Incidental Mutation 'R0453:Tdrd9'
ID 39803
Institutional Source Beutler Lab
Gene Symbol Tdrd9
Ensembl Gene ENSMUSG00000054003
Gene Name tudor domain containing 9
Synonyms 4930441E05Rik
MMRRC Submission 038653-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.192) question?
Stock # R0453 (G1)
Quality Score 128
Status Validated
Chromosome 12
Chromosomal Location 111937993-112035288 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 112034673 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Serine to Proline at position 1371 (S1371P)
Ref Sequence ENSEMBL: ENSMUSP00000078022 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000079009]
AlphaFold Q14BI7
Predicted Effect probably benign
Transcript: ENSMUST00000079009
AA Change: S1371P

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000078022
Gene: ENSMUSG00000054003
AA Change: S1371P

DomainStartEndE-ValueType
low complexity region 29 40 N/A INTRINSIC
low complexity region 70 81 N/A INTRINSIC
DEXDc 132 327 5.64e-21 SMART
HELICc 404 502 3.22e-16 SMART
low complexity region 547 561 N/A INTRINSIC
HA2 565 666 1.9e-20 SMART
TUDOR 944 1003 1.52e-7 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000191808
Predicted Effect probably benign
Transcript: ENSMUST00000192125
Predicted Effect noncoding transcript
Transcript: ENSMUST00000193630
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.3%
  • 10x: 96.4%
  • 20x: 93.6%
Validation Efficiency 99% (97/98)
MGI Phenotype PHENOTYPE: Male homozygous mice are sterile, displaying small testis, arrest of male meiosis and abnormal spermatocyte morphology. Females are fertile. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 97 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acad10 T A 5: 121,765,445 (GRCm39) K843* probably null Het
Adam26b T C 8: 43,973,387 (GRCm39) I538M probably benign Het
Adamtsl1 T C 4: 86,150,852 (GRCm39) Y337H probably damaging Het
Ak7 T C 12: 105,682,307 (GRCm39) M156T probably damaging Het
Aldh3a1 A G 11: 61,106,338 (GRCm39) M238V probably benign Het
Asic4 T A 1: 75,450,155 (GRCm39) probably benign Het
AW551984 A G 9: 39,511,937 (GRCm39) S25P probably damaging Het
Bbs7 T A 3: 36,661,818 (GRCm39) Y127F possibly damaging Het
Bco1 G A 8: 117,835,516 (GRCm39) E156K possibly damaging Het
Becn1 T C 11: 101,181,275 (GRCm39) D342G probably damaging Het
Birc6 T A 17: 74,956,749 (GRCm39) I3575N probably damaging Het
Brd10 T C 19: 29,731,068 (GRCm39) Y715C probably damaging Het
Cc2d2a A T 5: 43,860,636 (GRCm39) M522L probably benign Het
Cerkl A G 2: 79,172,795 (GRCm39) F293L probably benign Het
Chil3 T G 3: 106,056,221 (GRCm39) N311T probably benign Het
Cpeb2 T A 5: 43,443,056 (GRCm39) probably benign Het
Cpxm2 A G 7: 131,730,134 (GRCm39) S162P probably damaging Het
Cracr2b A C 7: 141,044,176 (GRCm39) E136A probably damaging Het
Cyp2a4 T A 7: 26,012,258 (GRCm39) M347K probably benign Het
Dicer1 C A 12: 104,668,889 (GRCm39) R1264S probably benign Het
Dlgap1 T A 17: 71,068,341 (GRCm39) N609K probably benign Het
Dnhd1 A G 7: 105,323,651 (GRCm39) T641A probably benign Het
Egfl8 T C 17: 34,833,856 (GRCm39) Y74C probably damaging Het
Esyt1 A G 10: 128,348,078 (GRCm39) S901P probably benign Het
Fam83e A T 7: 45,373,372 (GRCm39) D246V probably damaging Het
Galnt2 T C 8: 125,065,323 (GRCm39) probably benign Het
Hdc A G 2: 126,436,871 (GRCm39) probably benign Het
Herc1 A C 9: 66,307,054 (GRCm39) Q958P probably benign Het
Iqcg T A 16: 32,870,213 (GRCm39) probably benign Het
Iqub A T 6: 24,450,829 (GRCm39) F590Y probably damaging Het
Jak2 T C 19: 29,289,238 (GRCm39) I1130T probably benign Het
Kbtbd11 G A 8: 15,077,499 (GRCm39) A33T probably benign Het
Kcnip4 A G 5: 48,667,054 (GRCm39) L37P probably damaging Het
Klk6 A G 7: 43,477,963 (GRCm39) N112D probably damaging Het
Kmt2c G A 5: 25,559,745 (GRCm39) T1011I probably damaging Het
Knl1 A T 2: 118,898,869 (GRCm39) K190M probably damaging Het
Lama3 T A 18: 12,598,535 (GRCm39) S981T possibly damaging Het
Lrrc18 T C 14: 32,730,608 (GRCm39) L49P probably damaging Het
Lrrc31 T C 3: 30,741,674 (GRCm39) E245G probably damaging Het
Lypd10 T A 7: 24,413,712 (GRCm39) S243T probably benign Het
Macf1 T C 4: 123,338,737 (GRCm39) I2456M probably benign Het
Mcm6 T A 1: 128,261,292 (GRCm39) T771S probably benign Het
Met A C 6: 17,534,197 (GRCm39) Y680S possibly damaging Het
Mixl1 T A 1: 180,524,211 (GRCm39) T123S probably damaging Het
Myh8 A T 11: 67,183,731 (GRCm39) I787F probably benign Het
Myocd A G 11: 65,087,051 (GRCm39) F292S probably damaging Het
Neb T C 2: 52,203,902 (GRCm39) probably null Het
Nfe2l1 A G 11: 96,718,194 (GRCm39) S114P probably damaging Het
Nrxn2 T C 19: 6,541,551 (GRCm39) S986P probably damaging Het
Oprl1 T C 2: 181,360,527 (GRCm39) probably null Het
Or11h6 T C 14: 50,880,461 (GRCm39) V241A possibly damaging Het
Or4a73 A T 2: 89,421,095 (GRCm39) Y121* probably null Het
Or5b101 T G 19: 13,005,295 (GRCm39) T133P probably damaging Het
Or6c8 A G 10: 128,915,640 (GRCm39) F64S probably damaging Het
Or8b53 G A 9: 38,667,425 (GRCm39) G147D probably damaging Het
Or8c9 A T 9: 38,241,467 (GRCm39) T195S probably benign Het
Panx2 T A 15: 88,952,610 (GRCm39) I359N probably damaging Het
Pik3c2b T A 1: 133,005,134 (GRCm39) V545E probably damaging Het
Piwil4 T C 9: 14,638,748 (GRCm39) N259S probably benign Het
Plcxd2 A T 16: 45,800,919 (GRCm39) F102I probably damaging Het
Pld5 A T 1: 175,917,522 (GRCm39) M75K possibly damaging Het
Pmp22 T A 11: 63,041,929 (GRCm39) probably benign Het
Polr2a A G 11: 69,631,845 (GRCm39) S1074P possibly damaging Het
Pop1 T A 15: 34,526,352 (GRCm39) V649E possibly damaging Het
Prc1 A G 7: 79,962,850 (GRCm39) N548S probably damaging Het
Prss51 T C 14: 64,334,588 (GRCm39) L202P probably damaging Het
Rhpn1 T C 15: 75,585,428 (GRCm39) S576P possibly damaging Het
Rictor A G 15: 6,738,123 (GRCm39) D20G probably benign Het
Rpl13a-ps1 A T 19: 50,018,645 (GRCm39) L177* probably null Het
Rpl23a-ps1 T G 1: 46,021,087 (GRCm39) noncoding transcript Het
Saa2 A G 7: 46,402,902 (GRCm39) D51G probably damaging Het
Sec31a A T 5: 100,551,977 (GRCm39) probably benign Het
Secisbp2 G A 13: 51,837,361 (GRCm39) E841K possibly damaging Het
Serinc1 A G 10: 57,393,306 (GRCm39) Y437H probably damaging Het
Slc39a12 A T 2: 14,440,492 (GRCm39) H481L probably benign Het
Suz12 T A 11: 79,920,859 (GRCm39) N586K probably damaging Het
Synm T C 7: 67,386,630 (GRCm39) Y344C possibly damaging Het
Tas2r104 A G 6: 131,662,304 (GRCm39) V135A probably benign Het
Tg T A 15: 66,700,382 (GRCm39) D893E probably benign Het
Thoc5 C A 11: 4,868,217 (GRCm39) D423E possibly damaging Het
Trim11 G A 11: 58,881,361 (GRCm39) R418H probably damaging Het
Trim52 T G 14: 106,344,399 (GRCm39) V19G probably damaging Het
Tuba4a C A 1: 75,192,502 (GRCm39) V371L probably damaging Het
Ugt8a A G 3: 125,708,606 (GRCm39) V168A probably benign Het
Ulk1 C T 5: 110,938,951 (GRCm39) G496R probably damaging Het
Usp40 A G 1: 87,874,320 (GRCm39) *1236Q probably null Het
Vmn2r100 C A 17: 19,742,382 (GRCm39) P252Q possibly damaging Het
Vmn2r24 A G 6: 123,757,350 (GRCm39) probably null Het
Vmn2r53 A G 7: 12,316,338 (GRCm39) Y494H probably damaging Het
Vmn2r65 T A 7: 84,595,442 (GRCm39) D414V probably benign Het
Wdr26 A T 1: 181,010,444 (GRCm39) L519* probably null Het
Wnk1 A G 6: 119,940,112 (GRCm39) V173A probably damaging Het
Zfp217 C T 2: 169,957,382 (GRCm39) A539T probably benign Het
Zfp318 T C 17: 46,707,634 (GRCm39) S231P probably damaging Het
Zfp398 T C 6: 47,842,782 (GRCm39) V146A probably benign Het
Zfp410 T C 12: 84,378,486 (GRCm39) M270T probably damaging Het
Zfp445 A T 9: 122,682,578 (GRCm39) H454Q possibly damaging Het
Other mutations in Tdrd9
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01339:Tdrd9 APN 12 112,006,868 (GRCm39) missense probably damaging 1.00
IGL01373:Tdrd9 APN 12 112,006,868 (GRCm39) missense probably damaging 1.00
IGL01542:Tdrd9 APN 12 112,013,423 (GRCm39) missense possibly damaging 0.94
IGL02967:Tdrd9 APN 12 111,958,922 (GRCm39) missense possibly damaging 0.50
IGL03063:Tdrd9 APN 12 112,010,733 (GRCm39) missense probably benign 0.00
IGL03107:Tdrd9 APN 12 112,009,274 (GRCm39) missense probably damaging 0.98
R0433:Tdrd9 UTSW 12 111,992,015 (GRCm39) nonsense probably null
R0655:Tdrd9 UTSW 12 112,006,899 (GRCm39) missense probably damaging 1.00
R0666:Tdrd9 UTSW 12 111,974,014 (GRCm39) intron probably benign
R1073:Tdrd9 UTSW 12 111,989,693 (GRCm39) missense probably damaging 1.00
R1280:Tdrd9 UTSW 12 112,005,842 (GRCm39) missense probably damaging 1.00
R1386:Tdrd9 UTSW 12 112,011,238 (GRCm39) missense probably benign 0.21
R1521:Tdrd9 UTSW 12 112,002,844 (GRCm39) missense probably damaging 1.00
R1601:Tdrd9 UTSW 12 111,989,687 (GRCm39) nonsense probably null
R1651:Tdrd9 UTSW 12 111,991,140 (GRCm39) missense probably damaging 0.97
R1715:Tdrd9 UTSW 12 112,002,873 (GRCm39) missense possibly damaging 0.62
R1854:Tdrd9 UTSW 12 112,011,246 (GRCm39) missense probably damaging 1.00
R1905:Tdrd9 UTSW 12 112,030,061 (GRCm39) splice site probably benign
R2386:Tdrd9 UTSW 12 111,982,334 (GRCm39) missense probably damaging 1.00
R2863:Tdrd9 UTSW 12 111,997,695 (GRCm39) missense probably benign
R2915:Tdrd9 UTSW 12 112,006,895 (GRCm39) missense probably damaging 1.00
R2958:Tdrd9 UTSW 12 112,008,106 (GRCm39) missense probably damaging 0.97
R4033:Tdrd9 UTSW 12 111,958,973 (GRCm39) missense possibly damaging 0.58
R4087:Tdrd9 UTSW 12 111,979,920 (GRCm39) nonsense probably null
R4237:Tdrd9 UTSW 12 112,034,059 (GRCm39) nonsense probably null
R4482:Tdrd9 UTSW 12 111,980,935 (GRCm39) critical splice donor site probably null
R4501:Tdrd9 UTSW 12 112,009,243 (GRCm39) missense probably benign 0.00
R4502:Tdrd9 UTSW 12 111,960,259 (GRCm39) missense probably damaging 1.00
R4715:Tdrd9 UTSW 12 112,008,123 (GRCm39) missense probably benign 0.00
R4803:Tdrd9 UTSW 12 111,963,269 (GRCm39) nonsense probably null
R5218:Tdrd9 UTSW 12 112,029,909 (GRCm39) intron probably benign
R5275:Tdrd9 UTSW 12 112,018,346 (GRCm39) nonsense probably null
R5295:Tdrd9 UTSW 12 112,018,346 (GRCm39) nonsense probably null
R5301:Tdrd9 UTSW 12 112,002,963 (GRCm39) critical splice donor site probably null
R5339:Tdrd9 UTSW 12 111,993,556 (GRCm39) missense probably damaging 1.00
R5500:Tdrd9 UTSW 12 111,989,702 (GRCm39) missense probably benign 0.02
R5573:Tdrd9 UTSW 12 111,964,336 (GRCm39) splice site probably null
R5590:Tdrd9 UTSW 12 112,018,414 (GRCm39) missense probably benign 0.01
R5891:Tdrd9 UTSW 12 112,009,153 (GRCm39) missense probably damaging 1.00
R6056:Tdrd9 UTSW 12 111,951,475 (GRCm39) missense probably damaging 1.00
R6057:Tdrd9 UTSW 12 111,979,720 (GRCm39) missense possibly damaging 0.85
R6125:Tdrd9 UTSW 12 112,034,632 (GRCm39) missense possibly damaging 0.89
R6254:Tdrd9 UTSW 12 111,992,334 (GRCm39) splice site probably null
R6335:Tdrd9 UTSW 12 112,008,186 (GRCm39) critical splice donor site probably null
R6345:Tdrd9 UTSW 12 112,001,042 (GRCm39) missense probably damaging 0.99
R6792:Tdrd9 UTSW 12 111,993,547 (GRCm39) missense probably benign 0.01
R6956:Tdrd9 UTSW 12 112,002,788 (GRCm39) splice site probably benign
R6987:Tdrd9 UTSW 12 111,992,027 (GRCm39) missense possibly damaging 0.82
R7090:Tdrd9 UTSW 12 111,958,904 (GRCm39) missense probably benign
R7158:Tdrd9 UTSW 12 112,002,800 (GRCm39) missense probably benign 0.08
R7220:Tdrd9 UTSW 12 111,980,888 (GRCm39) missense probably damaging 1.00
R7478:Tdrd9 UTSW 12 111,951,476 (GRCm39) missense probably damaging 1.00
R7489:Tdrd9 UTSW 12 112,034,071 (GRCm39) missense probably benign 0.00
R7751:Tdrd9 UTSW 12 111,958,982 (GRCm39) missense probably benign 0.09
R7809:Tdrd9 UTSW 12 111,999,155 (GRCm39) missense probably damaging 0.99
R7844:Tdrd9 UTSW 12 111,964,386 (GRCm39) missense possibly damaging 0.63
R7854:Tdrd9 UTSW 12 112,013,395 (GRCm39) missense probably benign 0.00
R7903:Tdrd9 UTSW 12 112,018,410 (GRCm39) missense possibly damaging 0.95
R7938:Tdrd9 UTSW 12 111,997,649 (GRCm39) missense possibly damaging 0.86
R8018:Tdrd9 UTSW 12 112,010,822 (GRCm39) missense probably damaging 0.99
R8018:Tdrd9 UTSW 12 111,999,180 (GRCm39) missense probably benign 0.12
R8090:Tdrd9 UTSW 12 111,982,369 (GRCm39) missense probably damaging 1.00
R8157:Tdrd9 UTSW 12 111,951,500 (GRCm39) missense probably benign 0.44
R8198:Tdrd9 UTSW 12 112,006,863 (GRCm39) missense probably damaging 1.00
R8203:Tdrd9 UTSW 12 111,992,064 (GRCm39) missense probably damaging 1.00
R8512:Tdrd9 UTSW 12 112,012,627 (GRCm39) missense probably benign
R8721:Tdrd9 UTSW 12 112,002,889 (GRCm39) missense probably damaging 1.00
R8889:Tdrd9 UTSW 12 111,979,718 (GRCm39) missense probably benign 0.07
R8892:Tdrd9 UTSW 12 111,979,718 (GRCm39) missense probably benign 0.07
R9276:Tdrd9 UTSW 12 111,980,935 (GRCm39) critical splice donor site probably null
R9459:Tdrd9 UTSW 12 111,992,007 (GRCm39) missense probably damaging 1.00
R9484:Tdrd9 UTSW 12 112,012,684 (GRCm39) missense probably damaging 0.97
R9657:Tdrd9 UTSW 12 112,002,824 (GRCm39) missense possibly damaging 0.50
R9745:Tdrd9 UTSW 12 112,009,130 (GRCm39) missense probably damaging 0.99
X0018:Tdrd9 UTSW 12 112,005,763 (GRCm39) missense probably benign 0.24
Z1177:Tdrd9 UTSW 12 111,982,355 (GRCm39) missense probably damaging 1.00
Z1177:Tdrd9 UTSW 12 111,960,325 (GRCm39) missense probably damaging 0.96
Z1177:Tdrd9 UTSW 12 111,938,088 (GRCm39) missense probably benign 0.08
Predicted Primers PCR Primer
(F):5'- CGTCCATGTCCGTGAGCACATAATG -3'
(R):5'- ACAAACACGCTCTGGATCTTGTCTC -3'

Sequencing Primer
(F):5'- GTCCGTGAGCACATAATGATCTG -3'
(R):5'- GCCAAGTATTTAATACTGTGACCCC -3'
Posted On 2013-05-23