,730,498 (GRCm38)	T225A	unknown	Het
Igkv4-80	A	C	6: 69,016,665 (GRCm38)	S81A	probably benign	Het
Lamc3	A	T	2: 31,887,344 (GRCm38)	M1L	probably benign	Het
Lman1l	G	A	9: 57,615,619 (GRCm38)	R153*	probably null	Het
Myo16	A	G	8: 10,569,745 (GRCm38)	D1432G	probably benign	Het
Nwd2	A	T	5: 63,806,037 (GRCm38)	N988I	probably damaging	Het
Otx1	C	A	11: 21,997,037 (GRCm38)	A91S	probably damaging	Het
Parp14	T	C	16: 35,857,279 (GRCm38)	E773G	probably benign	Het
Psen1	T	A	12: 83,714,862 (GRCm38)	M146K	probably damaging	Het
Ptx4	G	A	17: 25,123,178 (GRCm38)	R209Q	probably benign	Het
Slc13a2	T	C	11: 78,400,808 (GRCm38)	T340A	probably damaging	Het
St8sia1	T	C	6: 142,963,708 (GRCm38)	K21E	probably damaging	Het
Stxbp1	T	C	2: 32,794,674 (GRCm38)	D581G	probably benign	Het
Sumo2	G	A	11: 115,534,660 (GRCm38)		probably benign	Het
Supt5	G	A	7: 28,316,083 (GRCm38)	P910S	probably benign	Het
Tbc1d30	T	C	10: 121,306,838 (GRCm38)	Q158R	possibly damaging	Het
Tenm2	T	A	11: 36,024,806 (GRCm38)	H1968L	probably damaging	Het
Trmt1	T	C	8: 84,695,232 (GRCm38)	Y220H	probably damaging	Het
Trp73	C	T	4: 154,104,838 (GRCm38)	E60K	possibly damaging	Het
Ttn	A	G	2: 76,787,069 (GRCm38)	Y8026H	probably damaging	Het
Zar1l	A	G	5: 150,517,585 (GRCm38)		probably null	Het
Zfp740	T	C	15: 102,209,205 (GRCm38)	Y117H	probably damaging	Het
Zp1	C	A	19: 10,920,554 (GRCm38)	V8F	possibly damaging	Het

Other mutations in Zfp941

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01393:Zfp941	APN	7	140,811,928 (GRCm38)	missense	probably damaging	1.00
IGL02399:Zfp941	APN	7	140,812,699 (GRCm38)	missense	probably benign	0.37
IGL03202:Zfp941	APN	7	140,813,053 (GRCm38)	missense	probably benign	0.02
R0025:Zfp941	UTSW	7	140,813,272 (GRCm38)	missense	probably benign	0.01
R0025:Zfp941	UTSW	7	140,813,272 (GRCm38)	missense	probably benign	0.01
R0226:Zfp941	UTSW	7	140,813,275 (GRCm38)	missense	probably damaging	1.00
R0945:Zfp941	UTSW	7	140,811,664 (GRCm38)	missense	probably damaging	0.99
R1455:Zfp941	UTSW	7	140,812,774 (GRCm38)	missense	probably benign	0.29
R1581:Zfp941	UTSW	7	140,812,120 (GRCm38)	missense	probably benign	0.03
R2474:Zfp941	UTSW	7	140,811,471 (GRCm38)	missense	probably damaging	1.00
R4052:Zfp941	UTSW	7	140,812,427 (GRCm38)	missense	possibly damaging	0.81
R4576:Zfp941	UTSW	7	140,811,590 (GRCm38)	nonsense	probably null
R4604:Zfp941	UTSW	7	140,812,211 (GRCm38)	missense	probably damaging	1.00
R5311:Zfp941	UTSW	7	140,811,959 (GRCm38)	nonsense	probably null
R5505:Zfp941	UTSW	7	140,811,917 (GRCm38)	missense	probably benign	0.03
R5549:Zfp941	UTSW	7	140,808,108 (GRCm38)	missense	possibly damaging	0.46
R5566:Zfp941	UTSW	7	140,812,766 (GRCm38)	missense	probably benign	0.01
R5723:Zfp941	UTSW	7	140,812,850 (GRCm38)	unclassified	probably benign
R5736:Zfp941	UTSW	7	140,813,060 (GRCm38)	missense	probably benign	0.01
R5861:Zfp941	UTSW	7	140,812,139 (GRCm38)	missense	probably damaging	1.00
R6041:Zfp941	UTSW	7	140,812,245 (GRCm38)	nonsense	probably null
R6058:Zfp941	UTSW	7	140,812,097 (GRCm38)	missense	probably damaging	1.00
R6226:Zfp941	UTSW	7	140,812,485 (GRCm38)	missense	probably benign	0.01
R6488:Zfp941	UTSW	7	140,812,750 (GRCm38)	missense	probably benign	0.37
R6824:Zfp941	UTSW	7	140,812,699 (GRCm38)	missense	probably benign	0.37
R7356:Zfp941	UTSW	7	140,812,115 (GRCm38)	missense	possibly damaging	0.66
R7554:Zfp941	UTSW	7	140,812,057 (GRCm38)	missense	possibly damaging	0.69
Z1177:Zfp941	UTSW	7	140,812,186 (GRCm38)	missense	possibly damaging	0.53

Predicted Primers

Posted On

2016-07-06