Mutagenetix > Incidental Mutation

Incidental Mutation 'R5190:Or9m2'

398034

Institutional Source

Beutler Lab

Gene Symbol

Or9m2

Ensembl Gene

ENSMUSG00000062793

Gene Name

olfactory receptor family 9 subfamily M member 2

Synonyms

GA_x6K02T2Q125-49480812-49481753, Olfr1158, MOR173-3

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.070) question?

Stock #

R5190 (G1)

Quality Score

225

Status

Not validated

Chromosome

Chromosomal Location

87820457-87821398 bp(+) (GRCm39)

Type of Mutation

nonsense

DNA Base Change (assembly)

T to A at 87821107 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Tyrosine to Stop codon at position 217 (Y217*)

Ref Sequence

ENSEMBL: ENSMUSP00000099682 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000102622]

AlphaFold

A2BHP7

Predicted Effect

probably null
Transcript: ENSMUST00000102622
AA Change: Y217*

SMART Domains

Protein: ENSMUSP00000099682
Gene: ENSMUSG00000062793
AA Change: Y217*

Domain	Start	End	E-Value	Type
Pfam:7tm_4	31	307	1.5e-45	PFAM
Pfam:7tm_1	41	289	4.5e-15	PFAM

Coding Region Coverage

1x: 99.2%
3x: 98.5%
10x: 96.9%
20x: 94.1%

Validation Efficiency

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 45 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
2700049A03Rik	G	T	12: 71,211,320 (GRCm39)	E685*	probably null	Het
2700049A03Rik	A	T	12: 71,211,321 (GRCm39)	E685V	possibly damaging	Het
Abca7	T	C	10: 79,835,427 (GRCm39)		probably null	Het
Abca8a	C	T	11: 109,980,735 (GRCm39)		probably null	Het
Ablim3	A	G	18: 61,952,982 (GRCm39)	Y361H	probably benign	Het
Acan	C	T	7: 78,748,289 (GRCm39)	T1020I	probably benign	Het
Baat	A	G	4: 49,499,652 (GRCm39)	L218P	probably damaging	Het
Bcl11b	C	A	12: 107,955,975 (GRCm39)	C58F	probably damaging	Het
Cand2	G	T	6: 115,766,474 (GRCm39)	A360S	probably damaging	Het
Cdh2	A	G	18: 16,783,372 (GRCm39)	V62A	possibly damaging	Het
Cep44	C	T	8: 56,985,831 (GRCm39)	V354I	probably benign	Het
Col3a1	G	A	1: 45,368,244 (GRCm39)	R309Q	unknown	Het
Col3a1	G	A	1: 45,383,967 (GRCm39)		probably benign	Het
Coq5	A	G	5: 115,433,839 (GRCm39)		probably null	Het
Crtac1	A	G	19: 42,322,347 (GRCm39)	I131T	possibly damaging	Het
Decr1	C	T	4: 15,924,270 (GRCm39)	V217M	probably damaging	Het
Dnajc13	A	G	9: 104,051,724 (GRCm39)	V1706A	probably benign	Het
Dop1a	A	G	9: 86,369,357 (GRCm39)	I63M	probably damaging	Het
F830045P16Rik	T	C	2: 129,314,635 (GRCm39)	D214G	probably benign	Het
Fam216a	T	A	5: 122,505,584 (GRCm39)		probably null	Het
Fdxacb1	A	C	9: 50,683,387 (GRCm39)	H248P	possibly damaging	Het
Gnai1	A	T	5: 18,496,596 (GRCm39)	V109E	probably benign	Het
Helz2	A	T	2: 180,872,550 (GRCm39)		probably null	Het
Itgam	T	C	7: 127,715,489 (GRCm39)		probably null	Het
Kcnh1	A	G	1: 192,187,836 (GRCm39)	S766G	probably benign	Het
Klra1	C	A	6: 130,352,241 (GRCm39)	C167F	probably damaging	Het
Krtap9-3	T	A	11: 99,488,808 (GRCm39)	T25S	probably benign	Het
Mapk6	T	C	9: 75,295,626 (GRCm39)	Y624C	probably damaging	Het
Or10ag2	A	G	2: 87,249,187 (GRCm39)	Y263C	probably damaging	Het
Or1ad8	T	G	11: 50,898,381 (GRCm39)	I194S	probably damaging	Het
Or2y1g	T	C	11: 49,171,209 (GRCm39)	V78A	probably damaging	Het
Or52e4	C	T	7: 104,705,660 (GRCm39)	S69L	probably damaging	Het
P3h2	A	G	16: 25,803,699 (GRCm39)	S356P	possibly damaging	Het
Pde12	C	T	14: 26,387,532 (GRCm39)		probably null	Het
Rln3	T	G	8: 84,769,866 (GRCm39)	K94N	probably damaging	Het
Skint5	T	C	4: 113,620,711 (GRCm39)	I668V	unknown	Het
Slitrk5	C	A	14: 111,916,852 (GRCm39)	Q159K	probably damaging	Het
Trim3	G	T	7: 105,268,716 (GRCm39)	N79K	probably damaging	Het
Tyw1	T	A	5: 130,296,756 (GRCm39)	C101*	probably null	Het
Ulk2	T	C	11: 61,672,537 (GRCm39)	T934A	probably benign	Het
Unc5b	T	C	10: 60,608,072 (GRCm39)	Y687C	probably benign	Het
Vmn1r195	C	T	13: 22,462,556 (GRCm39)	R9*	probably null	Het
Zfc3h1	T	G	10: 115,254,597 (GRCm39)	L1397R	probably damaging	Het
Zfp296	T	C	7: 19,311,332 (GRCm39)	V9A	probably benign	Het
Zfp423	T	A	8: 88,509,091 (GRCm39)	S397C	probably damaging	Het

Other mutations in Or9m2

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00272:Or9m2	APN	2	87,820,782 (GRCm39)	missense	probably damaging	1.00
IGL01287:Or9m2	APN	2	87,821,288 (GRCm39)	missense	probably benign	0.01
IGL01374:Or9m2	APN	2	87,820,892 (GRCm39)	missense	probably benign
IGL01821:Or9m2	APN	2	87,820,933 (GRCm39)	missense	probably benign	0.12
IGL01832:Or9m2	APN	2	87,820,513 (GRCm39)	missense	probably benign	0.02
IGL02327:Or9m2	APN	2	87,820,601 (GRCm39)	missense	probably damaging	1.00
IGL02580:Or9m2	APN	2	87,820,857 (GRCm39)	missense	probably benign	0.09
IGL03001:Or9m2	APN	2	87,820,493 (GRCm39)	missense	probably benign	0.43
IGL03196:Or9m2	APN	2	87,820,826 (GRCm39)	missense	possibly damaging	0.67
R0546:Or9m2	UTSW	2	87,820,816 (GRCm39)	nonsense	probably null
R1474:Or9m2	UTSW	2	87,821,334 (GRCm39)	missense	probably damaging	1.00
R1650:Or9m2	UTSW	2	87,821,145 (GRCm39)	missense	probably benign	0.01
R1757:Or9m2	UTSW	2	87,820,926 (GRCm39)	missense	probably damaging	0.99
R2992:Or9m2	UTSW	2	87,821,121 (GRCm39)	missense	probably benign	0.00
R4038:Or9m2	UTSW	2	87,821,262 (GRCm39)	missense	possibly damaging	0.88
R5871:Or9m2	UTSW	2	87,821,355 (GRCm39)	missense	possibly damaging	0.82
R8220:Or9m2	UTSW	2	87,820,496 (GRCm39)	missense	probably damaging	1.00
R8475:Or9m2	UTSW	2	87,820,536 (GRCm39)	missense	probably damaging	1.00
R8532:Or9m2	UTSW	2	87,820,913 (GRCm39)	missense	probably damaging	1.00
R9026:Or9m2	UTSW	2	87,820,568 (GRCm39)	missense	probably damaging	0.99
R9522:Or9m2	UTSW	2	87,821,175 (GRCm39)	missense	probably damaging	1.00
R9657:Or9m2	UTSW	2	87,821,310 (GRCm39)	missense	probably damaging	1.00

Predicted Primers

PCR Primer
(F):5'- TCAGCTGGCATTTGAAGCATTC -3'
(R):5'- CACAGAGGTCATTTTGTCAATATCC -3'

Sequencing Primer
(F):5'- AAGCATTCTTGGGTGGAACTATGAG -3'
(R):5'- TTACTGCCAGGTGAGAAG -3'

Posted On

2016-07-06