Incidental Mutation 'R5190:Cand2'
ID 398044
Institutional Source Beutler Lab
Gene Symbol Cand2
Ensembl Gene ENSMUSG00000030319
Gene Name cullin associated and neddylation dissociated 2 (putative)
Synonyms Tp120b, 2210404G23Rik
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R5190 (G1)
Quality Score 164
Status Not validated
Chromosome 6
Chromosomal Location 115751518-115782516 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to T at 115766474 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Alanine to Serine at position 360 (A360S)
Ref Sequence ENSEMBL: ENSMUSP00000075377 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000075995]
AlphaFold Q6ZQ73
Predicted Effect probably damaging
Transcript: ENSMUST00000075995
AA Change: A360S

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000075377
Gene: ENSMUSG00000030319
AA Change: A360S

DomainStartEndE-ValueType
low complexity region 325 347 N/A INTRINSIC
low complexity region 536 548 N/A INTRINSIC
low complexity region 553 562 N/A INTRINSIC
low complexity region 665 686 N/A INTRINSIC
low complexity region 736 748 N/A INTRINSIC
Pfam:HEAT 861 890 4.4e-5 PFAM
Pfam:TIP120 1044 1209 6e-64 PFAM
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.5%
  • 10x: 96.9%
  • 20x: 94.1%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 45 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2700049A03Rik G T 12: 71,211,320 (GRCm39) E685* probably null Het
2700049A03Rik A T 12: 71,211,321 (GRCm39) E685V possibly damaging Het
Abca7 T C 10: 79,835,427 (GRCm39) probably null Het
Abca8a C T 11: 109,980,735 (GRCm39) probably null Het
Ablim3 A G 18: 61,952,982 (GRCm39) Y361H probably benign Het
Acan C T 7: 78,748,289 (GRCm39) T1020I probably benign Het
Baat A G 4: 49,499,652 (GRCm39) L218P probably damaging Het
Bcl11b C A 12: 107,955,975 (GRCm39) C58F probably damaging Het
Cdh2 A G 18: 16,783,372 (GRCm39) V62A possibly damaging Het
Cep44 C T 8: 56,985,831 (GRCm39) V354I probably benign Het
Col3a1 G A 1: 45,368,244 (GRCm39) R309Q unknown Het
Col3a1 G A 1: 45,383,967 (GRCm39) probably benign Het
Coq5 A G 5: 115,433,839 (GRCm39) probably null Het
Crtac1 A G 19: 42,322,347 (GRCm39) I131T possibly damaging Het
Decr1 C T 4: 15,924,270 (GRCm39) V217M probably damaging Het
Dnajc13 A G 9: 104,051,724 (GRCm39) V1706A probably benign Het
Dop1a A G 9: 86,369,357 (GRCm39) I63M probably damaging Het
F830045P16Rik T C 2: 129,314,635 (GRCm39) D214G probably benign Het
Fam216a T A 5: 122,505,584 (GRCm39) probably null Het
Fdxacb1 A C 9: 50,683,387 (GRCm39) H248P possibly damaging Het
Gnai1 A T 5: 18,496,596 (GRCm39) V109E probably benign Het
Helz2 A T 2: 180,872,550 (GRCm39) probably null Het
Itgam T C 7: 127,715,489 (GRCm39) probably null Het
Kcnh1 A G 1: 192,187,836 (GRCm39) S766G probably benign Het
Klra1 C A 6: 130,352,241 (GRCm39) C167F probably damaging Het
Krtap9-3 T A 11: 99,488,808 (GRCm39) T25S probably benign Het
Mapk6 T C 9: 75,295,626 (GRCm39) Y624C probably damaging Het
Or10ag2 A G 2: 87,249,187 (GRCm39) Y263C probably damaging Het
Or1ad8 T G 11: 50,898,381 (GRCm39) I194S probably damaging Het
Or2y1g T C 11: 49,171,209 (GRCm39) V78A probably damaging Het
Or52e4 C T 7: 104,705,660 (GRCm39) S69L probably damaging Het
Or9m2 T A 2: 87,821,107 (GRCm39) Y217* probably null Het
P3h2 A G 16: 25,803,699 (GRCm39) S356P possibly damaging Het
Pde12 C T 14: 26,387,532 (GRCm39) probably null Het
Rln3 T G 8: 84,769,866 (GRCm39) K94N probably damaging Het
Skint5 T C 4: 113,620,711 (GRCm39) I668V unknown Het
Slitrk5 C A 14: 111,916,852 (GRCm39) Q159K probably damaging Het
Trim3 G T 7: 105,268,716 (GRCm39) N79K probably damaging Het
Tyw1 T A 5: 130,296,756 (GRCm39) C101* probably null Het
Ulk2 T C 11: 61,672,537 (GRCm39) T934A probably benign Het
Unc5b T C 10: 60,608,072 (GRCm39) Y687C probably benign Het
Vmn1r195 C T 13: 22,462,556 (GRCm39) R9* probably null Het
Zfc3h1 T G 10: 115,254,597 (GRCm39) L1397R probably damaging Het
Zfp296 T C 7: 19,311,332 (GRCm39) V9A probably benign Het
Zfp423 T A 8: 88,509,091 (GRCm39) S397C probably damaging Het
Other mutations in Cand2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01323:Cand2 APN 6 115,762,086 (GRCm39) missense probably benign
IGL01329:Cand2 APN 6 115,759,755 (GRCm39) missense probably benign 0.43
IGL01777:Cand2 APN 6 115,769,818 (GRCm39) missense probably damaging 0.99
IGL02008:Cand2 APN 6 115,780,599 (GRCm39) missense probably damaging 1.00
IGL02185:Cand2 APN 6 115,766,471 (GRCm39) missense probably benign 0.01
IGL02219:Cand2 APN 6 115,780,773 (GRCm39) missense probably damaging 1.00
IGL02240:Cand2 APN 6 115,780,623 (GRCm39) missense probably damaging 1.00
IGL02329:Cand2 APN 6 115,766,568 (GRCm39) missense probably damaging 1.00
IGL02396:Cand2 APN 6 115,768,149 (GRCm39) splice site probably benign
IGL02893:Cand2 APN 6 115,768,921 (GRCm39) missense probably damaging 1.00
IGL03161:Cand2 APN 6 115,769,698 (GRCm39) missense probably benign 0.45
IGL03170:Cand2 APN 6 115,774,861 (GRCm39) missense probably damaging 1.00
IGL03257:Cand2 APN 6 115,776,944 (GRCm39) missense possibly damaging 0.80
succor UTSW 6 115,768,153 (GRCm39) missense probably damaging 1.00
R0196:Cand2 UTSW 6 115,766,463 (GRCm39) missense probably damaging 1.00
R0390:Cand2 UTSW 6 115,751,614 (GRCm39) missense possibly damaging 0.90
R0534:Cand2 UTSW 6 115,764,197 (GRCm39) missense probably damaging 0.96
R0630:Cand2 UTSW 6 115,780,766 (GRCm39) missense probably damaging 1.00
R0631:Cand2 UTSW 6 115,780,766 (GRCm39) missense probably damaging 1.00
R0662:Cand2 UTSW 6 115,764,171 (GRCm39) missense probably benign 0.00
R0671:Cand2 UTSW 6 115,780,766 (GRCm39) missense probably damaging 1.00
R0708:Cand2 UTSW 6 115,780,766 (GRCm39) missense probably damaging 1.00
R0849:Cand2 UTSW 6 115,769,352 (GRCm39) missense probably damaging 1.00
R1992:Cand2 UTSW 6 115,762,093 (GRCm39) missense possibly damaging 0.88
R3428:Cand2 UTSW 6 115,766,668 (GRCm39) missense probably benign
R3773:Cand2 UTSW 6 115,762,178 (GRCm39) missense probably damaging 0.96
R4329:Cand2 UTSW 6 115,776,949 (GRCm39) missense possibly damaging 0.64
R4489:Cand2 UTSW 6 115,766,427 (GRCm39) missense probably damaging 1.00
R4553:Cand2 UTSW 6 115,769,172 (GRCm39) missense probably damaging 1.00
R4577:Cand2 UTSW 6 115,768,220 (GRCm39) missense probably damaging 1.00
R4634:Cand2 UTSW 6 115,774,948 (GRCm39) missense probably damaging 1.00
R4850:Cand2 UTSW 6 115,778,909 (GRCm39) missense probably benign 0.14
R5155:Cand2 UTSW 6 115,769,219 (GRCm39) missense probably benign 0.42
R5378:Cand2 UTSW 6 115,778,912 (GRCm39) missense probably benign 0.00
R5407:Cand2 UTSW 6 115,762,161 (GRCm39) missense possibly damaging 0.76
R5698:Cand2 UTSW 6 115,768,704 (GRCm39) missense probably damaging 1.00
R5701:Cand2 UTSW 6 115,774,893 (GRCm39) missense probably damaging 0.99
R6172:Cand2 UTSW 6 115,768,271 (GRCm39) missense probably benign 0.00
R6763:Cand2 UTSW 6 115,776,930 (GRCm39) missense probably benign 0.00
R6920:Cand2 UTSW 6 115,768,250 (GRCm39) missense possibly damaging 0.93
R7229:Cand2 UTSW 6 115,768,153 (GRCm39) missense probably damaging 1.00
R7520:Cand2 UTSW 6 115,762,212 (GRCm39) nonsense probably null
R8183:Cand2 UTSW 6 115,768,879 (GRCm39) missense probably benign 0.14
R8698:Cand2 UTSW 6 115,763,852 (GRCm39) missense probably damaging 1.00
R8755:Cand2 UTSW 6 115,769,941 (GRCm39) missense probably damaging 1.00
R8795:Cand2 UTSW 6 115,763,889 (GRCm39) missense probably benign 0.01
R8900:Cand2 UTSW 6 115,757,894 (GRCm39) missense probably benign 0.00
R9072:Cand2 UTSW 6 115,769,490 (GRCm39) missense probably damaging 0.99
R9242:Cand2 UTSW 6 115,768,923 (GRCm39) missense probably benign 0.27
R9262:Cand2 UTSW 6 115,759,730 (GRCm39) missense probably benign 0.27
R9547:Cand2 UTSW 6 115,759,757 (GRCm39) missense probably benign 0.00
R9676:Cand2 UTSW 6 115,769,122 (GRCm39) missense probably benign 0.26
Predicted Primers PCR Primer
(F):5'- CACAGGTGTTCACTAGGGTG -3'
(R):5'- CATATTGAGGTTTCTGCCAGTCTG -3'

Sequencing Primer
(F):5'- CCAGTGGGCTGAATACTGATCATC -3'
(R):5'- AGTCTGGGTGGGCTCCTC -3'
Posted On 2016-07-06