Mutagenetix > Incidental Mutation

Incidental Mutation 'R5170:Zfp941'

397504

Institutional Source

Beutler Lab

Gene Symbol

Zfp941

Ensembl Gene

ENSMUSG00000060314

Gene Name

zinc finger protein 941

Synonyms

BC066028

MMRRC Submission

042750-MU

Accession Numbers

Is this an essential gene?

Probably non essential (E-score: 0.060) question?

Stock #

R5170 (G1)

Quality Score

225

Status

Not validated

Chromosome

Chromosomal Location

140807449-140822178 bp(-) (GRCm38)

Type of Mutation

unclassified

DNA Base Change (assembly)

G to A at 140812957 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000147965 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000080651] [ENSMUST00000106052] [ENSMUST00000150053]

AlphaFold

Q3URY5

Predicted Effect

unknown
Transcript: ENSMUST00000080651
AA Change: P163L

SMART Domains

Protein: ENSMUSP00000079482
Gene: ENSMUSG00000060314
AA Change: P163L

Domain	Start	End	E-Value	Type
KRAB	4	65	3.88e-21	SMART
ZnF_C2H2	339	361	1.26e-2	SMART
ZnF_C2H2	367	389	1.12e-3	SMART
ZnF_C2H2	395	417	7.78e-3	SMART
ZnF_C2H2	423	445	1.12e-3	SMART
ZnF_C2H2	451	471	1.16e1	SMART
ZnF_C2H2	500	522	2.57e-3	SMART
ZnF_C2H2	528	550	7.9e-4	SMART
ZnF_C2H2	556	578	6.42e-4	SMART
ZnF_C2H2	584	606	1.38e-3	SMART
ZnF_C2H2	612	634	3.69e-4	SMART

Predicted Effect

unknown
Transcript: ENSMUST00000106052
AA Change: P163L

SMART Domains

Protein: ENSMUSP00000101667
Gene: ENSMUSG00000060314
AA Change: P163L

Domain	Start	End	E-Value	Type
KRAB	4	65	3.88e-21	SMART
ZnF_C2H2	339	361	1.26e-2	SMART
ZnF_C2H2	367	389	1.12e-3	SMART
ZnF_C2H2	395	417	7.78e-3	SMART
ZnF_C2H2	423	445	1.12e-3	SMART
ZnF_C2H2	451	471	1.16e1	SMART
ZnF_C2H2	500	522	2.57e-3	SMART
ZnF_C2H2	528	550	7.9e-4	SMART
ZnF_C2H2	556	578	6.42e-4	SMART
ZnF_C2H2	584	606	1.38e-3	SMART
ZnF_C2H2	612	634	3.69e-4	SMART
ZnF_C2H2	640	662	2.99e-4	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000150053

Coding Region Coverage

1x: 99.2%
3x: 98.6%
10x: 97.3%
20x: 95.4%

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 40 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Acox3	A	G	5: 35,588,625	I51V	probably benign	Het
Agbl2	A	G	2: 90,803,197	K559R	probably benign	Het
Arhgap30	A	G	1: 171,408,050	D664G	probably benign	Het
BC034090	A	G	1: 155,213,650	V798A	probably damaging	Het
Bdp1	A	T	13: 100,030,794	C2237*	probably null	Het
C3	C	T	17: 57,223,938	V388M	probably damaging	Het
Ccdc170	G	A	10: 4,514,200	E60K	probably damaging	Het
Cdh8	G	A	8: 99,279,550	T135M	probably damaging	Het
Cep131	G	T	11: 120,070,609	A572E	probably damaging	Het
Clec16a	A	G	16: 10,741,791	Y976C	probably benign	Het
Dmpk	C	G	7: 19,088,019	L301V	probably benign	Het
Eno3	A	G	11: 70,662,214	I393V	probably benign	Het
Fbxo47	A	G	11: 97,857,694	V305A	probably benign	Het
Fry	G	A	5: 150,429,854	V1779M	probably benign	Het
Gm15293	A	T	8: 21,201,680	D26V	probably damaging	Het
Gtse1	T	C	15: 85,864,264		probably null	Het
Gucy2e	A	T	11: 69,235,570	L328Q	probably damaging	Het
Ifi207	T	C	1: 173,730,498	T225A	unknown	Het
Igkv4-80	A	C	6: 69,016,665	S81A	probably benign	Het
Lamc3	A	T	2: 31,887,344	M1L	probably benign	Het
Lman1l	G	A	9: 57,615,619	R153*	probably null	Het
Myo16	A	G	8: 10,569,745	D1432G	probably benign	Het
Nwd2	A	T	5: 63,806,037	N988I	probably damaging	Het
Otx1	C	A	11: 21,997,037	A91S	probably damaging	Het
Parp14	T	C	16: 35,857,279	E773G	probably benign	Het
Psen1	T	A	12: 83,714,862	M146K	probably damaging	Het
Ptx4	G	A	17: 25,123,178	R209Q	probably benign	Het
Slc13a2	T	C	11: 78,400,808	T340A	probably damaging	Het
St8sia1	T	C	6: 142,963,708	K21E	probably damaging	Het
Stxbp1	T	C	2: 32,794,674	D581G	probably benign	Het
Sumo2	G	A	11: 115,534,660		probably benign	Het
Supt5	G	A	7: 28,316,083	P910S	probably benign	Het
Tbc1d30	T	C	10: 121,306,838	Q158R	possibly damaging	Het
Tenm2	T	A	11: 36,024,806	H1968L	probably damaging	Het
Trmt1	T	C	8: 84,695,232	Y220H	probably damaging	Het
Trp73	C	T	4: 154,104,838	E60K	possibly damaging	Het
Ttn	A	G	2: 76,787,069	Y8026H	probably damaging	Het
Zar1l	A	G	5: 150,517,585		probably null	Het
Zfp740	T	C	15: 102,209,205	Y117H	probably damaging	Het
Zp1	C	A	19: 10,920,554	V8F	possibly damaging	Het

Other mutations in Zfp941

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01393:Zfp941	APN	7	140811928	missense	probably damaging	1.00
IGL02399:Zfp941	APN	7	140812699	missense	probably benign	0.37
IGL03202:Zfp941	APN	7	140813053	missense	probably benign	0.02
R0025:Zfp941	UTSW	7	140813272	missense	probably benign	0.01
R0025:Zfp941	UTSW	7	140813272	missense	probably benign	0.01
R0226:Zfp941	UTSW	7	140813275	missense	probably damaging	1.00
R0945:Zfp941	UTSW	7	140811664	missense	probably damaging	0.99
R1455:Zfp941	UTSW	7	140812774	missense	probably benign	0.29
R1581:Zfp941	UTSW	7	140812120	missense	probably benign	0.03
R2474:Zfp941	UTSW	7	140811471	missense	probably damaging	1.00
R4052:Zfp941	UTSW	7	140812427	missense	possibly damaging	0.81
R4576:Zfp941	UTSW	7	140811590	nonsense	probably null
R4604:Zfp941	UTSW	7	140812211	missense	probably damaging	1.00
R5311:Zfp941	UTSW	7	140811959	nonsense	probably null
R5505:Zfp941	UTSW	7	140811917	missense	probably benign	0.03
R5549:Zfp941	UTSW	7	140808108	missense	possibly damaging	0.46
R5566:Zfp941	UTSW	7	140812766	missense	probably benign	0.01
R5723:Zfp941	UTSW	7	140812850	unclassified	probably benign
R5736:Zfp941	UTSW	7	140813060	missense	probably benign	0.01
R5861:Zfp941	UTSW	7	140812139	missense	probably damaging	1.00
R6041:Zfp941	UTSW	7	140812245	nonsense	probably null
R6058:Zfp941	UTSW	7	140812097	missense	probably damaging	1.00
R6226:Zfp941	UTSW	7	140812485	missense	probably benign	0.01
R6488:Zfp941	UTSW	7	140812750	missense	probably benign	0.37
R6824:Zfp941	UTSW	7	140812699	missense	probably benign	0.37
R7356:Zfp941	UTSW	7	140812115	missense	possibly damaging	0.66
R7554:Zfp941	UTSW	7	140812057	missense	possibly damaging	0.69
Z1177:Zfp941	UTSW	7	140812186	missense	possibly damaging	0.53

Predicted Primers

Posted On

2016-07-06