Incidental Mutation 'R5233:Fry'
ID 398098
Institutional Source Beutler Lab
Gene Symbol Fry
Ensembl Gene ENSMUSG00000056602
Gene Name FRY microtubule binding protein
Synonyms cg003, 9330186A19Rik
MMRRC Submission 042805-MU
Accession Numbers
Essential gene? Possibly non essential (E-score: 0.469) question?
Stock # R5233 (G1)
Quality Score 225
Status Validated
Chromosome 5
Chromosomal Location 150042110-150421218 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 150393185 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Aspartic acid to Glycine at position 605 (D605G)
Ref Sequence ENSEMBL: ENSMUSP00000144657 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000087204] [ENSMUST00000202566]
AlphaFold no structure available at present
Predicted Effect probably benign
Transcript: ENSMUST00000087204
AA Change: D2615G

PolyPhen 2 Score 0.374 (Sensitivity: 0.90; Specificity: 0.89)
SMART Domains Protein: ENSMUSP00000084454
Gene: ENSMUSG00000056602
AA Change: D2615G

DomainStartEndE-ValueType
Pfam:MOR2-PAG1_N 165 697 5.3e-170 PFAM
low complexity region 1014 1040 N/A INTRINSIC
Pfam:MOR2-PAG1_mid 1188 1380 1.2e-15 PFAM
Pfam:MOR2-PAG1_mid 1398 1534 1.5e-5 PFAM
Pfam:MOR2-PAG1_mid 1632 1704 1.8e-7 PFAM
Pfam:MOR2-PAG1_mid 1772 1906 4.9e-10 PFAM
low complexity region 1936 1956 N/A INTRINSIC
low complexity region 1962 1980 N/A INTRINSIC
Pfam:MOR2-PAG1_C 2050 2303 1.9e-74 PFAM
low complexity region 2369 2385 N/A INTRINSIC
low complexity region 2463 2482 N/A INTRINSIC
low complexity region 2525 2534 N/A INTRINSIC
low complexity region 2836 2852 N/A INTRINSIC
Predicted Effect unknown
Transcript: ENSMUST00000200863
AA Change: D247G
Predicted Effect noncoding transcript
Transcript: ENSMUST00000201196
Predicted Effect possibly damaging
Transcript: ENSMUST00000202566
AA Change: D605G

PolyPhen 2 Score 0.714 (Sensitivity: 0.86; Specificity: 0.92)
SMART Domains Protein: ENSMUSP00000144657
Gene: ENSMUSG00000056602
AA Change: D605G

DomainStartEndE-ValueType
Pfam:MOR2-PAG1_C 37 290 1.5e-71 PFAM
low complexity region 356 372 N/A INTRINSIC
low complexity region 447 472 N/A INTRINSIC
low complexity region 515 524 N/A INTRINSIC
low complexity region 832 848 N/A INTRINSIC
Meta Mutation Damage Score 0.1065 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.5%
  • 10x: 97.0%
  • 20x: 94.9%
Validation Efficiency 100% (56/56)
Allele List at MGI
Other mutations in this stock
Total: 51 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
9030619P08Rik T A 15: 75,301,801 (GRCm39) noncoding transcript Het
Aadat A G 8: 60,979,656 (GRCm39) I173V probably benign Het
Acsl6 G A 11: 54,216,432 (GRCm39) V200I possibly damaging Het
Alms1 T A 6: 85,633,353 (GRCm39) probably null Het
Arhgef17 A T 7: 100,530,576 (GRCm39) D1403E possibly damaging Het
Atp10b A G 11: 43,121,387 (GRCm39) T1017A probably benign Het
Capg C T 6: 72,532,509 (GRCm39) R25C probably damaging Het
Cd22 A G 7: 30,576,959 (GRCm39) I116T probably damaging Het
Cep135 AGTCTGCCTTTGG A 5: 76,739,690 (GRCm39) probably benign Het
Ciita A T 16: 10,327,265 (GRCm39) I277F possibly damaging Het
Col15a1 T C 4: 47,296,112 (GRCm39) V943A possibly damaging Het
Coq2 G A 5: 100,805,698 (GRCm39) H313Y possibly damaging Het
Csn3 C T 5: 88,077,694 (GRCm39) P67S probably benign Het
Csrnp3 A G 2: 65,852,684 (GRCm39) T359A possibly damaging Het
Cttnbp2nl A G 3: 104,912,357 (GRCm39) L509P probably damaging Het
Dclk3 A G 9: 111,297,749 (GRCm39) D431G probably benign Het
Dtx3l A T 16: 35,753,608 (GRCm39) C333S possibly damaging Het
Ear-ps2 G A 14: 44,284,517 (GRCm39) noncoding transcript Het
Fam171a1 G C 2: 3,179,390 (GRCm39) G72A probably damaging Het
Fbxw17 T C 13: 50,586,390 (GRCm39) probably benign Het
Fyn T C 10: 39,405,936 (GRCm39) F240S probably benign Het
Gcfc2 T C 6: 81,930,271 (GRCm39) L646P probably damaging Het
Gm5087 C T 14: 13,158,788 (GRCm38) noncoding transcript Het
Got2 T A 8: 96,602,477 (GRCm39) N91I probably benign Het
Hspa4 C T 11: 53,177,802 (GRCm39) V103I possibly damaging Het
Itgad A G 7: 127,792,600 (GRCm39) probably null Het
Krt33a A G 11: 99,904,961 (GRCm39) S182P probably damaging Het
Mcph1 T C 8: 18,721,254 (GRCm39) I694T probably damaging Het
Mmp15 T C 8: 96,097,696 (GRCm39) V502A probably benign Het
Mov10l1 T C 15: 88,867,235 (GRCm39) V23A probably benign Het
Myo9a T A 9: 59,817,900 (GRCm39) N2322K probably damaging Het
Ndst4 A G 3: 125,503,766 (GRCm39) Y11C probably damaging Het
Nell1 T C 7: 49,826,062 (GRCm39) F199S probably damaging Het
Nup210 C T 6: 91,003,951 (GRCm39) V646M probably damaging Het
Nup98 A T 7: 101,845,029 (GRCm39) S13R unknown Het
Nxf1 T C 19: 8,741,293 (GRCm39) I54T possibly damaging Het
Or8b38 A G 9: 37,973,446 (GRCm39) T277A probably damaging Het
Pcdh10 C A 3: 45,338,626 (GRCm39) R928S probably damaging Het
Pou3f3 A G 1: 42,737,438 (GRCm39) N378S probably benign Het
Rfx6 T A 10: 51,588,187 (GRCm39) Y109* probably null Het
Rorc T A 3: 94,304,632 (GRCm39) V339D probably benign Het
Scin T A 12: 40,127,558 (GRCm39) I411F probably benign Het
Serpind1 A G 16: 17,154,758 (GRCm39) Y195C probably damaging Het
Tas2r117 T C 6: 132,780,585 (GRCm39) V241A possibly damaging Het
Tet3 T A 6: 83,363,045 (GRCm39) E709V probably damaging Het
Trbc1 T A 6: 41,515,383 (GRCm39) probably benign Het
Vmn1r212 C A 13: 23,067,304 (GRCm39) G343V unknown Het
Vmn2r42 T A 7: 8,197,837 (GRCm39) K261* probably null Het
Xrcc5 T A 1: 72,379,209 (GRCm39) L438Q probably damaging Het
Zfp142 T C 1: 74,624,608 (GRCm39) N72S probably damaging Het
Zfp292 A T 4: 34,809,755 (GRCm39) S1096R probably damaging Het
Other mutations in Fry
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00327:Fry APN 5 150,263,869 (GRCm39) nonsense probably null
IGL00328:Fry APN 5 150,263,869 (GRCm39) nonsense probably null
IGL00841:Fry APN 5 150,346,189 (GRCm39) missense probably benign
IGL00938:Fry APN 5 150,293,645 (GRCm39) missense probably damaging 1.00
IGL01015:Fry APN 5 150,346,252 (GRCm39) missense probably benign 0.18
IGL01401:Fry APN 5 150,362,253 (GRCm39) missense probably benign
IGL01616:Fry APN 5 150,323,064 (GRCm39) missense probably damaging 1.00
IGL01616:Fry APN 5 150,362,276 (GRCm39) splice site probably null
IGL01748:Fry APN 5 150,269,116 (GRCm39) splice site probably benign
IGL01965:Fry APN 5 150,305,086 (GRCm39) missense probably damaging 1.00
IGL02030:Fry APN 5 150,395,083 (GRCm39) splice site probably benign
IGL02079:Fry APN 5 150,323,089 (GRCm39) missense probably damaging 0.97
IGL02087:Fry APN 5 150,327,059 (GRCm39) missense probably benign 0.23
IGL02113:Fry APN 5 150,323,070 (GRCm39) missense probably benign
IGL02209:Fry APN 5 150,360,491 (GRCm39) missense probably benign 0.00
IGL02250:Fry APN 5 150,326,899 (GRCm39) splice site probably benign
IGL02265:Fry APN 5 150,360,618 (GRCm39) missense probably damaging 1.00
IGL02486:Fry APN 5 150,414,642 (GRCm39) missense probably damaging 0.99
IGL02552:Fry APN 5 150,304,375 (GRCm39) missense probably damaging 1.00
IGL02881:Fry APN 5 150,282,516 (GRCm39) missense probably damaging 0.99
IGL03008:Fry APN 5 150,269,021 (GRCm39) missense possibly damaging 0.82
IGL03140:Fry APN 5 150,419,166 (GRCm39) missense probably damaging 0.98
IGL03171:Fry APN 5 150,304,274 (GRCm39) missense probably damaging 1.00
IGL03389:Fry APN 5 150,317,696 (GRCm39) missense probably damaging 1.00
IGL03404:Fry APN 5 150,249,633 (GRCm39) missense probably damaging 1.00
Brook UTSW 5 150,249,597 (GRCm39) missense probably damaging 1.00
haydn UTSW 5 150,341,929 (GRCm39) missense possibly damaging 0.94
miracle UTSW 5 150,360,624 (GRCm39) missense probably damaging 0.99
quickening UTSW 5 150,358,241 (GRCm39) missense probably damaging 1.00
seasons UTSW 5 150,389,902 (GRCm39) missense probably benign 0.06
Vivaldi UTSW 5 150,317,603 (GRCm39) missense possibly damaging 0.80
R0023:Fry UTSW 5 150,374,563 (GRCm39) missense possibly damaging 0.78
R0024:Fry UTSW 5 150,304,268 (GRCm39) missense probably benign 0.03
R0030:Fry UTSW 5 150,296,034 (GRCm39) nonsense probably null
R0053:Fry UTSW 5 150,384,842 (GRCm39) splice site probably benign
R0089:Fry UTSW 5 150,263,892 (GRCm39) missense possibly damaging 0.91
R0212:Fry UTSW 5 150,419,862 (GRCm39) missense probably damaging 0.99
R0241:Fry UTSW 5 150,183,811 (GRCm39) intron probably benign
R0265:Fry UTSW 5 150,358,241 (GRCm39) missense probably damaging 1.00
R0317:Fry UTSW 5 150,394,933 (GRCm39) missense probably damaging 1.00
R0532:Fry UTSW 5 150,402,226 (GRCm39) splice site probably benign
R0532:Fry UTSW 5 150,357,172 (GRCm39) unclassified probably benign
R0599:Fry UTSW 5 150,360,624 (GRCm39) missense probably damaging 0.99
R0631:Fry UTSW 5 150,419,817 (GRCm39) missense possibly damaging 0.82
R0723:Fry UTSW 5 150,419,825 (GRCm39) missense probably damaging 1.00
R0766:Fry UTSW 5 150,326,897 (GRCm39) splice site probably benign
R0790:Fry UTSW 5 150,389,902 (GRCm39) missense probably benign 0.06
R0928:Fry UTSW 5 150,360,549 (GRCm39) missense probably damaging 1.00
R1104:Fry UTSW 5 150,419,754 (GRCm39) missense probably damaging 1.00
R1144:Fry UTSW 5 150,341,929 (GRCm39) missense possibly damaging 0.94
R1172:Fry UTSW 5 150,404,959 (GRCm39) nonsense probably null
R1312:Fry UTSW 5 150,326,897 (GRCm39) splice site probably benign
R1347:Fry UTSW 5 150,419,283 (GRCm39) missense probably damaging 1.00
R1347:Fry UTSW 5 150,419,283 (GRCm39) missense probably damaging 1.00
R1437:Fry UTSW 5 150,233,890 (GRCm39) missense possibly damaging 0.92
R1458:Fry UTSW 5 150,304,324 (GRCm39) missense probably damaging 1.00
R1542:Fry UTSW 5 150,328,431 (GRCm39) missense probably benign 0.13
R1692:Fry UTSW 5 150,293,692 (GRCm39) missense probably damaging 1.00
R1826:Fry UTSW 5 150,360,174 (GRCm39) missense possibly damaging 0.82
R1874:Fry UTSW 5 150,269,386 (GRCm39) missense probably damaging 1.00
R1875:Fry UTSW 5 150,249,597 (GRCm39) missense probably damaging 1.00
R1881:Fry UTSW 5 150,401,511 (GRCm39) missense probably damaging 0.97
R1884:Fry UTSW 5 150,326,985 (GRCm39) missense probably benign 0.00
R1929:Fry UTSW 5 150,324,389 (GRCm39) missense probably null 0.02
R2066:Fry UTSW 5 150,293,584 (GRCm39) splice site probably benign
R2270:Fry UTSW 5 150,324,389 (GRCm39) missense probably null 0.02
R2356:Fry UTSW 5 150,394,897 (GRCm39) missense probably benign
R3720:Fry UTSW 5 150,378,037 (GRCm39) missense probably damaging 1.00
R3773:Fry UTSW 5 150,321,663 (GRCm39) missense probably damaging 0.96
R3824:Fry UTSW 5 150,419,884 (GRCm39) missense possibly damaging 0.94
R3902:Fry UTSW 5 150,269,392 (GRCm39) missense probably damaging 1.00
R3923:Fry UTSW 5 150,336,814 (GRCm39) missense probably benign
R4250:Fry UTSW 5 150,233,825 (GRCm39) missense probably damaging 0.99
R4332:Fry UTSW 5 150,305,128 (GRCm39) missense probably damaging 1.00
R4495:Fry UTSW 5 150,233,928 (GRCm39) missense probably damaging 1.00
R4610:Fry UTSW 5 150,309,569 (GRCm39) missense probably damaging 1.00
R4682:Fry UTSW 5 150,346,219 (GRCm39) missense probably damaging 1.00
R4732:Fry UTSW 5 150,309,472 (GRCm39) missense
R4733:Fry UTSW 5 150,309,472 (GRCm39) missense
R4755:Fry UTSW 5 150,321,719 (GRCm39) missense probably damaging 0.99
R4788:Fry UTSW 5 150,323,101 (GRCm39) missense probably benign 0.00
R4803:Fry UTSW 5 150,322,998 (GRCm39) missense probably benign 0.31
R4858:Fry UTSW 5 150,325,108 (GRCm39) missense possibly damaging 0.78
R4872:Fry UTSW 5 150,317,704 (GRCm39) critical splice donor site probably null
R4902:Fry UTSW 5 150,419,168 (GRCm39) missense probably benign 0.43
R4915:Fry UTSW 5 150,402,328 (GRCm39) missense probably benign 0.30
R4938:Fry UTSW 5 150,401,454 (GRCm39) missense probably damaging 1.00
R4983:Fry UTSW 5 150,321,719 (GRCm39) missense probably damaging 1.00
R5004:Fry UTSW 5 150,357,069 (GRCm39) missense probably benign 0.16
R5040:Fry UTSW 5 150,312,319 (GRCm39) missense probably damaging 0.99
R5145:Fry UTSW 5 150,293,689 (GRCm39) missense probably damaging 0.98
R5170:Fry UTSW 5 150,353,319 (GRCm39) missense probably benign 0.03
R5428:Fry UTSW 5 150,328,824 (GRCm39) missense possibly damaging 0.89
R5468:Fry UTSW 5 150,323,053 (GRCm39) missense probably benign 0.44
R5481:Fry UTSW 5 150,183,784 (GRCm39) missense probably benign 0.01
R5494:Fry UTSW 5 150,314,132 (GRCm39) missense probably damaging 1.00
R5538:Fry UTSW 5 150,419,313 (GRCm39) missense probably damaging 1.00
R5638:Fry UTSW 5 150,282,546 (GRCm39) missense possibly damaging 0.46
R5645:Fry UTSW 5 150,304,332 (GRCm39) missense probably damaging 1.00
R5716:Fry UTSW 5 150,293,686 (GRCm39) nonsense probably null
R5812:Fry UTSW 5 150,323,136 (GRCm39) missense probably damaging 0.99
R5813:Fry UTSW 5 150,323,136 (GRCm39) missense probably damaging 0.99
R5873:Fry UTSW 5 150,302,350 (GRCm39) missense probably damaging 1.00
R5933:Fry UTSW 5 150,314,265 (GRCm39) intron probably benign
R6037:Fry UTSW 5 150,351,644 (GRCm39) missense probably benign 0.03
R6037:Fry UTSW 5 150,351,644 (GRCm39) missense probably benign 0.03
R6158:Fry UTSW 5 150,378,037 (GRCm39) missense probably damaging 1.00
R6178:Fry UTSW 5 150,377,987 (GRCm39) missense probably damaging 1.00
R6481:Fry UTSW 5 150,309,479 (GRCm39) missense probably damaging 1.00
R6562:Fry UTSW 5 150,249,614 (GRCm39) missense probably damaging 1.00
R6676:Fry UTSW 5 150,304,387 (GRCm39) missense probably benign 0.22
R6717:Fry UTSW 5 150,419,777 (GRCm39) missense probably benign 0.00
R6828:Fry UTSW 5 150,389,911 (GRCm39) splice site probably null
R6874:Fry UTSW 5 150,360,768 (GRCm39) missense probably benign 0.00
R6930:Fry UTSW 5 150,351,695 (GRCm39) missense probably benign 0.00
R6963:Fry UTSW 5 150,381,309 (GRCm39) missense probably benign 0.17
R6965:Fry UTSW 5 150,339,685 (GRCm39) missense possibly damaging 0.79
R7051:Fry UTSW 5 150,318,634 (GRCm39) missense possibly damaging 0.93
R7085:Fry UTSW 5 150,362,214 (GRCm39) missense probably benign 0.02
R7108:Fry UTSW 5 150,414,555 (GRCm39) missense
R7108:Fry UTSW 5 150,319,251 (GRCm39) missense probably damaging 1.00
R7115:Fry UTSW 5 150,309,532 (GRCm39) missense probably damaging 1.00
R7116:Fry UTSW 5 150,319,334 (GRCm39) critical splice donor site probably null
R7197:Fry UTSW 5 150,393,232 (GRCm39) missense
R7256:Fry UTSW 5 150,390,251 (GRCm39) missense
R7318:Fry UTSW 5 150,360,458 (GRCm39) missense probably damaging 0.98
R7323:Fry UTSW 5 150,419,814 (GRCm39) missense
R7358:Fry UTSW 5 150,339,788 (GRCm39) missense probably benign
R7361:Fry UTSW 5 150,360,312 (GRCm39) missense possibly damaging 0.92
R7395:Fry UTSW 5 150,304,348 (GRCm39) missense possibly damaging 0.82
R7487:Fry UTSW 5 150,338,039 (GRCm39) missense possibly damaging 0.79
R7491:Fry UTSW 5 150,389,791 (GRCm39) missense
R7574:Fry UTSW 5 150,304,359 (GRCm39) missense probably benign 0.00
R7582:Fry UTSW 5 150,419,847 (GRCm39) missense
R7586:Fry UTSW 5 150,349,683 (GRCm39) missense probably damaging 1.00
R7650:Fry UTSW 5 150,336,883 (GRCm39) missense probably damaging 1.00
R7699:Fry UTSW 5 150,328,792 (GRCm39) missense probably damaging 0.98
R7700:Fry UTSW 5 150,328,792 (GRCm39) missense probably damaging 0.98
R7972:Fry UTSW 5 150,233,861 (GRCm39) missense probably benign 0.05
R8058:Fry UTSW 5 150,419,232 (GRCm39) missense
R8070:Fry UTSW 5 150,401,472 (GRCm39) missense
R8159:Fry UTSW 5 150,322,998 (GRCm39) missense probably benign 0.31
R8202:Fry UTSW 5 150,355,202 (GRCm39) missense probably damaging 1.00
R8261:Fry UTSW 5 150,369,372 (GRCm39) missense probably damaging 1.00
R8279:Fry UTSW 5 150,419,726 (GRCm39) missense
R8338:Fry UTSW 5 150,282,516 (GRCm39) missense probably damaging 0.99
R8370:Fry UTSW 5 150,319,284 (GRCm39) missense probably damaging 1.00
R8673:Fry UTSW 5 150,318,576 (GRCm39) missense possibly damaging 0.91
R8786:Fry UTSW 5 150,317,501 (GRCm39) missense probably benign 0.00
R8815:Fry UTSW 5 150,317,603 (GRCm39) missense possibly damaging 0.80
R8847:Fry UTSW 5 150,309,472 (GRCm39) missense
R9023:Fry UTSW 5 150,360,768 (GRCm39) missense probably benign 0.00
R9025:Fry UTSW 5 150,219,273 (GRCm39) intron probably benign
R9125:Fry UTSW 5 150,269,525 (GRCm39) missense probably damaging 0.97
R9172:Fry UTSW 5 150,336,793 (GRCm39) missense probably benign
R9262:Fry UTSW 5 150,305,109 (GRCm39) missense probably damaging 1.00
R9263:Fry UTSW 5 150,322,728 (GRCm39) missense probably damaging 1.00
R9293:Fry UTSW 5 150,419,297 (GRCm39) missense
R9368:Fry UTSW 5 150,401,403 (GRCm39) missense
R9401:Fry UTSW 5 150,302,403 (GRCm39) missense probably damaging 1.00
R9402:Fry UTSW 5 150,360,318 (GRCm39) missense probably damaging 1.00
R9402:Fry UTSW 5 150,357,161 (GRCm39) missense possibly damaging 0.91
R9420:Fry UTSW 5 150,356,994 (GRCm39) missense possibly damaging 0.72
R9557:Fry UTSW 5 150,389,781 (GRCm39) missense
R9647:Fry UTSW 5 150,292,984 (GRCm39) missense probably damaging 1.00
R9650:Fry UTSW 5 150,369,375 (GRCm39) missense probably damaging 1.00
R9655:Fry UTSW 5 150,362,251 (GRCm39) missense possibly damaging 0.90
R9664:Fry UTSW 5 150,282,488 (GRCm39) missense probably damaging 0.98
R9668:Fry UTSW 5 150,282,318 (GRCm39) missense probably damaging 1.00
R9732:Fry UTSW 5 150,328,758 (GRCm39) missense probably benign 0.00
R9773:Fry UTSW 5 150,322,728 (GRCm39) missense probably damaging 1.00
Z1177:Fry UTSW 5 150,233,902 (GRCm39) missense possibly damaging 0.80
Predicted Primers PCR Primer
(F):5'- TTTGGGCCAGGAGTAAGCAG -3'
(R):5'- TCCATGTTAGGAGGTCTCTGCG -3'

Sequencing Primer
(F):5'- CCAGGAGTAAGCAGGGCCATAG -3'
(R):5'- AGGAGGTCTCTGCGGTATGAG -3'
Posted On 2016-07-06