Incidental Mutation 'R5234:Or12e10'
ID 398184
Institutional Source Beutler Lab
Gene Symbol Or12e10
Ensembl Gene ENSMUSG00000068814
Gene Name olfactory receptor family 12 subfamily E member 10
Synonyms Olfr1145, GA_x6K02T2Q125-49311440-49312384, MOR264-19
MMRRC Submission 042806-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.057) question?
Stock # R5234 (G1)
Quality Score 225
Status Not validated
Chromosome 2
Chromosomal Location 87640166-87641143 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 87641112 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Alanine at position 316 (V316A)
Ref Sequence ENSEMBL: ENSMUSP00000088209 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000079711] [ENSMUST00000090707]
AlphaFold A2AVC7
Predicted Effect probably benign
Transcript: ENSMUST00000079711
AA Change: V305A

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000078649
Gene: ENSMUSG00000068814
AA Change: V305A

DomainStartEndE-ValueType
Pfam:7tm_4 37 314 3.4e-52 PFAM
Pfam:7tm_1 47 296 1.3e-19 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000090707
AA Change: V316A

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000088209
Gene: ENSMUSG00000068814
AA Change: V316A

DomainStartEndE-ValueType
transmembrane domain 21 38 N/A INTRINSIC
Pfam:7tm_4 48 325 6.2e-58 PFAM
Pfam:7tm_1 58 307 1.5e-19 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000118227
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.1%
  • 20x: 95.1%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 43 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca12 G A 1: 71,302,823 (GRCm39) T2132M probably damaging Het
Abca8b A T 11: 109,867,420 (GRCm39) F213I possibly damaging Het
Acot11 C T 4: 106,617,327 (GRCm39) G240R probably damaging Het
Adamts6 A G 13: 104,630,130 (GRCm39) Y1091C probably damaging Het
Adamtsl4 T C 3: 95,588,230 (GRCm39) M586V probably benign Het
Anapc4 T C 5: 53,006,118 (GRCm39) S336P probably damaging Het
Atp1a4 A T 1: 172,054,737 (GRCm39) I964K possibly damaging Het
Bcan A T 3: 87,903,453 (GRCm39) D246E probably damaging Het
Ccnf G A 17: 24,453,411 (GRCm39) R343* probably null Het
Col6a5 T C 9: 105,741,404 (GRCm39) H2505R probably damaging Het
Dlg5 T A 14: 24,242,930 (GRCm39) M72L probably damaging Het
Dnajc18 T C 18: 35,816,351 (GRCm39) T196A probably benign Het
Dnajc19 T A 3: 34,112,108 (GRCm39) I146F probably benign Het
Espnl A G 1: 91,272,515 (GRCm39) D581G probably benign Het
Fam167a T C 14: 63,689,787 (GRCm39) L28P probably damaging Het
Fra10ac1 T C 19: 38,204,294 (GRCm39) D94G probably damaging Het
Fut8 A G 12: 77,379,004 (GRCm39) H35R probably benign Het
Gad1-ps T A 10: 99,281,188 (GRCm39) noncoding transcript Het
Garin2 T A 12: 78,762,045 (GRCm39) Y236* probably null Het
Idh2 A T 7: 79,745,853 (GRCm39) V333E probably damaging Het
Inpp5f A G 7: 128,265,407 (GRCm39) I121V probably benign Het
Itga1 A T 13: 115,185,839 (GRCm39) Y54* probably null Het
Lax1 A G 1: 133,608,321 (GRCm39) V140A probably benign Het
Ncoa6 A G 2: 155,279,933 (GRCm39) F28L probably benign Het
Or1q1 T C 2: 36,887,107 (GRCm39) V95A probably benign Het
Polr2a T C 11: 69,627,666 (GRCm39) I1414V probably benign Het
Ppp1r14b A G 19: 6,954,227 (GRCm39) E115G possibly damaging Het
Prune2 A G 19: 17,096,032 (GRCm39) D512G probably damaging Het
Psmd11 A G 11: 80,319,566 (GRCm39) I19V probably benign Het
Pthlh C A 6: 147,158,592 (GRCm39) G123W probably damaging Het
Qars1 T A 9: 108,391,364 (GRCm39) L572Q probably damaging Het
Rubcn T C 16: 32,656,828 (GRCm39) I516V probably damaging Het
Sgsm3 A T 15: 80,892,145 (GRCm39) S238C probably damaging Het
Slc25a22 C A 7: 141,014,116 (GRCm39) probably benign Het
Slc4a1 G A 11: 102,252,209 (GRCm39) R5W probably benign Het
Tie1 G A 4: 118,339,959 (GRCm39) T356I probably benign Het
Tnn A T 1: 159,972,569 (GRCm39) H344Q possibly damaging Het
Tnrc6c G T 11: 117,651,555 (GRCm39) V1693F probably benign Het
Topaz1 C T 9: 122,619,258 (GRCm39) T1285M possibly damaging Het
Trank1 A T 9: 111,215,535 (GRCm39) S1822C probably damaging Het
Ttll11 A C 2: 35,830,745 (GRCm39) Y209D probably damaging Het
Unc45a C G 7: 79,978,547 (GRCm39) A634P probably benign Het
Vmn2r4 C T 3: 64,305,878 (GRCm39) V515I possibly damaging Het
Other mutations in Or12e10
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00901:Or12e10 APN 2 87,640,992 (GRCm39) missense probably damaging 1.00
IGL01335:Or12e10 APN 2 87,640,790 (GRCm39) missense probably damaging 1.00
PIT4418001:Or12e10 UTSW 2 87,640,938 (GRCm39) missense probably damaging 0.99
R1512:Or12e10 UTSW 2 87,640,988 (GRCm39) missense probably benign 0.23
R1700:Or12e10 UTSW 2 87,641,112 (GRCm39) missense probably benign
R2127:Or12e10 UTSW 2 87,640,685 (GRCm39) missense probably benign 0.09
R2162:Or12e10 UTSW 2 87,640,704 (GRCm39) missense probably damaging 1.00
R3707:Or12e10 UTSW 2 87,640,520 (GRCm39) missense probably damaging 1.00
R4327:Or12e10 UTSW 2 87,640,496 (GRCm39) missense probably benign 0.00
R4422:Or12e10 UTSW 2 87,640,989 (GRCm39) missense probably damaging 0.97
R4854:Or12e10 UTSW 2 87,640,934 (GRCm39) missense probably damaging 1.00
R5858:Or12e10 UTSW 2 87,640,985 (GRCm39) missense probably benign 0.22
R6229:Or12e10 UTSW 2 87,640,431 (GRCm39) missense probably damaging 1.00
R6991:Or12e10 UTSW 2 87,640,787 (GRCm39) missense possibly damaging 0.76
R7007:Or12e10 UTSW 2 87,640,230 (GRCm39) missense probably damaging 1.00
R7027:Or12e10 UTSW 2 87,641,060 (GRCm39) missense possibly damaging 0.90
R7260:Or12e10 UTSW 2 87,640,731 (GRCm39) missense probably damaging 0.98
R7624:Or12e10 UTSW 2 87,640,683 (GRCm39) missense probably damaging 1.00
R7794:Or12e10 UTSW 2 87,640,818 (GRCm39) missense probably damaging 0.97
R8029:Or12e10 UTSW 2 87,640,376 (GRCm39) missense probably benign 0.00
R8378:Or12e10 UTSW 2 87,640,394 (GRCm39) missense probably damaging 1.00
R8399:Or12e10 UTSW 2 87,640,568 (GRCm39) missense probably damaging 1.00
R8468:Or12e10 UTSW 2 87,641,082 (GRCm39) missense possibly damaging 0.95
R8514:Or12e10 UTSW 2 87,641,054 (GRCm39) missense probably damaging 0.97
R9045:Or12e10 UTSW 2 87,640,416 (GRCm39) missense probably damaging 1.00
R9446:Or12e10 UTSW 2 87,640,199 (GRCm39) missense probably benign 0.26
R9513:Or12e10 UTSW 2 87,640,187 (GRCm39) missense possibly damaging 0.91
R9548:Or12e10 UTSW 2 87,641,097 (GRCm39) missense probably damaging 1.00
R9749:Or12e10 UTSW 2 87,640,202 (GRCm39) missense probably benign 0.05
Z1088:Or12e10 UTSW 2 87,641,090 (GRCm39) missense probably damaging 0.99
Predicted Primers PCR Primer
(F):5'- GCAAAAGCCTTCTCCACTTG -3'
(R):5'- CTCATTGAAGATGAATGACCTTGCC -3'

Sequencing Primer
(F):5'- AAAAGCCTTCTCCACTTGTTCTTC -3'
(R):5'- TGACCTTGCCTAATACTAAGAGGC -3'
Posted On 2016-07-06