Mutagenetix > Incidental Mutation

Incidental Mutation 'R5187:Dnah5'

397983

Institutional Source

Beutler Lab

Gene Symbol

Dnah5

Ensembl Gene

ENSMUSG00000022262

Gene Name

dynein, axonemal, heavy chain 5

Synonyms

b2b1565Clo, b2b1134Clo, Mdnah5, b2b1537Clo, b2b1154Clo, Dnahc5

MMRRC Submission

042766-MU

Accession Numbers

NCBI RefSeq: NM_133365.3; MGI: 107718

Essential gene?

Probably essential (E-score: 0.776) question?

Stock #

R5187 (G1)

Quality Score

225

Status

Not validated

Chromosome

Chromosomal Location

28203752-28472052 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

G to A at 28272172 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Valine to Isoleucine at position 1041 (V1041I)

Ref Sequence

ENSEMBL: ENSMUSP00000069751 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000067048]

AlphaFold

no structure available at present

Predicted Effect

probably benign
Transcript: ENSMUST00000067048
AA Change: V1041I

PolyPhen 2 Score 0.415 (Sensitivity: 0.89; Specificity: 0.90)

SMART Domains

Protein: ENSMUSP00000069751
Gene: ENSMUSG00000022262
AA Change: V1041I

Domain	Start	End	E-Value	Type
Pfam:DHC_N1	247	802	2.3e-163	PFAM
low complexity region	1077	1088	N/A	INTRINSIC
low complexity region	1113	1128	N/A	INTRINSIC
Pfam:DHC_N2	1399	1807	2.3e-134	PFAM
AAA	1972	2108	2e-3	SMART
AAA	2251	2424	4.3e-3	SMART
AAA	2579	2777	2.2e-3	SMART
low complexity region	2874	2889	N/A	INTRINSIC
Pfam:AAA_8	2914	3186	3.2e-70	PFAM
Pfam:MT	3198	3546	1e-44	PFAM
Pfam:AAA_9	3567	3792	1.4e-86	PFAM
low complexity region	3889	3899	N/A	INTRINSIC
Pfam:Dynein_heavy	3930	4618	4.4e-246	PFAM

Coding Region Coverage

1x: 99.3%
3x: 98.7%
10x: 97.3%
20x: 95.5%

Validation Efficiency

MGI Phenotype

Strain: 2180081
Lethality: D14-D21
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a dynein protein, which is part of a microtubule-associated motor protein complex consisting of heavy, light, and intermediate chains. This protein is an axonemal heavy chain dynein. It functions as a force-generating protein with ATPase activity, whereby the release of ADP is thought to produce the force-producing power stroke. Mutations in this gene cause primary ciliary dyskinesia type 3, as well as Kartagener syndrome, which are both diseases due to ciliary defects. [provided by RefSeq, Oct 2009]
PHENOTYPE: Mice homozygous for a disruption in this gene display postnatal lethality, hydrocephalus, respiratory infections, situs inversus and ciliary immotility. [provided by MGI curators]

Allele List at MGI

All alleles(11) : Targeted(2) Gene trapped(1) Transgenic(1) Chemically induced(7)

Other mutations in this stock

Total: 65 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
2310035C23Rik	T	A	1: 105,718,809 (GRCm38)	L620*	probably null	Het
4930505A04Rik	C	T	11: 30,426,349 (GRCm38)	V173M	probably damaging	Het
Abcg5	A	G	17: 84,658,564 (GRCm38)	L628S	probably damaging	Het
Acbd3	C	T	1: 180,736,732 (GRCm38)	R201*	probably null	Het
Adsl	A	G	15: 80,948,905 (GRCm38)		probably benign	Het
Asic1	GCACC	GCACCACC	15: 99,698,803 (GRCm38)		probably benign	Het
Cachd1	T	C	4: 100,966,200 (GRCm38)	V483A	possibly damaging	Het
Calm1	T	C	12: 100,200,213 (GRCm38)	S19P	probably benign	Het
Casq1	T	C	1: 172,213,074 (GRCm38)	N313S	possibly damaging	Het
Cav2	G	T	6: 17,286,936 (GRCm38)	A64S	possibly damaging	Het
Ccdc114	A	G	7: 45,929,116 (GRCm38)	I77V	probably damaging	Het
Ccdc167	C	A	17: 29,705,511 (GRCm38)	A39S	possibly damaging	Het
Cd274	T	C	19: 29,382,536 (GRCm38)	L247P	probably benign	Het
Cdhr5	T	C	7: 141,274,448 (GRCm38)	E138G	probably damaging	Het
Cltb	C	T	13: 54,593,880 (GRCm38)	C81Y	probably benign	Het
Clvs1	T	C	4: 9,281,865 (GRCm38)	L103P	possibly damaging	Het
Cntrob	G	T	11: 69,321,891 (GRCm38)	Q106K	possibly damaging	Het
Ctsh	T	C	9: 90,054,590 (GRCm38)	L14P	probably damaging	Het
Cubn	T	C	2: 13,287,568 (GRCm38)	N3268S	probably damaging	Het
Cyb5r4	T	C	9: 87,026,948 (GRCm38)	V26A	possibly damaging	Het
Ddx18	A	G	1: 121,562,128 (GRCm38)	I184T	probably damaging	Het
Ddx60	T	A	8: 61,974,188 (GRCm38)	W766R	probably damaging	Het
Dnah2	C	T	11: 69,458,920 (GRCm38)	R2399Q	probably benign	Het
Dnajc21	A	T	15: 10,463,964 (GRCm38)	N38K	probably benign	Het
Ermap	T	C	4: 119,185,818 (GRCm38)		probably null	Het
Fam129a	T	A	1: 151,703,829 (GRCm38)	L433Q	possibly damaging	Het
Fryl	A	G	5: 73,086,600 (GRCm38)	L1209P	possibly damaging	Het
Gm5093	T	C	17: 46,439,873 (GRCm38)	E76G	possibly damaging	Het
Grk6	T	C	13: 55,451,706 (GRCm38)	C169R	probably damaging	Het
Hmgn1	A	T	16: 96,122,427 (GRCm38)		probably null	Het
Lpcat2b	T	A	5: 107,434,135 (GRCm38)	Y443*	probably null	Het
Macf1	T	A	4: 123,472,089 (GRCm38)	M1395L	probably benign	Het
Mllt10	C	T	2: 18,208,774 (GRCm38)	Q997*	probably null	Het
Mocos	T	A	18: 24,692,554 (GRCm38)	V722E	probably damaging	Het
Moxd2	A	T	6: 40,879,337 (GRCm38)	L534M	probably benign	Het
Mphosph10	T	C	7: 64,385,820 (GRCm38)	M368V	possibly damaging	Het
Myo15	G	A	11: 60,503,614 (GRCm38)	G2383D	probably damaging	Het
Myo5b	T	C	18: 74,701,674 (GRCm38)	I935T	possibly damaging	Het
Ndst4	T	A	3: 125,437,911 (GRCm38)	L43H	probably damaging	Het
Nsl1	A	G	1: 191,075,190 (GRCm38)	N189D	probably benign	Het
Olfr558	A	T	7: 102,709,661 (GRCm38)	H134L	probably damaging	Het
Pcdh8	T	C	14: 79,770,154 (GRCm38)	D323G	probably damaging	Het
Pkhd1	A	G	1: 20,209,224 (GRCm38)	S2957P	possibly damaging	Het
Prdm9	T	G	17: 15,562,893 (GRCm38)	E42D	probably damaging	Het
Rasal1	C	A	5: 120,675,395 (GRCm38)	H611Q	probably benign	Het
Rif1	T	A	2: 52,081,289 (GRCm38)	W260R	probably damaging	Het
Rpain	A	G	11: 70,973,832 (GRCm38)	D115G	probably benign	Het
Rpl3l	T	C	17: 24,732,455 (GRCm38)	V110A	possibly damaging	Het
Ryr2	T	A	13: 11,772,452 (GRCm38)	I1012F	probably damaging	Het
Sema4f	A	G	6: 82,917,650 (GRCm38)	V480A	probably benign	Het
Slc35a3	T	A	3: 116,681,145 (GRCm38)	K199N	probably damaging	Het
Slc5a6	T	C	5: 31,042,978 (GRCm38)	Y121C	probably damaging	Het
Slc7a14	T	C	3: 31,237,365 (GRCm38)		probably null	Het
Sort1	T	A	3: 108,324,676 (GRCm38)	I172N	probably damaging	Het
Spink5	C	A	18: 43,989,451 (GRCm38)	H328N	probably damaging	Het
Tbl1xr1	A	G	3: 22,209,606 (GRCm38)	D504G	probably damaging	Het
Tcaf3	C	T	6: 42,597,020 (GRCm38)	C86Y	possibly damaging	Het
Tfap2e	T	C	4: 126,734,641 (GRCm38)	D174G	probably benign	Het
Tmem42	T	C	9: 123,022,167 (GRCm38)	V65A	probably damaging	Het
Vmn1r225	C	G	17: 20,502,915 (GRCm38)	T206R	probably damaging	Het
Vmn2r38	A	G	7: 9,097,572 (GRCm38)	F65S	probably benign	Het
Vmn2r87	A	T	10: 130,497,339 (GRCm38)	L14Q	probably null	Het
Xirp2	T	C	2: 67,515,367 (GRCm38)	S2651P	probably benign	Het
Zfp429	G	A	13: 67,390,840 (GRCm38)	L162F	probably damaging	Het
Zhx1	A	T	15: 58,052,423 (GRCm38)	M809K	probably damaging	Het

Other mutations in Dnah5

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00226:Dnah5	APN	15	28,272,342 (GRCm38)	missense	probably benign
IGL00331:Dnah5	APN	15	28,421,620 (GRCm38)	missense	probably damaging	1.00
IGL00519:Dnah5	APN	15	28,444,218 (GRCm38)	missense	probably benign	0.10
IGL00537:Dnah5	APN	15	28,458,702 (GRCm38)	critical splice donor site	probably null
IGL01102:Dnah5	APN	15	28,410,003 (GRCm38)	critical splice donor site	probably null
IGL01126:Dnah5	APN	15	28,302,399 (GRCm38)	missense	possibly damaging	0.85
IGL01154:Dnah5	APN	15	28,458,656 (GRCm38)	missense	possibly damaging	0.75
IGL01349:Dnah5	APN	15	28,294,913 (GRCm38)	splice site	probably benign
IGL01353:Dnah5	APN	15	28,233,272 (GRCm38)	missense	probably benign	0.00
IGL01372:Dnah5	APN	15	28,230,490 (GRCm38)	missense	probably benign	0.00
IGL01390:Dnah5	APN	15	28,411,540 (GRCm38)	missense	probably benign	0.00
IGL01446:Dnah5	APN	15	28,326,669 (GRCm38)	missense	probably damaging	1.00
IGL01472:Dnah5	APN	15	28,331,726 (GRCm38)	missense	probably damaging	1.00
IGL01485:Dnah5	APN	15	28,331,726 (GRCm38)	missense	probably damaging	1.00
IGL01568:Dnah5	APN	15	28,229,652 (GRCm38)	missense	probably benign	0.01
IGL01592:Dnah5	APN	15	28,236,637 (GRCm38)	missense	probably benign	0.01
IGL01594:Dnah5	APN	15	28,311,334 (GRCm38)	missense	possibly damaging	0.87
IGL01677:Dnah5	APN	15	28,367,782 (GRCm38)	missense	probably damaging	1.00
IGL01845:Dnah5	APN	15	28,449,169 (GRCm38)	missense	probably benign	0.06
IGL01904:Dnah5	APN	15	28,307,364 (GRCm38)	missense	probably benign	0.09
IGL01913:Dnah5	APN	15	28,313,753 (GRCm38)	missense	possibly damaging	0.50
IGL01950:Dnah5	APN	15	28,290,289 (GRCm38)	missense	probably null	1.00
IGL01963:Dnah5	APN	15	28,370,536 (GRCm38)	missense	probably benign	0.12
IGL02008:Dnah5	APN	15	28,343,552 (GRCm38)	missense	probably damaging	0.98
IGL02088:Dnah5	APN	15	28,459,118 (GRCm38)	critical splice acceptor site	probably null
IGL02090:Dnah5	APN	15	28,240,041 (GRCm38)	splice site	probably benign
IGL02114:Dnah5	APN	15	28,397,124 (GRCm38)	missense	probably damaging	0.97
IGL02135:Dnah5	APN	15	28,247,885 (GRCm38)	missense	possibly damaging	0.50
IGL02232:Dnah5	APN	15	28,299,240 (GRCm38)	missense	probably damaging	1.00
IGL02386:Dnah5	APN	15	28,340,381 (GRCm38)	missense	probably damaging	1.00
IGL02475:Dnah5	APN	15	28,219,150 (GRCm38)	missense	probably benign	0.09
IGL02626:Dnah5	APN	15	28,307,276 (GRCm38)	missense	possibly damaging	0.94
IGL02650:Dnah5	APN	15	28,289,047 (GRCm38)	splice site	probably benign
IGL02651:Dnah5	APN	15	28,350,622 (GRCm38)	missense	probably benign	0.05
IGL02652:Dnah5	APN	15	28,366,187 (GRCm38)	missense	probably damaging	0.99
IGL02670:Dnah5	APN	15	28,409,296 (GRCm38)	missense	probably damaging	1.00
IGL02697:Dnah5	APN	15	28,445,143 (GRCm38)	missense	probably benign	0.00
IGL02721:Dnah5	APN	15	28,234,243 (GRCm38)	critical splice acceptor site	probably null
IGL02858:Dnah5	APN	15	28,453,212 (GRCm38)	missense	possibly damaging	0.65
IGL02859:Dnah5	APN	15	28,383,625 (GRCm38)	missense	probably benign	0.01
IGL02945:Dnah5	APN	15	28,270,426 (GRCm38)	missense	probably benign	0.00
IGL02949:Dnah5	APN	15	28,272,185 (GRCm38)	missense	probably benign	0.32
IGL02971:Dnah5	APN	15	28,384,461 (GRCm38)	missense	probably damaging	1.00
IGL03017:Dnah5	APN	15	28,340,325 (GRCm38)	missense	possibly damaging	0.93
IGL03177:Dnah5	APN	15	28,295,399 (GRCm38)	missense	probably damaging	0.97
IGL03212:Dnah5	APN	15	28,290,163 (GRCm38)	missense	probably benign	0.08
IGL03224:Dnah5	APN	15	28,459,154 (GRCm38)	missense	probably damaging	1.00
IGL03231:Dnah5	APN	15	28,311,148 (GRCm38)	missense	probably damaging	1.00
IGL03273:Dnah5	APN	15	28,458,649 (GRCm38)	missense	probably damaging	0.98
IGL03294:Dnah5	APN	15	28,233,295 (GRCm38)	critical splice donor site	probably null
IGL03331:Dnah5	APN	15	28,419,940 (GRCm38)	missense	probably damaging	1.00
IGL03337:Dnah5	APN	15	28,290,141 (GRCm38)	missense	probably benign	0.10
IGL03367:Dnah5	APN	15	28,234,327 (GRCm38)	missense	possibly damaging	0.95
Firtel	UTSW	15	28,448,367 (GRCm38)	missense	possibly damaging	0.95
lowbar	UTSW	15	28,311,133 (GRCm38)	splice site	probably null
notherone	UTSW	15	28,340,406 (GRCm38)	missense	probably benign	0.13
scheffler	UTSW	15	28,438,091 (GRCm38)	splice site	probably benign
IGL02837:Dnah5	UTSW	15	28,269,400 (GRCm38)	missense	probably benign
P0008:Dnah5	UTSW	15	28,302,387 (GRCm38)	missense	probably damaging	1.00
P0014:Dnah5	UTSW	15	28,403,473 (GRCm38)	missense	probably damaging	1.00
PIT4687001:Dnah5	UTSW	15	28,383,577 (GRCm38)	missense	probably damaging	0.98
R0030:Dnah5	UTSW	15	28,451,517 (GRCm38)	missense	probably benign	0.34
R0087:Dnah5	UTSW	15	28,350,613 (GRCm38)	missense	probably damaging	1.00
R0099:Dnah5	UTSW	15	28,239,934 (GRCm38)	missense	probably damaging	1.00
R0102:Dnah5	UTSW	15	28,245,751 (GRCm38)	splice site	probably benign
R0102:Dnah5	UTSW	15	28,245,751 (GRCm38)	splice site	probably benign
R0104:Dnah5	UTSW	15	28,453,353 (GRCm38)	missense	possibly damaging	0.88
R0112:Dnah5	UTSW	15	28,263,679 (GRCm38)	missense	probably benign	0.00
R0122:Dnah5	UTSW	15	28,378,363 (GRCm38)	missense	probably damaging	1.00
R0126:Dnah5	UTSW	15	28,246,319 (GRCm38)	missense	probably benign	0.00
R0127:Dnah5	UTSW	15	28,294,925 (GRCm38)	missense	probably damaging	1.00
R0233:Dnah5	UTSW	15	28,333,070 (GRCm38)	missense	probably damaging	1.00
R0310:Dnah5	UTSW	15	28,299,110 (GRCm38)	missense	probably benign	0.19
R0386:Dnah5	UTSW	15	28,383,581 (GRCm38)	missense	probably damaging	1.00
R0421:Dnah5	UTSW	15	28,229,541 (GRCm38)	missense	possibly damaging	0.79
R0481:Dnah5	UTSW	15	28,383,599 (GRCm38)	missense	probably benign	0.31
R0514:Dnah5	UTSW	15	28,366,321 (GRCm38)	missense	probably damaging	1.00
R0609:Dnah5	UTSW	15	28,327,779 (GRCm38)	missense	probably benign
R0720:Dnah5	UTSW	15	28,313,861 (GRCm38)	missense	probably null	0.98
R0731:Dnah5	UTSW	15	28,311,143 (GRCm38)	missense	possibly damaging	0.78
R0747:Dnah5	UTSW	15	28,444,187 (GRCm38)	missense	possibly damaging	0.64
R0747:Dnah5	UTSW	15	28,444,186 (GRCm38)	missense	probably damaging	0.99
R0766:Dnah5	UTSW	15	28,448,487 (GRCm38)	missense	probably null	0.89
R0849:Dnah5	UTSW	15	28,263,599 (GRCm38)	missense	probably damaging	0.96
R1034:Dnah5	UTSW	15	28,302,471 (GRCm38)	missense	probably damaging	1.00
R1084:Dnah5	UTSW	15	28,343,452 (GRCm38)	missense	probably benign	0.01
R1148:Dnah5	UTSW	15	28,421,690 (GRCm38)	missense	probably damaging	1.00
R1148:Dnah5	UTSW	15	28,421,690 (GRCm38)	missense	probably damaging	1.00
R1200:Dnah5	UTSW	15	28,246,257 (GRCm38)	missense	possibly damaging	0.88
R1208:Dnah5	UTSW	15	28,327,731 (GRCm38)	missense	probably damaging	1.00
R1208:Dnah5	UTSW	15	28,327,731 (GRCm38)	missense	probably damaging	1.00
R1269:Dnah5	UTSW	15	28,238,511 (GRCm38)	missense	probably damaging	1.00
R1373:Dnah5	UTSW	15	28,313,918 (GRCm38)	splice site	probably benign
R1401:Dnah5	UTSW	15	28,401,913 (GRCm38)	missense	probably damaging	1.00
R1413:Dnah5	UTSW	15	28,370,409 (GRCm38)	missense	probably benign
R1430:Dnah5	UTSW	15	28,345,857 (GRCm38)	missense	probably benign	0.37
R1457:Dnah5	UTSW	15	28,403,542 (GRCm38)	critical splice donor site	probably null
R1468:Dnah5	UTSW	15	28,230,463 (GRCm38)	nonsense	probably null
R1468:Dnah5	UTSW	15	28,230,463 (GRCm38)	nonsense	probably null
R1560:Dnah5	UTSW	15	28,420,003 (GRCm38)	missense	probably damaging	1.00
R1568:Dnah5	UTSW	15	28,409,177 (GRCm38)	missense	probably damaging	0.98
R1574:Dnah5	UTSW	15	28,252,423 (GRCm38)	missense	probably benign	0.00
R1574:Dnah5	UTSW	15	28,252,423 (GRCm38)	missense	probably benign	0.00
R1603:Dnah5	UTSW	15	28,449,180 (GRCm38)	missense	probably benign	0.09
R1603:Dnah5	UTSW	15	28,294,985 (GRCm38)	splice site	probably benign
R1673:Dnah5	UTSW	15	28,290,148 (GRCm38)	missense	probably benign
R1755:Dnah5	UTSW	15	28,326,636 (GRCm38)	missense	probably damaging	0.99
R1785:Dnah5	UTSW	15	28,313,786 (GRCm38)	missense	probably damaging	1.00
R1786:Dnah5	UTSW	15	28,313,786 (GRCm38)	missense	probably damaging	1.00
R1789:Dnah5	UTSW	15	28,270,426 (GRCm38)	missense	probably benign	0.00
R1817:Dnah5	UTSW	15	28,246,400 (GRCm38)	nonsense	probably null
R1819:Dnah5	UTSW	15	28,246,400 (GRCm38)	nonsense	probably null
R1834:Dnah5	UTSW	15	28,409,124 (GRCm38)	missense	probably benign	0.00
R1855:Dnah5	UTSW	15	28,411,669 (GRCm38)	missense	possibly damaging	0.88
R1870:Dnah5	UTSW	15	28,331,713 (GRCm38)	nonsense	probably null
R1871:Dnah5	UTSW	15	28,331,713 (GRCm38)	nonsense	probably null
R1987:Dnah5	UTSW	15	28,343,591 (GRCm38)	missense	probably damaging	0.99
R1988:Dnah5	UTSW	15	28,343,591 (GRCm38)	missense	probably damaging	0.99
R1989:Dnah5	UTSW	15	28,343,591 (GRCm38)	missense	probably damaging	0.99
R2062:Dnah5	UTSW	15	28,366,270 (GRCm38)	missense	probably damaging	1.00
R2069:Dnah5	UTSW	15	28,312,388 (GRCm38)	splice site	probably null
R2121:Dnah5	UTSW	15	28,297,005 (GRCm38)	splice site	probably benign
R2128:Dnah5	UTSW	15	28,408,321 (GRCm38)	missense	probably benign	0.00
R2129:Dnah5	UTSW	15	28,408,321 (GRCm38)	missense	probably benign	0.00
R2151:Dnah5	UTSW	15	28,444,091 (GRCm38)	missense	probably damaging	1.00
R2159:Dnah5	UTSW	15	28,252,545 (GRCm38)	missense	probably benign	0.00
R2207:Dnah5	UTSW	15	28,343,671 (GRCm38)	missense	probably benign	0.11
R2231:Dnah5	UTSW	15	28,408,417 (GRCm38)	critical splice donor site	probably null
R2232:Dnah5	UTSW	15	28,408,417 (GRCm38)	critical splice donor site	probably null
R2282:Dnah5	UTSW	15	28,327,302 (GRCm38)	missense	probably damaging	0.99
R2305:Dnah5	UTSW	15	28,387,767 (GRCm38)	missense	probably benign	0.25
R2339:Dnah5	UTSW	15	28,313,882 (GRCm38)	missense	probably benign	0.00
R2437:Dnah5	UTSW	15	28,307,391 (GRCm38)	critical splice donor site	probably null
R2696:Dnah5	UTSW	15	28,278,576 (GRCm38)	missense	probably benign	0.00
R3156:Dnah5	UTSW	15	28,438,091 (GRCm38)	splice site	probably benign
R3431:Dnah5	UTSW	15	28,295,267 (GRCm38)	missense	probably benign	0.20
R3700:Dnah5	UTSW	15	28,387,791 (GRCm38)	missense	possibly damaging	0.72
R3724:Dnah5	UTSW	15	28,270,420 (GRCm38)	missense	probably benign	0.08
R3732:Dnah5	UTSW	15	28,409,122 (GRCm38)	missense	possibly damaging	0.64
R3872:Dnah5	UTSW	15	28,411,510 (GRCm38)	missense	possibly damaging	0.50
R4063:Dnah5	UTSW	15	28,420,998 (GRCm38)	missense	probably damaging	0.98
R4072:Dnah5	UTSW	15	28,340,298 (GRCm38)	nonsense	probably null
R4075:Dnah5	UTSW	15	28,293,791 (GRCm38)	missense	probably benign
R4245:Dnah5	UTSW	15	28,219,189 (GRCm38)	missense	probably benign
R4254:Dnah5	UTSW	15	28,438,102 (GRCm38)	missense	probably benign	0.07
R4255:Dnah5	UTSW	15	28,438,102 (GRCm38)	missense	probably benign	0.07
R4392:Dnah5	UTSW	15	28,289,229 (GRCm38)	missense	probably benign	0.19
R4552:Dnah5	UTSW	15	28,397,154 (GRCm38)	missense	probably benign	0.19
R4574:Dnah5	UTSW	15	28,367,763 (GRCm38)	missense	probably benign	0.05
R4577:Dnah5	UTSW	15	28,289,250 (GRCm38)	missense	probably benign	0.06
R4587:Dnah5	UTSW	15	28,304,599 (GRCm38)	missense	probably damaging	1.00
R4631:Dnah5	UTSW	15	28,419,994 (GRCm38)	missense	probably damaging	1.00
R4631:Dnah5	UTSW	15	28,401,953 (GRCm38)	missense	probably damaging	1.00
R4676:Dnah5	UTSW	15	28,295,260 (GRCm38)	missense	possibly damaging	0.65
R4707:Dnah5	UTSW	15	28,372,375 (GRCm38)	missense	probably damaging	0.97
R4754:Dnah5	UTSW	15	28,420,955 (GRCm38)	splice site	probably null
R4767:Dnah5	UTSW	15	28,270,474 (GRCm38)	missense	probably benign	0.02
R4857:Dnah5	UTSW	15	28,345,807 (GRCm38)	missense	probably benign	0.00
R4883:Dnah5	UTSW	15	28,343,638 (GRCm38)	missense	probably benign	0.00
R4889:Dnah5	UTSW	15	28,235,792 (GRCm38)	missense	probably benign	0.01
R4946:Dnah5	UTSW	15	28,387,904 (GRCm38)	missense	probably damaging	1.00
R4946:Dnah5	UTSW	15	28,326,557 (GRCm38)	missense	probably damaging	0.96
R4947:Dnah5	UTSW	15	28,272,372 (GRCm38)	missense	probably benign
R5033:Dnah5	UTSW	15	28,421,678 (GRCm38)	missense	probably damaging	0.96
R5164:Dnah5	UTSW	15	28,408,292 (GRCm38)	missense	probably benign	0.00
R5175:Dnah5	UTSW	15	28,448,404 (GRCm38)	missense	probably damaging	1.00
R5182:Dnah5	UTSW	15	28,311,278 (GRCm38)	missense	probably damaging	0.99
R5272:Dnah5	UTSW	15	28,350,665 (GRCm38)	missense	probably benign
R5308:Dnah5	UTSW	15	28,229,651 (GRCm38)	missense	possibly damaging	0.80
R5310:Dnah5	UTSW	15	28,311,328 (GRCm38)	missense	probably damaging	1.00
R5322:Dnah5	UTSW	15	28,384,244 (GRCm38)	missense	probably benign	0.41
R5398:Dnah5	UTSW	15	28,293,726 (GRCm38)	missense	probably benign
R5596:Dnah5	UTSW	15	28,343,608 (GRCm38)	missense	probably damaging	1.00
R5603:Dnah5	UTSW	15	28,419,932 (GRCm38)	missense	probably damaging	1.00
R5619:Dnah5	UTSW	15	28,302,435 (GRCm38)	missense	probably damaging	1.00
R5656:Dnah5	UTSW	15	28,421,064 (GRCm38)	missense	probably benign	0.03
R5741:Dnah5	UTSW	15	28,246,367 (GRCm38)	missense	probably benign	0.11
R5754:Dnah5	UTSW	15	28,401,868 (GRCm38)	missense	probably benign	0.01
R5763:Dnah5	UTSW	15	28,311,152 (GRCm38)	missense	probably damaging	1.00
R5824:Dnah5	UTSW	15	28,313,821 (GRCm38)	missense	probably benign	0.00
R5836:Dnah5	UTSW	15	28,383,592 (GRCm38)	missense	probably damaging	1.00
R5838:Dnah5	UTSW	15	28,290,195 (GRCm38)	missense	probably benign	0.00
R5864:Dnah5	UTSW	15	28,297,013 (GRCm38)	missense	possibly damaging	0.83
R5895:Dnah5	UTSW	15	28,234,453 (GRCm38)	splice site	probably null
R5896:Dnah5	UTSW	15	28,272,060 (GRCm38)	missense	probably benign
R5899:Dnah5	UTSW	15	28,448,367 (GRCm38)	missense	possibly damaging	0.95
R5905:Dnah5	UTSW	15	28,387,833 (GRCm38)	missense	probably damaging	1.00
R5924:Dnah5	UTSW	15	28,307,327 (GRCm38)	missense	probably benign	0.41
R5927:Dnah5	UTSW	15	28,335,718 (GRCm38)	missense	probably benign	0.00
R5929:Dnah5	UTSW	15	28,311,208 (GRCm38)	missense	probably damaging	1.00
R5929:Dnah5	UTSW	15	28,311,207 (GRCm38)	missense	probably benign	0.01
R5931:Dnah5	UTSW	15	28,453,279 (GRCm38)	missense	probably damaging	0.99
R5964:Dnah5	UTSW	15	28,458,584 (GRCm38)	missense	possibly damaging	0.49
R5975:Dnah5	UTSW	15	28,234,282 (GRCm38)	missense	probably damaging	1.00
R5993:Dnah5	UTSW	15	28,299,226 (GRCm38)	missense	probably benign	0.09
R6016:Dnah5	UTSW	15	28,327,884 (GRCm38)	missense	probably damaging	1.00
R6028:Dnah5	UTSW	15	28,387,833 (GRCm38)	missense	probably damaging	1.00
R6065:Dnah5	UTSW	15	28,230,468 (GRCm38)	missense	possibly damaging	0.47
R6117:Dnah5	UTSW	15	28,270,420 (GRCm38)	missense	probably damaging	0.99
R6143:Dnah5	UTSW	15	28,233,231 (GRCm38)	missense	probably benign	0.05
R6146:Dnah5	UTSW	15	28,459,185 (GRCm38)	missense	probably benign
R6154:Dnah5	UTSW	15	28,204,031 (GRCm38)	missense	probably benign	0.15
R6164:Dnah5	UTSW	15	28,378,343 (GRCm38)	missense	probably benign	0.08
R6266:Dnah5	UTSW	15	28,335,627 (GRCm38)	missense	possibly damaging	0.67
R6321:Dnah5	UTSW	15	28,372,411 (GRCm38)	missense	probably damaging	0.99
R6349:Dnah5	UTSW	15	28,238,511 (GRCm38)	missense	probably damaging	1.00
R6431:Dnah5	UTSW	15	28,349,824 (GRCm38)	missense	possibly damaging	0.52
R6467:Dnah5	UTSW	15	28,438,183 (GRCm38)	missense	probably benign	0.10
R6564:Dnah5	UTSW	15	28,367,745 (GRCm38)	missense	probably benign
R6607:Dnah5	UTSW	15	28,445,200 (GRCm38)	missense	possibly damaging	0.95
R6619:Dnah5	UTSW	15	28,409,120 (GRCm38)	missense	probably benign	0.03
R6633:Dnah5	UTSW	15	28,293,787 (GRCm38)	missense	probably benign	0.27
R6647:Dnah5	UTSW	15	28,403,487 (GRCm38)	missense	probably benign	0.02
R6782:Dnah5	UTSW	15	28,449,156 (GRCm38)	missense	possibly damaging	0.89
R6797:Dnah5	UTSW	15	28,233,238 (GRCm38)	nonsense	probably null
R6797:Dnah5	UTSW	15	28,451,463 (GRCm38)	missense	probably damaging	1.00
R6831:Dnah5	UTSW	15	28,411,515 (GRCm38)	missense	possibly damaging	0.88
R6849:Dnah5	UTSW	15	28,278,624 (GRCm38)	missense	probably benign	0.14
R6871:Dnah5	UTSW	15	28,229,640 (GRCm38)	missense	probably benign	0.32
R6936:Dnah5	UTSW	15	28,409,268 (GRCm38)	missense	probably damaging	1.00
R6943:Dnah5	UTSW	15	28,235,720 (GRCm38)	missense	probably damaging	1.00
R7030:Dnah5	UTSW	15	28,333,062 (GRCm38)	missense	probably benign	0.00
R7030:Dnah5	UTSW	15	28,238,592 (GRCm38)	missense	probably benign
R7032:Dnah5	UTSW	15	28,326,650 (GRCm38)	missense	probably damaging	1.00
R7063:Dnah5	UTSW	15	28,233,248 (GRCm38)	missense	probably benign	0.00
R7094:Dnah5	UTSW	15	28,453,336 (GRCm38)	missense	probably damaging	0.98
R7097:Dnah5	UTSW	15	28,453,264 (GRCm38)	missense	probably benign	0.00
R7126:Dnah5	UTSW	15	28,349,837 (GRCm38)	missense	probably benign	0.03
R7153:Dnah5	UTSW	15	28,365,522 (GRCm38)	splice site	probably null
R7209:Dnah5	UTSW	15	28,459,225 (GRCm38)	missense	possibly damaging	0.71
R7276:Dnah5	UTSW	15	28,367,838 (GRCm38)	missense	probably damaging	1.00
R7320:Dnah5	UTSW	15	28,270,470 (GRCm38)	missense	probably null	0.33
R7350:Dnah5	UTSW	15	28,235,819 (GRCm38)	critical splice donor site	probably null
R7380:Dnah5	UTSW	15	28,370,378 (GRCm38)	missense	probably damaging	1.00
R7438:Dnah5	UTSW	15	28,346,952 (GRCm38)	missense	probably damaging	0.99
R7499:Dnah5	UTSW	15	28,302,450 (GRCm38)	missense	probably damaging	1.00
R7513:Dnah5	UTSW	15	28,370,415 (GRCm38)	missense	probably benign
R7519:Dnah5	UTSW	15	28,390,483 (GRCm38)	missense	probably damaging	0.98
R7524:Dnah5	UTSW	15	28,297,066 (GRCm38)	missense	possibly damaging	0.50
R7556:Dnah5	UTSW	15	28,290,243 (GRCm38)	missense	probably null	0.43
R7570:Dnah5	UTSW	15	28,346,952 (GRCm38)	missense	probably damaging	1.00
R7585:Dnah5	UTSW	15	28,401,868 (GRCm38)	missense	probably benign	0.09
R7642:Dnah5	UTSW	15	28,247,979 (GRCm38)	critical splice donor site	probably null
R7670:Dnah5	UTSW	15	28,246,232 (GRCm38)	splice site	probably null
R7763:Dnah5	UTSW	15	28,313,855 (GRCm38)	missense	probably damaging	1.00
R7821:Dnah5	UTSW	15	28,411,532 (GRCm38)	missense	possibly damaging	0.89
R7826:Dnah5	UTSW	15	28,367,812 (GRCm38)	missense	probably damaging	1.00
R7872:Dnah5	UTSW	15	28,245,684 (GRCm38)	missense	probably damaging	0.99
R7889:Dnah5	UTSW	15	28,448,414 (GRCm38)	nonsense	probably null
R7919:Dnah5	UTSW	15	28,350,596 (GRCm38)	missense	probably damaging	1.00
R7920:Dnah5	UTSW	15	28,453,222 (GRCm38)	missense	probably benign	0.00
R7936:Dnah5	UTSW	15	28,345,837 (GRCm38)	missense	possibly damaging	0.64
R7996:Dnah5	UTSW	15	28,409,177 (GRCm38)	missense	probably damaging	0.98
R8063:Dnah5	UTSW	15	28,230,583 (GRCm38)	missense	probably benign
R8084:Dnah5	UTSW	15	28,387,953 (GRCm38)	missense	probably damaging	1.00
R8105:Dnah5	UTSW	15	28,372,402 (GRCm38)	missense	probably benign
R8114:Dnah5	UTSW	15	28,239,976 (GRCm38)	missense	probably benign	0.01
R8142:Dnah5	UTSW	15	28,384,373 (GRCm38)	missense	probably benign	0.36
R8153:Dnah5	UTSW	15	28,384,430 (GRCm38)	missense	probably damaging	1.00
R8161:Dnah5	UTSW	15	28,350,704 (GRCm38)	missense	possibly damaging	0.79
R8174:Dnah5	UTSW	15	28,311,133 (GRCm38)	splice site	probably null
R8187:Dnah5	UTSW	15	28,384,209 (GRCm38)	missense	probably damaging	1.00
R8194:Dnah5	UTSW	15	28,453,268 (GRCm38)	missense	probably damaging	0.99
R8280:Dnah5	UTSW	15	28,408,392 (GRCm38)	missense	probably benign	0.01
R8291:Dnah5	UTSW	15	28,263,597 (GRCm38)	missense	probably benign	0.03
R8324:Dnah5	UTSW	15	28,346,865 (GRCm38)	missense	probably damaging	1.00
R8347:Dnah5	UTSW	15	28,236,666 (GRCm38)	missense	possibly damaging	0.90
R8356:Dnah5	UTSW	15	28,444,167 (GRCm38)	missense	probably benign	0.03
R8356:Dnah5	UTSW	15	28,444,323 (GRCm38)	missense	probably null	0.02
R8361:Dnah5	UTSW	15	28,331,810 (GRCm38)	missense	probably damaging	0.98
R8375:Dnah5	UTSW	15	28,327,343 (GRCm38)	missense	probably benign	0.00
R8474:Dnah5	UTSW	15	28,247,832 (GRCm38)	missense	probably benign	0.00
R8481:Dnah5	UTSW	15	28,419,795 (GRCm38)	missense	probably benign	0.00
R8494:Dnah5	UTSW	15	28,345,831 (GRCm38)	missense	probably benign	0.32
R8495:Dnah5	UTSW	15	28,409,268 (GRCm38)	missense	probably damaging	0.97
R8519:Dnah5	UTSW	15	28,299,099 (GRCm38)	missense	probably benign	0.07
R8683:Dnah5	UTSW	15	28,289,221 (GRCm38)	missense	probably benign	0.00
R8739:Dnah5	UTSW	15	28,345,860 (GRCm38)	missense	probably benign	0.01
R8752:Dnah5	UTSW	15	28,290,219 (GRCm38)	missense	probably benign	0.00
R8784:Dnah5	UTSW	15	28,387,951 (GRCm38)	missense	probably benign	0.16
R8813:Dnah5	UTSW	15	28,229,573 (GRCm38)	missense	probably damaging	1.00
R8862:Dnah5	UTSW	15	28,459,356 (GRCm38)	splice site	probably benign
R8873:Dnah5	UTSW	15	28,219,188 (GRCm38)	missense	probably benign
R8885:Dnah5	UTSW	15	28,327,740 (GRCm38)	missense	probably damaging	1.00
R8901:Dnah5	UTSW	15	28,365,569 (GRCm38)	missense	possibly damaging	0.76
R9025:Dnah5	UTSW	15	28,409,266 (GRCm38)	missense	probably damaging	1.00
R9037:Dnah5	UTSW	15	28,247,958 (GRCm38)	missense	probably benign	0.05
R9057:Dnah5	UTSW	15	28,390,868 (GRCm38)	missense	probably damaging	1.00
R9059:Dnah5	UTSW	15	28,245,666 (GRCm38)	missense	probably benign
R9065:Dnah5	UTSW	15	28,293,790 (GRCm38)	missense	probably benign	0.09
R9098:Dnah5	UTSW	15	28,419,961 (GRCm38)	missense
R9118:Dnah5	UTSW	15	28,401,848 (GRCm38)	frame shift	probably null
R9149:Dnah5	UTSW	15	28,387,768 (GRCm38)	missense	probably benign	0.00
R9184:Dnah5	UTSW	15	28,340,406 (GRCm38)	missense	probably benign	0.13
R9205:Dnah5	UTSW	15	28,448,334 (GRCm38)	missense	possibly damaging	0.88
R9297:Dnah5	UTSW	15	28,203,908 (GRCm38)	start gained	probably benign
R9302:Dnah5	UTSW	15	28,239,886 (GRCm38)	missense	probably benign	0.03
R9310:Dnah5	UTSW	15	28,448,433 (GRCm38)	missense	probably damaging	1.00
R9318:Dnah5	UTSW	15	28,203,908 (GRCm38)	start gained	probably benign
R9405:Dnah5	UTSW	15	28,272,160 (GRCm38)	missense	probably benign
R9424:Dnah5	UTSW	15	28,272,140 (GRCm38)	missense	probably benign	0.01
R9467:Dnah5	UTSW	15	28,366,147 (GRCm38)	missense	possibly damaging	0.94
R9469:Dnah5	UTSW	15	28,421,000 (GRCm38)	missense	probably benign	0.06
R9548:Dnah5	UTSW	15	28,327,879 (GRCm38)	missense	possibly damaging	0.79
R9564:Dnah5	UTSW	15	28,290,276 (GRCm38)	missense	probably benign	0.04
R9576:Dnah5	UTSW	15	28,272,140 (GRCm38)	missense	probably benign	0.01
R9593:Dnah5	UTSW	15	28,236,628 (GRCm38)	missense	probably benign
R9644:Dnah5	UTSW	15	28,230,504 (GRCm38)	missense	probably damaging	0.98
R9655:Dnah5	UTSW	15	28,242,754 (GRCm38)	missense	probably benign
R9657:Dnah5	UTSW	15	28,409,943 (GRCm38)	missense	probably damaging	1.00
R9704:Dnah5	UTSW	15	28,247,819 (GRCm38)	missense	probably benign	0.00
R9797:Dnah5	UTSW	15	28,233,170 (GRCm38)	missense	probably benign	0.34
RF009:Dnah5	UTSW	15	28,204,019 (GRCm38)	missense	probably benign	0.00
X0011:Dnah5	UTSW	15	28,408,381 (GRCm38)	missense	probably benign	0.16
X0018:Dnah5	UTSW	15	28,269,354 (GRCm38)	missense	probably benign	0.00
X0022:Dnah5	UTSW	15	28,270,411 (GRCm38)	missense	probably benign	0.01
X0023:Dnah5	UTSW	15	28,384,308 (GRCm38)	missense	probably damaging	0.99
X0028:Dnah5	UTSW	15	28,470,477 (GRCm38)	missense	probably damaging	1.00
Z1088:Dnah5	UTSW	15	28,366,357 (GRCm38)	missense	probably null	0.10
Z1088:Dnah5	UTSW	15	28,384,230 (GRCm38)	missense	probably damaging	1.00
Z1177:Dnah5	UTSW	15	28,295,311 (GRCm38)	missense	probably damaging	0.98
Z1177:Dnah5	UTSW	15	28,270,403 (GRCm38)	missense	probably benign	0.00
Z1177:Dnah5	UTSW	15	28,270,354 (GRCm38)	missense	probably benign	0.32
Z1177:Dnah5	UTSW	15	28,387,763 (GRCm38)	missense	possibly damaging	0.72

Predicted Primers

PCR Primer
(F):5'- CCCATTACATGTGTATTATGTGTGC -3'
(R):5'- ACCTCAGCGTCTGAATCACTG -3'

Sequencing Primer
(F):5'- GTGCTTTAATTTTTGGCAGAGTC -3'
(R):5'- AGCGTCTGAATCACTGTCTTCG -3'

Posted On

2016-07-06