Mutagenetix > Incidental Mutations

Incidental Mutation 'R5185:Olfr1097'

397794

Institutional Source

Beutler Lab

Gene Symbol

Olfr1097

Ensembl Gene

ENSMUSG00000075170

Gene Name

olfactory receptor 1097

Synonyms

MOR206-2, GA_x6K02T2Q125-48376288-48375341

MMRRC Submission

042764-MU

Accession Numbers

Is this an essential gene?

Probably non essential (E-score: 0.059) question?

Stock #

R5185 (G1)

Quality Score

225

Status

Validated

Chromosome

Chromosomal Location

86886773-86892216 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 86890602 bp

Zygosity

Heterozygous

Amino Acid Change

Aspartic acid to Glycine at position 191 (D191G)

Ref Sequence

ENSEMBL: ENSMUSP00000150400 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000111576] [ENSMUST00000217403]

Predicted Effect

probably benign
Transcript: ENSMUST00000111576
AA Change: D191G

PolyPhen 2 Score 0.417 (Sensitivity: 0.89; Specificity: 0.90)

SMART Domains

Protein: ENSMUSP00000107202
Gene: ENSMUSG00000075170
AA Change: D191G

Domain	Start	End	E-Value	Type
Pfam:7tm_4	31	308	8e-52	PFAM
Pfam:7tm_1	41	312	4.2e-20	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000217403
AA Change: D191G

PolyPhen 2 Score 0.417 (Sensitivity: 0.89; Specificity: 0.90)

Meta Mutation Damage Score

0.2452

Coding Region Coverage

1x: 99.3%
3x: 98.7%
10x: 97.3%
20x: 95.4%

Validation Efficiency

95% (70/74)

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 67 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Acsf2	T	C	11: 94,562,911	Y408C	probably damaging	Het
Aox4	T	C	1: 58,254,318	L943S	probably damaging	Het
Ap1g1	G	A	8: 109,863,326		probably benign	Het
Arsb	T	C	13: 93,794,159	S212P	probably damaging	Het
Arsi	A	G	18: 60,916,912	N289S	probably damaging	Het
Atp6v1h	T	A	1: 5,095,642	F72I	probably damaging	Het
Atxn7	T	C	14: 14,090,063	I336T	probably benign	Het
Bak1	G	A	17: 27,022,748	P65L	possibly damaging	Het
Bcl6	A	T	16: 23,972,947	M219K	possibly damaging	Het
Brd3	T	C	2: 27,462,448	K157E	probably damaging	Het
Ccdc171	T	G	4: 83,663,655	S674A	possibly damaging	Het
Cfap43	A	G	19: 47,780,394	I737T	probably benign	Het
Cul9	A	T	17: 46,525,832	V1089D	possibly damaging	Het
Dffa	C	A	4: 149,117,430	A155E	probably benign	Het
Dnhd1	G	A	7: 105,703,209	R2523Q	probably damaging	Het
Efcab12	T	A	6: 115,823,490	M191L	probably benign	Het
Efl1	T	C	7: 82,772,499	L1018P	probably damaging	Het
Fcho1	A	G	8: 71,714,956		probably benign	Het
Fndc3b	T	A	3: 27,457,070	T764S	probably benign	Het
Gm29125	T	C	1: 80,384,231		noncoding transcript	Het
Gm5108	A	G	5: 67,944,610		probably benign	Het
Gm9949	T	G	18: 62,180,565		probably benign	Het
Golgb1	T	C	16: 36,875,141		probably benign	Het
Gpd2	T	C	2: 57,340,204	Y323H	probably damaging	Het
Grip1	T	G	10: 119,931,259	D96E	probably benign	Het
Hmcn1	T	C	1: 150,656,741	I3132V	probably benign	Het
Hsd17b1	T	C	11: 101,080,198	W327R	possibly damaging	Het
Htra2	G	A	6: 83,054,242	P62L	probably benign	Het
Kdr	A	T	5: 75,952,417		probably null	Het
Kif14	T	A	1: 136,527,469	C1626*	probably null	Het
Kmt2a	A	T	9: 44,820,246		probably benign	Het
Krt15	T	C	11: 100,133,433	T321A	probably damaging	Het
Lactbl1	A	T	4: 136,631,045	H109L	probably benign	Het
Lilra6	T	A	7: 3,914,636	H120L	probably benign	Het
Lpcat2	G	A	8: 92,869,737	S134N	probably benign	Het
Mpp4	T	C	1: 59,125,583	D465G	probably benign	Het
Naip2	A	T	13: 100,189,351	D16E	probably damaging	Het
Nek5	C	T	8: 22,083,381	A520T	possibly damaging	Het
Nfatc2	A	G	2: 168,570,707	F132L	possibly damaging	Het
Nlrp3	C	A	11: 59,565,084	T902N	probably benign	Het
Olfr1230	A	T	2: 89,296,387	H294Q	probably benign	Het
Olfr149	A	T	9: 39,701,876	W298R	probably benign	Het
Olfr58	T	C	9: 19,783,376	M81T	probably damaging	Het
Pcdhb16	T	C	18: 37,480,089	S701P	possibly damaging	Het
Phf7	A	G	14: 31,248,037		probably null	Het
Plpp4	G	A	7: 129,316,304	V68M	probably damaging	Het
Pnma2	A	T	14: 66,916,129	M1L	possibly damaging	Het
Pnmal2	A	T	7: 16,945,976	D295V	probably damaging	Het
Rad21l	T	C	2: 151,657,462	D270G	probably benign	Het
Ralgapa2	C	A	2: 146,388,486		probably null	Het
Rasal3	A	T	17: 32,396,790	L334Q	probably damaging	Het
Rfx4	G	T	10: 84,863,250	R240L	probably damaging	Het
Rnf19b	T	A	4: 129,083,920	C642*	probably null	Het
Slc28a2	G	A	2: 122,458,194	E594K	probably benign	Het
Spata31	G	T	13: 64,917,526	W15L	possibly damaging	Het
Spink5	T	C	18: 44,015,644	S925P	probably damaging	Het
Svep1	C	T	4: 58,084,534	G1865S	probably damaging	Het
Tg	T	C	15: 66,773,474	L791P	probably damaging	Het
Thbs4	A	C	13: 92,775,167	V247G	probably damaging	Het
Tpcn2	A	T	7: 145,255,454	F705Y	probably damaging	Het
Try10	A	T	6: 41,356,549	H76L	probably damaging	Het
Ttn	C	T	2: 76,939,221	V2695I	probably damaging	Het
Tut1	C	A	19: 8,955,450	T49N	probably benign	Het
Vmn1r17	A	G	6: 57,360,843	V130A	probably benign	Het
Xdh	G	A	17: 73,925,011	R235C	probably damaging	Het
Yipf4	A	G	17: 74,492,475	D70G	probably null	Het
Zfp108	G	T	7: 24,260,738	K251N	probably benign	Het

Other mutations in Olfr1097

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00336:Olfr1097	APN	2	86890245	missense	probably benign
IGL01674:Olfr1097	APN	2	86890749	missense	probably benign
IGL02089:Olfr1097	APN	2	86891116	missense	possibly damaging	0.86
IGL02201:Olfr1097	APN	2	86891076	missense	probably damaging	0.97
IGL02426:Olfr1097	APN	2	86890620	missense	probably damaging	1.00
IGL02469:Olfr1097	APN	2	86891155	missense	possibly damaging	0.91
IGL02489:Olfr1097	APN	2	86890995	missense	probably damaging	1.00
IGL02817:Olfr1097	APN	2	86890593	missense	probably benign
R0042:Olfr1097	UTSW	2	86890491	missense	probably damaging	1.00
R0605:Olfr1097	UTSW	2	86890419	missense	possibly damaging	0.65
R1867:Olfr1097	UTSW	2	86890612	missense	probably damaging	0.98
R2412:Olfr1097	UTSW	2	86890834	missense	probably benign	0.01
R4465:Olfr1097	UTSW	2	86891150	missense	probably benign
R4520:Olfr1097	UTSW	2	86891019	missense	probably benign	0.20
R5329:Olfr1097	UTSW	2	86890620	missense	probably damaging	1.00
R5496:Olfr1097	UTSW	2	86890314	missense	probably damaging	1.00
R5496:Olfr1097	UTSW	2	86890315	missense	probably damaging	1.00
R5847:Olfr1097	UTSW	2	86890332	missense	probably damaging	0.99
R6288:Olfr1097	UTSW	2	86890882	missense	probably benign	0.01
R6906:Olfr1097	UTSW	2	86890747	missense	probably benign
R7161:Olfr1097	UTSW	2	86890649	missense	probably benign	0.01
R7256:Olfr1097	UTSW	2	86890612	missense	probably damaging	0.98
R7404:Olfr1097	UTSW	2	86890873	missense	probably benign	0.05

Predicted Primers

PCR Primer
(F):5'- ACAGTGACTCCTATAAGATGTGAGG -3'
(R):5'- TCAATGGCCTATGACCGCTATG -3'

Sequencing Primer
(F):5'- GCACATGTAGAGAAGGCTTTGTGC -3'
(R):5'- ATGACCGCTATGTAGCTATCTGCAAC -3'

Posted On

2016-07-06