Incidental Mutation 'R5184:Usp25'
ID 397775
Institutional Source Beutler Lab
Gene Symbol Usp25
Ensembl Gene ENSMUSG00000022867
Gene Name ubiquitin specific peptidase 25
Synonyms
MMRRC Submission 042763-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R5184 (G1)
Quality Score 225
Status Validated
Chromosome 16
Chromosomal Location 76810594-76913668 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 76906115 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Glutamic Acid to Glycine at position 857 (E857G)
Ref Sequence ENSEMBL: ENSMUSP00000023580 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000023580]
AlphaFold P57080
PDB Structure Solution Structure of RSGI RUH-013, a UBA domain in Mouse cDNA [SOLUTION NMR]
Predicted Effect probably benign
Transcript: ENSMUST00000023580
AA Change: E857G

PolyPhen 2 Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)
SMART Domains Protein: ENSMUSP00000023580
Gene: ENSMUSG00000022867
AA Change: E857G

DomainStartEndE-ValueType
PDB:1VDL|A 1 67 2e-35 PDB
Blast:UBA 17 56 9e-16 BLAST
UIM 97 116 5.27e-3 SMART
Pfam:UIM 124 140 6.7e-3 PFAM
Pfam:UCH 168 655 9.3e-55 PFAM
Pfam:UCH_1 169 632 3.1e-14 PFAM
coiled coil region 685 714 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000232351
Meta Mutation Damage Score 0.0651 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.1%
  • 20x: 94.6%
Validation Efficiency 98% (63/64)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Ubiquitin (MIM 191339) is a highly conserved 76-amino acid protein involved in regulation of intracellular protein breakdown, cell cycle regulation, and stress response. Ubiquitin is released from degraded proteins by disassembly of the polyubiquitin chains, which is mediated by ubiquitin-specific proteases (USPs), such as USP25 (Valero et al., 1999 [PubMed 10644437]).[supplied by OMIM, Mar 2008]
PHENOTYPE: Mice homozygous for a gene trap allele exhibit increased severity of IL17-induced pulmonary inflammation and MOG-induced experimental autoimmune encephalomyelitis. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 59 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aph1a T A 3: 95,803,051 (GRCm39) probably null Het
Arid3a A G 10: 79,786,603 (GRCm39) E452G possibly damaging Het
Barhl2 A G 5: 106,605,506 (GRCm39) S68P unknown Het
Carf T C 1: 60,147,333 (GRCm39) S17P probably damaging Het
Ccdc90b A G 7: 92,224,019 (GRCm39) D145G probably damaging Het
Cyp7a1 A T 4: 6,271,207 (GRCm39) N316K probably benign Het
Daam2 A G 17: 49,801,419 (GRCm39) I106T possibly damaging Het
Dmtf1 A G 5: 9,176,641 (GRCm39) V437A probably benign Het
E2f2 A T 4: 135,911,751 (GRCm39) Y254F possibly damaging Het
Ehmt1 G T 2: 24,767,509 (GRCm39) P135T probably damaging Het
Ern2 T C 7: 121,779,182 (GRCm39) T221A probably benign Het
Fam227b G A 2: 125,958,043 (GRCm39) P241S probably damaging Het
Fermt1 A G 2: 132,783,883 (GRCm39) V42A possibly damaging Het
Fgf3 A G 7: 144,396,547 (GRCm39) D187G probably damaging Het
Flnb T A 14: 7,901,945 (GRCm38) V936E probably damaging Het
Herc2 T C 7: 55,772,099 (GRCm39) Y1093H probably damaging Het
Invs A G 4: 48,283,242 (GRCm39) probably benign Het
Katnb1 T A 8: 95,824,608 (GRCm39) I534N possibly damaging Het
Kcnq5 A T 1: 21,472,711 (GRCm39) D826E probably damaging Het
Klra9 A T 6: 130,165,675 (GRCm39) N113K probably benign Het
Knl1 A G 2: 118,899,657 (GRCm39) K453E probably damaging Het
Lgi4 C T 7: 30,770,182 (GRCm39) probably benign Het
Lpin3 A G 2: 160,739,058 (GRCm39) S289G probably benign Het
Mapre1 T A 2: 153,599,987 (GRCm39) V137E possibly damaging Het
Mark4 A G 7: 19,181,168 (GRCm39) F144L possibly damaging Het
Mogat2 G T 7: 98,872,842 (GRCm39) A114E possibly damaging Het
Msh2 C A 17: 88,030,841 (GRCm39) A906E probably benign Het
Nell2 A G 15: 95,425,690 (GRCm39) L19P possibly damaging Het
Nfia A T 4: 97,671,585 (GRCm39) K98N probably damaging Het
Nutm1 T A 2: 112,079,345 (GRCm39) T857S possibly damaging Het
Or14a257 TG T 7: 86,138,499 (GRCm39) probably null Het
Or52a5 T C 7: 103,426,611 (GRCm39) K314E probably benign Het
Or8g17 T A 9: 38,929,998 (GRCm39) I280F probably damaging Het
Pde10a T C 17: 9,195,987 (GRCm39) L706P probably damaging Het
Penk A G 4: 4,134,296 (GRCm39) L117P probably damaging Het
Pgap1 A G 1: 54,521,015 (GRCm39) S876P probably damaging Het
Pmfbp1 T C 8: 110,254,399 (GRCm39) I478T possibly damaging Het
Pole G A 5: 110,442,800 (GRCm39) E318K possibly damaging Het
Prr12 C A 7: 44,695,801 (GRCm39) V1222L unknown Het
Prune2 T C 19: 17,193,721 (GRCm39) S3070P possibly damaging Het
Rnf19a A G 15: 36,244,342 (GRCm39) C573R probably benign Het
Rp1l1 T C 14: 64,267,629 (GRCm39) S1072P probably damaging Het
Rskr T C 11: 78,183,573 (GRCm39) F194L probably benign Het
Semp2l1 A T 1: 32,584,729 (GRCm39) C394S probably damaging Het
Sh3pxd2a T C 19: 47,261,850 (GRCm39) N315S possibly damaging Het
Snph T C 2: 151,436,464 (GRCm39) I86V probably damaging Het
Sox6 A G 7: 115,376,463 (GRCm39) Y90H probably damaging Het
Tbc1d13 T A 2: 30,032,323 (GRCm39) C145S probably benign Het
Tcp11l1 T C 2: 104,530,289 (GRCm39) E65G probably damaging Het
Thrb G T 14: 18,011,181 (GRCm38) E186* probably null Het
Tmem101 A G 11: 102,047,059 (GRCm39) Y38H possibly damaging Het
Trarg1 T A 11: 76,571,134 (GRCm39) L50Q probably damaging Het
Urb1 A T 16: 90,580,162 (GRCm39) probably null Het
Usp10 G A 8: 120,683,420 (GRCm39) V764I possibly damaging Het
Vmn1r17 A G 6: 57,337,828 (GRCm39) V130A probably benign Het
Wdr35 T C 12: 9,068,142 (GRCm39) L775P probably damaging Het
Xpnpep1 T C 19: 53,001,845 (GRCm39) T134A probably benign Het
Zbtb10 T C 3: 9,329,731 (GRCm39) V363A probably damaging Het
Zfp108 G T 7: 23,960,163 (GRCm39) K251N probably benign Het
Other mutations in Usp25
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00846:Usp25 APN 16 76,859,293 (GRCm39) missense probably damaging 1.00
IGL01359:Usp25 APN 16 76,856,141 (GRCm39) missense probably damaging 1.00
IGL01380:Usp25 APN 16 76,890,566 (GRCm39) missense probably benign 0.06
IGL01614:Usp25 APN 16 76,874,005 (GRCm39) missense probably damaging 1.00
IGL02065:Usp25 APN 16 76,880,670 (GRCm39) missense probably benign 0.06
IGL02271:Usp25 APN 16 76,912,335 (GRCm39) missense probably damaging 1.00
IGL03184:Usp25 APN 16 76,878,541 (GRCm39) missense probably damaging 1.00
IGL03046:Usp25 UTSW 16 76,871,754 (GRCm39) missense probably damaging 1.00
R0433:Usp25 UTSW 16 76,906,105 (GRCm39) missense probably benign 0.02
R0741:Usp25 UTSW 16 76,868,596 (GRCm39) missense possibly damaging 0.80
R0944:Usp25 UTSW 16 76,878,335 (GRCm39) splice site probably benign
R1324:Usp25 UTSW 16 76,877,275 (GRCm39) missense probably damaging 0.98
R1341:Usp25 UTSW 16 76,912,331 (GRCm39) missense probably benign
R1373:Usp25 UTSW 16 76,859,273 (GRCm39) splice site probably benign
R1641:Usp25 UTSW 16 76,868,559 (GRCm39) missense possibly damaging 0.89
R1777:Usp25 UTSW 16 76,878,442 (GRCm39) missense probably damaging 1.00
R1813:Usp25 UTSW 16 76,911,838 (GRCm39) missense probably benign 0.00
R1960:Usp25 UTSW 16 76,873,259 (GRCm39) missense probably damaging 1.00
R2256:Usp25 UTSW 16 76,910,682 (GRCm39) missense probably benign
R2271:Usp25 UTSW 16 76,873,317 (GRCm39) missense probably damaging 0.97
R4404:Usp25 UTSW 16 76,912,341 (GRCm39) missense probably damaging 1.00
R4408:Usp25 UTSW 16 76,912,341 (GRCm39) missense probably damaging 1.00
R4502:Usp25 UTSW 16 76,912,284 (GRCm39) missense probably damaging 1.00
R4604:Usp25 UTSW 16 76,912,303 (GRCm39) missense probably damaging 1.00
R4612:Usp25 UTSW 16 76,830,833 (GRCm39) missense possibly damaging 0.92
R4744:Usp25 UTSW 16 76,911,877 (GRCm39) missense probably damaging 1.00
R4867:Usp25 UTSW 16 76,847,355 (GRCm39) missense probably damaging 1.00
R4932:Usp25 UTSW 16 76,830,870 (GRCm39) critical splice donor site probably null
R5087:Usp25 UTSW 16 76,874,007 (GRCm39) missense probably benign 0.00
R5165:Usp25 UTSW 16 76,873,293 (GRCm39) missense possibly damaging 0.85
R5307:Usp25 UTSW 16 76,890,594 (GRCm39) missense probably benign
R5331:Usp25 UTSW 16 76,847,446 (GRCm39) missense probably damaging 1.00
R5355:Usp25 UTSW 16 76,847,342 (GRCm39) missense probably damaging 1.00
R5479:Usp25 UTSW 16 76,904,801 (GRCm39) missense possibly damaging 0.51
R5619:Usp25 UTSW 16 76,830,833 (GRCm39) missense probably benign 0.22
R5646:Usp25 UTSW 16 76,847,360 (GRCm39) missense probably benign 0.34
R5946:Usp25 UTSW 16 76,911,942 (GRCm39) nonsense probably null
R6013:Usp25 UTSW 16 76,873,909 (GRCm39) missense probably benign 0.00
R6418:Usp25 UTSW 16 76,859,330 (GRCm39) missense probably damaging 1.00
R6653:Usp25 UTSW 16 76,856,176 (GRCm39) missense probably benign 0.29
R6709:Usp25 UTSW 16 76,880,820 (GRCm39) missense probably benign
R6987:Usp25 UTSW 16 76,874,068 (GRCm39) missense probably damaging 1.00
R7418:Usp25 UTSW 16 76,910,730 (GRCm39) nonsense probably null
R7500:Usp25 UTSW 16 76,874,089 (GRCm39) missense probably damaging 1.00
R7886:Usp25 UTSW 16 76,910,659 (GRCm39) missense probably damaging 0.99
R7961:Usp25 UTSW 16 76,856,150 (GRCm39) missense probably damaging 1.00
R8005:Usp25 UTSW 16 76,873,956 (GRCm39) missense probably benign
R8046:Usp25 UTSW 16 76,906,063 (GRCm39) missense probably damaging 1.00
R8069:Usp25 UTSW 16 76,865,943 (GRCm39) missense possibly damaging 0.58
R8140:Usp25 UTSW 16 76,868,569 (GRCm39) nonsense probably null
R8167:Usp25 UTSW 16 76,904,819 (GRCm39) missense probably damaging 1.00
R8437:Usp25 UTSW 16 76,830,800 (GRCm39) missense probably damaging 1.00
R8704:Usp25 UTSW 16 76,856,178 (GRCm39) missense probably benign 0.00
R8903:Usp25 UTSW 16 76,878,421 (GRCm39) missense probably damaging 1.00
R9123:Usp25 UTSW 16 76,911,969 (GRCm39) critical splice donor site probably null
R9276:Usp25 UTSW 16 76,910,721 (GRCm39) missense probably benign 0.09
R9286:Usp25 UTSW 16 76,904,864 (GRCm39) missense probably damaging 1.00
R9368:Usp25 UTSW 16 76,904,843 (GRCm39) missense probably damaging 1.00
R9489:Usp25 UTSW 16 76,874,046 (GRCm39) missense probably damaging 1.00
R9515:Usp25 UTSW 16 76,852,076 (GRCm39) missense probably damaging 1.00
R9516:Usp25 UTSW 16 76,852,076 (GRCm39) missense probably damaging 1.00
R9580:Usp25 UTSW 16 76,880,682 (GRCm39) missense probably benign 0.00
R9605:Usp25 UTSW 16 76,874,046 (GRCm39) missense probably damaging 1.00
R9667:Usp25 UTSW 16 76,874,123 (GRCm39) critical splice donor site probably null
X0065:Usp25 UTSW 16 76,878,444 (GRCm39) missense probably damaging 1.00
Z1176:Usp25 UTSW 16 76,878,409 (GRCm39) missense probably damaging 1.00
Z1176:Usp25 UTSW 16 76,868,680 (GRCm39) missense possibly damaging 0.93
Z1176:Usp25 UTSW 16 76,868,679 (GRCm39) missense probably damaging 0.98
Z1176:Usp25 UTSW 16 76,910,718 (GRCm39) missense probably benign
Z1176:Usp25 UTSW 16 76,880,801 (GRCm39) missense probably benign
Predicted Primers PCR Primer
(F):5'- ATCCCACTGGCAATTGTGAAG -3'
(R):5'- AGAAGAACATTCAGCAGGCTC -3'

Sequencing Primer
(F):5'- CCCACTGGCAATTGTGAAGATTTTG -3'
(R):5'- GAACATTCAGCAGGCTCTTTATTTGC -3'
Posted On 2016-07-06