Incidental Mutation 'R0454:Pld1'
| ID |
39842 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Pld1
|
| Ensembl Gene |
ENSMUSG00000027695 |
| Gene Name |
phospholipase D1 |
| Synonyms |
Pld1a, Pld1b |
| MMRRC Submission |
038654-MU
|
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
R0454 (G1)
|
| Quality Score |
225 |
|
Status
|
Not validated
|
| Chromosome |
3 |
| Chromosomal Location |
27992844-28187511 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to C
at 28178724 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Serine to Proline
at position 873
(S873P)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000113810
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000067757]
[ENSMUST00000120834]
[ENSMUST00000123539]
|
| AlphaFold |
no structure available at present |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000067757
AA Change: S873P
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000064694
Gene: ENSMUSG00000027695
AA Change: S873P
| Domain | Start | End | E-Value | Type |
|---|
|
PX
|
79 |
209 |
7.97e-25 |
SMART |
|
PH
|
220 |
330 |
5.71e-9 |
SMART |
|
PLDc
|
459 |
486 |
6.6e-6 |
SMART |
|
low complexity region
|
503 |
517 |
N/A |
INTRINSIC |
|
low complexity region
|
575 |
589 |
N/A |
INTRINSIC |
|
PLDc
|
853 |
880 |
1.34e-6 |
SMART |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000120834
AA Change: S873P
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000113810
Gene: ENSMUSG00000027695
AA Change: S873P
| Domain | Start | End | E-Value | Type |
|---|
|
PX
|
79 |
209 |
7.97e-25 |
SMART |
|
PH
|
220 |
330 |
5.71e-9 |
SMART |
|
PLDc
|
459 |
486 |
6.6e-6 |
SMART |
|
low complexity region
|
503 |
517 |
N/A |
INTRINSIC |
|
low complexity region
|
575 |
589 |
N/A |
INTRINSIC |
|
PLDc
|
853 |
880 |
1.34e-6 |
SMART |
|
| Predicted Effect |
unknown
Transcript: ENSMUST00000123539
AA Change: S911P
|
| SMART Domains |
Protein: ENSMUSP00000118727
Gene: ENSMUSG00000027695
AA Change: S911P
| Domain | Start | End | E-Value | Type |
|---|
|
PX
|
79 |
209 |
7.97e-25 |
SMART |
|
PH
|
220 |
330 |
5.71e-9 |
SMART |
|
PLDc
|
459 |
486 |
6.6e-6 |
SMART |
|
low complexity region
|
503 |
517 |
N/A |
INTRINSIC |
|
low complexity region
|
575 |
586 |
N/A |
INTRINSIC |
|
| Predicted Effect |
unknown
Transcript: ENSMUST00000126594
AA Change: S93P
|
| SMART Domains |
Protein: ENSMUSP00000121569
Gene: ENSMUSG00000027695
AA Change: S93P
| Domain | Start | End | E-Value | Type |
|---|
|
PLDc
|
74 |
101 |
1.34e-6 |
SMART |
|
| Predicted Effect |
unknown
Transcript: ENSMUST00000148827
AA Change: S707P
|
| SMART Domains |
Protein: ENSMUSP00000120273
Gene: ENSMUSG00000027695
AA Change: S707P
| Domain | Start | End | E-Value | Type |
|---|
|
PH
|
32 |
142 |
5.71e-9 |
SMART |
|
PLDc
|
271 |
298 |
6.6e-6 |
SMART |
|
low complexity region
|
315 |
329 |
N/A |
INTRINSIC |
|
low complexity region
|
387 |
401 |
N/A |
INTRINSIC |
|
PLDc
|
665 |
715 |
2.5e1 |
SMART |
|
| Coding Region Coverage |
- 1x: 99.2%
- 3x: 98.4%
- 10x: 96.6%
- 20x: 93.8%
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a phosphatidylcholine-specific phospholipase which catalyzes the hydrolysis of phosphatidylcholine in order to yield phosphatidic acid and choline. The enzyme may play a role in signal transduction and subcellular trafficking. Alternative splicing results in multiple transcript variants with both catalytic and regulatory properties. [provided by RefSeq, Sep 2011]
PHENOTYPE: Homozygotes for a null allele show reduced tumor growth and angiogenesis. Homozygotes for a second null allele show abnormal hepatic autophagy after food restriction. Homozygotes for a third null allele show altered platelet activation and protection from thrombosis and ischemic brain injury. [provided by MGI curators]
|
| Allele List at MGI |
All alleles(3) : Targeted, other(2) Gene trapped(1) |
| Other mutations in this stock |
Total: 93 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 4930447F04Rik |
T |
C |
X: 65,347,274 (GRCm39) |
E91G |
unknown |
Het |
| Acot1 |
A |
G |
12: 84,064,113 (GRCm39) |
Q407R |
probably benign |
Het |
| Adcy10 |
T |
A |
1: 165,398,297 (GRCm39) |
Y1465N |
probably damaging |
Het |
| Ahsa2 |
T |
A |
11: 23,440,702 (GRCm39) |
I249F |
probably damaging |
Het |
| Arhgap10 |
T |
C |
8: 77,977,594 (GRCm39) |
N721S |
probably damaging |
Het |
| Arrdc4 |
T |
G |
7: 68,391,619 (GRCm39) |
E216A |
probably damaging |
Het |
| Axin1 |
T |
C |
17: 26,392,637 (GRCm39) |
V306A |
probably benign |
Het |
| Cct3 |
T |
C |
3: 88,210,173 (GRCm39) |
|
probably null |
Het |
| Cfap58 |
G |
A |
19: 47,963,119 (GRCm39) |
|
probably null |
Het |
| Chd9 |
T |
C |
8: 91,699,859 (GRCm39) |
S49P |
possibly damaging |
Het |
| Clcn2 |
C |
A |
16: 20,529,178 (GRCm39) |
|
probably null |
Het |
| Col26a1 |
T |
C |
5: 136,783,047 (GRCm39) |
N286D |
probably benign |
Het |
| Cpt1b |
T |
A |
15: 89,308,596 (GRCm39) |
I111F |
possibly damaging |
Het |
| Cyp4f16 |
T |
A |
17: 32,756,061 (GRCm39) |
I30N |
probably damaging |
Het |
| Ddc |
T |
G |
11: 11,830,587 (GRCm39) |
D19A |
possibly damaging |
Het |
| Depdc1a |
T |
A |
3: 159,222,537 (GRCm39) |
|
probably null |
Het |
| Evc2 |
T |
A |
5: 37,574,828 (GRCm39) |
C1028S |
possibly damaging |
Het |
| Fam228a |
T |
C |
12: 4,781,457 (GRCm39) |
E134G |
probably damaging |
Het |
| Fasl |
T |
C |
1: 161,615,523 (GRCm39) |
E111G |
probably benign |
Het |
| Fbxw10 |
A |
G |
11: 62,767,564 (GRCm39) |
N800S |
possibly damaging |
Het |
| Fras1 |
T |
C |
5: 96,910,524 (GRCm39) |
S3318P |
probably damaging |
Het |
| G3bp1 |
T |
C |
11: 55,389,452 (GRCm39) |
F383L |
probably damaging |
Het |
| Gad1 |
T |
A |
2: 70,409,545 (GRCm39) |
M212K |
probably damaging |
Het |
| Gm17455 |
T |
G |
10: 60,238,752 (GRCm39) |
S6A |
probably benign |
Het |
| Grm5 |
T |
C |
7: 87,779,997 (GRCm39) |
S1146P |
probably damaging |
Het |
| Gsn |
T |
C |
2: 35,194,651 (GRCm39) |
L649P |
probably damaging |
Het |
| H2-DMb1 |
A |
G |
17: 34,374,685 (GRCm39) |
T112A |
probably benign |
Het |
| Hcn3 |
T |
A |
3: 89,060,201 (GRCm39) |
I148F |
probably damaging |
Het |
| Hdac10 |
T |
C |
15: 89,009,961 (GRCm39) |
|
probably null |
Het |
| Hk3 |
C |
A |
13: 55,156,518 (GRCm39) |
D619Y |
probably damaging |
Het |
| Ifi44 |
T |
A |
3: 151,451,134 (GRCm39) |
R272S |
possibly damaging |
Het |
| Il1rap |
A |
C |
16: 26,517,625 (GRCm39) |
D275A |
probably damaging |
Het |
| Irag2 |
A |
G |
6: 145,113,710 (GRCm39) |
R293G |
possibly damaging |
Het |
| Itgam |
A |
T |
7: 127,707,152 (GRCm39) |
N660I |
probably benign |
Het |
| Itpr3 |
T |
C |
17: 27,332,793 (GRCm39) |
M1853T |
probably benign |
Het |
| Lrrc8c |
A |
C |
5: 105,754,965 (GRCm39) |
K247Q |
probably damaging |
Het |
| Map3k21 |
T |
C |
8: 126,668,858 (GRCm39) |
S815P |
probably benign |
Het |
| Mast4 |
A |
G |
13: 102,888,068 (GRCm39) |
S1114P |
probably damaging |
Het |
| Myh8 |
C |
T |
11: 67,194,591 (GRCm39) |
Q1601* |
probably null |
Het |
| Nhlrc2 |
A |
G |
19: 56,558,959 (GRCm39) |
D148G |
probably damaging |
Het |
| Nos1 |
T |
A |
5: 118,081,385 (GRCm39) |
S1196T |
probably benign |
Het |
| Nsmaf |
C |
T |
4: 6,424,874 (GRCm39) |
|
probably null |
Het |
| Obscn |
T |
C |
11: 58,890,449 (GRCm39) |
D7361G |
unknown |
Het |
| Or2t35 |
T |
C |
14: 14,407,777 (GRCm38) |
V183A |
probably damaging |
Het |
| Or52ad1 |
C |
A |
7: 102,996,085 (GRCm39) |
A17S |
probably benign |
Het |
| Or5bw2 |
C |
T |
7: 6,573,359 (GRCm39) |
A123V |
probably damaging |
Het |
| Pank3 |
T |
G |
11: 35,668,536 (GRCm39) |
M175R |
probably benign |
Het |
| Papolg |
A |
G |
11: 23,829,868 (GRCm39) |
|
probably null |
Het |
| Pcdhb21 |
G |
A |
18: 37,647,566 (GRCm39) |
D232N |
probably damaging |
Het |
| Pcdhb22 |
T |
C |
18: 37,651,925 (GRCm39) |
F131S |
probably damaging |
Het |
| Pik3r6 |
G |
A |
11: 68,419,608 (GRCm39) |
A140T |
possibly damaging |
Het |
| Pinlyp |
T |
C |
7: 24,241,947 (GRCm39) |
T87A |
possibly damaging |
Het |
| Pld5 |
T |
A |
1: 176,102,295 (GRCm39) |
Y49F |
probably benign |
Het |
| Polq |
T |
C |
16: 36,855,252 (GRCm39) |
V449A |
probably damaging |
Het |
| Prkca |
A |
G |
11: 107,869,106 (GRCm39) |
V69A |
probably benign |
Het |
| Ptk6 |
A |
G |
2: 180,844,075 (GRCm39) |
S75P |
possibly damaging |
Het |
| Ptprq |
G |
A |
10: 107,418,391 (GRCm39) |
Q1662* |
probably null |
Het |
| Ptprt |
C |
A |
2: 161,395,742 (GRCm39) |
A1144S |
probably damaging |
Het |
| Rrm1 |
T |
A |
7: 102,116,133 (GRCm39) |
W684R |
probably damaging |
Het |
| Ryr1 |
T |
A |
7: 28,735,500 (GRCm39) |
M4093L |
probably damaging |
Het |
| Scnn1a |
C |
T |
6: 125,299,189 (GRCm39) |
L90F |
probably damaging |
Het |
| Slc25a19 |
G |
T |
11: 115,508,423 (GRCm39) |
Y188* |
probably null |
Het |
| Slc31a1 |
C |
T |
4: 62,303,866 (GRCm39) |
|
probably benign |
Het |
| Slc5a11 |
C |
G |
7: 122,864,458 (GRCm39) |
S351R |
possibly damaging |
Het |
| Slc6a17 |
A |
G |
3: 107,384,183 (GRCm39) |
L387P |
probably benign |
Het |
| Slitrk6 |
A |
T |
14: 110,987,364 (GRCm39) |
L781H |
probably damaging |
Het |
| Spam1 |
T |
A |
6: 24,797,837 (GRCm39) |
L331Q |
probably damaging |
Het |
| Spata32 |
A |
G |
11: 103,100,125 (GRCm39) |
W127R |
probably damaging |
Het |
| Spring1 |
A |
G |
5: 118,393,886 (GRCm39) |
E88G |
possibly damaging |
Het |
| Spta1 |
T |
G |
1: 174,041,508 (GRCm39) |
I1324S |
probably damaging |
Het |
| St6galnac4 |
A |
G |
2: 32,484,330 (GRCm39) |
Y176C |
probably damaging |
Het |
| Stk10 |
A |
G |
11: 32,546,724 (GRCm39) |
E327G |
probably damaging |
Het |
| Stxbp5l |
T |
A |
16: 36,954,646 (GRCm39) |
Y912F |
possibly damaging |
Het |
| Tchp |
G |
A |
5: 114,858,243 (GRCm39) |
E459K |
probably benign |
Het |
| Terf2 |
C |
T |
8: 107,822,842 (GRCm39) |
W100* |
probably null |
Het |
| Thoc2l |
T |
G |
5: 104,666,077 (GRCm39) |
S200A |
probably benign |
Het |
| Thrsp |
T |
C |
7: 97,066,634 (GRCm39) |
N26S |
probably damaging |
Het |
| Tln1 |
C |
A |
4: 43,553,504 (GRCm39) |
R297L |
probably benign |
Het |
| Tmeff2 |
C |
A |
1: 50,967,234 (GRCm39) |
T43N |
possibly damaging |
Het |
| Tmx1 |
C |
T |
12: 70,499,947 (GRCm39) |
A2V |
possibly damaging |
Het |
| Tnks1bp1 |
T |
A |
2: 84,902,481 (GRCm39) |
L1053Q |
probably damaging |
Het |
| Trmt10b |
A |
T |
4: 45,304,286 (GRCm39) |
K107N |
probably damaging |
Het |
| Trpa1 |
A |
T |
1: 14,955,972 (GRCm39) |
|
probably null |
Het |
| Trrap |
A |
G |
5: 144,783,287 (GRCm39) |
K3371R |
probably damaging |
Het |
| Tuba3b |
G |
A |
6: 145,563,995 (GRCm39) |
V14I |
probably benign |
Het |
| Usp19 |
T |
C |
9: 108,371,439 (GRCm39) |
|
probably null |
Het |
| Usp28 |
C |
A |
9: 48,950,401 (GRCm39) |
D615E |
possibly damaging |
Het |
| Utp20 |
T |
C |
10: 88,657,931 (GRCm39) |
D43G |
probably benign |
Het |
| Vmn1r58 |
T |
G |
7: 5,413,997 (GRCm39) |
K78Q |
possibly damaging |
Het |
| Vmn2r10 |
T |
C |
5: 109,151,327 (GRCm39) |
M96V |
probably benign |
Het |
| Wdr90 |
T |
C |
17: 26,079,023 (GRCm39) |
E273G |
probably damaging |
Het |
| Xpc |
C |
T |
6: 91,468,208 (GRCm39) |
A860T |
probably benign |
Het |
| Zscan21 |
T |
C |
5: 138,131,865 (GRCm39) |
I463T |
possibly damaging |
Het |
|
| Other mutations in Pld1 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00944:Pld1
|
APN |
3 |
28,099,247 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL01090:Pld1
|
APN |
3 |
28,142,816 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL01140:Pld1
|
APN |
3 |
28,132,386 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL01646:Pld1
|
APN |
3 |
28,153,813 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01830:Pld1
|
APN |
3 |
28,102,153 (GRCm39) |
splice site |
probably benign |
|
|
IGL01946:Pld1
|
APN |
3 |
28,178,766 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02139:Pld1
|
APN |
3 |
28,174,961 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL02189:Pld1
|
APN |
3 |
28,174,932 (GRCm39) |
missense |
probably benign |
0.03 |
|
IGL02476:Pld1
|
APN |
3 |
28,102,188 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02540:Pld1
|
APN |
3 |
28,083,309 (GRCm39) |
unclassified |
probably benign |
|
|
IGL02649:Pld1
|
APN |
3 |
28,141,378 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL02720:Pld1
|
APN |
3 |
28,141,411 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02831:Pld1
|
APN |
3 |
28,130,574 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL02953:Pld1
|
APN |
3 |
28,166,396 (GRCm39) |
missense |
probably benign |
0.03 |
|
IGL03005:Pld1
|
APN |
3 |
28,141,402 (GRCm39) |
missense |
possibly damaging |
0.78 |
|
IGL03251:Pld1
|
APN |
3 |
28,142,814 (GRCm39) |
missense |
probably benign |
0.06 |
|
IGL03331:Pld1
|
APN |
3 |
28,139,994 (GRCm39) |
missense |
probably damaging |
1.00 |
|
A9681:Pld1
|
UTSW |
3 |
28,139,981 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL03134:Pld1
|
UTSW |
3 |
28,083,316 (GRCm39) |
missense |
probably benign |
0.01 |
|
P0023:Pld1
|
UTSW |
3 |
28,102,274 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0054:Pld1
|
UTSW |
3 |
28,150,033 (GRCm39) |
splice site |
probably benign |
|
|
R0054:Pld1
|
UTSW |
3 |
28,150,033 (GRCm39) |
splice site |
probably benign |
|
|
R0282:Pld1
|
UTSW |
3 |
28,132,422 (GRCm39) |
missense |
probably benign |
|
|
R0372:Pld1
|
UTSW |
3 |
28,142,787 (GRCm39) |
splice site |
probably null |
|
|
R0492:Pld1
|
UTSW |
3 |
28,163,966 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R0505:Pld1
|
UTSW |
3 |
28,174,971 (GRCm39) |
missense |
possibly damaging |
0.69 |
|
R0667:Pld1
|
UTSW |
3 |
28,133,327 (GRCm39) |
splice site |
probably null |
|
|
R0678:Pld1
|
UTSW |
3 |
28,174,933 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0980:Pld1
|
UTSW |
3 |
28,178,724 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1200:Pld1
|
UTSW |
3 |
28,103,435 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1235:Pld1
|
UTSW |
3 |
28,082,883 (GRCm39) |
missense |
probably benign |
0.05 |
|
R1657:Pld1
|
UTSW |
3 |
28,125,336 (GRCm39) |
missense |
probably benign |
0.04 |
|
R1670:Pld1
|
UTSW |
3 |
28,103,389 (GRCm39) |
missense |
probably benign |
0.17 |
|
R1705:Pld1
|
UTSW |
3 |
28,125,426 (GRCm39) |
critical splice donor site |
probably null |
|
|
R1815:Pld1
|
UTSW |
3 |
28,163,917 (GRCm39) |
missense |
probably benign |
0.04 |
|
R2215:Pld1
|
UTSW |
3 |
28,132,542 (GRCm39) |
missense |
probably benign |
0.16 |
|
R3435:Pld1
|
UTSW |
3 |
28,178,772 (GRCm39) |
missense |
probably benign |
0.13 |
|
R3522:Pld1
|
UTSW |
3 |
28,085,396 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4206:Pld1
|
UTSW |
3 |
28,174,932 (GRCm39) |
missense |
probably benign |
0.03 |
|
R4553:Pld1
|
UTSW |
3 |
28,178,851 (GRCm39) |
missense |
probably benign |
|
|
R4612:Pld1
|
UTSW |
3 |
28,185,882 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R4623:Pld1
|
UTSW |
3 |
28,083,393 (GRCm39) |
missense |
probably benign |
0.01 |
|
R4840:Pld1
|
UTSW |
3 |
28,130,700 (GRCm39) |
missense |
probably benign |
0.10 |
|
R4869:Pld1
|
UTSW |
3 |
28,163,951 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
R4982:Pld1
|
UTSW |
3 |
28,085,447 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R5087:Pld1
|
UTSW |
3 |
28,178,731 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5182:Pld1
|
UTSW |
3 |
28,099,230 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5384:Pld1
|
UTSW |
3 |
28,079,469 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6243:Pld1
|
UTSW |
3 |
28,149,954 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R6345:Pld1
|
UTSW |
3 |
28,184,896 (GRCm39) |
intron |
probably benign |
|
|
R6692:Pld1
|
UTSW |
3 |
28,095,348 (GRCm39) |
missense |
probably benign |
0.15 |
|
R6881:Pld1
|
UTSW |
3 |
28,132,563 (GRCm39) |
missense |
possibly damaging |
0.77 |
|
R7197:Pld1
|
UTSW |
3 |
28,078,401 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7267:Pld1
|
UTSW |
3 |
28,130,550 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7284:Pld1
|
UTSW |
3 |
28,185,882 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R7293:Pld1
|
UTSW |
3 |
28,141,435 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7440:Pld1
|
UTSW |
3 |
28,095,419 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7524:Pld1
|
UTSW |
3 |
28,078,470 (GRCm39) |
missense |
possibly damaging |
0.77 |
|
R7747:Pld1
|
UTSW |
3 |
28,141,338 (GRCm39) |
missense |
possibly damaging |
0.66 |
|
R7882:Pld1
|
UTSW |
3 |
28,099,158 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7936:Pld1
|
UTSW |
3 |
28,130,651 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8033:Pld1
|
UTSW |
3 |
28,083,359 (GRCm39) |
missense |
probably benign |
0.02 |
|
R8269:Pld1
|
UTSW |
3 |
28,079,388 (GRCm39) |
missense |
probably benign |
0.17 |
|
R8316:Pld1
|
UTSW |
3 |
28,078,361 (GRCm39) |
missense |
probably benign |
|
|
R8427:Pld1
|
UTSW |
3 |
28,142,795 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R8523:Pld1
|
UTSW |
3 |
28,140,025 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8832:Pld1
|
UTSW |
3 |
28,177,846 (GRCm39) |
missense |
|
|
|
R8850:Pld1
|
UTSW |
3 |
28,166,439 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R9143:Pld1
|
UTSW |
3 |
28,132,643 (GRCm39) |
intron |
probably benign |
|
|
R9549:Pld1
|
UTSW |
3 |
28,125,381 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R9648:Pld1
|
UTSW |
3 |
28,174,900 (GRCm39) |
missense |
probably damaging |
0.99 |
|
Z1088:Pld1
|
UTSW |
3 |
28,083,392 (GRCm39) |
missense |
probably benign |
|
|
Z1176:Pld1
|
UTSW |
3 |
28,185,726 (GRCm39) |
nonsense |
probably null |
|
|
Z1176:Pld1
|
UTSW |
3 |
28,130,682 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- TCAATTGTGTGTCCTGCACAGCC -3'
(R):5'- CTGAGCCCCTGCTCTGTGAAAC -3'
Sequencing Primer
(F):5'- ggtccagaaccatgccag -3'
(R):5'- CCCTGCTCTGTGAAACTAATAATAC -3'
|
| Posted On |
2013-05-23 |
Incidental Mutation