Incidental Mutation 'R5235:Acot11'
ID 398284
Institutional Source Beutler Lab
Gene Symbol Acot11
Ensembl Gene ENSMUSG00000034853
Gene Name acyl-CoA thioesterase 11
Synonyms 2010309H15Rik, Thea, 1110020M10Rik, Them1, BFIT1
MMRRC Submission 042807-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.185) question?
Stock # R5235 (G1)
Quality Score 225
Status Not validated
Chromosome 4
Chromosomal Location 106601752-106662195 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to T at 106617327 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Glycine to Arginine at position 240 (G240R)
Ref Sequence ENSEMBL: ENSMUSP00000099823 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000065253] [ENSMUST00000102762] [ENSMUST00000140541] [ENSMUST00000145061] [ENSMUST00000148688] [ENSMUST00000156567]
AlphaFold Q8VHQ9
Predicted Effect probably damaging
Transcript: ENSMUST00000065253
AA Change: G260R

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000069636
Gene: ENSMUSG00000034853
AA Change: G260R

DomainStartEndE-ValueType
Pfam:4HBT 84 157 7e-10 PFAM
Pfam:4HBT 255 331 2.6e-13 PFAM
START 405 603 1.49e-27 SMART
Predicted Effect probably damaging
Transcript: ENSMUST00000102762
AA Change: G240R

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000099823
Gene: ENSMUSG00000034853
AA Change: G240R

DomainStartEndE-ValueType
Pfam:4HBT 64 136 7.2e-10 PFAM
Pfam:4HBT 235 311 6.7e-13 PFAM
START 385 583 1.49e-27 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000140541
SMART Domains Protein: ENSMUSP00000124567
Gene: ENSMUSG00000034853

DomainStartEndE-ValueType
PDB:3B7K|C 32 71 3e-10 PDB
SCOP:d1lo7a_ 37 69 2e-3 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000144809
Predicted Effect probably benign
Transcript: ENSMUST00000145061
SMART Domains Protein: ENSMUSP00000125123
Gene: ENSMUSG00000034853

DomainStartEndE-ValueType
Pfam:4HBT 49 107 4.4e-7 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000148688
SMART Domains Protein: ENSMUSP00000124385
Gene: ENSMUSG00000034853

DomainStartEndE-ValueType
PDB:3B7K|C 28 93 6e-23 PDB
SCOP:d1lo7a_ 33 93 5e-4 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000156567
SMART Domains Protein: ENSMUSP00000123942
Gene: ENSMUSG00000034853

DomainStartEndE-ValueType
PDB:3B7K|C 43 89 8e-11 PDB
SCOP:d1lo7a_ 48 80 2e-3 SMART
Meta Mutation Damage Score 0.9500 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.2%
  • 20x: 95.3%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the acyl-CoA thioesterase family which catalyse the conversion of activated fatty acids to the corresponding non-esterified fatty acid and coenzyme A. Expression of a mouse homolog in brown adipose tissue is induced by low temperatures and repressed by warm temperatures. Higher levels of expression of the mouse homolog has been found in obesity-resistant mice compared with obesity-prone mice, suggesting a role of acyl-CoA thioesterase 11 in obesity. Alternative splicing results in transcript variants. [provided by RefSeq, Nov 2010]
PHENOTYPE: Mice homozygous for a null mutation display resistance to high fat diet induced obesity, inflammation and hepatic steatosis, increased energy expenditure, increased brown adipose tissue amount, and increased food intake. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 38 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2610021A01Rik C A 7: 41,274,256 (GRCm39) H126Q possibly damaging Het
Aga A G 8: 53,967,361 (GRCm39) H124R probably damaging Het
Ank1 G A 8: 23,572,212 (GRCm39) G49R probably damaging Het
Aox1 G T 1: 58,096,714 (GRCm39) V270L possibly damaging Het
Arfrp1 T C 2: 181,001,298 (GRCm39) H145R probably benign Het
Atg14 G A 14: 47,805,656 (GRCm39) R70C probably damaging Het
Atg3 A G 16: 44,979,520 (GRCm39) T20A probably benign Het
C3ar1 A G 6: 122,827,881 (GRCm39) L112P probably damaging Het
Clip2 G A 5: 134,551,645 (GRCm39) T159M possibly damaging Het
Csmd3 T C 15: 47,492,674 (GRCm39) T3156A probably benign Het
Dag1 T C 9: 108,084,897 (GRCm39) Y748C probably damaging Het
Dek A T 13: 47,239,955 (GRCm39) probably null Het
Fras1 G A 5: 96,748,609 (GRCm39) V695M probably benign Het
Gpx7 A G 4: 108,258,189 (GRCm39) S135P probably damaging Het
Ido2 A T 8: 25,037,202 (GRCm39) I168N probably damaging Het
Lca5 A T 9: 83,305,107 (GRCm39) L233* probably null Het
Liph A C 16: 21,802,785 (GRCm39) L95V probably damaging Het
Mast1 A T 8: 85,640,068 (GRCm39) L1113Q probably damaging Het
Nlrx1 C T 9: 44,175,047 (GRCm39) G243D probably damaging Het
Or4ac1-ps1 G A 2: 88,370,769 (GRCm39) noncoding transcript Het
Or5d40 T A 2: 88,015,912 (GRCm39) D230E probably benign Het
Otoa T C 7: 120,755,693 (GRCm39) L1033P probably damaging Het
Ovol3 A T 7: 29,932,899 (GRCm39) Y179N possibly damaging Het
Papss2 A G 19: 32,616,619 (GRCm39) N215S probably benign Het
Pcdhga8 T C 18: 37,860,488 (GRCm39) Y515H probably damaging Het
Phlda1 CCAGCCCCAACCTCAGCCCCAACCTCAGCCCCAACC CCAGCCCCAACCTCAGCCCCAACC 10: 111,343,252 (GRCm39) probably benign Het
Scn2a A T 2: 65,582,355 (GRCm39) N1568Y probably damaging Het
Sec16b A T 1: 157,362,334 (GRCm39) I251F probably benign Het
Slc29a4 T A 5: 142,704,523 (GRCm39) I355N probably damaging Het
Snx29 G T 16: 11,231,110 (GRCm39) C39F possibly damaging Het
Spata16 A G 3: 26,721,781 (GRCm39) M101V probably benign Het
Stat2 T C 10: 128,126,901 (GRCm39) probably null Het
Tdpoz8 A G 3: 92,981,393 (GRCm39) D137G probably damaging Het
Tnrc6c G T 11: 117,651,555 (GRCm39) V1693F probably benign Het
Tpm3 A G 3: 89,993,802 (GRCm39) E97G probably damaging Het
Ugt8a A C 3: 125,661,129 (GRCm39) H454Q probably damaging Het
Vmn2r27 T A 6: 124,169,013 (GRCm39) I706L probably damaging Het
Wdfy3 T C 5: 101,994,972 (GRCm39) I3256V probably null Het
Other mutations in Acot11
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01330:Acot11 APN 4 106,628,681 (GRCm39) missense probably benign 0.00
IGL01896:Acot11 APN 4 106,628,564 (GRCm39) missense probably damaging 1.00
IGL02408:Acot11 APN 4 106,615,578 (GRCm39) missense probably damaging 1.00
IGL03053:Acot11 APN 4 106,613,050 (GRCm39) nonsense probably null
IGL03156:Acot11 APN 4 106,611,333 (GRCm39) missense probably damaging 1.00
R0266:Acot11 UTSW 4 106,607,185 (GRCm39) missense probably damaging 0.99
R0485:Acot11 UTSW 4 106,619,224 (GRCm39) missense probably damaging 1.00
R0537:Acot11 UTSW 4 106,619,652 (GRCm39) missense probably benign 0.10
R0707:Acot11 UTSW 4 106,617,329 (GRCm39) missense probably damaging 1.00
R0969:Acot11 UTSW 4 106,617,277 (GRCm39) critical splice donor site probably null
R1109:Acot11 UTSW 4 106,606,545 (GRCm39) missense probably benign 0.01
R1785:Acot11 UTSW 4 106,619,232 (GRCm39) missense probably damaging 1.00
R1786:Acot11 UTSW 4 106,619,232 (GRCm39) missense probably damaging 1.00
R1965:Acot11 UTSW 4 106,606,550 (GRCm39) missense probably damaging 1.00
R2076:Acot11 UTSW 4 106,627,910 (GRCm39) missense probably damaging 0.99
R2509:Acot11 UTSW 4 106,612,516 (GRCm39) missense possibly damaging 0.90
R4558:Acot11 UTSW 4 106,605,563 (GRCm39) missense probably damaging 1.00
R4565:Acot11 UTSW 4 106,617,327 (GRCm39) missense probably damaging 1.00
R4567:Acot11 UTSW 4 106,617,327 (GRCm39) missense probably damaging 1.00
R4847:Acot11 UTSW 4 106,617,327 (GRCm39) missense probably damaging 1.00
R4881:Acot11 UTSW 4 106,612,502 (GRCm39) critical splice donor site probably null
R5234:Acot11 UTSW 4 106,617,327 (GRCm39) missense probably damaging 1.00
R5409:Acot11 UTSW 4 106,617,327 (GRCm39) missense probably damaging 1.00
R5430:Acot11 UTSW 4 106,617,327 (GRCm39) missense probably damaging 1.00
R5518:Acot11 UTSW 4 106,607,207 (GRCm39) missense probably benign 0.24
R5763:Acot11 UTSW 4 106,617,327 (GRCm39) missense probably damaging 1.00
R5787:Acot11 UTSW 4 106,617,327 (GRCm39) missense probably damaging 1.00
R5788:Acot11 UTSW 4 106,617,327 (GRCm39) missense probably damaging 1.00
R5933:Acot11 UTSW 4 106,617,327 (GRCm39) missense probably damaging 1.00
R5934:Acot11 UTSW 4 106,617,327 (GRCm39) missense probably damaging 1.00
R6093:Acot11 UTSW 4 106,617,327 (GRCm39) missense probably damaging 1.00
R6104:Acot11 UTSW 4 106,613,094 (GRCm39) missense probably damaging 1.00
R6726:Acot11 UTSW 4 106,617,327 (GRCm39) missense probably damaging 1.00
R6727:Acot11 UTSW 4 106,617,327 (GRCm39) missense probably damaging 1.00
R6728:Acot11 UTSW 4 106,617,327 (GRCm39) missense probably damaging 1.00
R6734:Acot11 UTSW 4 106,617,327 (GRCm39) missense probably damaging 1.00
R7242:Acot11 UTSW 4 106,619,690 (GRCm39) missense probably benign 0.00
R7257:Acot11 UTSW 4 106,615,599 (GRCm39) missense probably damaging 1.00
R7360:Acot11 UTSW 4 106,606,548 (GRCm39) missense possibly damaging 0.94
R8125:Acot11 UTSW 4 106,617,277 (GRCm39) critical splice donor site probably null
R8393:Acot11 UTSW 4 106,617,390 (GRCm39) missense probably benign 0.23
R9020:Acot11 UTSW 4 106,605,615 (GRCm39) missense probably damaging 1.00
R9404:Acot11 UTSW 4 106,615,509 (GRCm39) missense possibly damaging 0.61
R9633:Acot11 UTSW 4 106,613,178 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- TAGGGTTCTCCTAGCAGAGCAC -3'
(R):5'- AACGTTTCAGGGTATGGAGG -3'

Sequencing Primer
(F):5'- GTTCTCCTAGCAGAGCACCCAAG -3'
(R):5'- GTGTCATTGTCCCAGGGC -3'
Posted On 2016-07-06