Incidental Mutation 'R5186:St18'
ID 397852
Institutional Source Beutler Lab
Gene Symbol St18
Ensembl Gene ENSMUSG00000033740
Gene Name suppression of tumorigenicity 18
Synonyms Nzf3, Myt3
MMRRC Submission 042765-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R5186 (G1)
Quality Score 225
Status Not validated
Chromosome 1
Chromosomal Location 6487231-6860940 bp(+) (GRCm38)
Type of Mutation splice site
DNA Base Change (assembly) T to A at 6802317 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000131417 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000043578] [ENSMUST00000131494] [ENSMUST00000139838] [ENSMUST00000140079] [ENSMUST00000150761] [ENSMUST00000151281] [ENSMUST00000163727]
AlphaFold Q80TY4
Predicted Effect probably null
Transcript: ENSMUST00000043578
SMART Domains Protein: ENSMUSP00000042056
Gene: ENSMUSG00000033740

DomainStartEndE-ValueType
low complexity region 188 198 N/A INTRINSIC
Pfam:zf-C2HC 365 392 7.8e-15 PFAM
Pfam:zf-C2HC 409 437 4.2e-17 PFAM
Pfam:MYT1 476 713 1.3e-75 PFAM
Pfam:zf-C2HC 721 749 4e-19 PFAM
Pfam:zf-C2HC 765 793 1.7e-19 PFAM
Pfam:zf-C2HC 813 841 1.1e-17 PFAM
Pfam:zf-C2HC 866 893 9.1e-15 PFAM
coiled coil region 918 987 N/A INTRINSIC
Predicted Effect probably null
Transcript: ENSMUST00000131494
SMART Domains Protein: ENSMUSP00000117789
Gene: ENSMUSG00000033740

DomainStartEndE-ValueType
low complexity region 188 198 N/A INTRINSIC
Pfam:zf-C2HC 363 393 2.6e-17 PFAM
Pfam:zf-C2HC 407 437 1e-18 PFAM
Pfam:MYT1 476 714 1.5e-116 PFAM
Pfam:zf-C2HC 719 749 1e-19 PFAM
Pfam:zf-C2HC 763 793 1.3e-20 PFAM
Pfam:zf-C2HC 811 841 8.9e-19 PFAM
Pfam:zf-C2HC 864 894 1.3e-16 PFAM
coiled coil region 918 987 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000132207
Predicted Effect probably null
Transcript: ENSMUST00000139838
SMART Domains Protein: ENSMUSP00000118129
Gene: ENSMUSG00000033740

DomainStartEndE-ValueType
low complexity region 188 198 N/A INTRINSIC
Predicted Effect probably null
Transcript: ENSMUST00000140079
SMART Domains Protein: ENSMUSP00000118322
Gene: ENSMUSG00000033740

DomainStartEndE-ValueType
low complexity region 188 198 N/A INTRINSIC
Pfam:zf-C2HC 363 393 2.6e-17 PFAM
Pfam:zf-C2HC 407 437 1e-18 PFAM
Pfam:MYT1 476 714 1.5e-116 PFAM
Pfam:zf-C2HC 719 749 1e-19 PFAM
Pfam:zf-C2HC 763 793 1.3e-20 PFAM
Pfam:zf-C2HC 811 841 8.9e-19 PFAM
Pfam:zf-C2HC 864 894 1.3e-16 PFAM
coiled coil region 918 987 N/A INTRINSIC
Predicted Effect probably null
Transcript: ENSMUST00000150761
SMART Domains Protein: ENSMUSP00000120298
Gene: ENSMUSG00000033740

DomainStartEndE-ValueType
low complexity region 188 198 N/A INTRINSIC
Pfam:zf-C2HC 363 393 2.6e-17 PFAM
Pfam:zf-C2HC 407 437 1e-18 PFAM
Pfam:MYT1 476 714 1.5e-116 PFAM
Pfam:zf-C2HC 719 749 1e-19 PFAM
Pfam:zf-C2HC 763 793 1.3e-20 PFAM
Pfam:zf-C2HC 811 841 8.9e-19 PFAM
Pfam:zf-C2HC 864 894 1.3e-16 PFAM
coiled coil region 918 987 N/A INTRINSIC
Predicted Effect probably null
Transcript: ENSMUST00000151281
SMART Domains Protein: ENSMUSP00000122055
Gene: ENSMUSG00000033740

DomainStartEndE-ValueType
low complexity region 188 198 N/A INTRINSIC
Pfam:zf-C2HC 363 393 2.6e-17 PFAM
Pfam:zf-C2HC 407 437 1e-18 PFAM
Pfam:MYT1 476 714 1.5e-116 PFAM
Pfam:zf-C2HC 719 749 1e-19 PFAM
Pfam:zf-C2HC 763 793 1.3e-20 PFAM
Pfam:zf-C2HC 811 841 8.9e-19 PFAM
Pfam:zf-C2HC 864 894 1.3e-16 PFAM
coiled coil region 918 987 N/A INTRINSIC
Predicted Effect probably null
Transcript: ENSMUST00000163727
SMART Domains Protein: ENSMUSP00000131417
Gene: ENSMUSG00000033740

DomainStartEndE-ValueType
low complexity region 188 198 N/A INTRINSIC
Pfam:zf-C2HC 365 392 7.8e-15 PFAM
Pfam:zf-C2HC 409 437 4.2e-17 PFAM
Pfam:MYT1 476 713 1.3e-75 PFAM
Pfam:zf-C2HC 721 749 4e-19 PFAM
Pfam:zf-C2HC 765 793 1.7e-19 PFAM
Pfam:zf-C2HC 813 841 1.1e-17 PFAM
Pfam:zf-C2HC 866 893 9.1e-15 PFAM
coiled coil region 918 987 N/A INTRINSIC
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.1%
  • 20x: 95.0%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 72 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca8a T C 11: 110,091,599 (GRCm38) I6V probably null Het
Aox1 A G 1: 58,068,370 (GRCm38) D601G probably damaging Het
Asic1 GCACC GCACCACC 15: 99,698,803 (GRCm38) probably benign Het
Cacna1g T G 11: 94,442,848 (GRCm38) N931T probably damaging Het
Ccdc14 T C 16: 34,721,585 (GRCm38) F511L probably damaging Het
Cd177 T A 7: 24,744,923 (GRCm38) E710V probably benign Het
Cep112 T C 11: 108,752,560 (GRCm38) C49R probably benign Het
Clip2 G A 5: 134,522,791 (GRCm38) T159M possibly damaging Het
Dnah2 T C 11: 69,435,884 (GRCm38) N3575S probably damaging Het
Dnah6 T A 6: 73,067,427 (GRCm38) I3234F probably damaging Het
Eci3 G T 13: 34,946,978 (GRCm38) A302E possibly damaging Het
Fam204a T C 19: 60,199,989 (GRCm38) K214E probably damaging Het
Fam78a T C 2: 32,082,654 (GRCm38) T85A possibly damaging Het
Flnb T C 14: 7,909,748 (GRCm38) Y1401H probably damaging Het
Foxl2 A T 9: 98,956,055 (GRCm38) D132V probably damaging Het
Frs2 C A 10: 117,078,842 (GRCm38) W57C probably damaging Het
Gm26558 G T 2: 70,661,417 (GRCm38) probably benign Het
Gpr139 A G 7: 119,144,840 (GRCm38) V174A probably benign Het
Grik5 T C 7: 25,015,819 (GRCm38) T676A probably damaging Het
H60c T C 10: 3,259,273 (GRCm38) probably null Het
Hspa1l A G 17: 34,978,469 (GRCm38) K495E probably damaging Het
Irgm1 C T 11: 48,866,217 (GRCm38) V256I probably benign Het
Kat7 T A 11: 95,286,416 (GRCm38) T293S probably benign Het
Lipg C T 18: 74,960,938 (GRCm38) V13I probably benign Het
Lrrn1 A T 6: 107,569,224 (GRCm38) Y661F probably damaging Het
Mllt3 A G 4: 87,840,995 (GRCm38) V272A probably benign Het
Mx1 G A 16: 97,455,494 (GRCm38) R162C probably benign Het
Myo18b T A 5: 112,871,470 (GRCm38) D647V probably damaging Het
Naf1 G A 8: 66,879,646 (GRCm38) V329I probably benign Het
Or4k40 A T 2: 111,420,774 (GRCm38) M59K probably damaging Het
Or52u1 A T 7: 104,588,211 (GRCm38) I153F probably damaging Het
Or8g22 A T 9: 39,046,969 (GRCm38) C194* probably null Het
P2rx5 G A 11: 73,171,790 (GRCm38) V442M possibly damaging Het
Pcdhb9 A G 18: 37,401,232 (GRCm38) E93G probably damaging Het
Pcdhga4 A T 18: 37,687,426 (GRCm38) N676I probably benign Het
Pgm5 A G 19: 24,820,128 (GRCm38) M230T probably damaging Het
Pik3c2g T C 6: 139,622,018 (GRCm38) V44A probably damaging Het
Pp2d1 T C 17: 53,508,140 (GRCm38) M519V probably benign Het
Ppp1r10 A G 17: 35,928,511 (GRCm38) E404G probably damaging Het
Prpf8 A T 11: 75,489,783 (GRCm38) E104V possibly damaging Het
Ptpa T C 2: 30,438,355 (GRCm38) probably null Het
Pygl A C 12: 70,201,344 (GRCm38) N248K probably damaging Het
Rbm8a A G 3: 96,630,932 (GRCm38) D102G probably damaging Het
Sema3d A G 5: 12,584,908 (GRCm38) D647G probably benign Het
Serpinb11 A T 1: 107,379,754 (GRCm38) D305V probably damaging Het
Slc12a8 T C 16: 33,617,208 (GRCm38) I337T probably damaging Het
Slc29a2 G A 19: 5,028,967 (GRCm38) R286Q probably benign Het
Slc2a3 T A 6: 122,735,583 (GRCm38) D234V probably damaging Het
Slco4a1 T C 2: 180,473,108 (GRCm38) V608A probably damaging Het
Spata31d1e A T 13: 59,743,739 (GRCm38) L89H probably damaging Het
Srrm2 C T 17: 23,816,587 (GRCm38) T831I probably benign Het
Tesk2 G C 4: 116,741,896 (GRCm38) G67A probably damaging Het
Tlr1 A T 5: 64,925,221 (GRCm38) L671H probably damaging Het
Tmem63b A T 17: 45,661,477 (GRCm38) Y735N possibly damaging Het
Tmprss11a C T 5: 86,420,079 (GRCm38) C263Y probably damaging Het
Trio A T 15: 27,897,991 (GRCm38) V345E probably damaging Het
Tut7 A G 13: 59,816,656 (GRCm38) probably null Het
Ubr5 A G 15: 37,997,916 (GRCm38) S1674P probably damaging Het
Uchl3 T A 14: 101,695,917 (GRCm38) C209S probably damaging Het
Uhmk1 T C 1: 170,211,167 (GRCm38) N206S probably damaging Het
Uhrf1 C T 17: 56,318,340 (GRCm38) R588W probably damaging Het
Usp28 T C 9: 49,010,250 (GRCm38) V256A probably damaging Het
Utrn C A 10: 12,728,777 (GRCm38) L552F probably damaging Het
Vmn1r55 A T 7: 5,146,986 (GRCm38) M146K probably damaging Het
Vmn1r57 A C 7: 5,221,108 (GRCm38) I211L probably benign Het
Zar1 C T 5: 72,577,399 (GRCm38) C316Y probably damaging Het
Zc3h11a A T 1: 133,621,674 (GRCm38) S750T probably damaging Het
Zfp366 G A 13: 99,246,168 (GRCm38) C613Y probably benign Het
Zfp37 A T 4: 62,191,256 (GRCm38) C524S probably damaging Het
Zfp516 T C 18: 82,957,093 (GRCm38) V472A probably benign Het
Zhx1 A T 15: 58,052,423 (GRCm38) M809K probably damaging Het
Zic1 T C 9: 91,364,371 (GRCm38) Y216C probably damaging Het
Other mutations in St18
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00089:St18 APN 1 6,802,572 (GRCm38) missense probably benign 0.07
IGL00840:St18 APN 1 6,833,594 (GRCm38) missense probably damaging 1.00
IGL01016:St18 APN 1 6,844,323 (GRCm38) missense probably damaging 0.98
IGL01116:St18 APN 1 6,802,632 (GRCm38) missense probably damaging 0.96
IGL01719:St18 APN 1 6,845,796 (GRCm38) splice site probably benign
IGL01885:St18 APN 1 6,844,372 (GRCm38) critical splice donor site probably null
IGL02486:St18 APN 1 6,820,083 (GRCm38) missense probably damaging 1.00
IGL02611:St18 APN 1 6,768,890 (GRCm38) splice site probably benign
IGL02742:St18 APN 1 6,802,316 (GRCm38) splice site probably benign
IGL02953:St18 APN 1 6,844,113 (GRCm38) splice site probably benign
IGL02999:St18 APN 1 6,817,605 (GRCm38) missense probably benign 0.01
IGL03092:St18 APN 1 6,768,894 (GRCm38) splice site probably benign
Smallish UTSW 1 6,855,473 (GRCm38) critical splice donor site probably null
IGL03055:St18 UTSW 1 6,802,735 (GRCm38) missense probably damaging 0.99
R0089:St18 UTSW 1 6,848,948 (GRCm38) missense probably benign 0.02
R0257:St18 UTSW 1 6,819,962 (GRCm38) missense probably benign 0.04
R0383:St18 UTSW 1 6,803,024 (GRCm38) missense probably damaging 1.00
R0588:St18 UTSW 1 6,817,738 (GRCm38) missense probably damaging 0.99
R0989:St18 UTSW 1 6,827,881 (GRCm38) missense probably benign 0.04
R1068:St18 UTSW 1 6,795,562 (GRCm38) missense probably benign 0.01
R1311:St18 UTSW 1 6,845,644 (GRCm38) missense probably damaging 1.00
R1530:St18 UTSW 1 6,845,569 (GRCm38) critical splice acceptor site probably null
R1723:St18 UTSW 1 6,810,685 (GRCm38) splice site probably benign
R1926:St18 UTSW 1 6,802,689 (GRCm38) missense probably benign 0.00
R1927:St18 UTSW 1 6,802,712 (GRCm38) missense probably benign 0.00
R2035:St18 UTSW 1 6,802,328 (GRCm38) missense probably benign 0.00
R2091:St18 UTSW 1 6,827,971 (GRCm38) missense probably benign 0.08
R2139:St18 UTSW 1 6,810,615 (GRCm38) missense possibly damaging 0.85
R2261:St18 UTSW 1 6,845,572 (GRCm38) missense probably damaging 0.96
R2300:St18 UTSW 1 6,855,402 (GRCm38) missense probably damaging 1.00
R2322:St18 UTSW 1 6,844,124 (GRCm38) nonsense probably null
R2846:St18 UTSW 1 6,845,587 (GRCm38) missense probably damaging 0.96
R3738:St18 UTSW 1 6,855,473 (GRCm38) critical splice donor site probably null
R3739:St18 UTSW 1 6,855,473 (GRCm38) critical splice donor site probably null
R3772:St18 UTSW 1 6,844,329 (GRCm38) missense probably damaging 1.00
R3805:St18 UTSW 1 6,802,353 (GRCm38) missense probably damaging 1.00
R3953:St18 UTSW 1 6,802,893 (GRCm38) missense probably damaging 0.99
R4034:St18 UTSW 1 6,855,473 (GRCm38) critical splice donor site probably null
R4036:St18 UTSW 1 6,827,786 (GRCm38) missense probably damaging 1.00
R4407:St18 UTSW 1 6,827,837 (GRCm38) missense probably benign 0.29
R4527:St18 UTSW 1 6,855,423 (GRCm38) missense probably damaging 1.00
R4740:St18 UTSW 1 6,817,604 (GRCm38) missense probably benign
R4838:St18 UTSW 1 6,802,905 (GRCm38) missense probably benign 0.01
R5182:St18 UTSW 1 6,817,653 (GRCm38) missense probably benign 0.03
R5354:St18 UTSW 1 6,844,171 (GRCm38) missense probably damaging 1.00
R5423:St18 UTSW 1 6,802,616 (GRCm38) missense possibly damaging 0.91
R5724:St18 UTSW 1 6,770,950 (GRCm38) missense probably benign 0.13
R6182:St18 UTSW 1 6,844,118 (GRCm38) splice site probably null
R6491:St18 UTSW 1 6,827,985 (GRCm38) nonsense probably null
R6503:St18 UTSW 1 6,795,397 (GRCm38) missense probably damaging 1.00
R7037:St18 UTSW 1 6,803,036 (GRCm38) missense possibly damaging 0.65
R7098:St18 UTSW 1 6,827,842 (GRCm38) missense probably damaging 1.00
R7132:St18 UTSW 1 6,859,127 (GRCm38) missense
R7144:St18 UTSW 1 6,833,594 (GRCm38) missense probably damaging 1.00
R7150:St18 UTSW 1 6,803,019 (GRCm38) missense probably damaging 1.00
R7334:St18 UTSW 1 6,802,559 (GRCm38) missense probably benign 0.00
R7502:St18 UTSW 1 6,827,970 (GRCm38) missense probably benign 0.09
R7729:St18 UTSW 1 6,802,537 (GRCm38) missense probably benign 0.00
R7848:St18 UTSW 1 6,857,445 (GRCm38) critical splice donor site probably null
R8088:St18 UTSW 1 6,828,005 (GRCm38) missense probably benign 0.00
R8299:St18 UTSW 1 6,802,992 (GRCm38) missense probably benign 0.01
R8338:St18 UTSW 1 6,809,292 (GRCm38) missense probably damaging 1.00
R8690:St18 UTSW 1 6,802,564 (GRCm38) missense probably benign
R8753:St18 UTSW 1 6,845,791 (GRCm38) missense probably damaging 1.00
R8808:St18 UTSW 1 6,810,602 (GRCm38) missense probably damaging 1.00
R8880:St18 UTSW 1 6,795,395 (GRCm38) nonsense probably null
R9055:St18 UTSW 1 6,802,982 (GRCm38) nonsense probably null
R9292:St18 UTSW 1 6,827,882 (GRCm38) missense probably benign 0.32
R9322:St18 UTSW 1 6,795,523 (GRCm38) missense probably benign 0.00
R9530:St18 UTSW 1 6,802,773 (GRCm38) missense probably benign 0.00
R9603:St18 UTSW 1 6,845,587 (GRCm38) missense probably damaging 1.00
R9611:St18 UTSW 1 6,802,923 (GRCm38) missense probably benign 0.00
R9639:St18 UTSW 1 6,859,022 (GRCm38) missense
R9644:St18 UTSW 1 6,859,052 (GRCm38) missense
R9740:St18 UTSW 1 6,803,063 (GRCm38) nonsense probably null
R9750:St18 UTSW 1 6,802,992 (GRCm38) missense probably benign 0.01
Predicted Primers PCR Primer
(F):5'- TCCATGTACTTACATATGCAGGC -3'
(R):5'- TCTCACATGTGGTCTGCAC -3'

Sequencing Primer
(F):5'- GTACTTACATATGCAGGCATGTG -3'
(R):5'- GCACAGACTCACTTTCCTCAAATTTG -3'
Posted On 2016-07-06